AU2019255370B2 - Synthetic RIG-I-like receptor agonists - Google Patents

Synthetic RIG-I-like receptor agonists Download PDF

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Publication number
AU2019255370B2
AU2019255370B2 AU2019255370A AU2019255370A AU2019255370B2 AU 2019255370 B2 AU2019255370 B2 AU 2019255370B2 AU 2019255370 A AU2019255370 A AU 2019255370A AU 2019255370 A AU2019255370 A AU 2019255370A AU 2019255370 B2 AU2019255370 B2 AU 2019255370B2
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agonist
rlr
polynucleotide
utp
sequence
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AU2019255370A1 (en
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Arthur M. Krieg
Aaron Jay MORRIS
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Checkmate Pharmaceuticals Inc
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Checkmate Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2019255370A 2018-04-19 2019-04-19 Synthetic RIG-I-like receptor agonists Active AU2019255370B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023229532A AU2023229532B2 (en) 2018-04-19 2023-09-13 Synthetic rig-i-like receptor agonists
AU2024287196A AU2024287196A1 (en) 2018-04-19 2024-12-23 Synthetic rig-i-like receptor agonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862659999P 2018-04-19 2018-04-19
US62/659,999 2018-04-19
PCT/US2019/028343 WO2019204743A1 (en) 2018-04-19 2019-04-19 Synthetic rig-i-like receptor agonists

Related Child Applications (1)

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AU2023229532A Division AU2023229532B2 (en) 2018-04-19 2023-09-13 Synthetic rig-i-like receptor agonists

Publications (2)

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AU2019255370A1 AU2019255370A1 (en) 2020-09-17
AU2019255370B2 true AU2019255370B2 (en) 2023-11-02

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AU2019255370A Active AU2019255370B2 (en) 2018-04-19 2019-04-19 Synthetic RIG-I-like receptor agonists
AU2023229532A Active AU2023229532B2 (en) 2018-04-19 2023-09-13 Synthetic rig-i-like receptor agonists
AU2024287196A Pending AU2024287196A1 (en) 2018-04-19 2024-12-23 Synthetic rig-i-like receptor agonists

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AU2024287196A Pending AU2024287196A1 (en) 2018-04-19 2024-12-23 Synthetic rig-i-like receptor agonists

Country Status (7)

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US (3) US10907161B2 (enExample)
EP (1) EP3781689A1 (enExample)
JP (3) JP7366057B2 (enExample)
CN (2) CN119286871A (enExample)
AU (3) AU2019255370B2 (enExample)
CA (1) CA3093715A1 (enExample)
WO (1) WO2019204743A1 (enExample)

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AU2023228912A1 (en) 2022-03-03 2024-09-19 Yale University Humanized 3e10 antibodies, variants, and antigen binding fragments thereof
CN115969971B (zh) * 2022-11-24 2023-08-18 珠海恩科生物科技有限公司 组合物在制备治疗肿瘤的药物中的应用
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