AR117576A1 - Derivados de sulfinilaminobenzamida y sulfonilaminobenzamida - Google Patents
Derivados de sulfinilaminobenzamida y sulfonilaminobenzamidaInfo
- Publication number
- AR117576A1 AR117576A1 ARP190101345A ARP190101345A AR117576A1 AR 117576 A1 AR117576 A1 AR 117576A1 AR P190101345 A ARP190101345 A AR P190101345A AR P190101345 A ARP190101345 A AR P190101345A AR 117576 A1 AR117576 A1 AR 117576A1
- Authority
- AR
- Argentina
- Prior art keywords
- membered
- nr13r13
- heterocyclyl
- cycloalkyl
- heteroalkyl
- Prior art date
Links
- XXBDMAUUFRYKKO-UHFFFAOYSA-N 2-(sulfinylamino)benzamide Chemical compound NC(=O)C1=CC=CC=C1N=S=O XXBDMAUUFRYKKO-UHFFFAOYSA-N 0.000 title 1
- CAWFFBLMSQUZPF-UHFFFAOYSA-N 2-(sulfonylamino)benzamide Chemical class NC(=O)C1=CC=CC=C1N=S(=O)=O CAWFFBLMSQUZPF-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 34
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 24
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 22
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 22
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 21
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 20
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 16
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 15
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 13
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 12
- -1 -NR13R13 Chemical group 0.000 abstract 11
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 11
- 125000005843 halogen group Chemical group 0.000 abstract 9
- 125000004043 oxo group Chemical group O=* 0.000 abstract 8
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 6
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 5
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 4
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 3
- 125000003367 polycyclic group Chemical group 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 125000004963 sulfonylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5022—Aromatic phosphines (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/50—Spiro compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/90—Ring systems containing bridged rings containing more than four rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/50—Fuel cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Se proporciona un compuesto de fórmula (1), en donde los grupos variables se definen en la presente. Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable, estereoisómero, mezclas de estereoisómeros, tautómeros o análogos deuterados de los mismos, en donde: Q se selecciona del grupo que consiste en -S(O)₂-, -S(O)-, -S(O)(NH)-, -S(O)(NR⁸)-; R¹ se selecciona de un grupo que consiste en: alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, -NR¹³R¹³, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, cicloalquilo C₃₋₁₂ y heterociclilo de 4 - 12 miembros, en donde cada alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, cicloalquilo C₃₋₁₂ y heterociclilo de 4 - 12 miembros están opcionalmente sustituidos adicionalmente con uno o más grupos R¹¹; R¹¹ se selecciona de un grupo que consiste en: hidroxilo, oxo, halo, -CN, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 a 12 miembros, arilo de 6 a 10 miembros, heteroarilo de 5 a 10 miembros, -P(O)R¹⁴R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH, -S(O)₀₋₂R¹⁴, -S(O)₁₋₂NR¹³R¹³, -SF₅, -NO₂, -NR¹³R¹³, -NR¹³SO₂R¹⁴, -OS(O)₂R¹⁴, -C(O)OR¹⁴, -C(O)R¹⁴, -NR¹³C(O)OR¹⁴, -NR¹³C(O)NR¹³R¹³, -NR¹³S(O)₂NR¹³R¹³, y -C(O)NR¹³R¹³, en donde cada alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros están opcionalmente sustituidos con uno o más grupos R⁹; cada R⁹ se selecciona independientemente del grupo que consiste en: -H, oxo, -OH, -CN, halo, alquilo C₁₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, -NR¹³R¹³, -NR¹³C(O)OR¹⁴, -OS(O)₂R¹⁴, -C(O)OR¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -S(O)₀₋₂R¹⁴, -S(O)₁₋₂NR¹³R¹³, -C(O)NR¹³R¹³, -NR¹³SO₂R¹⁴, -C(O)R¹⁴, -NR¹³C(O)NR¹³R¹³, -NR¹³S(O)₂NR¹³R¹³, SF₅ y -NO₂, en donde cada uno de alquilo C₁₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, y heteroarilo de 5 - 10 miembros están opcionalmente sustituidos con uno o más grupos R¹⁶; cada R¹³ se selecciona independientemente del grupo que consiste en -H, alquilo C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo C₃₋₆, arilo de 6 - 10 miembros, heterociclilo de 4 - 12 miembros y heteroarilo de 5 - 10 miembros, en donde el alquilo C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 6 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros están opcionalmente sustituidos con uno o más grupos R¹⁵; cada R¹⁴ se selecciona independientemente del grupo que consiste en: alquilo C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo C₃₋₆, arilo de 6 - 10 miembros, heterociclilo de 4 - 12 miembros y heteroarilo de 5 - 10 miembros, en donde el alquilo C₁₋₆, el hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 6 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros están opcionalmente sustituidos con uno o más grupos R¹⁵; cada R¹⁵ se selecciona independientemente de -H, halo, -CN, -OH, oxo, -NO₂, -SF₅, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, -S(O)(NH)R¹⁶, -S(O)(NR⁸)R¹⁶, -S(O)(NH)NR¹⁶R¹⁶, -S(O)(NR⁸)NR¹⁶R¹⁶, -S(O)₀₋₂R¹⁶, -S(O)₂NH₂, -NH₂, -S(O)NR¹⁶R¹⁶, C(O)R¹⁶, -C(O)NR¹⁶R¹⁶ y C(O)OR¹⁶, en donde cicloalquilo de 3 - 6 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros están opcionalmente sustituidos con uno o más grupos R¹⁶; cada R¹⁶ se selecciona independientemente de halo, -CN, -OH, -NH₂, oxo, -NO₂, -SF₅, alquilo C₁₋₃, haloalquilo C₁₋₃, alcoxi C₁₋₆, haloalcoxi C₁₋₆, hidroxialquilo C₁₋₆, tiohaloalquilo, sulfonilalquilo, sulfonilhaloalquilo, sulfonilcicloalquilo, cicloalquilo de 3 - 6 miembros, -C(O)NH₂ y -S(O)₂NH₂; R² se selecciona de un grupo que consiste en: -H, -CN, -F, -Cl, alquilo C₁₋₆, haloalquilo C₁₋₃, heteroalquilo C₁₋₃, alcoxi C₁₋₃ y haloalcoxi C₁₋₃; cada R³ y R⁴ se selecciona independientemente de un grupo que consiste en: -H, halo, -OH, -CN, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, heteroarilo de 5 - 10 miembros, -SF₅, -S(O)₀₋₂R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH, -NR¹³R¹³, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, -NR¹³C(O)OR¹⁴, trialquilsililo C₁₋₄, -C(O)R¹⁴, -C(O)OR¹⁴, -C(O)NR¹³R¹³, y -NO₂, en donde alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros son opcionalmente sustituidos con uno o más grupos R⁹; R⁵ se selecciona de un grupo que consiste en: -H, -CN, -F, -Cl, alquilo C₁₋₃, haloalquilo C₁₋₃, heteroalquilo C₁₋₃, alcoxi C₁₋₃ y haloalcoxi C₁₋₃; en donde R² y R³, o R³ y R⁴, o R⁴ y R⁵ pueden unirse opcionalmente junto con los átomos a los que están unidos, para formar un cicloalquilo de 5 - 6 miembros, un heterociclilo, fenilo de 5 - 6 miembros, o un heteroarilo de 5 - 6 miembros, cada uno de dichos grupos cíclico se fusionan respectivamente con el fenilo al que están unidos, y cada uno está opcionalmente sustituido con uno o más grupos R⁹; R⁶ se selecciona del grupo que consiste en: anillo carbobicíclico de 5 - 10 miembros, anillo tricíclico de 8 - 10 miembros, anillo heterobicíclico de 6 - 12 miembros y anillo policíclico de 8 - 12 miembros, en donde el anillo carbobicíclico de 5 - 10 miembros, el anillo tricíclico de 8 - 10 miembros, el anillo policíclico de 8 - 12 miembros, o el anillo heterobicíclico de 6 - 12 miembros puede ser fusionado, puenteado o espiro, y en el que el anillo carbobicíclico de 5 - 10 miembros, el anillo tricíclico de 8 - 10 miembros, el anillo heterocíclico de 6 - 12 miembros y el anillo policíclico de 8 - 12 miembros están sustituidos con uno o más R⁷; R⁷ se selecciona del grupo que consiste en: -H, halo, -CN, oxo, -OH, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, trialquilsililo C₁₋₄, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, -S(O)₀₋₂R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH, -NR¹³R¹³, -P(O)R¹⁴R¹⁴, -C(O)OH, -C(O)OR¹⁴, -C(O)NR¹³R¹³, -S(O)₂NR¹³R¹³, -C(O)R¹⁴, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, heterociclilo de 4 - 12 miembros; en donde cada uno de dichos heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, trialquilsililo C₁₋₄, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆ y cicloalquilo de 3 - 12 miembros están opcionalmente sustituidos con uno o más R¹⁵; y n es 1, 2 ó 3; R⁸ es alquilo C₁₋₆, -C(O)R¹⁴, cicloalquilo de 3 - 12 miembros, heteroalquilo C₁₋₆, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, heterociclilo de 4 - 12 miembros, -C(O)OR¹⁴, -C(O)NR¹³R¹³, y -SO₂R¹⁴, en donde cada uno de alquilo C₁₋₆, -C(O)R¹⁴, cicloalquilo de 3 - 12 miembros, heteroalquilo C₁₋₆, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, heterociclilo de 4 - 12 miembros está opcionalmente sustituido con halo, -CN, oxo, hidroxilo, alquilo C₁₋₆, alcoxi C₁₋₆, -S(O)₁₋₂R¹⁴, -S(O)₂NR¹³R¹³, -NO₂, -SF₅, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, hidroxialquilo C₁₋₆, -NR¹³R¹³, -C(O)OR¹⁴, heteroalquilo C₁₋₆, cicloalquilo de 3 - 6 miembros opcionalmente sustituido con uno o más R¹⁶, heterociclilo de 4 - 12 miembros opcionalmente sustituido con uno o más R¹⁶, arilo de 6 - 10 miembros opcionalmente sustituido con uno o más R¹⁶, heteroarilo de 5 - 10 miembros opcionalmente sustituido con uno o más R¹⁶; sujeto a las condiciones que (i) cuando R⁶ es un anillo carbocíclico C₈₋₁₂, y tanto R³ como R⁷ son H, entonces R⁴ se selecciona del grupo que consiste en: cicloalquilo C₇₋₁₂, alquenilo C₂₋₆, alquinilo C₂₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, heterociclilo de 4 miembros, heterociclilo de 7 miembros, heterociclilo monocíclico de 7 - 12 miembros, -SF₅, -NR¹³R¹³, -NR¹³C(O)OR¹⁴, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, trialquilsililo C₁₋₄, -C(O)R¹⁴, -C(O)OR¹⁴, -C(O)NR¹³R¹³, -S(O)₀₋₂R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH y -NO₂, en donde cicloalquilo C₇₋₁₂, alquenilo C₂₋₆, alquinilo C₂₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, heterociclilo de 4 miembros, heterociclilo de 7 miembros y heterociclilo monocíclico de 7 - 12 miembros están opcionalmente sustituidos con uno o más R⁹; el heterociclilo de 5 - 6 miembros está opcionalmente sustituido con R¹⁷; y el heterociclilo bicíclico de 8 - 10 miembros está opcionalmente sustituido con uno o más R¹⁸; (ii) cuando R⁶ es un anillo heterobicíclico de 8 - 10 miembros, R³ es H y R⁷ es -H, halo, ciano, oxo, -OH, alcoxi C₁₋₄, alquilo C₁₋₄ o halo-alquilo C₁₋₄, entonces R⁴ se selecciona del grupo que consiste en: cicloalquilo C₇₋₁₂, alquenilo C₂₋₆, alquinilo C₂₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, heterociclilo de 4 miembros, heterociclilo de 7 miembros, heterociclilo monocíclico de 7 - 12 miembros, -SF₅, -NR¹³R¹³, -NR¹³C(O)OR¹⁴, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, trialquilsililo C₁₋₄, -C(O)R¹⁴, -C(O)OR¹⁴, -C(O)NR¹³R¹³, -S(O)₀₋₂R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH, y -NO₂, en donde cicloalquilo C₇₋₁₂, alquenilo C₂₋₆, alquinilo C₂₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, heterociclilo de 4 miembros, heterociclilo de 7 miembros y heterociclilo monocíclico de 7 - 12 miembros están opcionalmente sustituidos con uno o más R⁹; el heterociclilo de 5 - 6 miembros está opcionalmente sustituido con R¹⁷, y el heterociclilo bicíclico de 8 - 10 miembros está opcionalmente sustituido con uno o más R¹⁸; (iii) cuando R⁶ es un anillo carbocíclico C₆₋₇, y R⁷ es H o metilo, entonces R³ se selecciona del grupo que consiste en: halo, -CN, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, -SF₅, -S(O)₀₋₂R¹⁴, -S(O)(NH)R¹⁴, -S(O)(NR⁸)R¹⁴, -S(O)(NH)NR¹³R¹³, -S(O)(NR⁸)NR¹³R¹³, -SH, -NR¹³R¹³, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, -NR¹³C(O)OR¹⁴, trialquilsililo C₁₋₄, -C(O)R¹⁴, -C(O)OR¹⁴, -C(O)NR¹³R¹³, y -NO₂, en donde alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros y heteroarilo de 5 - 10 miembros son opcionalmente sustituido con uno o más grupos R⁹; en donde R¹⁷ se selecciona de -OH, oxo, -CN, alquenilo C₂₋₆, alquinilo C₂₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 6 - 10 miembros, heteroarilo de 5 - 10 miembros, -S(O)₀₋₂R¹⁴, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, -NR¹³C(O)OR¹⁴, -C(O)R¹⁴, -C(O)OR¹⁴ y -C(O)NR¹³R¹³; y en donde R¹⁸ se selecciona de alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, hidroxialquilo C₁₋₆, heteroalquilo C₁₋₆, cicloalquilo de 3 - 12 miembros, heterociclilo de 4 - 12 miembros, arilo de 10 miembros, heteroarilo de 5 - 10 miembros, -S(O)₀₋₂R¹⁴, -NR¹³R¹³, -NR¹³SO₂R¹⁴, -NR¹³S(O)₂NR¹³R¹³, -NR¹³C(O)NR¹³R¹³, -NR¹³C(O)OR¹⁴, -C(O)R¹⁴, -C(O)OR¹⁴ y -C(O)NR¹³R¹³.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862674981P | 2018-05-22 | 2018-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR117576A1 true AR117576A1 (es) | 2021-08-18 |
Family
ID=66691073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101345A AR117576A1 (es) | 2018-05-22 | 2019-05-21 | Derivados de sulfinilaminobenzamida y sulfonilaminobenzamida |
Country Status (17)
Country | Link |
---|---|
US (2) | US11136290B2 (es) |
EP (1) | EP3796975B1 (es) |
JP (2) | JP7158500B2 (es) |
CN (1) | CN112204008A (es) |
AR (1) | AR117576A1 (es) |
AU (2) | AU2019272538B2 (es) |
CA (1) | CA3099051A1 (es) |
DK (1) | DK3796975T3 (es) |
ES (1) | ES2963524T3 (es) |
FI (1) | FI3796975T3 (es) |
HU (1) | HUE064831T2 (es) |
LT (1) | LT3796975T (es) |
PL (1) | PL3796975T3 (es) |
PT (1) | PT3796975T (es) |
SI (1) | SI3796975T1 (es) |
TW (2) | TWI820437B (es) |
WO (1) | WO2019226490A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3796975T3 (da) | 2018-05-22 | 2023-12-04 | Orsobio Inc | Sulfonylaminobenzamidderivater |
TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Fxr有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
WO2020257283A1 (en) | 2019-06-18 | 2020-12-24 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002018335A1 (fr) * | 2000-08-28 | 2002-03-07 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amine cyclique |
US8026264B2 (en) | 2003-05-29 | 2011-09-27 | Merck Sharp And Dohme Corp. | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 |
WO2005085188A2 (en) | 2004-03-02 | 2005-09-15 | Compass Pharmaceuticals Llc | Compounds and methods for anti-tumor therapy |
KR20130142801A (ko) * | 2012-06-20 | 2013-12-30 | 안국약품 주식회사 | 11β-HSD1 효소의 억제활성을 갖는 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
EP2990403A1 (en) * | 2014-08-29 | 2016-03-02 | Novartis Tiergesundheit AG | Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics |
CN107205971A (zh) * | 2014-11-18 | 2017-09-26 | 罗格斯,新泽西州立大学 | 用于治疗代谢疾病和癌症的新的线粒体解偶联剂 |
CA3024610A1 (en) * | 2016-05-18 | 2017-11-23 | David J. Augeri | Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer |
DK3796975T3 (da) | 2018-05-22 | 2023-12-04 | Orsobio Inc | Sulfonylaminobenzamidderivater |
WO2020257283A1 (en) * | 2019-06-18 | 2020-12-24 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
-
2019
- 2019-05-17 DK DK19728290.8T patent/DK3796975T3/da active
- 2019-05-17 CA CA3099051A patent/CA3099051A1/en active Pending
- 2019-05-17 AU AU2019272538A patent/AU2019272538B2/en active Active
- 2019-05-17 EP EP19728290.8A patent/EP3796975B1/en active Active
- 2019-05-17 ES ES19728290T patent/ES2963524T3/es active Active
- 2019-05-17 LT LTEPPCT/US2019/032925T patent/LT3796975T/lt unknown
- 2019-05-17 PL PL19728290.8T patent/PL3796975T3/pl unknown
- 2019-05-17 WO PCT/US2019/032925 patent/WO2019226490A1/en unknown
- 2019-05-17 US US16/415,787 patent/US11136290B2/en active Active
- 2019-05-17 HU HUE19728290A patent/HUE064831T2/hu unknown
- 2019-05-17 JP JP2020565357A patent/JP7158500B2/ja active Active
- 2019-05-17 SI SI201930655T patent/SI3796975T1/sl unknown
- 2019-05-17 CN CN201980034619.5A patent/CN112204008A/zh active Pending
- 2019-05-17 PT PT197282908T patent/PT3796975T/pt unknown
- 2019-05-17 FI FIEP19728290.8T patent/FI3796975T3/fi active
- 2019-05-21 AR ARP190101345A patent/AR117576A1/es unknown
- 2019-05-22 TW TW110122636A patent/TWI820437B/zh active
- 2019-05-22 TW TW108117594A patent/TWI732219B/zh active
-
2021
- 2021-08-31 US US17/463,011 patent/US20220055985A1/en active Pending
-
2022
- 2022-06-22 JP JP2022100465A patent/JP2022123114A/ja active Pending
- 2022-11-24 AU AU2022275470A patent/AU2022275470A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019226490A1 (en) | 2019-11-28 |
JP2021524856A (ja) | 2021-09-16 |
AU2019272538A1 (en) | 2020-11-19 |
CA3099051A1 (en) | 2019-11-28 |
HUE064831T2 (hu) | 2024-04-28 |
US20220055985A1 (en) | 2022-02-24 |
AU2022275470A1 (en) | 2023-01-05 |
TWI732219B (zh) | 2021-07-01 |
KR20210010925A (ko) | 2021-01-28 |
US11136290B2 (en) | 2021-10-05 |
PT3796975T (pt) | 2023-11-15 |
TWI820437B (zh) | 2023-11-01 |
TW202136209A (zh) | 2021-10-01 |
SI3796975T1 (sl) | 2024-02-29 |
EP3796975A1 (en) | 2021-03-31 |
ES2963524T3 (es) | 2024-03-27 |
FI3796975T3 (fi) | 2023-11-20 |
EP3796975B1 (en) | 2023-08-30 |
PL3796975T3 (pl) | 2024-02-26 |
DK3796975T3 (da) | 2023-12-04 |
US20190359565A1 (en) | 2019-11-28 |
CN112204008A (zh) | 2021-01-08 |
TW202003457A (zh) | 2020-01-16 |
JP2022123114A (ja) | 2022-08-23 |
JP7158500B2 (ja) | 2022-10-21 |
AU2019272538B2 (en) | 2022-08-25 |
LT3796975T (lt) | 2023-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR117139A1 (es) | Derivados de piridooxazinona como inhibidores de monoacilglicerol ligasa (magl) | |
AR117576A1 (es) | Derivados de sulfinilaminobenzamida y sulfonilaminobenzamida | |
AR095198A1 (es) | Derivados de triazolona de piridinilo y piridinilo fusionado | |
AR114793A1 (es) | Moduladores de enzimas modificadoras de metilo, composiciones y usos de los mismos | |
AR111407A1 (es) | Compuestos inhibidores de ask1 y usos de los mismos | |
AR089285A1 (es) | Derivados de betulina | |
AR062050A1 (es) | Derivados de amina utiles como agentes anti-cancerigenos | |
AR087328A1 (es) | Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak | |
AR093339A1 (es) | Analogos de spliceostatina y metodos para su preparacion | |
AR090191A1 (es) | Derivados del acido fenil alcanoico como agonistas gpr | |
AR113929A1 (es) | Compuestos heterocíclicos | |
AR100418A1 (es) | Compuestos y composiciones para inducir condrogénesis | |
AR092288A1 (es) | Ligandos del receptor ep1 | |
AR100713A1 (es) | Derivados de amida de compuestos de 1-oxa-4,9-diazaespiro undeceno que tienen actividad multimodal contra el dolor | |
AR092347A1 (es) | Derivados de azaindol | |
AR112907A1 (es) | Pirazoles inhibidores de monoacilglicerol lipasa (magl) | |
AR093035A1 (es) | Derivados de pirrolotriazinona como inhibidores de pi3k | |
CR20170371A (es) | Compuestos de benzoxaboral 4-sustituidos y uso de los mismos | |
PE20240687A1 (es) | Compuestos de indazol como inhibidores de cinasas | |
AR111271A1 (es) | Inhibidores dobles de magl y faah | |
AR111826A1 (es) | Compuestos bicíclicos 5,6 fusionados y composiciones para el tratamiento de las enfermedades parasitarias | |
AR120649A1 (es) | Antagonistas del receptor de crf y métodos de uso | |
AR119140A1 (es) | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas | |
AR125365A1 (es) | Derivados de 1h-pirazol como ligandos sigma | |
AR110936A1 (es) | COMPUESTOS DE INDOL PIPERIDINA CON ACTIVIDAD AGONISTA b ADRENÉRGICA Y ANTIMUSCARÍNICA |