SG11202101371TA - High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof - Google Patents
High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereofInfo
- Publication number
- SG11202101371TA SG11202101371TA SG11202101371TA SG11202101371TA SG11202101371TA SG 11202101371T A SG11202101371T A SG 11202101371TA SG 11202101371T A SG11202101371T A SG 11202101371TA SG 11202101371T A SG11202101371T A SG 11202101371TA SG 11202101371T A SG11202101371T A SG 11202101371TA
- Authority
- SG
- Singapore
- Prior art keywords
- paired
- applications
- high throughput
- throughput cloning
- bipartite immunoreceptor
- Prior art date
Links
- 238000010367 cloning Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862718227P | 2018-08-13 | 2018-08-13 | |
| US201862725842P | 2018-08-31 | 2018-08-31 | |
| US201862732898P | 2018-09-18 | 2018-09-18 | |
| US201962818355P | 2019-03-14 | 2019-03-14 | |
| US201962823831P | 2019-03-26 | 2019-03-26 | |
| PCT/US2019/046170 WO2020036875A1 (en) | 2018-08-13 | 2019-08-12 | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202101371TA true SG11202101371TA (en) | 2021-03-30 |
Family
ID=69525770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202101371TA SG11202101371TA (en) | 2018-08-13 | 2019-08-12 | High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11208457B2 (https=) |
| EP (1) | EP3837373B1 (https=) |
| JP (2) | JP7227374B2 (https=) |
| KR (2) | KR102543325B1 (https=) |
| CN (3) | CN116298309B (https=) |
| AU (1) | AU2019322834B2 (https=) |
| CA (1) | CA3108439A1 (https=) |
| IL (2) | IL294471B2 (https=) |
| MX (1) | MX2021001763A (https=) |
| SG (1) | SG11202101371TA (https=) |
| WO (1) | WO2020036875A1 (https=) |
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| CN111712468A (zh) | 2017-12-22 | 2020-09-25 | 北卡罗莱纳州立大学 | 聚合物荧光团、包含其的组合物及制备和使用其的方法 |
| CN116298309B (zh) | 2018-08-13 | 2024-04-02 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| US20210363543A1 (en) * | 2018-10-30 | 2021-11-25 | Nantbio, Inc. | Self Replicating RNA System |
| WO2020206238A2 (en) | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| WO2023091420A2 (en) * | 2021-11-16 | 2023-05-25 | TCR2 Therapeutics Inc. | Compositions and methods for t cell engineering |
| WO2023096890A1 (en) * | 2021-11-24 | 2023-06-01 | Rootpath Genomics, Inc. | Compositions and methods for polynucleotide assembly |
| CN115029341A (zh) * | 2022-05-23 | 2022-09-09 | 立凌生物制药(苏州)有限公司 | 一种快速克隆配对tcr序列检测方法及其应用 |
| WO2023179795A1 (zh) * | 2022-03-25 | 2023-09-28 | 立凌生物制药(苏州)有限公司 | 一种快速且简便地获得正确配对tcr的方法以及获得的tcr |
| CN114891779A (zh) * | 2022-03-31 | 2022-08-12 | 立凌生物制药(苏州)有限公司 | 一种克隆tcr序列的检测方法及其应用 |
| CN115725710A (zh) * | 2022-08-09 | 2023-03-03 | 立凌生物制药(苏州)有限公司 | 一种快速克隆肿瘤反应性tcr的方法及其应用 |
| WO2024077185A2 (en) * | 2022-10-06 | 2024-04-11 | The Regents Of The University Of California | Core-shell hydrogel particles with tunable porosity for digital nucleic acid assays |
| WO2024206549A2 (en) * | 2023-03-29 | 2024-10-03 | Cellicure, Inc. | Engineered immune cells and use thereof |
| CN116913417B (zh) * | 2023-04-07 | 2025-11-28 | 四川大学 | 一种dna结合小分子高通量筛选及表征方法 |
| JP2025071533A (ja) * | 2023-10-23 | 2025-05-08 | 美洛生物科技股▲ふん▼有限公司 | 新型誘導細胞質インビトロ転写様組成物およびその関連ワクチン医薬設計 |
| JP2025187393A (ja) * | 2024-06-13 | 2025-12-25 | 株式会社日立製作所 | Ｔ細胞受容体（ｔｃｒ）またはｂ細胞受容体（ｂｃｒ）の遺伝子検査方法および遺伝子検査キット |
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-
2019
- 2019-08-12 CN CN202310118607.9A patent/CN116298309B/zh active Active
- 2019-08-12 IL IL294471A patent/IL294471B2/en unknown
- 2019-08-12 CN CN201980067485.7A patent/CN112840031B/zh active Active
- 2019-08-12 KR KR1020217007322A patent/KR102543325B1/ko active Active
- 2019-08-12 CN CN202310093858.6A patent/CN116144706A/zh not_active Withdrawn
- 2019-08-12 KR KR1020237019408A patent/KR20230088518A/ko active Pending
- 2019-08-12 AU AU2019322834A patent/AU2019322834B2/en active Active
- 2019-08-12 JP JP2021532265A patent/JP7227374B2/ja active Active
- 2019-08-12 WO PCT/US2019/046170 patent/WO2020036875A1/en not_active Ceased
- 2019-08-12 IL IL280682A patent/IL280682B/en unknown
- 2019-08-12 MX MX2021001763A patent/MX2021001763A/es unknown
- 2019-08-12 CA CA3108439A patent/CA3108439A1/en active Pending
- 2019-08-12 SG SG11202101371TA patent/SG11202101371TA/en unknown
- 2019-08-12 EP EP19849196.1A patent/EP3837373B1/en active Active
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2021
- 2021-02-11 US US17/173,705 patent/US11208457B2/en active Active
- 2021-11-17 US US17/528,550 patent/US12098181B2/en active Active
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2023
- 2023-02-09 JP JP2023018149A patent/JP7475506B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL294471A (en) | 2022-09-01 |
| JP7475506B2 (ja) | 2024-04-26 |
| MX2021001763A (es) | 2021-04-19 |
| US12098181B2 (en) | 2024-09-24 |
| IL294471B1 (en) | 2024-03-01 |
| US20220135641A1 (en) | 2022-05-05 |
| CN116144706A (zh) | 2023-05-23 |
| US20210171600A1 (en) | 2021-06-10 |
| IL294471B2 (en) | 2024-07-01 |
| AU2019322834B2 (en) | 2024-07-18 |
| KR20230088518A (ko) | 2023-06-19 |
| JP7227374B2 (ja) | 2023-02-21 |
| EP3837373A1 (en) | 2021-06-23 |
| CN116298309A (zh) | 2023-06-23 |
| KR102543325B1 (ko) | 2023-06-13 |
| US11208457B2 (en) | 2021-12-28 |
| KR20210057043A (ko) | 2021-05-20 |
| CN116298309B (zh) | 2024-04-02 |
| CN112840031B (zh) | 2023-03-24 |
| CN112840031A (zh) | 2021-05-25 |
| CA3108439A1 (en) | 2020-02-20 |
| JP2023058615A (ja) | 2023-04-25 |
| EP3837373B1 (en) | 2024-06-12 |
| WO2020036875A1 (en) | 2020-02-20 |
| JP2021534245A (ja) | 2021-12-09 |
| EP3837373A4 (en) | 2022-07-06 |
| IL280682A (en) | 2021-03-25 |
| AU2019322834A1 (en) | 2021-03-18 |
| IL280682B (en) | 2022-08-01 |
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