JP2021534802A5 - - Google Patents
Info
- Publication number
- JP2021534802A5 JP2021534802A5 JP2021511646A JP2021511646A JP2021534802A5 JP 2021534802 A5 JP2021534802 A5 JP 2021534802A5 JP 2021511646 A JP2021511646 A JP 2021511646A JP 2021511646 A JP2021511646 A JP 2021511646A JP 2021534802 A5 JP2021534802 A5 JP 2021534802A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- domain
- antigen
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306153.0 | 2018-08-31 | ||
| EP18306153 | 2018-08-31 | ||
| EP19305809.6 | 2019-06-21 | ||
| EP19305809 | 2019-06-21 | ||
| PCT/EP2019/073257 WO2020043899A1 (en) | 2018-08-31 | 2019-08-30 | Chimeric antigen receptors against multiple hla-g isoforms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534802A JP2021534802A (ja) | 2021-12-16 |
| JP2021534802A5 true JP2021534802A5 (enExample) | 2022-09-07 |
| JP7394840B2 JP7394840B2 (ja) | 2023-12-08 |
Family
ID=67766182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511646A Active JP7394840B2 (ja) | 2018-08-31 | 2019-08-30 | 複数のhla-gアイソフォームに対するキメラ抗原レセプター |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US11117971B2 (enExample) |
| EP (1) | EP3843778A1 (enExample) |
| JP (1) | JP7394840B2 (enExample) |
| KR (1) | KR20210112295A (enExample) |
| CN (1) | CN112912105B (enExample) |
| AU (1) | AU2019328677A1 (enExample) |
| BR (1) | BR112021003757A2 (enExample) |
| IL (1) | IL281097A (enExample) |
| MX (1) | MX2021002316A (enExample) |
| SG (1) | SG11202101849XA (enExample) |
| WO (1) | WO2020043899A1 (enExample) |
| ZA (1) | ZA202101358B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| AR114789A1 (es) | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
| BR112021003757A2 (pt) | 2018-08-31 | 2021-05-25 | Invectys SA | receptores de antígenos quiméricos contra múltiplas isoformas de hla-g |
| BR112021005868A2 (pt) | 2018-09-27 | 2021-10-19 | Tizona Therapeutics | Anticorpos anti-hla-g, composições compreendendo anticorpos anti-hla-g e métodos de uso de anticorpos anti-hla-g |
| CN115996952A (zh) * | 2020-06-11 | 2023-04-21 | 提圣纳医疗公司 | 对hla-g和另一种抗原具有结合特异性的双特异性免疫细胞接合子 |
| WO2022129120A1 (en) | 2020-12-17 | 2022-06-23 | F. Hoffmann-La Roche Ag | Anti-hla-g antibodies and use thereof |
| EP4079846A1 (en) * | 2021-04-23 | 2022-10-26 | SVAR Life Science AB | Novel luciferases with improved properties |
| CA3221568A1 (en) * | 2021-05-26 | 2022-12-01 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor to target hla-g-positive cancers |
| TWI823402B (zh) * | 2021-07-21 | 2023-11-21 | 長聖國際生技股份有限公司 | 多特異性單域抗體嵌合抗原受體及t細胞銜接體、核酸、其表達細胞、其用途以及治療癌症之醫藥組合物 |
| US20240327492A1 (en) * | 2021-07-29 | 2024-10-03 | Nantcell, Inc. | Modified T Cell Receptors For The Prevention And Treatment Of Viral Infections And Cancer |
| CN116218780A (zh) * | 2021-12-03 | 2023-06-06 | 洪明奇 | 外泌体的生产及其用途 |
| CN114605543B (zh) * | 2021-12-17 | 2023-11-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g异构体分子hla-g5及hla-g6的单克隆抗体及其用途 |
| CN114380920B (zh) * | 2021-12-17 | 2024-06-28 | 广州达安基因股份有限公司 | 人甲胎蛋白融合蛋白及其制备方法和应用 |
| AU2023216270A1 (en) | 2022-02-04 | 2024-08-15 | Nkilt Therapeutics, Inc. | Chimeric ilt receptor compositions and methods |
| CN118946585A (zh) * | 2022-03-25 | 2024-11-12 | 怡诺安有限公司 | 抗hla-g嵌合抗原受体及其用途 |
| CN115112900B (zh) * | 2022-06-15 | 2024-08-16 | 四川大学华西医院 | 检测脂解激活脂蛋白受体的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途 |
| JP2025521577A (ja) * | 2022-06-24 | 2025-07-10 | エイチケー イノ.エヌ コーポレーション | 免疫チェックポイント制御因子を発現する免疫細胞及びその用途 |
| CN116284387B (zh) * | 2022-07-15 | 2025-10-03 | 台州恩泽医疗中心(集团) | 一种抗hla-g2及hla-g6分子的单克隆抗体及用途 |
| JP2025539410A (ja) * | 2022-11-28 | 2025-12-05 | インベクティス,インコーポレイティド | ヒト化抗hla-gキメラ抗原受容体及びそれらの使用 |
| CN116535500B (zh) * | 2022-11-30 | 2024-03-22 | 西南大学 | 马铃薯x病毒单克隆抗体pvx-6及其应用 |
| CN119569893B (zh) * | 2023-09-06 | 2025-10-31 | 上海恩凯细胞技术有限公司 | 特异性靶向肿瘤的嵌合抗原受体细胞及其制备方法和应用 |
| CN119569892A (zh) * | 2023-09-06 | 2025-03-07 | 上海恩凯细胞技术有限公司 | 特异性靶向肿瘤非经典hla分子的嵌合抗原受体的应用 |
| EP4793288A1 (en) * | 2023-10-12 | 2026-08-19 | Imbiologics Corp. | Antibody specifically binding to hla-g, and use thereof |
| CN118420786B (zh) * | 2024-06-12 | 2025-10-17 | 浙江大学医学院附属第一医院(浙江省第一医院) | 一种靶向her2和hla-g的双特异性嵌合抗原受体及其应用 |
Family Cites Families (49)
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|---|---|---|---|---|
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| JP3266311B2 (ja) | 1991-05-02 | 2002-03-18 | 生化学工業株式会社 | 新規ポリペプチドおよびこれを用いる抗hiv剤 |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| ES2185705T3 (es) | 1994-05-02 | 2003-05-01 | Bernd Groner | Proteina bifuncional, preparacion y uso. |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| EP0819171A1 (en) | 1995-04-07 | 1998-01-21 | The Regents Of The University Of California | Antibodies for the detection of hla-g |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| EP1235842A4 (en) | 1999-10-15 | 2003-04-23 | Univ Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| HK1052372A1 (zh) | 2000-02-24 | 2003-09-11 | Xcyte Therapies, Inc. | 细胞的同步刺激和富集 |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| WO2001096584A2 (en) | 2000-06-12 | 2001-12-20 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
| EP1967590A3 (en) | 2001-03-13 | 2008-09-17 | Novartis AG | Lentiviral packaging constructs |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US20100105136A1 (en) | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| EP2520643B8 (en) | 2007-12-07 | 2019-11-27 | Miltenyi Biotec B.V. & Co. KG | Sample processing systems and methods |
| US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
| CA2735456C (en) | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| LT2884999T (lt) | 2012-08-20 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Ląstelinės imunoterapijos būdas ir kompozicijos |
| EP2730588A1 (en) * | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US20190119385A1 (en) * | 2015-03-27 | 2019-04-25 | University Of Southern California | Hla-g as a novel target for car t-cell immunotherapy |
| CN107849102B (zh) * | 2015-05-15 | 2022-05-13 | 希望之城 | 嵌合抗原受体组合物 |
| CA3025681A1 (en) * | 2016-06-03 | 2017-12-07 | Invectys | Anti hla-g specific antibodies |
| EP3515493A4 (en) | 2016-09-23 | 2020-08-19 | University of Southern California | CHEMERICAL ANTIGEN RECEPTORS, COORESPONDENT COMPOSITIONS AND METHODS OF USE |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| BR112021003757A2 (pt) | 2018-08-31 | 2021-05-25 | Invectys SA | receptores de antígenos quiméricos contra múltiplas isoformas de hla-g |
| TWI694083B (zh) | 2018-09-17 | 2020-05-21 | 中國醫藥大學附設醫院 | 嵌合抗原受體、核酸、嵌合抗原受體表達質體、表達嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物 |
| TWI717880B (zh) | 2019-10-24 | 2021-02-01 | 中國醫藥大學附設醫院 | Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物 |
-
2019
- 2019-08-30 BR BR112021003757-8A patent/BR112021003757A2/pt unknown
- 2019-08-30 EP EP19759006.0A patent/EP3843778A1/en active Pending
- 2019-08-30 KR KR1020217009086A patent/KR20210112295A/ko active Pending
- 2019-08-30 WO PCT/EP2019/073257 patent/WO2020043899A1/en not_active Ceased
- 2019-08-30 MX MX2021002316A patent/MX2021002316A/es unknown
- 2019-08-30 CN CN201980066246.XA patent/CN112912105B/zh active Active
- 2019-08-30 SG SG11202101849XA patent/SG11202101849XA/en unknown
- 2019-08-30 AU AU2019328677A patent/AU2019328677A1/en not_active Abandoned
- 2019-08-30 JP JP2021511646A patent/JP7394840B2/ja active Active
-
2020
- 2020-10-22 US US17/077,502 patent/US11117971B2/en active Active
-
2021
- 2021-02-24 IL IL281097A patent/IL281097A/en unknown
- 2021-02-26 ZA ZA2021/01358A patent/ZA202101358B/en unknown
- 2021-09-10 US US17/471,744 patent/US11325977B2/en active Active
-
2022
- 2022-05-09 US US17/739,596 patent/US11505608B2/en active Active
- 2022-10-19 US US18/047,988 patent/US12297275B2/en active Active
-
2025
- 2025-04-22 US US19/185,979 patent/US20260070988A1/en active Pending
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