JP2021525705A5 - - Google Patents
Info
- Publication number
- JP2021525705A5 JP2021525705A5 JP2020565754A JP2020565754A JP2021525705A5 JP 2021525705 A5 JP2021525705 A5 JP 2021525705A5 JP 2020565754 A JP2020565754 A JP 2020565754A JP 2020565754 A JP2020565754 A JP 2020565754A JP 2021525705 A5 JP2021525705 A5 JP 2021525705A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pde1
- pharmaceutical product
- substituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862676638P | 2018-05-25 | 2018-05-25 | |
| US62/676,638 | 2018-05-25 | ||
| US201862688641P | 2018-06-22 | 2018-06-22 | |
| US62/688,641 | 2018-06-22 | ||
| PCT/US2019/033941 WO2019227004A1 (en) | 2018-05-25 | 2019-05-24 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021525705A JP2021525705A (ja) | 2021-09-27 |
| JP2021525705A5 true JP2021525705A5 (https=) | 2022-05-27 |
| JP7493460B2 JP7493460B2 (ja) | 2024-05-31 |
Family
ID=68616034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565754A Active JP7493460B2 (ja) | 2018-05-25 | 2019-05-24 | 有機化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20210205310A1 (https=) |
| EP (2) | EP4520399A3 (https=) |
| JP (1) | JP7493460B2 (https=) |
| KR (1) | KR20210013214A (https=) |
| CN (1) | CN112189013A (https=) |
| AU (1) | AU2019275453B2 (https=) |
| BR (1) | BR112020024037A2 (https=) |
| CA (1) | CA3099283A1 (https=) |
| IL (2) | IL278935B2 (https=) |
| MX (1) | MX2020012628A (https=) |
| WO (1) | WO2019227004A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020146384A1 (en) | 2019-01-07 | 2020-07-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
| MX2024010993A (es) * | 2022-03-11 | 2024-09-17 | Intra Cellular Therapies Inc | Compuestos organicos. |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
| JP2005289891A (ja) * | 2004-03-31 | 2005-10-20 | Zen Kubohara | Ｐｄｅ１阻害剤 |
| US7783679B2 (en) | 2005-01-12 | 2010-08-24 | Computer Associates Think, Inc. | Efficient processing of time series data |
| AU2006255028B2 (en) | 2005-06-06 | 2012-04-19 | Intra-Cellular Therapies, Inc. | Organic compounds |
| KR20090042227A (ko) | 2006-06-06 | 2009-04-29 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| EP2240028B1 (en) | 2007-12-06 | 2016-07-20 | Intra-Cellular Therapies, Inc. | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical |
| KR20120012831A (ko) | 2007-12-06 | 2012-02-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| BRPI0922809A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
| KR20110103949A (ko) | 2008-12-06 | 2011-09-21 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| MA32942B1 (fr) | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
| JP5778582B2 (ja) | 2008-12-06 | 2015-09-16 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| EP2367430B1 (en) | 2008-12-06 | 2014-08-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2367431B1 (en) | 2008-12-06 | 2015-08-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA2796756A1 (en) | 2010-04-22 | 2011-10-27 | Intra-Cellular Therapies, Inc. | Substituted pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines for the treatment of central nervous system disorders |
| WO2011153135A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
| EP2576551A4 (en) | 2010-05-31 | 2014-04-16 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| JP6051210B2 (ja) | 2011-06-10 | 2016-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| JP6224597B2 (ja) * | 2011-09-27 | 2017-11-01 | バイオメッド バレー ディスカバリーズ，インコーポレイティド | グリオーマを処置するための組成物及び方法 |
| AR091507A1 (es) | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
| EP2968338B1 (en) * | 2013-03-15 | 2019-01-09 | Intra-Cellular Therapies, Inc. | Pde1 inhibitors for use in the treatment and/or prevention of cns injuries, and pns diseases, disorders or injuries |
| KR102240326B1 (ko) | 2013-03-15 | 2021-04-13 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US20160045617A1 (en) * | 2013-04-10 | 2016-02-18 | Justin C. Lee | Treatment of proximal spinal muscular atrophy |
| TW201609713A (zh) | 2013-12-19 | 2016-03-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之喹唑啉－ｔｈｆ－胺 |
| JP6696904B2 (ja) * | 2014-01-08 | 2020-05-20 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 製剤および医薬組成物 |
| TW201611834A (en) | 2014-02-07 | 2016-04-01 | Lundbeck & Co As H | Hexahydrofuropyrroles as PDE1 inhibitors |
| KR20160138084A (ko) | 2014-04-04 | 2016-12-02 | 하. 룬드벡 아크티에셀스카브 | Pde1 저해제인 할로겐화된 퀴나졸린-thf-아민 |
| EP3157926B1 (en) * | 2014-06-20 | 2019-05-15 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10131671B2 (en) | 2014-08-07 | 2018-11-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA2961212C (en) | 2014-09-17 | 2024-02-06 | Intra-Cellular Therapies, Inc. | Compounds and methods |
| TW201629064A (zh) | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之三唑並吡酮 |
| TW201643167A (zh) | 2015-04-22 | 2016-12-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之咪唑並三酮 |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| CN110267908B (zh) | 2016-09-12 | 2023-08-22 | 麦斯卓微电子(南京)有限公司 | Mems致动系统和方法 |
| JP7134168B6 (ja) | 2016-09-12 | 2024-02-02 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
| US10918628B2 (en) * | 2016-10-11 | 2021-02-16 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Treatment of synucleinopathies |
| WO2018073251A1 (en) | 2016-10-18 | 2018-04-26 | H. Lundbeck A/S | Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors |
| WO2018093591A1 (en) * | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
| WO2020146384A1 (en) * | 2019-01-07 | 2020-07-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
-
2019
- 2019-05-24 MX MX2020012628A patent/MX2020012628A/es unknown
- 2019-05-24 IL IL278935A patent/IL278935B2/en unknown
- 2019-05-24 JP JP2020565754A patent/JP7493460B2/ja active Active
- 2019-05-24 WO PCT/US2019/033941 patent/WO2019227004A1/en not_active Ceased
- 2019-05-24 KR KR1020207037446A patent/KR20210013214A/ko not_active Ceased
- 2019-05-24 BR BR112020024037-0A patent/BR112020024037A2/pt unknown
- 2019-05-24 CA CA3099283A patent/CA3099283A1/en active Pending
- 2019-05-24 EP EP25152523.4A patent/EP4520399A3/en active Pending
- 2019-05-24 CN CN201980034445.2A patent/CN112189013A/zh active Pending
- 2019-05-24 IL IL322048A patent/IL322048A/en unknown
- 2019-05-24 EP EP19806748.0A patent/EP3802545A4/en active Pending
- 2019-05-24 US US17/059,160 patent/US20210205310A1/en active Pending
- 2019-05-24 AU AU2019275453A patent/AU2019275453B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022185107A5 (https=) | ||
| RU2429226C9 (ru) | Ингибиторы пролилгидроксилазы и способы их применения | |
| MX2025013001A (es) | Inhibidores espiro-heterocíclicos de las proteínas mutantes kras g12c y usos de los mismos. | |
| EA200601252A1 (ru) | Новый класс веществ, вызывающих дифференцировку клеток и являющихся ингибиторами гистондеацетилазы, и способы их применения | |
| ATE374763T1 (de) | Bisarylsulfonamid-derivate und ihre verwendung für krebs therapie | |
| JP2017528498A5 (https=) | ||
| EA026514B1 (ru) | Соединения обратного амида в качестве ингибиторов протеиндеацетилазы и способы их применения | |
| RU98117314A (ru) | Тропановые производные, их получение и применение | |
| AR060150A1 (es) | Heteropentaciclos activos como inhibidores de quinasas, y su uso para tratar trastornos de la proliferacion celular | |
| RU2005137403A (ru) | Новые замещенные 3-сера-индолы | |
| JP2025163128A5 (https=) | ||
| JP2021525705A5 (https=) | ||
| JP2022546711A5 (https=) | ||
| JP2023509359A5 (https=) | ||
| JP2023510746A5 (https=) | ||
| JP2020527173A5 (https=) | ||
| KR20050051658A (ko) | ＩｇＥ를 조절하고 세포 증식을 억제하기 위한 페닐-인돌화합물 | |
| MXPA06003250A (es) | Oximas de benzofurano substituidas. | |
| JP2008517923A5 (https=) | ||
| DE60221505D1 (de) | FAKTOR Xa BENZAMIDIN INHIBITOREN | |
| CA2617991A1 (en) | N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof | |
| BR112012017705B1 (pt) | Derivados de sulfonamidas de 3,4-diarilpirazóis como inibidores da proteína cinase | |
| RU2006128788A (ru) | Производные фенил[4-(3-фенил-1н-пиразол-4-ил)пиримидин-2-ил] амина в качестве igf-1r ингибиторов | |
| CA2526989A1 (en) | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | |
| JP2006522824A5 (https=) |