JP2025163128A5 - - Google Patents
Info
- Publication number
- JP2025163128A5 JP2025163128A5 JP2025128256A JP2025128256A JP2025163128A5 JP 2025163128 A5 JP2025163128 A5 JP 2025163128A5 JP 2025128256 A JP2025128256 A JP 2025128256A JP 2025128256 A JP2025128256 A JP 2025128256A JP 2025163128 A5 JP2025163128 A5 JP 2025163128A5
- Authority
- JP
- Japan
- Prior art keywords
- branched
- substituted
- unsubstituted
- straight
- reducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962847348P | 2019-05-14 | 2019-05-14 | |
| ILPCT/IL2020/050524 | 2020-05-14 | ||
| PCT/IL2020/050524 WO2020230134A1 (en) | 2019-05-14 | 2020-05-14 | Acss2 inhibitors and methods of use thereof |
| PCT/IL2021/050541 WO2021229571A1 (en) | 2019-05-14 | 2021-05-12 | Imidazole 3-oxide derivative based acss2 inhibitors and methods of use thereof |
| JP2022568774A JP7723011B2 (ja) | 2019-05-14 | 2021-05-12 | イミダゾール３－オキシド誘導体系ａｃｓｓ２阻害剤及びその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568774A Division JP7723011B2 (ja) | 2019-05-14 | 2021-05-12 | イミダゾール３－オキシド誘導体系ａｃｓｓ２阻害剤及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025163128A JP2025163128A (ja) | 2025-10-28 |
| JP2025163128A5 true JP2025163128A5 (https=) | 2025-11-06 |
Family
ID=73288933
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567839A Pending JP2022532719A (ja) | 2019-05-14 | 2020-05-14 | Ａｃｓｓ２阻害剤およびその使用方法 |
| JP2021567836A Pending JP2022532718A (ja) | 2019-05-14 | 2020-05-14 | Ａｃｓｓ２阻害剤およびその使用方法 |
| JP2022568774A Active JP7723011B2 (ja) | 2019-05-14 | 2021-05-12 | イミダゾール３－オキシド誘導体系ａｃｓｓ２阻害剤及びその使用方法 |
| JP2025128256A Pending JP2025163128A (ja) | 2019-05-14 | 2025-07-31 | イミダゾール３－オキシド誘導体系ａｃｓｓ２阻害剤及びその使用方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567839A Pending JP2022532719A (ja) | 2019-05-14 | 2020-05-14 | Ａｃｓｓ２阻害剤およびその使用方法 |
| JP2021567836A Pending JP2022532718A (ja) | 2019-05-14 | 2020-05-14 | Ａｃｓｓ２阻害剤およびその使用方法 |
| JP2022568774A Active JP7723011B2 (ja) | 2019-05-14 | 2021-05-12 | イミダゾール３－オキシド誘導体系ａｃｓｓ２阻害剤及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US12441689B2 (https=) |
| EP (3) | EP3983386A4 (https=) |
| JP (4) | JP2022532719A (https=) |
| KR (3) | KR20220024014A (https=) |
| CN (3) | CN114127049A (https=) |
| AU (3) | AU2020274645A1 (https=) |
| BR (2) | BR112021022977A2 (https=) |
| CA (3) | CA3136083A1 (https=) |
| IL (3) | IL297883A (https=) |
| MX (3) | MX2021013839A (https=) |
| SG (2) | SG11202112226WA (https=) |
| WO (3) | WO2020230136A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12133852B2 (en) | 2017-11-15 | 2024-11-05 | Epivario, Inc. | ACSS2 inhibitors and methods of use thereof |
| US11739078B2 (en) | 2019-02-22 | 2023-08-29 | Insilico Medicine Ip Limited | Methods of inhibiting kinases |
| US12441689B2 (en) * | 2019-05-14 | 2025-10-14 | Epivario, Inc. | ACSS2 inhibitors and methods of use thereof |
| CA3164134A1 (en) | 2019-12-06 | 2021-06-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofurans as modulators of sodium channels |
| CN112480085B (zh) * | 2020-12-17 | 2022-10-25 | 上海英诺富成生物科技有限公司 | 一种化合物或其药学上可接受的盐、异构体、前药、多晶型物或溶剂化物 |
| CA3208490A1 (en) | 2021-02-24 | 2022-09-01 | Aleksandrs Zavoronkovs | Analogs for the treatment of disease |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| CN114044754A (zh) * | 2021-11-23 | 2022-02-15 | 贵州大学 | 一类5-三氟甲基-4-吡唑衍生物的制备方法及其在抑制肿瘤细胞上的应用 |
| CN114716380B (zh) * | 2022-04-01 | 2024-06-21 | 新乡医学院 | 一种相转移催化的4-取代吡唑酮类化合物不对称氟化方法 |
| CN116808042A (zh) * | 2023-08-08 | 2023-09-29 | 江苏省人民医院（南京医科大学第一附属医院） | 乙酰辅酶a合成酶2抑制剂在治疗胰腺神经内分泌肿瘤中的应用 |
| CN118344267A (zh) * | 2024-04-17 | 2024-07-16 | 广东广康生化科技股份有限公司 | 一种联苯肼酯高效合成新方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE140966C (https=) | ||||
| DE2324893A1 (de) | 1973-05-17 | 1974-12-12 | Hoechst Ag | 1-hydroxy-imidazole und verfahren zu ihrer herstellung |
| US3905997A (en) | 1974-06-21 | 1975-09-16 | Warner Lambert Co | 3-Aryl-5-oxo-2-pyrazoline-4-carboxanilides and process therefor |
| US4207317A (en) * | 1978-03-13 | 1980-06-10 | Ciba-Geigy Corporation | 1-Aryl-4-carbamoyl-pyrazolin-5-ones |
| DD140966A1 (de) * | 1978-12-28 | 1980-04-09 | Doerthe Creuzburg | Mittel zur regulierung des pflanzenwachstums |
| JPH11291635A (ja) * | 1998-04-06 | 1999-10-26 | Mitsubishi Paper Mills Ltd | 感熱記録材料 |
| CN1325385A (zh) * | 1998-11-09 | 2001-12-05 | 詹姆斯·布莱克基金有限公司 | 胃泌素和缩胆囊素受体配体 |
| AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| EP1429765A2 (en) * | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| MX2007007226A (es) * | 2004-12-17 | 2007-08-21 | Lilly Co Eli | Antagonistas receptores novedosos de hormona concentradora de melanina (mch). |
| WO2007026215A1 (en) | 2005-08-29 | 2007-03-08 | Glenmark Pharmaceuticals S.A. | Pyrazole derivatives as cannabinoid receptor ligands, pharmaceutical compositions containing? them, and processes for their preparation |
| JP2013526540A (ja) * | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| US9073911B2 (en) * | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
| EP2794592A1 (en) * | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| WO2013159224A1 (en) * | 2012-04-25 | 2013-10-31 | University Of Manitoba | 2-carbamo(thio)yl-1,3- dioxopropyl derivatives in cancer therapy |
| WO2015175845A1 (en) * | 2014-05-15 | 2015-11-19 | Peloton Therapeutics, Inc. | Benzimidazole derivatives and uses thereof |
| WO2017120194A1 (en) | 2016-01-05 | 2017-07-13 | Incyte Corporation | Pyridine and pyridimine compounds as pi3k-gamma inhibitors |
| US11795162B2 (en) * | 2017-08-18 | 2023-10-24 | Saint Louis University | Modulators of the estrogen-related receptor |
| EP3687628A4 (en) * | 2017-09-26 | 2021-09-22 | The Trustees of The University of Pennsylvania | COMPOSITIONS AND METHODS TO INHIBIT ACSS2 |
| CA2984073A1 (en) | 2017-10-27 | 2019-04-27 | Nuchem Therapeutics Inc. | Inhibitors of polynucleotide repeat-associated rna foci and uses thereof |
| KR20200089291A (ko) * | 2017-11-15 | 2020-07-24 | 메타보메드 리미티드 | Acss2 저해제 및 이의 사용 방법 |
| US12441689B2 (en) * | 2019-05-14 | 2025-10-14 | Epivario, Inc. | ACSS2 inhibitors and methods of use thereof |
-
2020
- 2020-05-14 US US17/609,392 patent/US12441689B2/en active Active
- 2020-05-14 WO PCT/IL2020/050526 patent/WO2020230136A1/en not_active Ceased
- 2020-05-14 WO PCT/IL2020/050524 patent/WO2020230134A1/en not_active Ceased
- 2020-05-14 SG SG11202112226WA patent/SG11202112226WA/en unknown
- 2020-05-14 CA CA3136083A patent/CA3136083A1/en active Pending
- 2020-05-14 SG SG11202112277PA patent/SG11202112277PA/en unknown
- 2020-05-14 AU AU2020274645A patent/AU2020274645A1/en not_active Abandoned
- 2020-05-14 CA CA3136324A patent/CA3136324A1/en active Pending
- 2020-05-14 MX MX2021013839A patent/MX2021013839A/es unknown
- 2020-05-14 BR BR112021022977A patent/BR112021022977A2/pt not_active IP Right Cessation
- 2020-05-14 CN CN202080050593.6A patent/CN114127049A/zh active Pending
- 2020-05-14 CN CN202080045626.8A patent/CN114008025A/zh active Pending
- 2020-05-14 EP EP20806829.6A patent/EP3983386A4/en not_active Withdrawn
- 2020-05-14 EP EP20805317.3A patent/EP3969439A4/en not_active Withdrawn
- 2020-05-14 KR KR1020217040740A patent/KR20220024014A/ko not_active Ceased
- 2020-05-14 KR KR1020217040841A patent/KR20220024027A/ko not_active Withdrawn
- 2020-05-14 JP JP2021567839A patent/JP2022532719A/ja active Pending
- 2020-05-14 JP JP2021567836A patent/JP2022532718A/ja active Pending
- 2020-05-14 AU AU2020273727A patent/AU2020273727A1/en not_active Abandoned
- 2020-05-14 BR BR112021023030A patent/BR112021023030A2/pt not_active Application Discontinuation
- 2020-05-14 MX MX2021013786A patent/MX2021013786A/es unknown
-
2021
- 2021-05-12 JP JP2022568774A patent/JP7723011B2/ja active Active
- 2021-05-12 AU AU2021273125A patent/AU2021273125A1/en active Pending
- 2021-05-12 IL IL297883A patent/IL297883A/en unknown
- 2021-05-12 US US17/922,795 patent/US20230174507A1/en active Pending
- 2021-05-12 MX MX2022014214A patent/MX2022014214A/es unknown
- 2021-05-12 KR KR1020227043156A patent/KR20230012522A/ko active Pending
- 2021-05-12 CA CA3176666A patent/CA3176666A1/en active Pending
- 2021-05-12 CN CN202180038652.2A patent/CN115697974A/zh active Pending
- 2021-05-12 EP EP21803230.8A patent/EP4149928A4/en active Pending
- 2021-05-12 WO PCT/IL2021/050541 patent/WO2021229571A1/en not_active Ceased
- 2021-11-08 IL IL287937A patent/IL287937A/en unknown
- 2021-11-09 IL IL287973A patent/IL287973A/en unknown
-
2025
- 2025-07-31 JP JP2025128256A patent/JP2025163128A/ja active Pending
- 2025-09-08 US US19/321,644 patent/US20260085048A1/en active Pending
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