JP2021532158A5 - - Google Patents
Info
- Publication number
- JP2021532158A5 JP2021532158A5 JP2021505202A JP2021505202A JP2021532158A5 JP 2021532158 A5 JP2021532158 A5 JP 2021532158A5 JP 2021505202 A JP2021505202 A JP 2021505202A JP 2021505202 A JP2021505202 A JP 2021505202A JP 2021532158 A5 JP2021532158 A5 JP 2021532158A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkoxy
- alkyl
- thioalkoxy
- sulfhydryl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862712434P | 2018-07-31 | 2018-07-31 | |
| US62/712,434 | 2018-07-31 | ||
| PCT/US2019/044278 WO2020028461A1 (en) | 2018-07-31 | 2019-07-31 | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021532158A JP2021532158A (ja) | 2021-11-25 |
| JP2021532158A5 true JP2021532158A5 (https=) | 2022-08-04 |
| JPWO2020028461A5 JPWO2020028461A5 (https=) | 2022-08-04 |
| JP7613743B2 JP7613743B2 (ja) | 2025-01-15 |
Family
ID=67734803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021505202A Active JP7613743B2 (ja) | 2018-07-31 | 2019-07-31 | 転移性癌および化学療法抵抗性癌の治療のためのテトラヒドロキノリノ誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12162855B2 (https=) |
| EP (1) | EP3830079A1 (https=) |
| JP (1) | JP7613743B2 (https=) |
| CN (1) | CN112638881B (https=) |
| AU (1) | AU2019315444B2 (https=) |
| CA (1) | CA3107120A1 (https=) |
| IL (1) | IL280395B2 (https=) |
| WO (1) | WO2020028461A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112638881B (zh) | 2018-07-31 | 2025-01-07 | 普林斯顿大学托管委员会 | 用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物 |
| CA3168533A1 (en) * | 2020-01-24 | 2021-07-29 | The Trustees Of Princeton University | Heterocyclic compounds and uses thereof |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
| KR102925139B1 (ko) | 2021-04-22 | 2026-02-10 | 카요테라 인코포레이티드 | 헤테로시클릭 화합물 및 이의 용도 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60126270A (ja) * | 1983-12-14 | 1985-07-05 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPS61145162A (ja) * | 1984-12-19 | 1986-07-02 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| DE3701277A1 (de) | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| JPH01319453A (ja) * | 1988-06-22 | 1989-12-25 | Wakamoto Pharmaceut Co Ltd | 新規ベンゾキノン誘導体 |
| MXPA05012086A (es) | 2003-05-12 | 2006-02-22 | Pfizer Prod Inc | Inhibidores de benzamida del receptor p2x7. |
| CN102225926A (zh) * | 2003-11-07 | 2011-10-26 | 诺华疫苗和诊断公司 | 具有改进药物特性的喹啉酮类化合物的药学上可接受的盐 |
| US7875624B2 (en) * | 2004-02-20 | 2011-01-25 | Novartis Vaccines And Diagnostics, Inc. | Modulating and measuring cellular adhesion |
| JP2006349902A (ja) * | 2005-06-15 | 2006-12-28 | Fujifilm Holdings Corp | 黒白熱現像感光材料 |
| EP2021502A4 (en) * | 2006-05-09 | 2010-08-25 | Mas Metabolic Analytical Servi | GENES AND ATYPICAL MARKERS IN TYPE 2 DIABETES AND OBESITY |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| WO2013027168A1 (en) | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| KR102319882B1 (ko) * | 2014-02-19 | 2021-11-03 | 아비브 테라퓨틱스, 인크. | 암의 치료를 위한 폴리사이클릭 아미드와 결합하는 미토콘드리아 알데히드 탈수소효소 2 (aldh2) 및 그의 용도 |
| WO2015173169A1 (en) | 2014-05-12 | 2015-11-19 | Fondazione Istituto Italiano Di Tecnologia | Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| RU2743074C2 (ru) | 2014-08-01 | 2021-02-15 | Нуэволюшон А/С | Соединения, активные по отношению к бромодоменам |
| CN112638881B (zh) | 2018-07-31 | 2025-01-07 | 普林斯顿大学托管委员会 | 用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物 |
| CA3168533A1 (en) | 2020-01-24 | 2021-07-29 | The Trustees Of Princeton University | Heterocyclic compounds and uses thereof |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
| KR102925139B1 (ko) | 2021-04-22 | 2026-02-10 | 카요테라 인코포레이티드 | 헤테로시클릭 화합물 및 이의 용도 |
-
2019
- 2019-07-31 CN CN201980056669.3A patent/CN112638881B/zh active Active
- 2019-07-31 IL IL280395A patent/IL280395B2/en unknown
- 2019-07-31 EP EP19758540.9A patent/EP3830079A1/en active Pending
- 2019-07-31 JP JP2021505202A patent/JP7613743B2/ja active Active
- 2019-07-31 WO PCT/US2019/044278 patent/WO2020028461A1/en not_active Ceased
- 2019-07-31 CA CA3107120A patent/CA3107120A1/en active Pending
- 2019-07-31 AU AU2019315444A patent/AU2019315444B2/en active Active
-
2021
- 2021-01-29 US US17/162,827 patent/US12162855B2/en active Active
-
2024
- 2024-11-01 US US18/934,691 patent/US20250129046A1/en active Pending
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