CN115151304B - 小分子干扰素基因刺激因子(sting)拮抗剂 - Google Patents

小分子干扰素基因刺激因子(sting)拮抗剂 Download PDF

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CN115151304B
CN115151304B CN202180014531.4A CN202180014531A CN115151304B CN 115151304 B CN115151304 B CN 115151304B CN 202180014531 A CN202180014531 A CN 202180014531A CN 115151304 B CN115151304 B CN 115151304B
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benzo
dihydro
oxo
urea
optionally substituted
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CN115151304A (zh
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M·班纳吉
S·巴苏
R·K·什里瓦斯塔瓦
D·C·普里德
S·K·米蒂雅
R·高希
D·B·亚达夫
A·苏里亚
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Curadev Pharma Pvt Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D471/04—Ortho-condensed systems

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CN202180014531.4A 2020-02-12 2021-02-12 小分子干扰素基因刺激因子(sting)拮抗剂 Active CN115151304B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN202011006115 2020-02-12
GBGB2001884.2A GB202001884D0 (en) 2020-02-12 2020-02-12 Small molecule sting antagonists
GB2001884.2 2020-02-12
IN202011006115 2020-02-12
PCT/IB2021/051154 WO2021161230A1 (en) 2020-02-12 2021-02-12 Small molecule sting antagonists

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CN115151304A CN115151304A (zh) 2022-10-04
CN115151304B true CN115151304B (zh) 2025-02-11

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US (1) US20230124361A1 (enExample)
EP (1) EP4103278A1 (enExample)
JP (1) JP7817170B2 (enExample)
KR (1) KR20220141328A (enExample)
CN (1) CN115151304B (enExample)
AU (1) AU2021219370A1 (enExample)
CA (1) CA3166358A1 (enExample)
IL (1) IL295388A (enExample)
TW (1) TWI904134B (enExample)
WO (1) WO2021161230A1 (enExample)

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WO2025016379A1 (zh) * 2023-07-19 2025-01-23 中国科学院上海药物研究所 氮杂环丁烷类化合物及其医药用途
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