JP2021529191A5 - - Google Patents
Info
- Publication number
- JP2021529191A5 JP2021529191A5 JP2020572691A JP2020572691A JP2021529191A5 JP 2021529191 A5 JP2021529191 A5 JP 2021529191A5 JP 2020572691 A JP2020572691 A JP 2020572691A JP 2020572691 A JP2020572691 A JP 2020572691A JP 2021529191 A5 JP2021529191 A5 JP 2021529191A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- dihydro
- oxo
- naphthyridine
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690439P | 2018-06-27 | 2018-06-27 | |
| US62/690,439 | 2018-06-27 | ||
| US201962840459P | 2019-04-30 | 2019-04-30 | |
| US62/840,459 | 2019-04-30 | ||
| PCT/US2019/039135 WO2020006018A1 (en) | 2018-06-27 | 2019-06-26 | Substituted naphthyridinone compounds useful as t cell activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529191A JP2021529191A (ja) | 2021-10-28 |
| JP2021529191A5 true JP2021529191A5 (enExample) | 2022-07-04 |
| JP7432532B2 JP7432532B2 (ja) | 2024-02-16 |
Family
ID=67439335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020572691A Active JP7432532B2 (ja) | 2018-06-27 | 2019-06-26 | Ｔ細胞アクティベーターとして有用な置換ナフチリジノン化合物 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10669272B2 (enExample) |
| EP (1) | EP3814348B9 (enExample) |
| JP (1) | JP7432532B2 (enExample) |
| KR (1) | KR102767739B1 (enExample) |
| CN (1) | CN112654621B (enExample) |
| AU (1) | AU2019291794B2 (enExample) |
| BR (1) | BR112020026681A2 (enExample) |
| CA (1) | CA3104654A1 (enExample) |
| CL (1) | CL2020003260A1 (enExample) |
| CY (1) | CY1126280T1 (enExample) |
| DK (1) | DK3814348T3 (enExample) |
| ES (1) | ES2960754T3 (enExample) |
| FI (1) | FI3814348T3 (enExample) |
| HR (1) | HRP20231253T1 (enExample) |
| HU (1) | HUE064531T2 (enExample) |
| IL (1) | IL279728B2 (enExample) |
| LT (1) | LT3814348T (enExample) |
| MX (1) | MX2020013817A (enExample) |
| PE (1) | PE20210469A1 (enExample) |
| PL (1) | PL3814348T3 (enExample) |
| PT (1) | PT3814348T (enExample) |
| RS (1) | RS64641B1 (enExample) |
| SG (1) | SG11202012972YA (enExample) |
| SI (1) | SI3814348T1 (enExample) |
| SM (1) | SMT202300466T1 (enExample) |
| TW (1) | TW202019924A (enExample) |
| WO (1) | WO2020006018A1 (enExample) |
| ZA (1) | ZA202100555B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111471059B (zh) * | 2019-01-23 | 2022-12-02 | 药捷安康(南京)科技股份有限公司 | Pde9抑制剂及其用途 |
| JP7574215B2 (ja) | 2019-04-29 | 2024-10-28 | ソレント セラピューティクス，エルエルシー | ＭＲＧＸ２の阻害薬である３－アミノ－４Ｈ－ベンゾ［ｅ］［１，２，４］チアジアジン１，１－ジオキシド誘導体 |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| EP4065584A1 (en) | 2019-11-28 | 2022-10-05 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| WO2021105115A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| US12478621B2 (en) | 2019-11-28 | 2025-11-25 | Deutsches Krebsforschungszentrum | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| WO2021127554A1 (en) * | 2019-12-19 | 2021-06-24 | Bristol-Myers Squibb Company | Combinations of dgk inhibitors and checkpoint antagonists |
| JP7677976B2 (ja) * | 2019-12-23 | 2025-05-15 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔ細胞アクティベーターとして有用な置換ヘテロアリール化合物 |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
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| CA3162979A1 (en) * | 2019-12-23 | 2021-07-01 | Upender Velaparthi | Substituted piperazine derivatives useful as t cell activators |
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| CN115362003B (zh) | 2019-12-24 | 2024-03-22 | 卡尔那生物科学株式会社 | 二酰基甘油激酶调节化合物 |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CA3180670A1 (en) * | 2020-04-24 | 2021-10-28 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
| WO2021258010A1 (en) * | 2020-06-19 | 2021-12-23 | Gossamer Bio Services, Inc. | Oxime compounds useful as t cell activators |
| JP7604067B2 (ja) * | 2020-11-26 | 2024-12-23 | エルジー・ケム・リミテッド | ジアシルグリセロールキナーゼ阻害剤としての複素環化合物及びその用途 |
| WO2022114164A1 (ja) * | 2020-11-30 | 2022-06-02 | アステラス製薬株式会社 | ヘテロアリールカルボキシアミド化合物 |
| AU2021400725A1 (en) | 2020-12-16 | 2023-08-03 | Gossamer Bio Services, Inc. | Compounds useful as t cell activators |
| KR20230165771A (ko) | 2021-03-03 | 2023-12-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법 및 dgk 억제제의 조합 |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
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| CN117355531A (zh) | 2021-06-23 | 2024-01-05 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| MX2023014762A (es) * | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| CN118946556A (zh) * | 2022-02-01 | 2024-11-12 | 阿维纳斯运营公司 | Dgk靶向化合物及其用途 |
| IL315015A (en) | 2022-03-01 | 2024-10-01 | Insilico Medicine Ip Ltd | Diacylglycerol kinase (DGK) alpha inhibitors and their uses |
| EP4486745A4 (en) * | 2022-03-01 | 2026-03-11 | Insilico Medicine Ip Ltd | Diacylglycerol Kinase (DGK) Alpha Inhibitors and Their Uses |
| WO2023165525A1 (en) * | 2022-03-01 | 2023-09-07 | Insilico Medicine Ip Limited | Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023184327A1 (en) * | 2022-03-31 | 2023-10-05 | InventisBio Co., Ltd. | Kinase inhibitors, preparation methods and uses thereof |
| CN119998295A (zh) | 2022-06-08 | 2025-05-13 | 因赛特公司 | 作为dgk抑制剂的三环三唑并化合物 |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US20240083898A1 (en) * | 2022-08-15 | 2024-03-14 | Incyte Corporation | Tricyclic triazolo compounds as dgk inhibitors |
| KR20250061756A (ko) | 2022-09-08 | 2025-05-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법과 연속적 또는 간헐적 dgk 억제제 투여의 조합 |
| TW202436351A (zh) | 2023-02-06 | 2024-09-16 | 德商拜耳廠股份有限公司 | Ccr8抗體及dgk抑制劑之組合 |
| CN116375654B (zh) * | 2023-03-22 | 2024-12-31 | 湖北三峡实验室 | 一种由双甘肽制备2,5-二酮哌嗪的方法 |
| CN119143715B (zh) * | 2024-11-12 | 2025-03-14 | 天津匠新致成科技有限公司 | 二芳基团甲基哌嗪类化合物及其制备方法、药物组合物和应用 |
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2019
- 2019-06-26 CN CN201980055715.8A patent/CN112654621B/zh active Active
- 2019-06-26 MX MX2020013817A patent/MX2020013817A/es unknown
- 2019-06-26 WO PCT/US2019/039135 patent/WO2020006018A1/en not_active Ceased
- 2019-06-26 PE PE2020002111A patent/PE20210469A1/es unknown
- 2019-06-26 RS RS20230895A patent/RS64641B1/sr unknown
- 2019-06-26 US US16/452,679 patent/US10669272B2/en active Active
- 2019-06-26 HR HRP20231253TT patent/HRP20231253T1/hr unknown
- 2019-06-26 SG SG11202012972YA patent/SG11202012972YA/en unknown
- 2019-06-26 CA CA3104654A patent/CA3104654A1/en active Pending
- 2019-06-26 PL PL19744923.4T patent/PL3814348T3/pl unknown
- 2019-06-26 AU AU2019291794A patent/AU2019291794B2/en not_active Ceased
- 2019-06-26 LT LTEPPCT/US2019/039135T patent/LT3814348T/lt unknown
- 2019-06-26 EP EP19744923.4A patent/EP3814348B9/en active Active
- 2019-06-26 HU HUE19744923A patent/HUE064531T2/hu unknown
- 2019-06-26 JP JP2020572691A patent/JP7432532B2/ja active Active
- 2019-06-26 FI FIEP19744923.4T patent/FI3814348T3/fi active
- 2019-06-26 KR KR1020217002231A patent/KR102767739B1/ko active Active
- 2019-06-26 PT PT197449234T patent/PT3814348T/pt unknown
- 2019-06-26 ES ES19744923T patent/ES2960754T3/es active Active
- 2019-06-26 SI SI201930609T patent/SI3814348T1/sl unknown
- 2019-06-26 DK DK19744923.4T patent/DK3814348T3/da active
- 2019-06-26 SM SM20230466T patent/SMT202300466T1/it unknown
- 2019-06-26 BR BR112020026681-7A patent/BR112020026681A2/pt unknown
- 2019-06-27 TW TW108122537A patent/TW202019924A/zh unknown
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2020
- 2020-04-08 US US16/843,024 patent/US10954238B1/en active Active
- 2020-12-16 CL CL2020003260A patent/CL2020003260A1/es unknown
- 2020-12-23 IL IL279728A patent/IL279728B2/en unknown
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2021
- 2021-01-26 ZA ZA2021/00555A patent/ZA202100555B/en unknown
- 2021-02-01 US US17/164,009 patent/US11713316B2/en active Active
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2023
- 2023-10-31 CY CY20231100606T patent/CY1126280T1/el unknown
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