BR112021023030A2 - Compostos inibidores de acss2 e métodos de uso dos mesmos - Google Patents

Compostos inibidores de acss2 e métodos de uso dos mesmos

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Publication number
BR112021023030A2
BR112021023030A2 BR112021023030A BR112021023030A BR112021023030A2 BR 112021023030 A2 BR112021023030 A2 BR 112021023030A2 BR 112021023030 A BR112021023030 A BR 112021023030A BR 112021023030 A BR112021023030 A BR 112021023030A BR 112021023030 A2 BR112021023030 A2 BR 112021023030A2
Authority
BR
Brazil
Prior art keywords
methods
cancer
inhibitor compounds
acss2
alcoholism
Prior art date
Application number
BR112021023030A
Other languages
English (en)
Inventor
Andreas Goutopoulos
Harry Finch
Omri Erez
Philippe Nakache
Simone Botti
Original Assignee
Metabomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/411,168 external-priority patent/US10851064B2/en
Application filed by Metabomed Ltd filed Critical Metabomed Ltd
Publication of BR112021023030A2 publication Critical patent/BR112021023030A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

compostos inibidores de acss2 e métodos de uso dos mesmos. a presente invenção refere-se a novos inibidores de acss2 tendo atividade como terapia anticâncer, tratamento de alcoolismo e infecção viral (por exemplo, cmv), composição e métodos de preparação dos mesmos e usos dos mesmos para o tratamento de infecção viral, alcoolismo, esteatohepatite alcoólica (ash), esteatohepatite não-alcoólica (nash), obesidade/ganho de peso, ansiedade, depressão, transtorno de estresse pós-traumático, condições inflamatórias/autoimunes e câncer, incluindo câncer metastático, câncer avançado e câncer resistente a medicamentos de vários tipos.
BR112021023030A 2019-05-14 2020-05-14 Compostos inibidores de acss2 e métodos de uso dos mesmos BR112021023030A2 (pt)

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