CL2021000739A1 - Moléculas de unión a antígeno capaces de unirse al cúmulo de diferenciación 3 (cd3) y al cúmulo de diferenciación 137 (cd137) pero no simultáneamente - Google Patents

Moléculas de unión a antígeno capaces de unirse al cúmulo de diferenciación 3 (cd3) y al cúmulo de diferenciación 137 (cd137) pero no simultáneamente

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Publication number
CL2021000739A1
CL2021000739A1 CL2021000739A CL2021000739A CL2021000739A1 CL 2021000739 A1 CL2021000739 A1 CL 2021000739A1 CL 2021000739 A CL2021000739 A CL 2021000739A CL 2021000739 A CL2021000739 A CL 2021000739A CL 2021000739 A1 CL2021000739 A1 CL 2021000739A1
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CL
Chile
Prior art keywords
antigen
binding
differentiation
cluster
binding molecules
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CL2021000739A
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English (en)
Inventor
Shu Wen Samantha Ho
Shu Feng
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Chugai Pharmaceutical Co Ltd
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Publication of CL2021000739A1 publication Critical patent/CL2021000739A1/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

La presente invención se refiere a moléculas de unión a antígeno que se unen a CD3 y CD137 (4-1BB); a composiciones que comprenden la molécula de unión a antígeno; y a métodos de uso de los mismos. La presente invención proporciona moléculas de unión a antígeno que comprenden: una región variable de anticuerpo que es capaz de unirse a CD3 y CD137 (4-1BB), pero no se une a CD3 y CD137 al mismo tiempo; y una región variable que se une a un tercer antígeno diferente de CD3 y CD137. Tales moléculas de unión a antígeno exhiben una actividad de citotoxicidad dependiente de células T mejorada inducida por estas moléculas de unión a antígeno a través de la unión a los tres antígenos diferentes.
CL2021000739A 2018-09-28 2021-03-25 Moléculas de unión a antígeno capaces de unirse al cúmulo de diferenciación 3 (cd3) y al cúmulo de diferenciación 137 (cd137) pero no simultáneamente CL2021000739A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018185120 2018-09-28
JP2019104308 2019-06-04

Publications (1)

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CL2021000739A1 true CL2021000739A1 (es) 2021-09-24

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ID=69950671

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CL2021000739A CL2021000739A1 (es) 2018-09-28 2021-03-25 Moléculas de unión a antígeno capaces de unirse al cúmulo de diferenciación 3 (cd3) y al cúmulo de diferenciación 137 (cd137) pero no simultáneamente

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US (1) US20210388087A1 (es)
EP (1) EP3856785A4 (es)
JP (1) JP2022502010A (es)
KR (1) KR20210068079A (es)
CN (1) CN113166247A (es)
AU (1) AU2019347412A1 (es)
BR (1) BR112021005722A2 (es)
CA (1) CA3114154A1 (es)
CL (1) CL2021000739A1 (es)
CO (1) CO2021005528A2 (es)
CR (1) CR20210199A (es)
IL (1) IL281787A (es)
MA (1) MA53742A (es)
MX (1) MX2021003608A (es)
PE (1) PE20211072A1 (es)
PH (1) PH12021550662A1 (es)
SG (1) SG11202101912UA (es)
TW (1) TW202028238A (es)
WO (1) WO2020067419A1 (es)

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JP6628966B2 (ja) 2012-06-14 2020-01-15 中外製薬株式会社 改変されたＦｃ領域を含む抗原結合分子
CN113307873A (zh) 2013-11-11 2021-08-27 中外制药株式会社 含有改变了抗体可变区的抗原结合分子
TWI831044B (zh) 2014-11-11 2024-02-01 日商中外製藥股份有限公司 抗原結合分子、包含抗原結合分子的醫藥組合物以及製造及選擇抗原結合分子之方法
US11952422B2 (en) 2017-12-05 2024-04-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
US11667713B2 (en) 2017-12-28 2023-06-06 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
BR112022017526A2 (pt) * 2020-03-31 2022-10-18 Chugai Pharmaceutical Co Ltd Método para produzir moléculas de ligação de antígeno multiespecíficas
CN115315447A (zh) * 2020-03-31 2022-11-08 中外制药株式会社 免疫激活多特异性抗原结合分子及其用途
CN115397866A (zh) 2020-03-31 2022-11-25 中外制药株式会社 靶向dll3的多特异性抗原结合分子及其用途
CN115960242B (zh) * 2021-09-09 2023-10-17 广东东阳光药业股份有限公司 抗癌结合分子及其应用
WO2023053272A1 (en) * 2021-09-29 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Uses of dll3-targeting multispecific antigen-binding molecules
JP7470760B2 (ja) * 2021-09-29 2024-04-18 中外製薬株式会社 がんの治療に用いるための細胞傷害誘導治療剤
WO2023053282A1 (ja) * 2021-09-29 2023-04-06 中外製薬株式会社 がんの治療に用いるための細胞傷害誘導治療剤

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ES2694002T3 (es) 1999-01-15 2018-12-17 Genentech, Inc. Polipéptido que comprende una región Fc de IgG1 humana variante
EP2471813B1 (en) 2004-07-15 2014-12-31 Xencor, Inc. Optimized Fc variants
WO2014116846A2 (en) 2013-01-23 2014-07-31 Abbvie, Inc. Methods and compositions for modulating an immune response
CN113307873A (zh) * 2013-11-11 2021-08-27 中外制药株式会社 含有改变了抗体可变区的抗原结合分子
TWI726842B (zh) 2014-04-07 2021-05-11 日商中外製藥股份有限公司 免疫活化抗原結合分子
TWI831044B (zh) * 2014-11-11 2024-02-01 日商中外製藥股份有限公司 抗原結合分子、包含抗原結合分子的醫藥組合物以及製造及選擇抗原結合分子之方法
BR112019007267A2 (pt) * 2016-12-20 2019-07-09 Hoffmann La Roche anticorpo biespecífico anti-cd20/anti-cd3, produto farmacêutico, composição farmacêutica que compreende um anticorpo biespecífico anti-cd20/anti-cd3, uso de combinação de anticorpo biespecífico anti-cd20/anti-cd3 e um agonista de 4-1bb e método de tratamento ou retardamento da progressão de câncer em pacientes
US11952422B2 (en) * 2017-12-05 2024-04-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137

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KR20210068079A (ko) 2021-06-08
MX2021003608A (es) 2021-05-28
EP3856785A1 (en) 2021-08-04
WO2020067419A1 (en) 2020-04-02
CR20210199A (es) 2021-06-11
IL281787A (en) 2021-05-31
SG11202101912UA (en) 2021-04-29
US20210388087A1 (en) 2021-12-16
EP3856785A4 (en) 2022-07-06
PH12021550662A1 (en) 2021-12-13
TW202028238A (zh) 2020-08-01
PE20211072A1 (es) 2021-06-09
CA3114154A1 (en) 2020-04-02
CO2021005528A2 (es) 2021-07-30
JP2022502010A (ja) 2022-01-11
CN113166247A (zh) 2021-07-23
MA53742A (fr) 2022-01-05
AU2019347412A1 (en) 2021-05-27
BR112021005722A2 (pt) 2021-07-06

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