AU2019291794B2 - Substituted naphthyridinone compounds useful as T cell activators - Google Patents

Substituted naphthyridinone compounds useful as T cell activators Download PDF

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Publication number
AU2019291794B2
AU2019291794B2 AU2019291794A AU2019291794A AU2019291794B2 AU 2019291794 B2 AU2019291794 B2 AU 2019291794B2 AU 2019291794 A AU2019291794 A AU 2019291794A AU 2019291794 A AU2019291794 A AU 2019291794A AU 2019291794 B2 AU2019291794 B2 AU 2019291794B2
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Prior art keywords
methyl
oxo
dihydro
naphthyridine
carbonitrile
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AU2019291794A1 (en
Inventor
Louis S. Chupak
Chetan Padmakar Darne
Bireshwar Dasgupta
Min Ding
Robert G. Gentles
Yazhong Huang
Prasada Rao JALAGAM
Manjunatha Narayana Rao Kamble
Raju MANNOORI
Scott W. Martin
Ivar M. Mcdonald
Richard E. Olson
Hasibur RAHAMAN
Thiruvenkadam RAJA
Kotha Rathnakar REDDY
Saumya Roy
John S. Tokarski
Gopikishan TONUKUNURU
Sivasudar Velaiah
Upender Velaparthi
Jayakumar Sankara WARRIER
Xiaofan Zheng
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
AU2019291794A 2018-06-27 2019-06-26 Substituted naphthyridinone compounds useful as T cell activators Active AU2019291794B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862690439P 2018-06-27 2018-06-27
US62/690,439 2018-06-27
US201962840459P 2019-04-30 2019-04-30
US62/840,459 2019-04-30
PCT/US2019/039135 WO2020006018A1 (en) 2018-06-27 2019-06-26 Substituted naphthyridinone compounds useful as t cell activators

Publications (2)

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AU2019291794A1 AU2019291794A1 (en) 2021-02-11
AU2019291794B2 true AU2019291794B2 (en) 2022-06-16

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US12478621B2 (en) 2019-11-28 2025-11-25 Deutsches Krebsforschungszentrum Substituted aminoquinolones as dgkalpha inhibitors for immune activation
WO2021105115A1 (en) 2019-11-28 2021-06-03 Bayer Aktiengesellschaft Substituted aminoquinolones as dgkalpha inhibitors for immune activation
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AR120823A1 (es) * 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
MX2022006958A (es) 2019-12-23 2022-07-12 Bristol Myers Squibb Co Compuestos de quinazolinilo sustituidos utiles como activadores de celulas t.
ES3013568T3 (en) * 2019-12-23 2025-04-14 Bristol Myers Squibb Co Substituted heteroaryl compounds useful as t cell activators
BR112022012220A2 (pt) * 2019-12-23 2022-09-13 Bristol Myers Squibb Co Compostos de piperazina quinolinonil substituída úteis como ativadores de célula t
BR112022012222A2 (pt) * 2019-12-23 2022-09-13 Bristol Myers Squibb Co Derivados de piperazina substituídos úteis como ativadores de células t
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CA3222595A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
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WO2023122777A1 (en) * 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Oxime derivatives useful as t cell activators
WO2023150186A1 (en) * 2022-02-01 2023-08-10 Arvinas Operations, Inc. Dgk targeting compounds and uses thereof
WO2023165525A1 (en) * 2022-03-01 2023-09-07 Insilico Medicine Ip Limited Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof
TW202342478A (zh) * 2022-03-01 2023-11-01 香港商英矽智能科技知識產權有限公司 二醯基甘油激酶（ＤＧＫ）α抑制劑及其用途
CN118871438A (zh) 2022-03-01 2024-10-29 英矽智能科技知识产权有限公司 二酰基甘油激酶(DGK)α抑制剂及其用途
KR20240161147A (ko) 2022-03-14 2024-11-12 슬랩 파마슈티컬스 엘엘씨 다중 사이클릭 화합물
WO2023184327A1 (en) * 2022-03-31 2023-10-05 InventisBio Co., Ltd. Kinase inhibitors, preparation methods and uses thereof
CN120152717A (zh) 2022-09-08 2025-06-13 朱诺治疗学股份有限公司 T细胞疗法和连续或间歇dgk抑制剂给药的组合
TW202448461A (zh) 2023-02-06 2024-12-16 德商拜耳廠股份有限公司 Dgk（二醯基甘油激酶）抑制劑及免疫檢查點抑制劑及調節劑之組合
CN116375654B (zh) * 2023-03-22 2024-12-31 湖北三峡实验室 一种由双甘肽制备2,5-二酮哌嗪的方法
CN119143715B (zh) * 2024-11-12 2025-03-14 天津匠新致成科技有限公司 二芳基团甲基哌嗪类化合物及其制备方法、药物组合物和应用

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KR102767739B1 (ko) 2025-02-12
LT3814348T (lt) 2023-10-10
WO2020006018A1 (en) 2020-01-02
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