|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
EP0088046B1
(de)
|
1982-02-17 |
1987-12-09 |
Ciba-Geigy Ag |
Lipide in wässriger Phase
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
EP0143949B1
(en)
|
1983-11-01 |
1988-10-12 |
TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION |
Pharmaceutical composition containing urokinase
|
|
US4808608A
(en)
|
1986-01-23 |
1989-02-28 |
Merck & Co., Inc. |
Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
|
|
US5374426A
(en)
|
1986-09-03 |
1994-12-20 |
University Of Saskatchewan |
Rotavirus nucleocapsid protein VP6 in vaccine compositions
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5218105A
(en)
|
1990-07-27 |
1993-06-08 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
EP0563091A1
(en)
|
1990-12-20 |
1993-10-06 |
SMITHKLINE BEECHAM BIOLOGICALS s.a. |
Vaccines based on hepatitis b surface antigen
|
|
US6565841B1
(en)
|
1991-03-15 |
2003-05-20 |
Amgen, Inc. |
Pulmonary administration of granulocyte colony stimulating factor
|
|
US5470582A
(en)
|
1992-02-07 |
1995-11-28 |
Syntex (U.S.A.) Inc. |
Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
|
|
FR2693813B1
(fr)
|
1992-07-20 |
1994-08-19 |
Commissariat Energie Atomique |
Procédé de réalisation d'une image de référence synthétisée à partir de données contenues dans une base de données CAO.
|
|
FR2705099B1
(fr)
|
1993-05-12 |
1995-08-04 |
Centre Nat Rech Scient |
Oligonucléotides phosphorothioates triesters et procédé de préparation.
|
|
CN1185811A
(zh)
|
1995-03-31 |
1998-06-24 |
H·沃尔夫 |
依赖于逆转录病毒样颗粒的抗原呈递系统
|
|
GB9621091D0
(en)
|
1996-10-09 |
1996-11-27 |
Fondation Pour Le Perfectionem |
Attenuated microorganisms strains and their uses
|
|
JP3944914B2
(ja)
|
1996-10-14 |
2007-07-18 |
セイコーエプソン株式会社 |
累進多焦点レンズの製造方法
|
|
WO2000023955A1
(en)
|
1998-10-21 |
2000-04-27 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Virus-like particles for the induction of autoantibodies
|
|
MXPA01005389A
(es)
|
1998-11-30 |
2003-03-27 |
Cytos Biotechnology Ag |
Presentacion molecular ordenada de antigenos, metodos de preparacion y uso.
|
|
JP4713809B2
(ja)
|
2000-04-07 |
2011-06-29 |
ユニバーシティ オブ リードズ イノベイションズ リミテッド |
B型肝炎コア抗原融合タンパク質
|
|
EP1278542A2
(en)
|
2000-05-05 |
2003-01-29 |
Cytos Biotechnology AG |
Molecular antigen arrays and vaccines
|
|
ATE320493T1
(de)
|
2000-06-22 |
2006-04-15 |
Ucb Pharma Ltd |
Modifizierung des hepatitis b kernantigens
|
|
US20030138769A1
(en)
|
2000-08-16 |
2003-07-24 |
Birkett Ashley J. |
Immunogenic HBc chimer particles having enhanced stability
|
|
US7264810B2
(en)
|
2001-01-19 |
2007-09-04 |
Cytos Biotechnology Ag |
Molecular antigen array
|
|
EP1450856B1
(en)
|
2001-09-14 |
2009-11-11 |
Cytos Biotechnology AG |
Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use
|
|
DE10201743C2
(de)
|
2002-01-18 |
2003-12-18 |
Aesculap Ag & Co Kg |
Intramedulläres Osteosyntheseimplantat
|
|
DE60334303D1
(de)
|
2002-07-03 |
2010-11-04 |
Tasuku Honjo |
Immunpotenzierende zusammensetzungen
|
|
AU2003246690B2
(en)
|
2002-07-17 |
2010-03-11 |
Cytos Biotechnology Ag |
Molecular antigen arrays using a virus like particle derived from the AP205 coat protein
|
|
BR0312792A
(pt)
|
2002-07-19 |
2005-05-03 |
Cytos Biotechnology Ag |
Composições de vacinas contendo séries antigênicas de amilóide beta1-6
|
|
ATE390205T1
(de)
|
2002-12-10 |
2008-04-15 |
Haldor Topsoe As |
Verfahren zur katalytischen dehydrierung und katalysator dafür
|
|
CN101675993A
(zh)
|
2003-03-26 |
2010-03-24 |
赛托斯生物技术公司 |
Melan-a肽类似物-病毒样颗粒偶联物
|
|
US8685435B2
(en)
|
2004-04-30 |
2014-04-01 |
Allergan, Inc. |
Extended release biodegradable ocular implants
|
|
WO2006063252A2
(en)
|
2004-12-09 |
2006-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
ATE515566T1
(de)
|
2005-05-26 |
2011-07-15 |
Cytos Biotechnology Ag |
Skalierbares fermentationsverfahren
|
|
EP1736538A1
(en)
|
2005-06-21 |
2006-12-27 |
Cytos Biotechnology AG |
Process for the preparative purification of virus-like-particles (VLPs)
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
JP2010500011A
(ja)
|
2006-08-08 |
2010-01-07 |
ガンサー ハートマン |
5’リン酸オリゴヌクレオチドの構造および使用
|
|
PT2170959E
(pt)
|
2007-06-18 |
2014-01-07 |
Merck Sharp & Dohme |
Anticorpos para o receptor humano de morte programada pd-1
|
|
JP5721441B2
(ja)
|
2008-01-31 |
2015-05-20 |
キュアバック ゲーエムベーハーCurevac Gmbh |
免疫賦活剤/アジュバントとしての式(I)(NuGlXmGnNv)aで表される核酸分子及びその誘導体
|
|
US9738680B2
(en)
|
2008-05-21 |
2017-08-22 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5′ triphosphate oligonucleotide with blunt end and uses thereof
|
|
WO2010002851A1
(en)
|
2008-06-30 |
2010-01-07 |
Alnylam Pharmaceuticals, Inc. |
Silencing and rig-1 activation by dual function oligonucleotides
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
AU2009288078B2
(en)
|
2008-09-02 |
2014-10-30 |
Alnylam Pharmaceuticals, Inc. |
Synthetic methods and derivatives of triphosphate oligonucleotides
|
|
MX356367B
(es)
|
2008-12-09 |
2018-05-25 |
Genentech Inc |
Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
EP2857499A1
(en)
|
2010-10-01 |
2015-04-08 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
PT3682905T
(pt)
|
2011-10-03 |
2022-04-07 |
Modernatx Inc |
Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
|
|
JP2014532400A
(ja)
|
2011-10-31 |
2014-12-08 |
リボックス・ゲーエムベーハー |
免疫賦活用の二本鎖rna
|
|
BR112014012819B1
(pt)
|
2011-11-28 |
2022-08-16 |
Merck Patent Gmbh |
Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
|
|
WO2013097965A1
(en)
|
2011-12-30 |
2013-07-04 |
Riboxx Gmbh |
Triphosphate-containing double-stranded rna for immunostimulation
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
WO2013180295A1
(ja)
|
2012-06-01 |
2013-12-05 |
日本電信電話株式会社 |
パケット転送処理方法およびパケット転送処理装置
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
WO2014093924A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
PT2922554T
(pt)
|
2012-11-26 |
2022-06-28 |
Modernatx Inc |
Arn modificado nas porções terminais
|
|
US20140287023A1
(en)
|
2013-02-11 |
2014-09-25 |
Mcgill University |
5'-triphosphate oligoribonucleotides
|
|
WO2014164253A1
(en)
|
2013-03-09 |
2014-10-09 |
Moderna Therapeutics, Inc. |
Heterologous untranslated regions for mrna
|
|
US20160024181A1
(en)
|
2013-03-13 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
|
US10947543B2
(en)
*
|
2013-03-13 |
2021-03-16 |
Yale University |
Interferon production using short RNA duplexes
|
|
WO2014169049A1
(en)
*
|
2013-04-09 |
2014-10-16 |
Duke University |
2' fluoro-modified rnas as immunostimulators
|
|
US9775894B2
(en)
|
2013-07-09 |
2017-10-03 |
University Of Washington Through Its Center For Commercialization |
Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling
|
|
WO2015038746A1
(en)
|
2013-09-11 |
2015-03-19 |
Georgia Tech Research Corporation |
Compositions and methods for inhibiting gene expression
|
|
EP3083962B1
(en)
|
2013-12-16 |
2021-08-18 |
RiboxX GmbH |
Double-stranded polyc:poly(g/i) rna for immunostimulation and cancer treatment
|
|
US10273484B2
(en)
|
2014-03-24 |
2019-04-30 |
Riboxx Gmbh |
Double-stranded RNA conjugates and their use
|
|
US9300829B2
(en)
|
2014-04-04 |
2016-03-29 |
Canon Kabushiki Kaisha |
Image reading apparatus and correction method thereof
|
|
AU2015224518B2
(en)
|
2014-07-15 |
2017-03-09 |
Drifire, Llc |
Lightweight, dual hazard fabrics
|
|
EP3172324A4
(en)
*
|
2014-07-18 |
2018-04-25 |
Oregon Health & Science University |
5'-triphosphate oligoribonucleotides
|
|
CA2971734C
(en)
|
2014-12-22 |
2025-11-18 |
Pd-1 Acquisition Group, Llc |
Anti-pd-1 antibodies
|
|
WO2017121494A1
(en)
|
2016-01-15 |
2017-07-20 |
Riboxx Gmbh |
5'-triphosphated short immunostimulatory nucleotides, oligonucleotides and polynucleotides
|
|
EP3436031A4
(en)
*
|
2016-04-01 |
2019-09-18 |
Vycellix, Inc. |
Novel RNA construct and method of use therefor for increasing the therapeutic effects of cytotoxic cells and stem cells
|
|
CN109414461A
(zh)
|
2016-04-26 |
2019-03-01 |
曲生物制品公司 |
治疗性地触发靶组织中的先天性免疫应答
|
|
WO2017221076A1
(en)
|
2016-06-24 |
2017-12-28 |
Institut Pasteur |
Compositions and methods comprising measles virus defective interfering particles for the prevention of infectious diseases
|
|
WO2018172546A1
(en)
*
|
2017-03-24 |
2018-09-27 |
Rigontec Gmbh |
Method for designing rig-i ligands
|
|
US10736957B2
(en)
*
|
2017-12-19 |
2020-08-11 |
President And Fellows Of Harvard College |
Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences
|
|
JP7386161B2
(ja)
*
|
2017-12-19 |
2023-11-24 |
ブレイズ バイオサイエンス, インコーポレイテッド |
腫瘍ホーミング及び細胞透過性ペプチド免疫抗がん剤複合体、ならびにそれらの使用方法
|
|
BR112020020479A2
(pt)
|
2018-04-09 |
2021-01-12 |
Checkmate Pharmaceuticals |
Empacotamento de oligonucleotídeos em partículas similares a vírus
|
|
CN119286871A
(zh)
|
2018-04-19 |
2025-01-10 |
查美特制药公司 |
合成rig-i样受体激动剂
|
|
EP3791689A1
(en)
|
2018-05-08 |
2021-03-17 |
Telefonaktiebolaget Lm Ericsson (Publ) |
Methods and nodes for enabling management of traffic
|
|
EP3810151B1
(en)
*
|
2018-06-20 |
2025-08-06 |
Yale University |
Rig-i agonists and treatments using same
|
|
CA3155202A1
(en)
|
2019-10-23 |
2021-04-29 |
Arthur M. Krieg |
Synthetic rig-i-like receptor agonists
|
|
CN115376873A
(zh)
|
2021-05-18 |
2022-11-22 |
江苏鲁汶仪器有限公司 |
离子源装置及其使用方法和真空处理系统
|