CA3106031A1 - Method for treating epilepsy - Google Patents

Method for treating epilepsy Download PDF

Info

Publication number
CA3106031A1
CA3106031A1 CA3106031A CA3106031A CA3106031A1 CA 3106031 A1 CA3106031 A1 CA 3106031A1 CA 3106031 A CA3106031 A CA 3106031A CA 3106031 A CA3106031 A CA 3106031A CA 3106031 A1 CA3106031 A1 CA 3106031A1
Authority
CA
Canada
Prior art keywords
fenfluramine
norfenfluramine
epilepsy
compound
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3106031A
Other languages
English (en)
French (fr)
Inventor
Jeffrey Paul BECHARD
Robin Paul SHERRINGTON
Jean-Jacques Alexandre CADIEUX
Parisa Karimi TARI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of CA3106031A1 publication Critical patent/CA3106031A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3106031A 2018-07-27 2019-07-26 Method for treating epilepsy Pending CA3106031A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862711051P 2018-07-27 2018-07-27
US62/711,051 2018-07-27
PCT/US2019/043765 WO2020023923A1 (en) 2018-07-27 2019-07-26 Method for treating epilepsy

Publications (1)

Publication Number Publication Date
CA3106031A1 true CA3106031A1 (en) 2020-01-30

Family

ID=67551433

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3106031A Pending CA3106031A1 (en) 2018-07-27 2019-07-26 Method for treating epilepsy

Country Status (20)

Country Link
US (1) US20200030260A1 (enExample)
EP (1) EP3829558B1 (enExample)
JP (1) JP2021530541A (enExample)
KR (1) KR20210061332A (enExample)
CN (1) CN112930175A (enExample)
AU (1) AU2019310600A1 (enExample)
BR (1) BR112021001135A2 (enExample)
CA (1) CA3106031A1 (enExample)
CL (1) CL2021000196A1 (enExample)
CO (1) CO2021002087A2 (enExample)
CR (1) CR20210095A (enExample)
EA (1) EA202190369A1 (enExample)
ES (1) ES2988130T3 (enExample)
IL (1) IL280128A (enExample)
MA (1) MA53329A (enExample)
MX (1) MX2021000987A (enExample)
PE (1) PE20211065A1 (enExample)
PH (1) PH12021550176A1 (enExample)
SG (1) SG11202100682YA (enExample)
WO (1) WO2020023923A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
HRP20250898T1 (hr) 2015-12-22 2025-09-26 Zogenix International Limited Pripravci fenfluramina i postupci njihove pripreme
WO2017112701A1 (en) 2015-12-22 2017-06-29 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
JP2019526544A (ja) 2016-08-24 2019-09-19 ゾゲニクス インターナショナル リミテッド 5−ht2bアゴニストの形成を阻害するための製剤およびその使用方法
US10752623B2 (en) * 2018-08-31 2020-08-25 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
SG11202104378SA (en) 2018-11-19 2021-05-28 Zogenix International Ltd Methods of treating rett syndrome using fenfluramine
US11897995B2 (en) * 2019-07-18 2024-02-13 Basf Se Allophanate based dispersing agent
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
JP2024533015A (ja) * 2021-09-01 2024-09-12 ゾゲニクス インターナショナル リミテッド 脱髄性の疾患および病状の処置のためのフェンフルラミン
CN118873517A (zh) * 2024-07-05 2024-11-01 上海柯西医药科技发展有限公司 大麻二酚与5-ht2b受体激动剂的组合的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL270984A (enExample) 1960-11-05
GB1175516A (en) 1966-04-15 1969-12-23 Science Union & Cie New Phenyl-Aminopropane Derivatives and Preparations Containing them
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
PT762877E (pt) * 1994-06-03 2001-08-30 Thejmde Trust Arilalquilaminas meta-substituidas e suas aplicacoes terapeuticas e de diagnostico
ATE227120T1 (de) 1997-05-07 2002-11-15 Galen Chemicals Ltd Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron- vorläuferverbindungen
US6591909B1 (en) 2001-12-20 2003-07-15 Halliburton Energy Services, Inc. Whey protein retarder
US9549909B2 (en) * 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
EA201992474A3 (ru) * 2015-02-25 2020-05-31 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа Агонисты 5ht для лечения нарушений
JP6668045B2 (ja) * 2015-05-15 2020-03-18 ゾゲニクス インターナショナル リミテッド ドラベ症候群を処置するための選択的5−ht受容体アゴニストおよびアンタゴニスト
JP2017057188A (ja) * 2015-09-14 2017-03-23 ゾゲニクス インターナショナル リミテッド 特別な形態のてんかんの併用療法
GB201715919D0 (en) * 2017-09-29 2017-11-15 Gw Res Ltd use of cannabinoids in the treatment of epilepsy

Also Published As

Publication number Publication date
IL280128A (en) 2021-03-01
CR20210095A (es) 2021-06-01
BR112021001135A2 (pt) 2021-04-20
US20200030260A1 (en) 2020-01-30
MA53329A (fr) 2022-03-02
SG11202100682YA (en) 2021-02-25
KR20210061332A (ko) 2021-05-27
WO2020023923A1 (en) 2020-01-30
JP2021530541A (ja) 2021-11-11
AU2019310600A1 (en) 2021-02-11
EP3829558B1 (en) 2024-07-03
EA202190369A1 (ru) 2021-06-10
EP3829558A1 (en) 2021-06-09
CO2021002087A2 (es) 2021-04-30
CL2021000196A1 (es) 2021-12-31
PE20211065A1 (es) 2021-06-09
EP3829558C0 (en) 2024-07-03
PH12021550176A1 (en) 2021-10-11
MX2021000987A (es) 2021-06-15
CN112930175A (zh) 2021-06-08
ES2988130T3 (es) 2024-11-19

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EEER Examination request

Effective date: 20220926

EEER Examination request

Effective date: 20220926

EEER Examination request

Effective date: 20220926