JP2022088622A5 - - Google Patents
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- JP2022088622A5 JP2022088622A5 JP2022062568A JP2022062568A JP2022088622A5 JP 2022088622 A5 JP2022088622 A5 JP 2022088622A5 JP 2022062568 A JP2022062568 A JP 2022062568A JP 2022062568 A JP2022062568 A JP 2022062568A JP 2022088622 A5 JP2022088622 A5 JP 2022088622A5
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- JP
- Japan
- Prior art keywords
- gem
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- pharmaceutical product
- contained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 27
- 229960005277 gemcitabine Drugs 0.000 claims 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims 10
- 229940127557 pharmaceutical product Drugs 0.000 claims 10
- 239000002202 Polyethylene glycol Substances 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 235000013772 propylene glycol Nutrition 0.000 claims 9
- 229920002675 Polyoxyl Polymers 0.000 claims 8
- 125000005456 glyceride group Chemical group 0.000 claims 8
- 229920000136 polysorbate Polymers 0.000 claims 7
- 229950008882 polysorbate Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000004094 surface-active agent Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000012052 hydrophilic carrier Substances 0.000 claims 3
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 3
- -1 polyoxyethylene Polymers 0.000 claims 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229940070765 laurate Drugs 0.000 claims 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 229940049964 oleate Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 1
- WECGLUPZRHILCT-HZJYTTRNSA-N rac-1-monolinoleoylglycerol Chemical group CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC(O)CO WECGLUPZRHILCT-HZJYTTRNSA-N 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003900 succinic acid esters Chemical class 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662344660P | 2016-06-02 | 2016-06-02 | |
| US62/344,660 | 2016-06-02 | ||
| PCT/CN2017/086942 WO2017206940A1 (en) | 2016-06-02 | 2017-06-02 | Metronomic oral gemcitabine for cancer therapy |
| JP2018562559A JP2019517490A (ja) | 2016-06-02 | 2017-06-02 | がん療法のためのメトロノミック経口ゲムシタビン |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562559A Division JP2019517490A (ja) | 2016-06-02 | 2017-06-02 | がん療法のためのメトロノミック経口ゲムシタビン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022088622A JP2022088622A (ja) | 2022-06-14 |
| JP2022088622A5 true JP2022088622A5 (enExample) | 2022-06-21 |
Family
ID=60479058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562559A Pending JP2019517490A (ja) | 2016-06-02 | 2017-06-02 | がん療法のためのメトロノミック経口ゲムシタビン |
| JP2022062568A Pending JP2022088622A (ja) | 2016-06-02 | 2022-04-04 | がん療法のためのメトロノミック経口ゲムシタビン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018562559A Pending JP2019517490A (ja) | 2016-06-02 | 2017-06-02 | がん療法のためのメトロノミック経口ゲムシタビン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10835548B2 (enExample) |
| EP (1) | EP3463298B1 (enExample) |
| JP (2) | JP2019517490A (enExample) |
| KR (1) | KR102383824B1 (enExample) |
| CN (2) | CN114224865A (enExample) |
| AU (1) | AU2017273495B2 (enExample) |
| CA (1) | CA3026144A1 (enExample) |
| ES (1) | ES2898024T3 (enExample) |
| TW (1) | TWI814703B (enExample) |
| WO (1) | WO2017206940A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3980023A4 (en) * | 2019-06-06 | 2023-08-02 | Board of Regents, The University of Texas System | LIPID NANOPARTICLES CONTAINING PHARMACEUTICALS AND/OR NUTRACEUTICALS AND RELATED METHODS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA2598239C (en) | 2005-02-18 | 2019-10-29 | Abraxis Bioscience, Inc. | Nanoparticulate formulations of taxanes and carrier proteins for use in combination chemotherapy |
| AU2009297091B2 (en) | 2008-09-23 | 2015-03-05 | Nektar Therapeutics | Compositions and methods for achieving sustained therapeutic drug concentrations in a subject |
| WO2010039039A1 (en) * | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
| US20100273730A1 (en) * | 2009-04-27 | 2010-10-28 | Innopharmax, Inc. | Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof |
| CN101926779A (zh) * | 2010-08-19 | 2010-12-29 | 苏州特瑞药业有限公司 | 一种吉西他滨固体脂质纳米粒及其制备方法与用途 |
| WO2013058294A1 (ja) * | 2011-10-18 | 2013-04-25 | 味の素株式会社 | 膵臓癌及び／又は胆道癌治療薬 |
| US20150283237A1 (en) | 2014-04-02 | 2015-10-08 | Mitchell S. Felder | Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer |
-
2017
- 2017-06-02 CN CN202210080120.1A patent/CN114224865A/zh active Pending
- 2017-06-02 KR KR1020187038225A patent/KR102383824B1/ko active Active
- 2017-06-02 ES ES17805885T patent/ES2898024T3/es active Active
- 2017-06-02 WO PCT/CN2017/086942 patent/WO2017206940A1/en not_active Ceased
- 2017-06-02 JP JP2018562559A patent/JP2019517490A/ja active Pending
- 2017-06-02 CN CN201780033938.5A patent/CN109310631A/zh active Pending
- 2017-06-02 US US15/612,116 patent/US10835548B2/en active Active
- 2017-06-02 EP EP17805885.5A patent/EP3463298B1/en active Active
- 2017-06-02 AU AU2017273495A patent/AU2017273495B2/en active Active
- 2017-06-02 TW TW106118362A patent/TWI814703B/zh active
- 2017-06-02 CA CA3026144A patent/CA3026144A1/en active Pending
-
2022
- 2022-04-04 JP JP2022062568A patent/JP2022088622A/ja active Pending
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