JP2023513241A5 - - Google Patents
Info
- Publication number
- JP2023513241A5 JP2023513241A5 JP2022548420A JP2022548420A JP2023513241A5 JP 2023513241 A5 JP2023513241 A5 JP 2023513241A5 JP 2022548420 A JP2022548420 A JP 2022548420A JP 2022548420 A JP2022548420 A JP 2022548420A JP 2023513241 A5 JP2023513241 A5 JP 2023513241A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- dihydro
- urea
- indole
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202011006115 | 2020-02-12 | ||
| GBGB2001884.2A GB202001884D0 (en) | 2020-02-12 | 2020-02-12 | Small molecule sting antagonists |
| GB2001884.2 | 2020-02-12 | ||
| IN202011006115 | 2020-02-12 | ||
| PCT/IB2021/051154 WO2021161230A1 (en) | 2020-02-12 | 2021-02-12 | Small molecule sting antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023513241A JP2023513241A (ja) | 2023-03-30 |
| JP2023513241A5 true JP2023513241A5 (enExample) | 2024-02-09 |
| JP7817170B2 JP7817170B2 (ja) | 2026-02-18 |
Family
ID=74858477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022548420A Active JP7817170B2 (ja) | 2020-02-12 | 2021-02-12 | 小分子ｓｔｉｎｇアンタゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230124361A1 (enExample) |
| EP (1) | EP4103278A1 (enExample) |
| JP (1) | JP7817170B2 (enExample) |
| KR (1) | KR20220141328A (enExample) |
| CN (1) | CN115151304B (enExample) |
| AU (1) | AU2021219370A1 (enExample) |
| CA (1) | CA3166358A1 (enExample) |
| IL (1) | IL295388A (enExample) |
| TW (1) | TWI904134B (enExample) |
| WO (1) | WO2021161230A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| KR20230152654A (ko) | 2020-12-30 | 2023-11-03 | 타이라 바이오사이언시스, 인크. | 키나아제 억제제로서의 인다졸 화합물 |
| JP2024502470A (ja) * | 2021-01-08 | 2024-01-19 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| AU2022326885A1 (en) * | 2021-08-11 | 2024-02-15 | Curadev Pharma Pvt. Ltd. | Small molecule urea derivatives as sting antagonists |
| WO2023017451A1 (en) * | 2021-08-11 | 2023-02-16 | Curadev Pharma Pvt. Ltd. | Small molecule sting antagonists |
| CN115710255B (zh) * | 2021-08-23 | 2025-05-06 | 上海交通大学 | 一类含有苯并杂环取代的脲类衍生物及其制备和用途 |
| WO2023109912A1 (en) * | 2021-12-16 | 2023-06-22 | Beigene, Ltd. | 3, 4-dihydroisoquinolin-1 (2h) -ones derivatives as sting antagonists and the use thereof |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| CN116789641A (zh) * | 2022-03-17 | 2023-09-22 | 中国科学院上海药物研究所 | 二氢异喹啉类化合物及其医药用途 |
| JP2023144194A (ja) * | 2022-03-28 | 2023-10-11 | 株式会社 伊藤園 | 呼吸器炎症予防剤、該呼吸器炎症予防剤の予防評価方法及び呼吸器炎症の予防方法 |
| WO2023223309A1 (en) * | 2022-05-14 | 2023-11-23 | Carmel Haifa University Economic Corporation Ltd. | Sting inhibitors and use thereof |
| US20260021107A1 (en) * | 2022-07-25 | 2026-01-22 | Inimmune Corp. | Stimulator of interferon genes agonists |
| WO2024064358A1 (en) * | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN116178256B (zh) * | 2023-04-19 | 2023-07-07 | 烟台大学 | 以sting为靶点的药用化合物及其制备方法和用途 |
| WO2025016379A1 (zh) * | 2023-07-19 | 2025-01-23 | 中国科学院上海药物研究所 | 氮杂环丁烷类化合物及其医药用途 |
| AU2024335572A1 (en) * | 2023-09-07 | 2026-03-19 | Xenon Pharmaceuticals Inc. | Benzo-fused heterocyclic compounds and uses thereof |
| CN118436670B (zh) * | 2024-05-11 | 2025-02-14 | 中山大学中山眼科中心 | cGAMP在构建视网膜血管性疾病动物模型中的应用 |
| CN120794957A (zh) * | 2024-05-14 | 2025-10-17 | 中国药科大学 | 苯并含氮杂环类sting抑制剂及其医药用途 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9511355D0 (en) * | 1995-06-06 | 1995-08-02 | Fujisawa Pharmaceutical Co | Urea derivatives |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| AR016817A1 (es) * | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7700592B2 (en) * | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
| WO2007024949A2 (en) * | 2005-08-25 | 2007-03-01 | Schering Corporation | Alpha2c adrenoreceptor agonists |
| CN101903357A (zh) * | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| US8969342B2 (en) * | 2009-03-20 | 2015-03-03 | Brandeis University | Compounds and methods for treating mammalian gastrointestinal microbial infections |
| US8969325B2 (en) * | 2011-12-19 | 2015-03-03 | Abbvie Inc. | TRPV1 antagonists |
| US20170146519A1 (en) * | 2015-11-20 | 2017-05-25 | Oregon Health & Science University | Sting agonists and methods of selecting sting agonists |
| US11076597B2 (en) * | 2015-12-28 | 2021-08-03 | Cas Center For Excellence In Molecular Plant Sciences | High stress resistant plant growth regulator and preparation method and use thereof |
| TW201818964A (zh) * | 2016-09-30 | 2018-06-01 | 瑞士商諾伊曼特醫療公司 | 使用色胺酸羥化酶抑制劑之方法 |
| CA3047098A1 (en) * | 2016-12-16 | 2018-06-21 | Jia Zhou | Inhibitors of bromodomain-containing protein 4 (brd4) |
| US11098026B2 (en) * | 2017-03-13 | 2021-08-24 | Impetis Biosciences Limited | Fused bicyclic compounds, compositions and applications thereof |
| US20200138827A1 (en) * | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| UA125730C2 (uk) | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
| CN109232358A (zh) * | 2017-07-10 | 2019-01-18 | 复旦大学 | 吲哚类衍生物或其盐及其制备方法和用途 |
| CN109305944B (zh) * | 2017-07-28 | 2022-09-02 | 深圳睿熙生物科技有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
| US10336701B2 (en) * | 2017-08-10 | 2019-07-02 | Janssen Pharmaceutica Nv | Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists |
| TW201920104A (zh) * | 2017-08-31 | 2019-06-01 | 美商馬愈法瑪公司 | 外核苷酸焦磷酸酶-磷酸二酯酶1(enpp-1)抑制劑及其用途 |
| CN109836393B (zh) * | 2017-11-29 | 2022-11-15 | 沈阳中化农药化工研发有限公司 | 一种环己烯羧酸铵盐类化合物及其应用 |
| TW202016081A (zh) * | 2018-06-21 | 2020-05-01 | 英商克拉德夫製藥有限公司 | 人類ｓｔｉｎｇ之小分子調節劑、結合物及治療應用 |
| CN120004785A (zh) * | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| EP3818053B1 (en) * | 2018-07-05 | 2023-03-29 | Sanford Burnham Prebys Medical Discovery Institute | Fused ring compound having urea structure |
| CN110066282B (zh) * | 2019-06-10 | 2020-07-10 | 南开大学 | 一种吡唑并嘧啶酮类化合物及其制备方法和应用 |
-
2021
- 2021-02-12 CA CA3166358A patent/CA3166358A1/en active Pending
- 2021-02-12 AU AU2021219370A patent/AU2021219370A1/en active Pending
- 2021-02-12 EP EP21710056.9A patent/EP4103278A1/en active Pending
- 2021-02-12 WO PCT/IB2021/051154 patent/WO2021161230A1/en not_active Ceased
- 2021-02-12 JP JP2022548420A patent/JP7817170B2/ja active Active
- 2021-02-12 IL IL295388A patent/IL295388A/en unknown
- 2021-02-12 US US17/798,552 patent/US20230124361A1/en active Pending
- 2021-02-12 KR KR1020227031301A patent/KR20220141328A/ko active Pending
- 2021-02-12 CN CN202180014531.4A patent/CN115151304B/zh active Active
- 2021-02-17 TW TW110105380A patent/TWI904134B/zh active
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