|
US3625214A
(en)
|
1970-05-18 |
1971-12-07 |
Alza Corp |
Drug-delivery device
|
|
US4906474A
(en)
|
1983-03-22 |
1990-03-06 |
Massachusetts Institute Of Technology |
Bioerodible polyanhydrides for controlled drug delivery
|
|
US4789734A
(en)
|
1985-08-06 |
1988-12-06 |
La Jolla Cancer Research Foundation |
Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
|
|
EP0545913B1
(en)
|
1986-08-18 |
1999-02-24 |
Emisphere Technologies, Inc. |
Delivery systems for pharmacological agents
|
|
US5811128A
(en)
|
1986-10-24 |
1998-09-22 |
Southern Research Institute |
Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
EP0678034B1
(en)
|
1993-01-11 |
1999-05-26 |
Dana Farber Cancer Institute |
Inducing cytotoxic t lymphocyte responses
|
|
AU2668897A
(en)
|
1996-04-19 |
1997-11-12 |
Genetic Therapy, Inc. |
Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents
|
|
US6207392B1
(en)
|
1997-11-25 |
2001-03-27 |
The Regents Of The University Of California |
Semiconductor nanocrystal probes for biological applications and process for making and using such probes
|
|
US20010006948A1
(en)
*
|
1998-11-25 |
2001-07-05 |
James D. Kang |
Gene transfer to intervertebral disc cells
|
|
US20020132978A1
(en)
|
2000-03-21 |
2002-09-19 |
Hans-Peter Gerber |
VEGF-modulated genes and methods employing them
|
|
CA2442670A1
(en)
|
2001-04-13 |
2002-10-24 |
The Trustees Of The University Of Pennsylvania |
Method of treating or retarding the development of blindness
|
|
US20040072774A1
(en)
*
|
2002-02-23 |
2004-04-15 |
Giovanni Manfredi |
Methods for expressing and targeting mitochondrial-DNA-encoded peptides and uses thereof
|
|
US7405284B2
(en)
*
|
2002-10-18 |
2008-07-29 |
University Of Florida Research Foundation, Inc. |
Reducing cellular dysfunction caused by mitochondrial gene mutations
|
|
EP1751275B1
(en)
*
|
2004-06-01 |
2017-08-16 |
Avigen, Inc. |
Compositions and methods to prevent aav vector aggregation
|
|
US20130022979A1
(en)
|
2005-04-18 |
2013-01-24 |
Genesis Genomics Inc. |
3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
|
|
ES2541771T3
(es)
|
2005-05-03 |
2015-07-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Expresión de una proteína mitocondrial mediante un enfoque alotópico mejorado
|
|
CA2667705A1
(en)
|
2006-10-23 |
2008-05-29 |
University Of Florida Research Foundation, Inc. |
Suppression of mitochondrial oxidative stress
|
|
US20100022517A1
(en)
*
|
2006-12-18 |
2010-01-28 |
Richards Lori A |
Ophthalmic formulation of rho kinase inhibitor compound
|
|
EP2565649B1
(en)
|
2007-06-20 |
2015-04-15 |
Galapagos N.V. |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
|
|
ES2563984T3
(es)
|
2008-10-22 |
2016-03-17 |
Quark Pharmaceuticals, Inc. |
Métodos para el tratamiento de trastornos oculares
|
|
DK2529020T3
(en)
|
2010-01-28 |
2018-08-06 |
Childrens Hospital Philadelphia |
SCALABLE PREPARATION PLATF FOR CLEANING VIRAL VECTORS AND CLEANED VIRAL VECTORS FOR USE IN GENTHERAPY
|
|
CN102517304B
(zh)
|
2011-12-16 |
2013-08-28 |
中国农业科学院生物技术研究所 |
重组葡萄糖氧化酶的优化基因及其表达载体和应用
|
|
AU2013243948A1
(en)
*
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
US20160289674A1
(en)
|
2012-04-02 |
2016-10-06 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of membrane proteins
|
|
CN102634527B
(zh)
|
2012-04-11 |
2013-11-06 |
华中科技大学同济医学院附属同济医院 |
重组人nadh脱氢酶亚单位4基因及其表达载体构建方法
|
|
TWI690322B
(zh)
|
2012-10-02 |
2020-04-11 |
法商傳斯堅公司 |
含病毒的調配物及其使用
|
|
US9066966B2
(en)
*
|
2013-02-01 |
2015-06-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia
|
|
US9567376B2
(en)
*
|
2013-02-08 |
2017-02-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
EP2992892A1
(en)
*
|
2014-09-05 |
2016-03-09 |
Universität zu Köln |
Fusion protein for use in the treatment of mitochondrial diseases
|
|
US10493141B2
(en)
|
2014-09-17 |
2019-12-03 |
The University Of Iowa Research Foundation |
Viral RNA segments as immunomodulatory agents and vaccine components
|
|
CN104450747B
(zh)
*
|
2014-09-23 |
2018-02-09 |
武汉纽福斯生物科技有限公司 |
用于治疗Leber遗传性视神经病变的重组腺相关病毒‑NADH脱氢酶亚单位4基因全长以及药剂
|
|
HK1248570A1
(zh)
*
|
2015-05-29 |
2018-10-19 |
西德奈克西斯公司 |
D2o稳定化的药物制剂
|
|
EP3322297B1
(en)
|
2015-07-13 |
2024-12-04 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
WO2018102672A1
(en)
|
2016-12-04 |
2018-06-07 |
Alavi Khorassani Moghadam Marcel Victor |
Methods for treating diseases related to mitochondrial stress
|
|
US20180207293A1
(en)
|
2017-01-25 |
2018-07-26 |
2C Tech Corp. |
Nanoparticles for sustained ophthalmic drug delivery and methods of use
|
|
BR112019017327A2
(pt)
*
|
2017-03-01 |
2020-04-14 |
Univ Pennsylvania |
terapia gênica para distúrbios oculares
|
|
EP3441069B1
(en)
|
2017-08-11 |
2023-04-05 |
Unity Biotechnology, Inc. |
Treatment of diabetic retinopathy using pharmaceutical agents that eliminate senescent cells
|
|
US20210163898A1
(en)
|
2018-04-16 |
2021-06-03 |
The Children's Hospital Of Philadelphia |
Mitochondrial rna import for treating mitochondrial disease
|
|
CN112384625A
(zh)
|
2018-06-11 |
2021-02-19 |
珍视生物股份公司 |
重组aav载体及其使用方法
|
|
CN110846392A
(zh)
|
2018-08-20 |
2020-02-28 |
武汉纽福斯生物科技有限公司 |
一种重组腺相关病毒或含其的试剂盒及其应用
|
|
CN111068071A
(zh)
|
2018-10-22 |
2020-04-28 |
武汉纽福斯生物科技有限公司 |
基因治疗Leber遗传学视神经病变
|
|
KR20240014102A
(ko)
|
2018-06-29 |
2024-01-31 |
우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 |
레버 유전성 시신경병증의 치료를 위한 조성물 및 방법
|
|
WO2020010491A1
(zh)
|
2018-07-09 |
2020-01-16 |
武汉纽福斯生物科技有限公司 |
编码人nadh脱氢酶亚单位4蛋白的核酸及其应用
|
|
CN111073899B
(zh)
|
2018-10-19 |
2021-01-01 |
武汉纽福斯生物科技有限公司 |
一种编码人nadh脱氢酶亚单位4蛋白的核酸及其应用
|
|
CA3109432A1
(en)
|
2018-08-20 |
2020-02-27 |
Wuhan Neurophth Biotechnology Limited Company |
Compositions and methods for treating leber's hereditary optic neuropathy
|
|
WO2020038352A1
(en)
|
2018-08-20 |
2020-02-27 |
Wuhan Neurophth Biological Technology Limited Company |
Compositions and methods for treating leber's hereditary optic neuropathy
|
|
CN113025633B
(zh)
|
2019-12-09 |
2024-08-27 |
武汉纽福斯生物科技有限公司 |
编码人nadh脱氢酶亚单位1蛋白的核酸及其应用
|