|
US1268002A
(en)
|
1917-09-12 |
1918-05-28 |
William M Goodwin |
Measuring instrument.
|
|
US4166452A
(en)
|
1976-05-03 |
1979-09-04 |
Generales Constantine D J Jr |
Apparatus for testing human responses to stimuli
|
|
US4256108A
(en)
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
|
US4265874A
(en)
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
|
US5604294A
(en)
|
1991-09-05 |
1997-02-18 |
Luly; Jay R. |
Macrocyclic immunomodulators
|
|
IL120266A
(en)
|
1996-02-28 |
2005-05-17 |
Pfizer |
Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
|
|
GB9604926D0
(en)
|
1996-03-08 |
1996-05-08 |
Sandoz Ltd |
Organic compounds
|
|
JP4875978B2
(ja)
*
|
2004-03-15 |
2012-02-15 |
武田薬品工業株式会社 |
アミノフェニルプロパン酸誘導体
|
|
EP2418202B1
(en)
|
2006-03-31 |
2014-01-29 |
Novartis AG |
(4-[4-[5-(substituted amino)-pyridin-2-yl]phenyl]-cyclohexyl)-acetic acid derivatives as DGAT inhibitors
|
|
DE102006017175A1
(de)
|
2006-04-12 |
2007-10-18 |
Robert Bosch Gmbh |
Balancierter Serienmischer für Hochfrequenzsignale
|
|
WO2008008059A1
(en)
|
2006-07-12 |
2008-01-17 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents ans uses thereof
|
|
US20080194557A1
(en)
|
2007-01-18 |
2008-08-14 |
Joseph Barbosa |
Methods and compositions for the treatment of pain, inflammation and cancer
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
CN105705489B
(zh)
|
2013-09-04 |
2019-04-26 |
百时美施贵宝公司 |
用作免疫调节剂的化合物
|
|
EA029661B1
(ru)
|
2013-09-06 |
2018-04-30 |
Ауриген Дискавери Текнолоджиз Лимитед |
Производные 1,3,4-оксадиазола и 1,3,4-тиадиазола в качестве иммуномодуляторов
|
|
HUE038169T2
(hu)
|
2013-09-06 |
2018-09-28 |
Aurigene Discovery Tech Ltd |
1,2,4-Oxadiazol származékok mint immunomodulátorok
|
|
US9850225B2
(en)
|
2014-04-14 |
2017-12-26 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
JP6816107B2
(ja)
|
2015-08-07 |
2021-01-20 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
インダニルアミノピリジルシクロプロパンカルボン酸、医薬組成物及びこれらの使用
|
|
NL1041468B1
(en)
|
2015-09-08 |
2017-03-22 |
Bosch Gmbh Robert |
Metal ring component of a drive belt for a continuously variable transmisson.
|
|
EP3347358B1
(en)
|
2015-09-09 |
2019-11-27 |
Boehringer Ingelheim International GmbH |
[{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof
|
|
US10745382B2
(en)
|
2015-10-15 |
2020-08-18 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
WO2017070089A1
(en)
|
2015-10-19 |
2017-04-27 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
SG10202004618TA
(en)
|
2015-11-19 |
2020-06-29 |
Incyte Corp |
Heterocyclic compounds as immunomodulators
|
|
MA44075A
(fr)
|
2015-12-17 |
2021-05-19 |
Incyte Corp |
Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1
|
|
AU2016379372A1
(en)
|
2015-12-22 |
2018-08-02 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
EP3190103A1
(en)
|
2016-01-08 |
2017-07-12 |
Rijksuniversiteit Groningen |
Inhibitors of the pd-1/pd-l1 protein/protein interaction
|
|
SG11201808626WA
(en)
|
2016-04-07 |
2018-10-30 |
Chemocentryx Inc |
Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
|
|
AR108396A1
(es)
|
2016-05-06 |
2018-08-15 |
Incyte Corp |
Compuestos heterocíclicos como inmunomoduladores
|
|
WO2017202275A1
(zh)
|
2016-05-23 |
2017-11-30 |
中国医学科学院药物研究所 |
溴代苄醚衍生物、及其制法和药物组合物与用途
|
|
WO2017205464A1
(en)
|
2016-05-26 |
2017-11-30 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
HUE060256T2
(hu)
|
2016-06-20 |
2023-02-28 |
Incyte Corp |
Heterociklusos vegyületek mint immunmodulátorok
|
|
US10639284B2
(en)
*
|
2016-06-27 |
2020-05-05 |
Chemocentryx, Inc. |
Immunomodulator compounds
|
|
KR102482673B1
(ko)
|
2016-07-05 |
2022-12-30 |
광저우 맥시노벨 파마수티컬스 씨오., 엘티디. |
방향족 아세틸렌 또는 방향족 에틸렌계 화합물, 그의 중간체, 제조 방법, 약물 조성물 및 용도
|
|
EA201990221A1
(ru)
|
2016-07-08 |
2019-06-28 |
Бристол-Маерс Сквибб Компани |
1,3-дигидроксифенильные производные, применимые в качестве иммуномодуляторов
|
|
EP3484866B1
(en)
|
2016-07-14 |
2022-09-07 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
WO2018044783A1
(en)
|
2016-08-29 |
2018-03-08 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
US10144706B2
(en)
|
2016-09-01 |
2018-12-04 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
WO2018045142A1
(en)
|
2016-09-02 |
2018-03-08 |
Polaris Pharmaceuticals, Inc. |
Immune checkpoint inhibitors, compositions and methods thereof
|
|
US10771492B2
(en)
|
2016-09-22 |
2020-09-08 |
Microsoft Technology Licensing, Llc |
Enterprise graph method of threat detection
|
|
EP3558970B1
(en)
|
2016-12-20 |
2021-09-01 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
WO2018119263A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds derivatives as pd-l1 internalization inducers
|
|
JP7101678B2
(ja)
|
2016-12-22 |
2022-07-15 |
インサイト・コーポレイション |
免疫調節剤としての複素環式化合物
|
|
LT3558990T
(lt)
|
2016-12-22 |
2022-12-27 |
Incyte Corporation |
Tetrahidroimidazo[4,5-c]piridino dariniai kaip pd-l1 internalizavimo induktoriai
|
|
US20180179202A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
ES2874756T3
(es)
|
2016-12-22 |
2021-11-05 |
Incyte Corp |
Derivados de triazolo[1,5-A]piridina como inmunomoduladores
|
|
WO2018119221A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Pyridine derivatives as immunomodulators
|
|
EP3564237A4
(en)
|
2016-12-29 |
2020-06-10 |
Shenzhen Chipscreen Biosciences Co., Ltd. |
UREA COMPOUND AND PRODUCTION METHOD AND USE THEREOF
|
|
CN108395443B
(zh)
|
2017-02-04 |
2021-05-04 |
广州丹康医药生物有限公司 |
抑制程序性死亡受体配体1的环状化合物及其用途
|
|
CN110461829B
(zh)
|
2017-03-27 |
2023-02-28 |
百时美施贵宝公司 |
作为免疫调节剂的取代的异喹啉衍生物
|
|
BR102018007822A2
(pt)
|
2017-04-20 |
2018-11-06 |
Gilead Sciences, Inc. |
composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
|
|
TW201841896A
(zh)
|
2017-04-26 |
2018-12-01 |
大陸商南京聖和藥業股份有限公司 |
作為pd—l1抑制劑的雜環類化合物
|
|
CN108863963B
(zh)
|
2017-05-08 |
2022-05-27 |
南京圣和药物研发有限公司 |
作为pd-l1抑制剂的杂环类化合物
|
|
US10919852B2
(en)
|
2017-07-28 |
2021-02-16 |
Chemocentryx, Inc. |
Immunomodulator compounds
|
|
US10392405B2
(en)
|
2017-08-08 |
2019-08-27 |
Chemocentryx, Inc. |
Macrocyclic immunomodulators
|
|
EP3669872A4
(en)
|
2017-08-18 |
2021-05-05 |
Shanghai Ennovabio Pharmaceuticals Co., Ltd. |
FORMYL PYRIDINE DERIVATIVE WITH PD-L1 INHIBITORING EFFECT, MANUFACTURING METHOD FOR IT AND USE THEREOF
|
|
CA3293051A1
(en)
|
2017-09-25 |
2026-03-02 |
Chemocentryx, Inc. |
Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
|
|
CN111051332B
(zh)
|
2017-10-03 |
2024-09-06 |
百时美施贵宝公司 |
免疫调节剂
|
|
CN109665968B
(zh)
|
2017-10-16 |
2022-02-22 |
四川科伦博泰生物医药股份有限公司 |
并环化合物及其制备方法和用途
|
|
CN109678796B
(zh)
|
2017-10-19 |
2023-01-10 |
上海长森药业有限公司 |
Pd-1/pd-l1小分子抑制剂及其制备方法和用途
|
|
CN109721527B
(zh)
|
2017-10-27 |
2024-03-12 |
广州丹康医药生物有限公司 |
一种新型抗pd-l1化合物、其应用及含其的组合物
|
|
US11629135B2
(en)
|
2017-11-06 |
2023-04-18 |
Jubilant Prodell Llc |
Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
|
|
CN109956898B
(zh)
|
2017-12-22 |
2021-03-26 |
上海海雁医药科技有限公司 |
免疫调节剂及其制法与医药上的用途
|
|
CN109988144B
(zh)
|
2017-12-29 |
2024-07-05 |
广州再极医药科技有限公司 |
芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用
|
|
KR102738303B1
(ko)
|
2018-01-23 |
2024-12-03 |
브리스톨-마이어스 스큅 컴퍼니 |
면역조정제로서 유용한 2,8-디아실-2,8-디아자스피로[5.5]운데칸 화합물
|
|
WO2019149183A1
(zh)
|
2018-02-05 |
2019-08-08 |
上海和誉生物医药科技有限公司 |
一种联芳基衍生物、其制备方法和在药学上的应用
|
|
CR20200347A
(es)
|
2018-02-13 |
2020-09-23 |
Gilead Sciences Inc |
Inhibidores pd-1/pd-l1
|
|
US10568874B2
(en)
*
|
2018-02-22 |
2020-02-25 |
Chemocentryx, Inc. |
Indane-amines as PD-L1 antagonists
|
|
CN112041312A
(zh)
|
2018-03-01 |
2020-12-04 |
百时美施贵宝公司 |
用作免疫调节剂的化合物
|
|
CN111788193B
(zh)
|
2018-03-13 |
2023-04-04 |
广东东阳光药业有限公司 |
Pd-1/pd-l1类小分子抑制剂及其在药物中的应用
|
|
MX2020009517A
(es)
|
2018-03-13 |
2021-01-20 |
Jubilant Prodel LLC |
Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1.
|
|
SMT202500157T1
(it)
|
2018-03-30 |
2025-05-12 |
Incyte Corp |
Composti eterociclici come immunomodulatori
|
|
JP2021520342A
(ja)
|
2018-04-03 |
2021-08-19 |
ベータ ファーマシューティカルズ カンパニー リミテッド |
免疫調節物質、組成物及びそれらの方法
|
|
TWI712412B
(zh)
|
2018-04-19 |
2020-12-11 |
美商基利科學股份有限公司 |
Pd‐1/pd‐l1抑制劑
|
|
HUE061503T2
(hu)
|
2018-05-11 |
2023-07-28 |
Incyte Corp |
Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok
|
|
TWI798463B
(zh)
|
2018-07-11 |
2023-04-11 |
大陸商上海和譽生物醫藥科技有限公司 |
免疫抑制劑及其製備方法和在藥學上的應用
|
|
CN112384500B
(zh)
|
2018-07-12 |
2024-05-14 |
贝达药业股份有限公司 |
免疫调节剂及其组合物和制备方法
|
|
SG11202012425QA
(en)
|
2018-07-13 |
2021-01-28 |
Gilead Sciences Inc |
Pd-1/pd-l1 inhibitors
|
|
US20210300909A1
(en)
|
2018-07-19 |
2021-09-30 |
Betta Pharmaceuticals Co., Ltd |
Immunomodulators, compositions and methods thereof
|
|
CN112566900B
(zh)
|
2018-07-19 |
2024-04-26 |
贝达药业股份有限公司 |
免疫调节剂及其组合物和制备方法
|
|
US20210347785A1
(en)
|
2018-08-01 |
2021-11-11 |
Shanghai Ennovabio Pharmaceuticals Co., Ltd. |
Preparation and application of aromatic compound having immunoregulatory function
|
|
US20210236476A1
(en)
|
2018-08-29 |
2021-08-05 |
Chemocentryx, Inc. |
Methods of treating cancer with small molecule pd-l1 inhibitors
|
|
CN109336857A
(zh)
|
2018-11-13 |
2019-02-15 |
南方医科大学 |
一种含取代联苯的黄酮及其应用
|
|
CN109438263A
(zh)
|
2018-11-28 |
2019-03-08 |
南方医科大学 |
一种含取代联苯的萘及其应用
|
|
CN109503546A
(zh)
|
2019-01-10 |
2019-03-22 |
南方医科大学 |
一种间苯二酚二苯甲醚及其应用
|
|
CN109776377B
(zh)
|
2019-02-01 |
2021-08-24 |
沈阳药科大学 |
吲哚啉类化合物及其制备方法和应用
|
|
CN109776445B
(zh)
|
2019-03-28 |
2022-12-06 |
中国药科大学 |
苯并噁二唑类化合物及其制备方法和医药用途
|
|
WO2020232256A1
(en)
|
2019-05-15 |
2020-11-19 |
Chemocentryx, Inc. |
Triaryl compounds for treatment of pd-l1 diseases
|
|
CN110200959A
(zh)
|
2019-05-30 |
2019-09-06 |
天津科技大学 |
一种黄酮类化合物的应用
|
|
CN110128415B
(zh)
|
2019-05-31 |
2022-03-25 |
沈阳药科大学 |
用作免疫调节剂的吲哚啉类化合物及其制备方法
|
|
WO2020257549A2
(en)
|
2019-06-20 |
2020-12-24 |
Chemocentryx, Inc. |
Compounds for treatment of pd-l1 diseases
|
|
BR112021025888A2
(pt)
|
2019-07-10 |
2022-04-26 |
Chemocentryx Inc |
Indanos como inibidores de pd-l1
|
|
ES3064674T3
(en)
|
2019-10-16 |
2026-04-28 |
Chemocentryx Inc |
Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases
|
|
JP7736678B2
(ja)
|
2019-10-16 |
2025-09-09 |
ケモセントリックス，インコーポレイティド |
Ｐｄ－ｌ１疾患の処置のためのヘテロアリール－ビフェニルアミド
|
|
MX2022016554A
(es)
|
2020-06-23 |
2023-04-10 |
Chemocentryx Inc |
Métodos de tratamiento del cáncer mediante derivados heteroaril-bifenil-amida.
|