JP2021534245A5 - - Google Patents
Info
- Publication number
- JP2021534245A5 JP2021534245A5 JP2021532265A JP2021532265A JP2021534245A5 JP 2021534245 A5 JP2021534245 A5 JP 2021534245A5 JP 2021532265 A JP2021532265 A JP 2021532265A JP 2021532265 A JP2021532265 A JP 2021532265A JP 2021534245 A5 JP2021534245 A5 JP 2021534245A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- tcrs
- target
- reactive
- tcr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023018149A JP7475506B2 (ja) | 2018-08-13 | 2023-02-09 | 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862718227P | 2018-08-13 | 2018-08-13 | |
| US62/718,227 | 2018-08-13 | ||
| US201862725842P | 2018-08-31 | 2018-08-31 | |
| US62/725,842 | 2018-08-31 | ||
| US201862732898P | 2018-09-18 | 2018-09-18 | |
| US62/732,898 | 2018-09-18 | ||
| US201962818355P | 2019-03-14 | 2019-03-14 | |
| US62/818,355 | 2019-03-14 | ||
| US201962823831P | 2019-03-26 | 2019-03-26 | |
| US62/823,831 | 2019-03-26 | ||
| PCT/US2019/046170 WO2020036875A1 (en) | 2018-08-13 | 2019-08-12 | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023018149A Division JP7475506B2 (ja) | 2018-08-13 | 2023-02-09 | 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534245A JP2021534245A (ja) | 2021-12-09 |
| JP2021534245A5 true JP2021534245A5 (https=) | 2022-08-19 |
| JP7227374B2 JP7227374B2 (ja) | 2023-02-21 |
Family
ID=69525770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532265A Active JP7227374B2 (ja) | 2018-08-13 | 2019-08-12 | 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用 |
| JP2023018149A Active JP7475506B2 (ja) | 2018-08-13 | 2023-02-09 | 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023018149A Active JP7475506B2 (ja) | 2018-08-13 | 2023-02-09 | 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11208457B2 (https=) |
| EP (1) | EP3837373B1 (https=) |
| JP (2) | JP7227374B2 (https=) |
| KR (2) | KR102543325B1 (https=) |
| CN (3) | CN116298309B (https=) |
| AU (1) | AU2019322834B2 (https=) |
| CA (1) | CA3108439A1 (https=) |
| IL (2) | IL294471B2 (https=) |
| MX (1) | MX2021001763A (https=) |
| SG (1) | SG11202101371TA (https=) |
| WO (1) | WO2020036875A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111712468A (zh) | 2017-12-22 | 2020-09-25 | 北卡罗莱纳州立大学 | 聚合物荧光团、包含其的组合物及制备和使用其的方法 |
| CN116298309B (zh) | 2018-08-13 | 2024-04-02 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| US20210363543A1 (en) * | 2018-10-30 | 2021-11-25 | Nantbio, Inc. | Self Replicating RNA System |
| WO2020206238A2 (en) | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| WO2023091420A2 (en) * | 2021-11-16 | 2023-05-25 | TCR2 Therapeutics Inc. | Compositions and methods for t cell engineering |
| WO2023096890A1 (en) * | 2021-11-24 | 2023-06-01 | Rootpath Genomics, Inc. | Compositions and methods for polynucleotide assembly |
| CN115029341A (zh) * | 2022-05-23 | 2022-09-09 | 立凌生物制药(苏州)有限公司 | 一种快速克隆配对tcr序列检测方法及其应用 |
| WO2023179795A1 (zh) * | 2022-03-25 | 2023-09-28 | 立凌生物制药(苏州)有限公司 | 一种快速且简便地获得正确配对tcr的方法以及获得的tcr |
| CN114891779A (zh) * | 2022-03-31 | 2022-08-12 | 立凌生物制药(苏州)有限公司 | 一种克隆tcr序列的检测方法及其应用 |
| CN115725710A (zh) * | 2022-08-09 | 2023-03-03 | 立凌生物制药(苏州)有限公司 | 一种快速克隆肿瘤反应性tcr的方法及其应用 |
| WO2024077185A2 (en) * | 2022-10-06 | 2024-04-11 | The Regents Of The University Of California | Core-shell hydrogel particles with tunable porosity for digital nucleic acid assays |
| WO2024206549A2 (en) * | 2023-03-29 | 2024-10-03 | Cellicure, Inc. | Engineered immune cells and use thereof |
| CN116913417B (zh) * | 2023-04-07 | 2025-11-28 | 四川大学 | 一种dna结合小分子高通量筛选及表征方法 |
| JP2025071533A (ja) * | 2023-10-23 | 2025-05-08 | 美洛生物科技股▲ふん▼有限公司 | 新型誘導細胞質インビトロ転写様組成物およびその関連ワクチン医薬設計 |
| JP2025187393A (ja) * | 2024-06-13 | 2025-12-25 | 株式会社日立製作所 | Ｔ細胞受容体（ｔｃｒ）またはｂ細胞受容体（ｂｃｒ）の遺伝子検査方法および遺伝子検査キット |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6607878B2 (en) | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| KR20030032922A (ko) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| JP2004537313A (ja) | 2001-07-31 | 2004-12-16 | クローンテック ラボラトリーズ インク． | 細胞内のプロテアーゼ活性を検出する方法 |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| MX2008000985A (es) | 2005-07-21 | 2008-04-07 | Abbott Lab | Expresion de gen multiple que incluye construcciones y metodos sorf (cuadro de lectura abierta simple) con poliproteinas, pro-proteinas y proteolisis. |
| US9029085B2 (en) | 2007-03-07 | 2015-05-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
| US8454906B2 (en) | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
| EP3150724A1 (en) | 2008-12-19 | 2017-04-05 | President and Fellows of Harvard College | Particle-assisted nucleic acid sequencing |
| CA3285826A1 (en) | 2012-02-22 | 2026-03-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| EP3461910B1 (en) | 2012-04-19 | 2020-08-26 | Life Technologies Corporation | Nucleic acid amplification |
| US20150005199A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US20150005200A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US20140378345A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| AU2013302756C1 (en) | 2012-08-14 | 2018-05-17 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US11203783B2 (en) * | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| NZ724320A (en) * | 2014-03-14 | 2022-05-27 | Adaptimmune Ltd | Tcr libraries |
| US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
| US20150298091A1 (en) | 2014-04-21 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for barcoding nucleic acids |
| EP3950944A1 (en) * | 2014-09-15 | 2022-02-09 | AbVitro LLC | High-throughput nucleotide library sequencing |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| BR112017008877A2 (pt) | 2014-10-29 | 2018-07-03 | 10X Genomics Inc | métodos e composições para sequenciamento de ácido nucleico-alvo |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| AU2016253964B2 (en) * | 2015-04-27 | 2022-07-07 | Abvitro Llc | Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| GB201516275D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| MX2018003534A (es) | 2015-09-25 | 2019-04-25 | Abvitro Llc | Proceso de alto rendimiento para identificacion de blanco de receptor de celula t de secuencias de receptor de celula t apareadas de manera natural. |
| KR20190006952A (ko) * | 2016-03-31 | 2019-01-21 | 라이언 티씨알 피티이. 리미티드 | 외인성 바이러스-특이적 t 세포 수용체 (tcr)를 발현하는 비-활성화된 t 세포 |
| WO2017177217A2 (en) * | 2016-04-08 | 2017-10-12 | Unum Therapeutics | Chimeric receptors and uses thereof in immune therapy |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| JP2020503883A (ja) | 2017-01-13 | 2020-02-06 | アジェナス インコーポレイテッド | Ｎｙ−ｅｓｏ−１に結合するｔ細胞受容体およびその使用方法 |
| US20200231974A1 (en) | 2017-07-18 | 2020-07-23 | Genovie Ab | A two-component vector library system for rapid assembly and diversification of full-length t-cell receptor open reading frames |
| WO2019126466A1 (en) | 2017-12-22 | 2019-06-27 | Rootpath Genomics, Inc. | Compositions and methods for barcoding |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| CA3099308A1 (en) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Compositions and methods for enhancing the killing of target cells by nk cells |
| CN116298309B (zh) | 2018-08-13 | 2024-04-02 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| WO2020206238A2 (en) | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| EP4061487A4 (en) | 2019-11-19 | 2023-12-20 | Rootpath Genomics, Inc. | COMPOSITIONS AND METHODS FOR IDENTIFYING T CELL RECEPTOR |
-
2019
- 2019-08-12 CN CN202310118607.9A patent/CN116298309B/zh active Active
- 2019-08-12 IL IL294471A patent/IL294471B2/en unknown
- 2019-08-12 CN CN201980067485.7A patent/CN112840031B/zh active Active
- 2019-08-12 KR KR1020217007322A patent/KR102543325B1/ko active Active
- 2019-08-12 CN CN202310093858.6A patent/CN116144706A/zh not_active Withdrawn
- 2019-08-12 KR KR1020237019408A patent/KR20230088518A/ko active Pending
- 2019-08-12 AU AU2019322834A patent/AU2019322834B2/en active Active
- 2019-08-12 JP JP2021532265A patent/JP7227374B2/ja active Active
- 2019-08-12 WO PCT/US2019/046170 patent/WO2020036875A1/en not_active Ceased
- 2019-08-12 IL IL280682A patent/IL280682B/en unknown
- 2019-08-12 MX MX2021001763A patent/MX2021001763A/es unknown
- 2019-08-12 CA CA3108439A patent/CA3108439A1/en active Pending
- 2019-08-12 SG SG11202101371TA patent/SG11202101371TA/en unknown
- 2019-08-12 EP EP19849196.1A patent/EP3837373B1/en active Active
-
2021
- 2021-02-11 US US17/173,705 patent/US11208457B2/en active Active
- 2021-11-17 US US17/528,550 patent/US12098181B2/en active Active
-
2023
- 2023-02-09 JP JP2023018149A patent/JP7475506B2/ja active Active
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