|
US4647447A
(en)
|
1981-07-24 |
1987-03-03 |
Schering Aktiengesellschaft |
Diagnostic media
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5304121A
(en)
|
1990-12-28 |
1994-04-19 |
Boston Scientific Corporation |
Drug delivery system making use of a hydrogel polymer coating
|
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
|
US5395619A
(en)
|
1993-03-03 |
1995-03-07 |
Liposome Technology, Inc. |
Lipid-polymer conjugates and liposomes
|
|
US5886026A
(en)
|
1993-07-19 |
1999-03-23 |
Angiotech Pharmaceuticals Inc. |
Anti-angiogenic compositions and methods of use
|
|
US5637684A
(en)
|
1994-02-23 |
1997-06-10 |
Isis Pharmaceuticals, Inc. |
Phosphoramidate and phosphorothioamidate oligomeric compounds
|
|
US6211244B1
(en)
|
1994-10-21 |
2001-04-03 |
Nps Pharmaceuticals, Inc. |
Calcium receptor-active compounds
|
|
US6099562A
(en)
|
1996-06-13 |
2000-08-08 |
Schneider (Usa) Inc. |
Drug coating with topcoat
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
US5817856A
(en)
|
1995-12-11 |
1998-10-06 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Radiation-protective phospholipid and method
|
|
US5830600A
(en)
|
1996-05-24 |
1998-11-03 |
Sri International |
Nonflammable/self-extinguishing electrolytes for batteries
|
|
JPH10175987A
(ja)
|
1996-12-13 |
1998-06-30 |
Nof Corp |
重合性基含有有機リン酸エステル化合物およびその製造方法
|
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US5922897A
(en)
|
1998-05-29 |
1999-07-13 |
Xerox Corporation |
Surfactant processes
|
|
US20030165849A1
(en)
|
2000-11-28 |
2003-09-04 |
Biliang Zhang |
Methods and reagents for introducing a sulfhydryl group into the 5'-terminus of RNA
|
|
US6320041B1
(en)
|
2001-04-13 |
2001-11-20 |
Trilink Biotechnologies, Inc. |
Pre-activated carbonyl linkers for the modification of oligonucleotides
|
|
US6743905B2
(en)
|
2001-04-16 |
2004-06-01 |
Applera Corporation |
Mobility-modified nucleobase polymers and methods of using same
|
|
CA2446904A1
(en)
|
2001-05-24 |
2003-04-03 |
Alexza Pharmaceuticals, Inc. |
Delivery of drug esters through an inhalation route
|
|
US20100240730A1
(en)
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
WO2004073620A2
(en)
|
2003-02-14 |
2004-09-02 |
Quanta Biodesign, Ltd |
The selective and specific preparation of discrete peg compounds
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US20070276139A1
(en)
|
2004-02-10 |
2007-11-29 |
Quanlai Song |
Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis
|
|
MXPA06010782A
(es)
|
2004-03-23 |
2007-03-28 |
Complex Biosystems Gmbh |
Ligador de profarmaco.
|
|
JP2008501765A
(ja)
*
|
2004-06-11 |
2008-01-24 |
ノボ ノルディスク アクティーゼルスカブ |
Ｇｌｐ−１アゴニストを用いた薬剤誘発性肥満の中和
|
|
US20060063147A1
(en)
|
2004-09-21 |
2006-03-23 |
Chernov Boris K |
Omega-amino-PEG-phosphoramidites and conjugates thereof
|
|
TW200612993A
(en)
|
2004-10-08 |
2006-05-01 |
Alza Corp |
Lipopolymer conjugates
|
|
AU2006304856A1
(en)
|
2005-10-21 |
2007-04-26 |
Synageva Biopharma Corp. |
Glycolated and glycosylated poultry derived therapeutic proteins
|
|
WO2007055789A2
(en)
|
2005-10-31 |
2007-05-18 |
Neose Technologies, Inc. |
Expression of soluble therapeutic proteins
|
|
AU2006316903B8
(en)
|
2005-11-23 |
2010-10-14 |
F. Hoffmann-La Roche Ag |
Polynucleotide labelling reagent
|
|
JP5096363B2
(ja)
*
|
2005-12-16 |
2012-12-12 |
ネクター セラピューティックス |
Ｇｌｐ−１のポリマ複合体
|
|
JP5140824B2
(ja)
|
2006-04-19 |
2013-02-13 |
国立大学法人 東京大学 |
リゾホスファチジルスレオニンおよびその誘導体
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
TWI409081B
(zh)
|
2006-11-09 |
2013-09-21 |
Alcon Res Ltd |
用於藥物輸送之水不溶性聚合物基質
|
|
US8883146B2
(en)
|
2007-11-30 |
2014-11-11 |
Abbvie Inc. |
Protein formulations and methods of making same
|
|
US20130195888A1
(en)
|
2007-11-30 |
2013-08-01 |
Abbvie |
Ultrafiltration and diafiltration formulation methods for protein processing
|
|
MX2010008024A
(es)
|
2008-02-01 |
2010-12-21 |
Ascendis Pharma As |
Profarmaco que comprende un enlazador que se puede separar por si mismo.
|
|
TWI451876B
(zh)
|
2008-06-13 |
2014-09-11 |
Lilly Co Eli |
聚乙二醇化之離脯胰島素化合物
|
|
JP5642673B2
(ja)
|
2008-07-10 |
2014-12-17 |
セリナ・セラピユーテイツクス・インコーポレーテツド |
不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物
|
|
WO2010033216A1
(en)
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of nesiritide peptides
|
|
ES2608457T3
(es)
|
2009-05-20 |
2017-04-11 |
Biomarin Pharmaceutical Inc. |
Variantes de péptido natriurético de tipo C
|
|
EP2459227B1
(en)
|
2009-07-31 |
2021-03-17 |
Ascendis Pharma A/S |
Prodrugs containing an aromatic amine connected by an amide bond to a carrier
|
|
EP2525830B1
(en)
|
2010-01-22 |
2016-05-11 |
Ascendis Pharma A/S |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
EA023925B1
(ru)
*
|
2010-04-27 |
2016-07-29 |
Зилэнд Фарма А/С |
Пептидные конъюгаты агонистов рецептора glp-1 и их применение
|
|
EP2566335B1
(en)
|
2010-05-05 |
2016-06-29 |
Prolynx Llc |
Controlled release of active compounds from macromolecular conjugates
|
|
US9387245B2
(en)
|
2010-08-06 |
2016-07-12 |
University Of Colorado, A Body Corporate |
Methods and compositions for the inhibition of fructokinase
|
|
CA2821411C
(en)
|
2010-12-13 |
2020-02-25 |
Quiapeg Pharmaceuticals Ab |
Functionalized polymers
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
HK1198913A1
(en)
|
2011-08-12 |
2015-06-19 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
CN102321170B
(zh)
*
|
2011-09-14 |
2013-11-13 |
深圳翰宇药业股份有限公司 |
利拉鲁肽变构体及其缀合物
|
|
CA3114356C
(en)
|
2012-06-12 |
2023-08-22 |
Quiapeg Pharmaceuticals Ab |
Conjugates of biologically active molecules to functionalized polymers
|
|
EP2910573B1
(en)
|
2012-10-19 |
2020-02-19 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugate produced by binding through linker having hydrophilic structure
|
|
JP6701077B2
(ja)
|
2013-12-19 |
2020-05-27 |
シアトル ジェネティックス， インコーポレイテッド |
標的化薬物結合体と使用するためのメチレンカルバメートリンカー
|
|
AR100639A1
(es)
*
|
2014-05-29 |
2016-10-19 |
Hanmi Pharm Ind Co Ltd |
Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
|
|
SG10201811124YA
(en)
|
2014-06-20 |
2019-01-30 |
Abgenomics Int Inc |
Her2 antibody-drug conjugates
|
|
JP6369721B2
(ja)
|
2014-07-04 |
2018-08-08 |
国立大学法人 東京大学 |
リゾホスファチジルセリン誘導体
|
|
CN104725628B
(zh)
|
2014-10-01 |
2018-04-17 |
厦门赛诺邦格生物科技股份有限公司 |
一种含可降解基团的单一官能化支化聚乙二醇、制备方法及其生物相关物质
|
|
EP3242689A1
(en)
|
2015-01-09 |
2017-11-15 |
Ascendis Pharma Growth Disorders A/S |
Cnp prodrugs
|
|
CN107614020A
(zh)
|
2015-03-18 |
2018-01-19 |
免疫生化公司 |
靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物
|
|
CA2994853C
(en)
|
2015-08-14 |
2023-06-27 |
Rc Biotechnologies, Inc. |
Covalent linkers in antibody-drug conjugates and methods of making and using the same
|
|
LT3400019T
(lt)
|
2016-01-08 |
2022-12-12 |
Ascendis Pharma Growth Disorders A/S |
Cnp provaistai su prie žiedo fragmento prijungtu nešikliu
|
|
MX2018008061A
(es)
|
2016-01-08 |
2018-08-23 |
Ascendis Pharma Growth Disorders As |
Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes.
|
|
GB201607827D0
(en)
|
2016-05-04 |
2016-06-15 |
Bicycle Therapeutics Ltd |
Bicyclic peptide-toxin conjugates specific for MT1-MMP
|
|
EP3565638B8
(en)
|
2017-01-06 |
2024-04-10 |
BicycleRD Limited |
Bicycle conjugate for treating cancer
|
|
BR102017004833A2
(pt)
|
2017-03-10 |
2018-10-30 |
Leite Miguel |
produto bactericida/germicida/fungicida/esporocida extraído dos ácidos graxos a ser administrado via oral em animais de criação monogástricos e/ou ruminantes e método de obtenção
|
|
EP4011396A1
(en)
*
|
2017-03-10 |
2022-06-15 |
QuiaPEG Pharmaceuticals AB |
Releasable conjugates
|
|
TW202003044A
(zh)
|
2018-03-09 |
2020-01-16 |
瑞典商奎亞培格製藥公司 |
可釋放之抗體結合物
|
|
AU2019340472A1
(en)
|
2018-09-12 |
2021-04-01 |
Quiapeg Pharmaceuticals Ab |
Releasable GLP-1 conjugates
|