JP2021528497A - 薬物がコーティングされたマイクロニードル及びその製造方法 - Google Patents
薬物がコーティングされたマイクロニードル及びその製造方法 Download PDFInfo
- Publication number
- JP2021528497A JP2021528497A JP2021520888A JP2021520888A JP2021528497A JP 2021528497 A JP2021528497 A JP 2021528497A JP 2021520888 A JP2021520888 A JP 2021520888A JP 2021520888 A JP2021520888 A JP 2021520888A JP 2021528497 A JP2021528497 A JP 2021528497A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- chemical formula
- microneedle
- silica
- reactive group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[Si]1(*)S(C)(C)O[Si](OS(C)C)O1 Chemical compound C[Si]1(*)S(C)(C)O[Si](OS(C)C)O1 0.000 description 2
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
- A45D44/22—Face shaping devices, e.g. chin straps; Wrinkle removers, e.g. stretching the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
- B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
- B81B1/008—Microtips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00111—Tips, pillars, i.e. raised structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/055—Microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
- B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
- B81C2201/0176—Chemical vapour Deposition
- B81C2201/0178—Oxidation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Manufacturing & Machinery (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Physics & Mathematics (AREA)
- Geometry (AREA)
- Inorganic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Computer Hardware Design (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Ceramic Engineering (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
【選択図】図1
Description
Claims (12)
- (a)シリカ(SiO2)含有マイクロニードルの表面を改質して、スルフヒドリル(Sulfhydryl、−SH)反応基を含むシリカ(SiO2)含有マイクロニードルを製造するステップと、
(b)薬物に、スルフヒドリル(Sulfhydryl、−SH)反応基を含むリンカーを結合させて、スルフヒドリル(Sulfhydryl、−SH)反応基を含む薬物を製造するステップと、
(c)スルフヒドリル(Sulfhydryl、−SH)反応基を含むシリカ(SiO2)含有マイクロニードルと、スルフヒドリル(Sulfhydryl、−SH)反応基を含む薬物とを酸化反応させるステップと、を含む、化学式1で表され、皮膚浸透後に酸化還元反応によって薬物が放出されることを特徴とする、薬物がコーティングされたマイクロニードルの製造方法。
[化学式1]
MN−S−S−D
(式中、MNはシリカ(SiO2)含有マイクロニードルであり、S−Sはジスルフィド結合であり、Dは薬物である。) - 前記シリカ(SiO2)含有マイクロニードルが海綿動物由来の針状骨片であることを特徴とする、請求項1に記載の薬物がコーティングされたマイクロニードルの製造方法。
- 前記シリカ(SiO2)含有マイクロニードルの表面改質は、
シリカ(SiO2)含有マイクロニードルに、3−メルカプトプロピル−メチルジメトキシシラン((3−Mercaptopropyl)methyldimethoxysilane)、3−メルカプトプロピル−トリメトキシシラン)(3−Mercaptopropyl)trimethoxysilane)、N−[3−(トリメトキシシリル)プロピル]エチレンジアミン(N−[3−(Trimethoxysilyl)propyl]ethylenediamine)、チオグリコール酸(Thioglycolic acid、3−Mercaptopropionic acid)、11−メルカプトウンデカン酸(11−Mercaptoundecanoic acid)及び3,3’−ジチオジプロピオン酸(3,3’−Dithiodipropionic acid)よりなる群から選択される1種を攪拌させることを特徴とする、請求項1に記載の薬物がコーティングされたマイクロニードルの製造方法。 - 前記スルフヒドリル(Sulfhydryl、−SH)反応基を含む薬物は、下記化学式2〜8よりなる群から選択される1以上であることを特徴とする、請求項1に記載の薬物がコーティングされたマイクロニードルの製造方法。
[化学式2]:Lys−His−Gly−X
[化学式3]:Gly−His−Lys−X
[化学式4]:Ser−Lys−Thr−Thr−Lys−X
[化学式5]:Lys−Thr−Thr−Lys−Ser−X
[化学式6]:Arg−Arg−Gln−Met−Glu−Glu−X
[化学式7]:Glu−Glu−Met−Gln−Arg−Arg−X
[化学式8]:
(前記化学式2〜8中、Xは、チオグリコール酸(Thioglycolic acid)、3−メルカプトプロピオン酸(3−Mercaptopropionic acid)、11−メルカプトウンデカン酸(11−Mercaptoundecanoic acid)及びシステイン(cysteine)よりなる群から選択される1種以上である。) - 前記スルフヒドリル(Sulfhydryl、−SH)反応基を含むシリカ(SiO2)含有マイクロニードルと、スルフヒドリル(Sulfhydryl、−SH)反応基を含む薬物との酸化反応は、ヨウ素(Iodine)、リン酸カリウム(Potassium Phosphate)、2,3−ジクロロ−5,6−ジシアノ−p−ベンゾキノン(2,3−Dichloro−5,6−dicyano−p−benzoquinone、DDQ)、デヒドロアスコルビン酸(Dehydroascorbic acid)、過酸化水素(H2O2)、及び酸素(O2)よりなる群から選択される1種以上の酸化剤によって行われることを特徴とする、請求項1に記載の薬物がコーティングされたマイクロニードルの製造方法。
- 化学式1で表され、皮膚浸透後に酸化還元反応によって薬物が放出されることを特徴とする、薬物がコーティングされたマイクロニードル。
[化学式1]
MN−S−S−D
(式中、MNはシリカ(SiO2)含有マイクロニードルであり、S−Sはジスルフィド結合であり、Dは薬物である。) - 前記シリカ(SiO2)含有マイクロニードルは海綿動物由来の針状骨片であることを特徴とする、請求項6に記載のマイクロニードル。
- 前記化学式1で表されるマイクロニードルは、スルフヒドリル(−SH)反応基を含むシリカ(SiO2)含有マイクロニードルと、スルフヒドリル(−SH)反応基を含む薬物との結合で製造されたことを特徴とする、請求項6に記載のマイクロニードル。
- 前記シリカ(SiO2)含有マイクロニードルは、スルフヒドリル(Sulfhydryl、−SH)反応基を0.8×10−6mol/g〜10×10−6mol/g含むことを特徴とする、請求項8に記載のマイクロニードル。
- 前記スルフヒドリル(Sulfhydryl、−SH)反応基を含む薬物は、下記化学式2〜8よりなる群から選択される1以上であることを特徴とする、請求項8に記載のマイクロニードル。
[化学式2]:Lys−His−Gly−X
[化学式3]:Gly−His−Lys−X
[化学式4]:Ser−Lys−Thr−Thr−Lys−X
[化学式5]:Lys−Thr−Thr−Lys−Ser−X
[化学式6]:Arg−Arg−Gln−Met−Glu−Glu−X
[化学式7]:Glu−Glu−Met−Gln−Arg−Arg−X
[化学式8]:
(前記化学式2〜8中、Xは、チオグリコール酸(Thioglycolic acid)、3−メルカプトプロピオン酸(3−Mercaptopropionic acid)、11−メルカプトウンデカン酸(11−Mercaptoundecanoic acid)及びシステイン(cysteine)よりなる群から選択される1種以上である。) - 請求項6〜10のいずれか一項に記載のマイクロニードルを含む化粧品組成物。
- 前記化粧品は、柔軟化粧水、栄養化粧水、栄養クリーム、マッサージクリーム、エッセンス、アンプル、ジェル、アイクリーム、クレンジングクリーム、クレンジングフォーム、クレンジングウォーター、パック、スプレー及びパウダーよりなる群から選択されることを特徴とする、請求項11に記載の化粧品組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180076060A KR101933685B1 (ko) | 2018-06-29 | 2018-06-29 | 약물이 코팅된 마이크로 니들 및 이의 제조방법 |
KR10-2018-0076060 | 2018-06-29 | ||
PCT/KR2018/016032 WO2020004745A1 (ko) | 2018-06-29 | 2018-12-17 | 약물이 코팅된 마이크로 니들 및 이의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021528497A true JP2021528497A (ja) | 2021-10-21 |
JP7091558B2 JP7091558B2 (ja) | 2022-06-27 |
Family
ID=65008401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021520888A Active JP7091558B2 (ja) | 2018-06-29 | 2018-12-17 | 薬物がコーティングされたマイクロニードル及びその製造方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20210196899A1 (ja) |
EP (1) | EP3824875B1 (ja) |
JP (1) | JP7091558B2 (ja) |
KR (1) | KR101933685B1 (ja) |
CN (1) | CN112351770A (ja) |
ES (1) | ES2966735T3 (ja) |
WO (1) | WO2020004745A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102235343B1 (ko) * | 2019-08-14 | 2021-04-02 | 주식회사 에스알바이오텍 | 깊은 주름 개선에 효과적인 펩타이드 복합 마이크로니들을 포함하는 화장품 조합물 및 적용방법 |
KR102214403B1 (ko) * | 2019-08-14 | 2021-02-09 | 주식회사 에스알바이오텍 | 펩타이드 복합 마이크로니들 및 이를 포함하는 화장품 조성물 |
CN114376569B (zh) * | 2022-01-19 | 2023-10-13 | 浙江大学 | 用于救治低血糖的载胰高血糖素可穿戴设备 |
KR102404932B1 (ko) * | 2022-02-24 | 2022-06-07 | (주)비엔 | 피부개선에 유효한 성분과 다이아몬드가 코팅된 스피큘 제조방법 및 이를 포함하는 다이아몬드 스피큘 화장료 조성물 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20160064410A (ko) * | 2014-11-28 | 2016-06-08 | 김형길 | 스피큘을 포함하는 피부관리용 화장품 조성물 및 이의 제조방법 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3960828A (en) * | 1974-03-20 | 1976-06-01 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Catalytic hydrogenolysis of protected sulfur containing peptides |
IL105600A (en) * | 1993-05-04 | 1999-12-31 | Allon Blank | Pharmaceutical and cosmetic compositions with increased rate of transdermal penetration and antioxidation protection against degradation containing derivatives of thioglycolic and mercaptopropionic acids some such novel compounds and their use |
JP2008531725A (ja) * | 2005-03-03 | 2008-08-14 | ルバンス セラピュティックス インク. | オリゴペプチドの局所適用及び経皮送達のための組成物及び方法 |
KR20090087877A (ko) * | 2006-10-05 | 2009-08-18 | 마리아 빌라니 | 피부 연마 기구 또는 피부 재생 수단으로서의 스폰질라 골편의 용도 |
KR100937389B1 (ko) | 2009-01-23 | 2010-01-19 | (주)스킨메디언스 | 해면 골편을 이용한 피부 관리 화장품 조성물의 제조방법 |
WO2010111533A2 (en) * | 2009-03-25 | 2010-09-30 | Kai Pharmaceuticals, Inc. | Transdermal delivery of pkc modulatory peptides through microporated skin |
WO2011148994A1 (ja) * | 2010-05-28 | 2011-12-01 | 久光製薬株式会社 | 微小突起付きアレイを有するデバイス |
CN102018615A (zh) * | 2010-12-21 | 2011-04-20 | 方存云 | 柔性负压杯 |
SG11201402731RA (en) * | 2011-12-01 | 2014-06-27 | Innovations Materium | Silica microcapsules, process of making the same and uses thereof |
US20180116938A1 (en) * | 2015-04-06 | 2018-05-03 | Lg Household & Health Care Ltd. | Soluble microneedle for delivering proteins or peptides |
WO2016163753A1 (ko) * | 2015-04-06 | 2016-10-13 | 주식회사 엘지생활건강 | 단백질 또는 펩타이드 전달용 용해성 마이크로니들 |
KR101728125B1 (ko) * | 2015-10-15 | 2017-04-19 | (주)비엔 | 해면 골편을 함유하는 화장료 조성물의 제조방법 |
KR101810231B1 (ko) | 2016-04-01 | 2017-12-18 | 주식회사 아미코스메틱 | 프로폴리스 미세침 분말을 함유하는 화장료 조성물 |
CN112957606A (zh) * | 2016-04-27 | 2021-06-15 | 厦门大学 | 皮肤物理促渗剂及其应用 |
KR101847984B1 (ko) * | 2016-07-25 | 2018-04-11 | 서울대학교산학협력단 | 약물 전달 장치 |
KR101854446B1 (ko) | 2017-01-10 | 2018-06-14 | 주식회사 아미코스메틱 | 상동나무 추출물과 미세침을 함유하는 화장료 조성물 |
-
2018
- 2018-06-29 KR KR1020180076060A patent/KR101933685B1/ko active IP Right Grant
- 2018-12-17 JP JP2021520888A patent/JP7091558B2/ja active Active
- 2018-12-17 CN CN201880095210.XA patent/CN112351770A/zh active Pending
- 2018-12-17 US US17/056,695 patent/US20210196899A1/en active Pending
- 2018-12-17 WO PCT/KR2018/016032 patent/WO2020004745A1/ko active Application Filing
- 2018-12-17 ES ES18923974T patent/ES2966735T3/es active Active
- 2018-12-17 EP EP18923974.2A patent/EP3824875B1/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20160064410A (ko) * | 2014-11-28 | 2016-06-08 | 김형길 | 스피큘을 포함하는 피부관리용 화장품 조성물 및 이의 제조방법 |
Non-Patent Citations (3)
Title |
---|
ADVANCED DRUG DELIVERY REVIEWS, vol. 55, JPN6022000771, 2003, pages 199 - 215, ISSN: 0004681499 * |
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 477, JPN6022000773, 2014, pages 613 - 622, ISSN: 0004681500 * |
PROCEEDINGS OF THE 28TH IEEE EMBS ANNUAL INTERNATIONAL CONFERENCE, vol. p.4088-4091, JPN6022000772, 2006, ISSN: 0004681498 * |
Also Published As
Publication number | Publication date |
---|---|
EP3824875A1 (en) | 2021-05-26 |
ES2966735T3 (es) | 2024-04-24 |
CN112351770A (zh) | 2021-02-09 |
JP7091558B2 (ja) | 2022-06-27 |
EP3824875C0 (en) | 2023-10-11 |
EP3824875B1 (en) | 2023-10-11 |
KR101933685B1 (ko) | 2018-12-28 |
WO2020004745A1 (ko) | 2020-01-02 |
US20210196899A1 (en) | 2021-07-01 |
EP3824875A4 (en) | 2022-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7091558B2 (ja) | 薬物がコーティングされたマイクロニードル及びその製造方法 | |
JP2649531B2 (ja) | 化粧学的活性物質と結合した有機シリコン化合物からなる生成物 | |
EP1265570B1 (en) | Soluble keratin peptide | |
CN113599492B (zh) | 一种抗衰老的药品或化妆品及其制备方法 | |
TW201018492A (en) | Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions | |
JP5787285B2 (ja) | 線維芽細胞増殖促進剤、角化細胞遊走・増殖促進剤、エラスチン産生促進剤、ヒートショックタンパク質47産生促進剤、α−平滑筋アクチン(α−SMA)産生促進剤、及び光老化防止剤。 | |
MX2010009485A (es) | Composiciones farmaceuticas o cosmeticas que comprenden inhibidores de metaloproteinasa. | |
CN113559238B (zh) | 一种含有活性肽并具有抗衰老作用的药品或化妆品 | |
ES2324192A1 (es) | Derivados peptidos utiles en el tratamiento, cuidado o limpieza de la piel, mucosa, cuero cabelludo o uñas. | |
CN110997694A (zh) | 可用于治疗和/或护理皮肤、毛发、指甲和/或粘膜的化合物 | |
JP2016166236A (ja) | 胎盤由来成分を含有するシワ改善用組成物 | |
JP2002534454A (ja) | 加齢皮膚の徴候を処置するための組成物におけるロスマリヌス属の植物抽出物の使用 | |
JP2013540715A (ja) | 皮膚弾力改善用化粧料組成物 | |
WO2007021065A1 (en) | Cosmetic composition containing enzyme and amino acid | |
JP2003267848A (ja) | サブスタンスpアンタゴニストまたはcgrpアンタゴニストを含有するケラチン繊維のパーマネント変形のための組成物 | |
JP4252444B2 (ja) | 傷の治療および再上皮形成のための糖蛋白質の使用 | |
US11045471B2 (en) | Melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promotor and wrinkle ameliorant | |
KR100558751B1 (ko) | 피부보습용 화장료 조성물 | |
JP2002284668A (ja) | クスミの予防・治療剤 | |
KR20070119971A (ko) | 나노 은이 함유된 피부개선 기능을 갖는 기능성 화장품 | |
JP5423002B2 (ja) | 亜鉛を有効成分として含有するコラーゲン合成促進剤 | |
JP2000136147A (ja) | 生体ヒアルロン酸合成促進剤 | |
KR102214403B1 (ko) | 펩타이드 복합 마이크로니들 및 이를 포함하는 화장품 조성물 | |
RU2195255C2 (ru) | Косметическое и дерматологическое средство и способ обработки кожи и/или кератиновых материалов | |
TW202133874A (zh) | 用於化妝品及醫藥之胜肽及組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201222 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210909 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220112 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220411 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220607 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220615 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7091558 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |