AU2017273495B2 - Metronomic oral gemcitabine for cancer therapy - Google Patents

Metronomic oral gemcitabine for cancer therapy Download PDF

Info

Publication number
AU2017273495B2
AU2017273495B2 AU2017273495A AU2017273495A AU2017273495B2 AU 2017273495 B2 AU2017273495 B2 AU 2017273495B2 AU 2017273495 A AU2017273495 A AU 2017273495A AU 2017273495 A AU2017273495 A AU 2017273495A AU 2017273495 B2 AU2017273495 B2 AU 2017273495B2
Authority
AU
Australia
Prior art keywords
gem
amount
formulation
group
mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017273495A
Other languages
English (en)
Other versions
AU2017273495A1 (en
Inventor
Wei-hua HAO
Chang-Shan Hsu
Shu-Piing HSUEH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innopharmax Inc
Original Assignee
Innopharmax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innopharmax Inc filed Critical Innopharmax Inc
Publication of AU2017273495A1 publication Critical patent/AU2017273495A1/en
Application granted granted Critical
Publication of AU2017273495B2 publication Critical patent/AU2017273495B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2017273495A 2016-06-02 2017-06-02 Metronomic oral gemcitabine for cancer therapy Active AU2017273495B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344660P 2016-06-02 2016-06-02
US62/344,660 2016-06-02
PCT/CN2017/086942 WO2017206940A1 (en) 2016-06-02 2017-06-02 Metronomic oral gemcitabine for cancer therapy

Publications (2)

Publication Number Publication Date
AU2017273495A1 AU2017273495A1 (en) 2018-12-20
AU2017273495B2 true AU2017273495B2 (en) 2023-01-12

Family

ID=60479058

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017273495A Active AU2017273495B2 (en) 2016-06-02 2017-06-02 Metronomic oral gemcitabine for cancer therapy

Country Status (10)

Country Link
US (1) US10835548B2 (enExample)
EP (1) EP3463298B1 (enExample)
JP (2) JP2019517490A (enExample)
KR (1) KR102383824B1 (enExample)
CN (2) CN114224865A (enExample)
AU (1) AU2017273495B2 (enExample)
CA (1) CA3026144A1 (enExample)
ES (1) ES2898024T3 (enExample)
TW (1) TWI814703B (enExample)
WO (1) WO2017206940A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3980023A4 (en) * 2019-06-06 2023-08-02 Board of Regents, The University of Texas System LIPID NANOPARTICLES CONTAINING PHARMACEUTICALS AND/OR NUTRACEUTICALS AND RELATED METHODS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100273730A1 (en) * 2009-04-27 2010-10-28 Innopharmax, Inc. Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
CA2598239C (en) 2005-02-18 2019-10-29 Abraxis Bioscience, Inc. Nanoparticulate formulations of taxanes and carrier proteins for use in combination chemotherapy
AU2009297091B2 (en) 2008-09-23 2015-03-05 Nektar Therapeutics Compositions and methods for achieving sustained therapeutic drug concentrations in a subject
WO2010039039A1 (en) * 2008-10-03 2010-04-08 Clavis Pharma Asa Oral formulations of gemcitabine derivatives
CN101926779A (zh) * 2010-08-19 2010-12-29 苏州特瑞药业有限公司 一种吉西他滨固体脂质纳米粒及其制备方法与用途
WO2013058294A1 (ja) * 2011-10-18 2013-04-25 味の素株式会社 膵臓癌及び／又は胆道癌治療薬
US20150283237A1 (en) 2014-04-02 2015-10-08 Mitchell S. Felder Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100273730A1 (en) * 2009-04-27 2010-10-28 Innopharmax, Inc. Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof

Also Published As

Publication number Publication date
EP3463298A1 (en) 2019-04-10
JP2019517490A (ja) 2019-06-24
CA3026144A1 (en) 2017-12-07
CN109310631A (zh) 2019-02-05
KR102383824B1 (ko) 2022-04-06
EP3463298B1 (en) 2021-09-01
KR20190015420A (ko) 2019-02-13
TW201808309A (zh) 2018-03-16
WO2017206940A1 (en) 2017-12-07
ES2898024T3 (es) 2022-03-03
US10835548B2 (en) 2020-11-17
US20170348341A1 (en) 2017-12-07
TWI814703B (zh) 2023-09-11
CN114224865A (zh) 2022-03-25
JP2022088622A (ja) 2022-06-14
EP3463298A4 (en) 2020-01-01
AU2017273495A1 (en) 2018-12-20

Similar Documents

Publication Publication Date Title
RU2532362C2 (ru) Самомикроэмульгирующаяся оральная фармацевтическая композиция, содержащая гидрофильное лекарственное средство, и способ ее приготовления
CA3149460C (en) Drug composition containing abiraterone acetate, and preparation method therefor and application thereof
CA2626579A1 (en) Formulation comprising a drug of low water solubility and method of use thereof
CN102770131A (zh) 卡巴他赛的新颖抗肿瘤用途
US20170232017A1 (en) Treatment of cancer
KR20210005714A (ko) 비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조합 조성물 및 이의 사용 방법
KR20210008527A (ko) 비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조성물 및 이의 사용 방법
JP2025160200A (ja) クマリン誘導体を含有する、細胞増殖性疾患の治療又は予防用医薬
CN111542317A (zh) 用于治疗或预防细胞增殖性疾病的香豆素衍生物
JP2022502471A (ja) 化学療法誘発性の悪心および嘔吐を治療するための方法および製剤
CN105283178A (zh) 用于治疗癌症的包含mps-1激酶抑制剂和有丝分裂抑制剂的组合
PL211114B1 (pl) Zastosowanie pochodnej epotilonowej w leczeniu choroby nowotworowej
AU2017273495B2 (en) Metronomic oral gemcitabine for cancer therapy
US20060235059A1 (en) Cancer treatment with epothilones
CN101357134A (zh) 抗肿瘤效果增强剂和抗肿瘤剂
TW201716064A (zh) 供治療癌症之口服投予紫杉醇及Ｐ－ｇｐ抑制劑的治療性組合
US9402847B2 (en) Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
JP2022088622A5 (enExample)
JP7707329B2 (ja) クマリン誘導体を含有する、細胞増殖性疾患の治療又は予防用医薬
WO2022170398A1 (en) Formulations for improved bioavailability of fenretinide
US20060205795A1 (en) Cancer treatment with epothilones
JP2022505222A (ja) テセタキセルを用いてｃｎｓ腫瘍を治療する方法
HK1255299A1 (en) Use of combination of anti-pd-1 antibody and vegfr inhibitor in preparation of drug for treating cancers

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)