JP2021530541A - てんかんの治療方法 - Google Patents

てんかんの治療方法 Download PDF

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Publication number
JP2021530541A
JP2021530541A JP2021503108A JP2021503108A JP2021530541A JP 2021530541 A JP2021530541 A JP 2021530541A JP 2021503108 A JP2021503108 A JP 2021503108A JP 2021503108 A JP2021503108 A JP 2021503108A JP 2021530541 A JP2021530541 A JP 2021530541A
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JP
Japan
Prior art keywords
epilepsy
compound
fenfluramine
pharmaceutically acceptable
norfenfluramine
Prior art date
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Pending
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JP2021503108A
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English (en)
Japanese (ja)
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JPWO2020023923A5 (enExample
Inventor
ジェフリー ポール ベチャード
ロビン ポール シェリントン
ジャン−ジャック アレクサンドル カディウー
パリサ カリミ タリ
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of JP2021530541A publication Critical patent/JP2021530541A/ja
Publication of JPWO2020023923A5 publication Critical patent/JPWO2020023923A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2021503108A 2018-07-27 2019-07-26 てんかんの治療方法 Pending JP2021530541A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862711051P 2018-07-27 2018-07-27
US62/711,051 2018-07-27
PCT/US2019/043765 WO2020023923A1 (en) 2018-07-27 2019-07-26 Method for treating epilepsy

Publications (2)

Publication Number Publication Date
JP2021530541A true JP2021530541A (ja) 2021-11-11
JPWO2020023923A5 JPWO2020023923A5 (enExample) 2022-08-02

Family

ID=67551433

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021503108A Pending JP2021530541A (ja) 2018-07-27 2019-07-26 てんかんの治療方法

Country Status (20)

Country Link
US (1) US20200030260A1 (enExample)
EP (1) EP3829558B1 (enExample)
JP (1) JP2021530541A (enExample)
KR (1) KR20210061332A (enExample)
CN (1) CN112930175A (enExample)
AU (1) AU2019310600A1 (enExample)
BR (1) BR112021001135A2 (enExample)
CA (1) CA3106031A1 (enExample)
CL (1) CL2021000196A1 (enExample)
CO (1) CO2021002087A2 (enExample)
CR (1) CR20210095A (enExample)
EA (1) EA202190369A1 (enExample)
ES (1) ES2988130T3 (enExample)
IL (1) IL280128A (enExample)
MA (1) MA53329A (enExample)
MX (1) MX2021000987A (enExample)
PE (1) PE20211065A1 (enExample)
PH (1) PH12021550176A1 (enExample)
SG (1) SG11202100682YA (enExample)
WO (1) WO2020023923A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
SG11201804811WA (en) 2015-12-22 2018-07-30 Zogenix International Ltd Fenfluramine compositions and methods of preparing the same
KR20180095674A (ko) 2015-12-22 2018-08-27 조게닉스 인터내셔널 리미티드 대사 저항성 펜플루라민 유사체 및 그 사용 방법
RU2746000C2 (ru) 2016-08-24 2021-04-05 Зодженикс Интернэшнл Лимитед Состав для ингибирования образования агонистов 5-ht2b и способы его применения
WO2020047312A1 (en) * 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
US12144787B2 (en) 2018-11-19 2024-11-19 Zogenix International Limited Method of treating patients with a mutation in cyclin-dependent kinase-like 5 (CDKL5)
CN114127150A (zh) * 2019-07-18 2022-03-01 巴斯夫欧洲公司 脲基甲酸酯基分散剂
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
US20230078820A1 (en) * 2021-09-01 2023-03-16 Zogenix International Limited Fenfluramine for treatment of demyelinating diseases and conditions
CN118873517A (zh) * 2024-07-05 2024-11-01 上海柯西医药科技发展有限公司 大麻二酚与5-ht2b受体激动剂的组合的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016216438A (ja) * 2015-05-15 2016-12-22 ゾゲニクス インターナショナル リミテッド ドラベ症候群を処置するための選択的５−ｈｔ受容体アゴニストおよびアンタゴニスト
JP2017057188A (ja) * 2015-09-14 2017-03-23 ゾゲニクス インターナショナル リミテッド 特別な形態のてんかんの併用療法
JP2018506555A (ja) * 2015-02-25 2018-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 障害を治療するための５ｈｔ作動薬

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL270984A (enExample) 1960-11-05
GB1175516A (en) 1966-04-15 1969-12-23 Science Union & Cie New Phenyl-Aminopropane Derivatives and Preparations Containing them
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
WO1995033455A1 (en) * 1994-06-03 1995-12-14 Elmaleh David R Meta substituted arylalkylamines and therapeutic and diagnostic uses thereof
JP2001524124A (ja) 1997-05-07 2001-11-27 ガレン（ケミカルズ）リミティド テストステロンおよびテストステロン前駆体の投与のための膣内薬物送達用具
US6591909B1 (en) 2001-12-20 2003-07-15 Halliburton Energy Services, Inc. Whey protein retarder
US9549909B2 (en) * 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
GB201715919D0 (en) * 2017-09-29 2017-11-15 Gw Res Ltd use of cannabinoids in the treatment of epilepsy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018506555A (ja) * 2015-02-25 2018-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 障害を治療するための５ｈｔ作動薬
JP2016216438A (ja) * 2015-05-15 2016-12-22 ゾゲニクス インターナショナル リミテッド ドラベ症候群を処置するための選択的５−ｈｔ受容体アゴニストおよびアンタゴニスト
JP2017057188A (ja) * 2015-09-14 2017-03-23 ゾゲニクス インターナショナル リミテッド 特別な形態のてんかんの併用療法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EPILEPSIA, vol. 53, no. 7, JPN6023024234, 2012, pages 1131 - 1139, ISSN: 0005264649 *
MARTIN, PARTHENA ET AL.: "An Examination of the Mechanism of Action of Fenfluramine in Dravet Syndrome: A Look beyond Serotoni", BIOLOGICAL PSYCHIATRY, vol. 81, JPN6023024235, 2017, pages 268, ISSN: 0005264648 *
PHARMACOLOGY, BIOCHEMISTRY AND BEHAVIOR, vol. 71, JPN6023024236, 2002, pages 825 - 836, ISSN: 0005264647 *
RICHARD B. ROTHMAN ET AL.: "(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepineph", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 305, no. 3, JPN6024006336, 2003, pages 1191 - 1199, ISSN: 0005264650 *

Also Published As

Publication number Publication date
WO2020023923A1 (en) 2020-01-30
CA3106031A1 (en) 2020-01-30
EA202190369A1 (ru) 2021-06-10
AU2019310600A1 (en) 2021-02-11
EP3829558C0 (en) 2024-07-03
MX2021000987A (es) 2021-06-15
CL2021000196A1 (es) 2021-12-31
CO2021002087A2 (es) 2021-04-30
CR20210095A (es) 2021-06-01
EP3829558B1 (en) 2024-07-03
ES2988130T3 (es) 2024-11-19
SG11202100682YA (en) 2021-02-25
KR20210061332A (ko) 2021-05-27
IL280128A (en) 2021-03-01
MA53329A (fr) 2022-03-02
PE20211065A1 (es) 2021-06-09
EP3829558A1 (en) 2021-06-09
BR112021001135A2 (pt) 2021-04-20
CN112930175A (zh) 2021-06-08
US20200030260A1 (en) 2020-01-30
PH12021550176A1 (en) 2021-10-11

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