JP2021530517A - ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物 - Google Patents

ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物 Download PDF

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JP2021530517A
JP2021530517A JP2021502478A JP2021502478A JP2021530517A JP 2021530517 A JP2021530517 A JP 2021530517A JP 2021502478 A JP2021502478 A JP 2021502478A JP 2021502478 A JP2021502478 A JP 2021502478A JP 2021530517 A JP2021530517 A JP 2021530517A
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day
patient
diabetic patient
treatment
placebo
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JP2021530517A5 (https=
JPWO2020016335A5 (https=
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アンナ・マリア・ラングキルデ
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AstraZeneca AB
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AstraZeneca AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021502478A 2018-07-19 2019-07-18 ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物 Withdrawn JP2021530517A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024094819A JP2024133492A (ja) 2018-07-19 2024-06-12 ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物

Applications Claiming Priority (3)

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US201862700463P 2018-07-19 2018-07-19
US62/700,463 2018-07-19
PCT/EP2019/069323 WO2020016335A1 (en) 2018-07-19 2019-07-18 Methods of treating hfpef employing dapagliflozin and compositions comprising the same

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JP2024094819A Division JP2024133492A (ja) 2018-07-19 2024-06-12 ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物

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JP2021530517A true JP2021530517A (ja) 2021-11-11
JP2021530517A5 JP2021530517A5 (https=) 2022-07-19
JPWO2020016335A5 JPWO2020016335A5 (https=) 2022-07-19

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JP2021502478A Withdrawn JP2021530517A (ja) 2018-07-19 2019-07-18 ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物
JP2024094819A Pending JP2024133492A (ja) 2018-07-19 2024-06-12 ダパグリフロジンを使用してＨＦｐＥＦを処置する方法、及びダパグリフロジンを含む組成物

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US (2) US11826376B2 (https=)
EP (1) EP3823631A1 (https=)
JP (2) JP2021530517A (https=)
KR (1) KR20210034039A (https=)
CN (1) CN112512530A (https=)
AU (4) AU2019304032B2 (https=)
BR (1) BR112021000139A2 (https=)
CA (1) CA3105626A1 (https=)
CL (1) CL2021000107A1 (https=)
CR (1) CR20210029A (https=)
EA (1) EA202190226A1 (https=)
IL (2) IL319642A (https=)
JO (1) JOP20210009A1 (https=)
MA (1) MA53175A (https=)
MX (2) MX2021000601A (https=)
MY (1) MY210508A (https=)
PE (1) PE20210644A1 (https=)
PH (1) PH12021550121A1 (https=)
SG (1) SG11202100417RA (https=)
UA (1) UA129183C2 (https=)
WO (1) WO2020016335A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021000139A2 (pt) 2018-07-19 2021-04-06 Astrazeneca Ab Métodos de tratamento da hfpef empregando dapagliflozina e composições compreendendo a mesma
WO2021037400A1 (en) 2019-08-30 2021-03-04 Astrazeneca Ab Methods of treating heart failure with reduced ejection fraction with dapagliflozin
CN117510447B (zh) * 2023-11-08 2025-08-12 河北医科大学 一种达格列净-吡格列酮共无定形物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009545525A (ja) * 2006-06-28 2009-12-24 ブリストル−マイヤーズ スクイブ カンパニー 糖尿病の治療用ｓｇｌｔ２阻害剤としてのアミノ酸を有する（１ｓ）−１，５−アンヒドロ−１−ｃ−（３−（（フェニル）メチル）フェニル）−ｄ−グルシトール誘導体の結晶性溶媒和物および複合体
WO2017157816A1 (en) * 2016-03-16 2017-09-21 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising empagliflozin and uses thereof

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