JP2021524856A5 - - Google Patents
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- Publication number
- JP2021524856A5 JP2021524856A5 JP2020565357A JP2020565357A JP2021524856A5 JP 2021524856 A5 JP2021524856 A5 JP 2021524856A5 JP 2020565357 A JP2020565357 A JP 2020565357A JP 2020565357 A JP2020565357 A JP 2020565357A JP 2021524856 A5 JP2021524856 A5 JP 2021524856A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- alkyl
- heteroalkyl
- cycloalkyl
- hydroxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 159
- 125000000623 heterocyclic group Chemical group 0.000 claims 138
- 125000003545 alkoxy group Chemical group 0.000 claims 121
- 125000003118 aryl group Chemical group 0.000 claims 111
- 125000000753 cycloalkyl group Chemical group 0.000 claims 109
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 107
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 97
- 125000001072 heteroaryl group Chemical group 0.000 claims 95
- 125000004093 cyano group Chemical group *C#N 0.000 claims 83
- 150000001875 compounds Chemical class 0.000 claims 67
- 239000000203 mixture Substances 0.000 claims 65
- 150000003839 salts Chemical class 0.000 claims 62
- 125000005843 halogen group Chemical group 0.000 claims 61
- 229910052799 carbon Inorganic materials 0.000 claims 60
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 44
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 40
- -1 -OH Chemical group 0.000 claims 34
- 125000004043 oxo group Chemical group O=* 0.000 claims 34
- 125000004404 heteroalkyl group Chemical group 0.000 claims 30
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 25
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 19
- 125000005103 alkyl silyl group Chemical group 0.000 claims 16
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 14
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 13
- 125000004438 haloalkoxy group Chemical group 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- 125000002619 bicyclic group Chemical group 0.000 claims 9
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000003367 polycyclic group Chemical group 0.000 claims 3
- 125000005370 alkoxysilyl group Chemical group 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000004930 Fatty Liver Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
- 150000001975 deuterium Chemical class 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 0 **Nc(c(*)c(*)c(*)c1)c1C(NC1(CC2)CCC2(*)CC1)=O Chemical compound **Nc(c(*)c(*)c(*)c1)c1C(NC1(CC2)CCC2(*)CC1)=O 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022100465A JP7687996B6 (ja) | 2018-05-22 | 2022-06-22 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
| JP2024113624A JP2024153692A (ja) | 2018-05-22 | 2024-07-16 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862674981P | 2018-05-22 | 2018-05-22 | |
| US62/674,981 | 2018-05-22 | ||
| PCT/US2019/032925 WO2019226490A1 (en) | 2018-05-22 | 2019-05-17 | Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022100465A Division JP7687996B6 (ja) | 2018-05-22 | 2022-06-22 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021524856A JP2021524856A (ja) | 2021-09-16 |
| JP2021524856A5 true JP2021524856A5 (https=) | 2021-12-09 |
| JP7158500B2 JP7158500B2 (ja) | 2022-10-21 |
Family
ID=66691073
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020565357A Active JP7158500B2 (ja) | 2018-05-22 | 2019-05-17 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
| JP2022100465A Active JP7687996B6 (ja) | 2018-05-22 | 2022-06-22 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
| JP2024113624A Withdrawn JP2024153692A (ja) | 2018-05-22 | 2024-07-16 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022100465A Active JP7687996B6 (ja) | 2018-05-22 | 2022-06-22 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
| JP2024113624A Withdrawn JP2024153692A (ja) | 2018-05-22 | 2024-07-16 | スルフィニルアミノベンズアミドおよびスルホニルアミノベンズアミド誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11136290B2 (https=) |
| EP (1) | EP3796975B1 (https=) |
| JP (3) | JP7158500B2 (https=) |
| KR (1) | KR102667831B1 (https=) |
| CN (3) | CN118791407A (https=) |
| AR (1) | AR117576A1 (https=) |
| AU (2) | AU2019272538B2 (https=) |
| DK (1) | DK3796975T3 (https=) |
| ES (1) | ES2963524T3 (https=) |
| FI (1) | FI3796975T3 (https=) |
| HU (1) | HUE064831T2 (https=) |
| LT (1) | LT3796975T (https=) |
| PL (1) | PL3796975T3 (https=) |
| PT (1) | PT3796975T (https=) |
| SI (1) | SI3796975T1 (https=) |
| SM (1) | SMT202300420T1 (https=) |
| TW (2) | TWI820437B (https=) |
| WO (1) | WO2019226490A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3796975T (lt) | 2018-05-22 | 2023-12-11 | Orsobio, Inc. | Sulfonilaminobenzamido dariniai |
| TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Ｆｘｒ有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
| US20200397807A1 (en) | 2019-06-18 | 2020-12-24 | MitoPower, LLC | Nicotinyl riboside compounds and their uses |
| CA3180229A1 (en) * | 2020-05-29 | 2021-12-02 | Cathy A. Swindlehurst | Biarylsulfonamides and pharmaceutical compositions thereof, and their use for treating fibrotic lung disease |
| WO2025259921A1 (en) * | 2024-06-13 | 2025-12-18 | Orsobio, Inc. | Compounds for modulating energy expenditure |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62257158A (ja) | 1986-04-30 | 1987-11-09 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| DE19642451A1 (de) | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| AU2001280187A1 (en) | 2000-08-28 | 2002-03-13 | Toray Industries, Inc. | Cyclic amine derivatives |
| CN1795181A (zh) * | 2003-05-29 | 2006-06-28 | 麦克公司 | 用作11β－羟基类固醇脱氢酶－1抑制剂的三唑衍生物 |
| GB0323845D0 (en) | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| JP2005126374A (ja) | 2003-10-24 | 2005-05-19 | Kissei Pharmaceut Co Ltd | 新規なアデノシンａ２ａ受容体拮抗剤 |
| WO2005077122A2 (en) | 2004-02-11 | 2005-08-25 | Irm Llc | Compounds and compositions as lxr modulators |
| WO2005085188A2 (en) * | 2004-03-02 | 2005-09-15 | Compass Pharmaceuticals Llc | Compounds and methods for anti-tumor therapy |
| WO2008022267A2 (en) | 2006-08-17 | 2008-02-21 | Wellstat Therapeutics Corporation | Combination treatment for metabolic disorders |
| TW200825054A (en) | 2006-10-18 | 2008-06-16 | Wyeth Corp | Quinoline compounds |
| AU2008234017B2 (en) | 2007-03-30 | 2011-09-22 | F. Hoffmann-La Roche Ag | Imidazolidinone derivatives |
| GB0708141D0 (en) | 2007-04-26 | 2007-06-06 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| EP2210891A1 (en) | 2009-01-26 | 2010-07-28 | Domain Therapeutics | New adenosine receptor ligands and uses thereof |
| KR20120049214A (ko) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | 발열성 지방세포를 증가시키는 방법 |
| AU2012245996B2 (en) | 2011-04-22 | 2016-09-01 | Pfizer Inc. | Pyrazolospiroketone derivatives for use as acetyl-CoA carboxylase inhibitors |
| KR20130142801A (ko) * | 2012-06-20 | 2013-12-30 | 안국약품 주식회사 | １１β－ＨＳＤ１ 효소의 억제활성을 갖는 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| US9376420B2 (en) | 2012-10-25 | 2016-06-28 | Yuhan Corporation | 4,5-dihydro-1H-pyrazole derivative or salts thereof, and pharmaceutical composition comprising same |
| EP2990403A1 (en) | 2014-08-29 | 2016-03-02 | Novartis Tiergesundheit AG | Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics |
| CA2968299A1 (en) | 2014-11-18 | 2016-05-26 | Rutgers, The State University Of New Jersey | Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer |
| AR103232A1 (es) | 2014-12-22 | 2017-04-26 | Bristol Myers Squibb Co | ANTAGONISTAS DE TGFbR |
| FR3037959B1 (fr) | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US10227315B2 (en) | 2016-05-18 | 2019-03-12 | Rutgers, The State University Of New Jersey | Mitochondrial uncouplers for treatment of metabolic diseases and cancer |
| LT3796975T (lt) | 2018-05-22 | 2023-12-11 | Orsobio, Inc. | Sulfonilaminobenzamido dariniai |
| TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Ｆｘｒ有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
| US20200397807A1 (en) * | 2019-06-18 | 2020-12-24 | MitoPower, LLC | Nicotinyl riboside compounds and their uses |
| JPWO2023090411A1 (https=) | 2021-11-19 | 2023-05-25 |
-
2019
- 2019-05-17 LT LTEPPCT/US2019/032925T patent/LT3796975T/lt unknown
- 2019-05-17 WO PCT/US2019/032925 patent/WO2019226490A1/en not_active Ceased
- 2019-05-17 HU HUE19728290A patent/HUE064831T2/hu unknown
- 2019-05-17 ES ES19728290T patent/ES2963524T3/es active Active
- 2019-05-17 PT PT197282908T patent/PT3796975T/pt unknown
- 2019-05-17 KR KR1020207036425A patent/KR102667831B1/ko active Active
- 2019-05-17 JP JP2020565357A patent/JP7158500B2/ja active Active
- 2019-05-17 SM SM20230420T patent/SMT202300420T1/it unknown
- 2019-05-17 US US16/415,787 patent/US11136290B2/en active Active
- 2019-05-17 DK DK19728290.8T patent/DK3796975T3/da active
- 2019-05-17 SI SI201930655T patent/SI3796975T1/sl unknown
- 2019-05-17 CN CN202410775407.5A patent/CN118791407A/zh active Pending
- 2019-05-17 CN CN201980034619.5A patent/CN112204008B/zh active Active
- 2019-05-17 PL PL19728290.8T patent/PL3796975T3/pl unknown
- 2019-05-17 EP EP19728290.8A patent/EP3796975B1/en active Active
- 2019-05-17 CN CN202410518403.9A patent/CN118638096A/zh active Pending
- 2019-05-17 AU AU2019272538A patent/AU2019272538B2/en active Active
- 2019-05-17 FI FIEP19728290.8T patent/FI3796975T3/fi active
- 2019-05-21 AR ARP190101345A patent/AR117576A1/es not_active Application Discontinuation
- 2019-05-22 TW TW110122636A patent/TWI820437B/zh active
- 2019-05-22 TW TW108117594A patent/TWI732219B/zh active
-
2021
- 2021-08-31 US US17/463,011 patent/US12049439B2/en active Active
-
2022
- 2022-06-22 JP JP2022100465A patent/JP7687996B6/ja active Active
- 2022-11-24 AU AU2022275470A patent/AU2022275470C1/en active Active
-
2024
- 2024-06-13 US US18/742,992 patent/US12606522B2/en active Active
- 2024-07-16 JP JP2024113624A patent/JP2024153692A/ja not_active Withdrawn
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