JP2021513861A5 - - Google Patents

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Publication number
JP2021513861A5
JP2021513861A5 JP2020544270A JP2020544270A JP2021513861A5 JP 2021513861 A5 JP2021513861 A5 JP 2021513861A5 JP 2020544270 A JP2020544270 A JP 2020544270A JP 2020544270 A JP2020544270 A JP 2020544270A JP 2021513861 A5 JP2021513861 A5 JP 2021513861A5
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Japan
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aso
camk2d
seq
nucleotides
lna
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JP2020544270A
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JP7500426B2 (ja
JP2021513861A (ja
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Priority claimed from PCT/US2019/018947 external-priority patent/WO2019165067A1/en
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JP2020544270A 2018-02-21 2019-02-21 Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用 Active JP7500426B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862633502P 2018-02-21 2018-02-21
US62/633,502 2018-02-21
US201862635954P 2018-02-27 2018-02-27
US62/635,954 2018-02-27
US201862665998P 2018-05-02 2018-05-02
US62/665,998 2018-05-02
US201862778679P 2018-12-12 2018-12-12
US62/778,679 2018-12-12
PCT/US2019/018947 WO2019165067A1 (en) 2018-02-21 2019-02-21 Camk2d antisense oligonucleotides and uses thereof

Publications (3)

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JP2021513861A JP2021513861A (ja) 2021-06-03
JP2021513861A5 true JP2021513861A5 (https=) 2022-03-01
JP7500426B2 JP7500426B2 (ja) 2024-06-17

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JP2020544270A Active JP7500426B2 (ja) 2018-02-21 2019-02-21 Ｃａｍｋ２ｄアンチセンスオリゴヌクレオチドおよびその使用

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US (2) US11083444B2 (https=)
EP (1) EP3755800A1 (https=)
JP (1) JP7500426B2 (https=)
KR (1) KR20200140805A (https=)
CN (1) CN112020559A (https=)
AU (1) AU2019226001B2 (https=)
BR (1) BR112020016347A2 (https=)
CA (1) CA3091789A1 (https=)
IL (2) IL320427A (https=)
MX (1) MX2020008581A (https=)
SG (1) SG11202007652UA (https=)
WO (1) WO2019165067A1 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE524121T1 (de) 2004-11-24 2011-09-15 Abdou Samy Vorrichtungen zur platzierung eines orthopädischen intervertebralen implantats
US8764806B2 (en) 2009-12-07 2014-07-01 Samy Abdou Devices and methods for minimally invasive spinal stabilization and instrumentation
US11998184B2 (en) * 2010-03-11 2024-06-04 Globus Medical, Inc Tissue retractor and methods of use
US8845728B1 (en) 2011-09-23 2014-09-30 Samy Abdou Spinal fixation devices and methods of use
US20130226240A1 (en) 2012-02-22 2013-08-29 Samy Abdou Spinous process fixation devices and methods of use
US9198767B2 (en) 2012-08-28 2015-12-01 Samy Abdou Devices and methods for spinal stabilization and instrumentation
US9320617B2 (en) 2012-10-22 2016-04-26 Cogent Spine, LLC Devices and methods for spinal stabilization and instrumentation
US10857003B1 (en) 2015-10-14 2020-12-08 Samy Abdou Devices and methods for vertebral stabilization
US10898175B2 (en) 2016-10-04 2021-01-26 Jgmg Bengochea, Llc Retractor extension clip systems
US10973648B1 (en) 2016-10-25 2021-04-13 Samy Abdou Devices and methods for vertebral bone realignment
US10744000B1 (en) 2016-10-25 2020-08-18 Samy Abdou Devices and methods for vertebral bone realignment
MX2020008581A (es) 2018-02-21 2020-09-21 Bristol Myers Squibb Co Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos.
US11806250B2 (en) 2018-02-22 2023-11-07 Warsaw Orthopedic, Inc. Expandable spinal implant system and method of using same
US11179248B2 (en) 2018-10-02 2021-11-23 Samy Abdou Devices and methods for spinal implantation
KR20200071198A (ko) 2018-12-10 2020-06-19 네오이뮨텍, 인코퍼레이티드 Nrf2 발현 조절 기반 T 세포 항암면역치료법
US11602337B2 (en) 2019-04-24 2023-03-14 Nuvasive, Inc. Transmission assembly
US11547395B2 (en) 2019-06-18 2023-01-10 Nuvasive, Inc. Tissue retraction system
JP7337964B2 (ja) 2019-06-18 2023-09-04 ニューヴェイジヴ，インコーポレイテッド 組織牽引システム
CN110731803B (zh) * 2019-11-20 2021-05-25 吕振乾 一种心外科手术辅助器
US11944286B2 (en) * 2020-01-24 2024-04-02 Lsi Solutions, Inc. Surgical rib retractor
WO2021158810A1 (en) 2020-02-05 2021-08-12 Bristol-Myers Squibb Company Oligonucleotides for splice modulation of camk2d
US11224415B1 (en) * 2020-07-10 2022-01-18 Warsaw Orthopedic, Inc. Tissue retractor
US12383249B2 (en) * 2020-07-10 2025-08-12 Warsaw Orthopedic, Inc. Tissue retractor, retraction modules, and associated methods
US12349889B2 (en) * 2020-07-10 2025-07-08 Warsaw Orthopedic, Inc. Tissue retractor, retraction modules, and associated methods
US12096923B2 (en) * 2020-07-10 2024-09-24 Warsaw Orthopedic, Inc. Tissue retractor, retraction modules, and associated methods
US12121453B2 (en) 2020-11-05 2024-10-22 Warsaw Orthopedic, Inc. Dual wedge expandable implant with eyelets, system, and method of use
US12171439B2 (en) 2020-11-05 2024-12-24 Warsaw Orthopedic, Inc. Protected drill
US11833059B2 (en) 2020-11-05 2023-12-05 Warsaw Orthopedic, Inc. Expandable inter-body device, expandable plate system, and associated methods
US12318308B2 (en) 2020-11-05 2025-06-03 Warsaw Orthopedic, Inc. Dual expandable inter-body device
US11963881B2 (en) 2020-11-05 2024-04-23 Warsaw Orthopedic, Inc. Expandable inter-body device, system, and method
US12239544B2 (en) 2020-11-05 2025-03-04 Warsaw Orthopedic, Inc. Rhomboid shaped implants
US11376134B1 (en) 2020-11-05 2022-07-05 Warsaw Orthopedic, Inc. Dual expanding spinal implant, system, and method of use
US11638653B2 (en) 2020-11-05 2023-05-02 Warsaw Orthopedic, Inc. Surgery instruments with a movable handle
US11517443B2 (en) 2020-11-05 2022-12-06 Warsaw Orthopedic, Inc. Dual wedge expandable implant, system and method of use
US11291554B1 (en) 2021-05-03 2022-04-05 Medtronic, Inc. Unibody dual expanding interbody implant
US11395743B1 (en) 2021-05-04 2022-07-26 Warsaw Orthopedic, Inc. Externally driven expandable interbody and related methods
US11517363B2 (en) 2020-11-05 2022-12-06 Warsaw Orthopedic, Inc. Screw driver and complimentary screws
US11285014B1 (en) 2020-11-05 2022-03-29 Warsaw Orthopedic, Inc. Expandable inter-body device, system, and method
WO2022251644A1 (en) 2021-05-28 2022-12-01 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
US12485019B2 (en) 2021-06-24 2025-12-02 Warsaw Orthopedic, Inc. Parallel jaw inserter
US11612499B2 (en) 2021-06-24 2023-03-28 Warsaw Orthopedic, Inc. Expandable interbody implant
US12268614B2 (en) 2021-06-24 2025-04-08 Warsaw Orthopedic, Inc. Interbody implant with adjusting shims
US12414863B2 (en) 2021-06-24 2025-09-16 Warsaw Orthopedic, Inc. Expandable interbody implant and corresponding surgical tool
US12295865B2 (en) 2021-06-24 2025-05-13 Warsaw Orthopedic, Inc. Expandable interbody implant and corresponding inserter
US12440349B2 (en) 2021-11-01 2025-10-14 Warsaw Orthopedic, Inc. Expandable interbody implant and breakoff screw
US11730608B2 (en) 2021-07-13 2023-08-22 Warsaw Orthopedic, Inc. Monoblock expandable interbody implant
IL311962A (en) 2021-10-14 2024-06-01 Lonza Sales Ag Modified producer cells for extracellular vesicle production
US11850163B2 (en) 2022-02-01 2023-12-26 Warsaw Orthopedic, Inc. Interbody implant with adjusting shims
JP2025516823A (ja) 2022-05-19 2025-05-30 ライエル・イミュノファーマ・インコーポレイテッド Ｎｒ４ａ３を標的とするポリヌクレオチド及びその使用
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
CN118853661A (zh) * 2023-04-28 2024-10-29 时夕(广州)生物科技有限公司 编辑rna的方法、组合物及其应用
US12533241B2 (en) 2023-05-16 2026-01-27 Warsaw Orthopedic, Inc. Distracting and angling expandable interbody device
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749088A (en) 1971-06-23 1973-07-31 W Kohlmann Surgical retractor device
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE69233046T2 (de) 1991-10-24 2004-03-04 Isis Pharmaceuticals, Inc., Carlsfeld Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
AU5442198A (en) 1996-11-13 1998-06-03 Q.B.I. Enterprises Ltd. Gene identification method
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ／エス オリゴヌクレオチド類似体
US6139493A (en) * 1998-07-08 2000-10-31 Koros; Tibor B. Retractor with adjustable length blades and light pipe guides
ES2234563T5 (es) 1999-02-12 2018-01-17 Daiichi Sankyo Company, Limited Nuevos análogos de nucleósidos y oligonucleótidos
US7053207B2 (en) 1999-05-04 2006-05-30 Exiqon A/S L-ribo-LNA analogues
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
GB2375172A (en) 2000-02-07 2002-11-06 Quark Biotech Inc Fas pathway genes
WO2002060330A1 (en) * 2001-01-29 2002-08-08 Stephen Ritland Retractor and method for spinal pedicle screw placement
WO2005060667A2 (en) 2003-12-19 2005-07-07 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain
AU2002324700A1 (en) 2001-08-14 2003-03-03 Bayer Ag Nucleic acid and amino acid sequences involved in pain
EP1470247A2 (en) 2001-11-05 2004-10-27 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias
WO2003065006A2 (en) 2002-01-31 2003-08-07 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cancer
US20040101855A1 (en) * 2002-11-22 2004-05-27 Isis Pharmaceuticals Inc. Modulation of PPAR binding protein expression
US9259144B2 (en) 2002-07-11 2016-02-16 Nuvasive, Inc. Surgical access system and related methods
WO2004012817A2 (en) 2002-07-31 2004-02-12 Kylix B.V. Use of genes identified to be involved in tumor development for the development of anti-cancer drugs
WO2004033476A1 (en) 2002-10-11 2004-04-22 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer
US7850608B2 (en) 2002-10-25 2010-12-14 K2M, Inc. Minimal incision maximal access MIS spine instrumentation and method
WO2004046160A2 (en) * 2002-11-18 2004-06-03 Santaris Pharma A/S Amino-lna, thio-lna and alpha-l-oxy-ln
US7691057B2 (en) 2003-01-16 2010-04-06 Nuvasive, Inc. Surgical access system and related methods
US7256200B2 (en) 2003-02-10 2007-08-14 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Method and composition for potentiating an oplate analgesic
US7819801B2 (en) 2003-02-27 2010-10-26 Nuvasive, Inc. Surgical access system and related methods
US20050085436A1 (en) 2003-07-08 2005-04-21 Hao Li Method to treat conditions associated with insulin signalling dysregulation
US7481766B2 (en) 2003-08-14 2009-01-27 Synthes (U.S.A.) Multiple-blade retractor
US20050137461A1 (en) * 2003-12-18 2005-06-23 Depuy Spine, Inc. Telescoping blade assembly and instruments for adjusting an adjustable blade
US7374927B2 (en) * 2004-05-03 2008-05-20 Affymetrix, Inc. Methods of analysis of degraded nucleic acid samples
US9622732B2 (en) 2004-10-08 2017-04-18 Nuvasive, Inc. Surgical access system and related methods
JP2006223228A (ja) 2005-02-18 2006-08-31 Dainippon Sumitomo Pharma Co Ltd 自己免疫疾患治療剤のスクリーニング方法
US20060287584A1 (en) * 2005-06-16 2006-12-21 Javier Garcia-Bengochia Surgical retractor extensions
CN1904900A (zh) * 2005-07-28 2007-01-31 中国科学院生物物理研究所 人类的内源性siRNA序列及其应用和筛选方法
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
US7863414B2 (en) * 2005-11-18 2011-01-04 The Board Of Regents Of The University Of Texas Systems Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain
WO2007090071A2 (en) 2006-01-27 2007-08-09 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
EP1994172A4 (en) * 2006-03-07 2009-11-18 Telethon Inst For Child Health METHOD FOR THE DIAGNOSIS AND / OR PREDICTION OF THE DEVELOPMENT OF ALLERGIC DISEASE AND AGENTS FOR TREATMENT AND / OR PREVENTING THEREOF
JP2009536222A (ja) 2006-05-05 2009-10-08 アイシス ファーマシューティカルズ， インコーポレーテッド Ｐｃｓｋ９の発現を調節するための化合物および方法
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
WO2008020435A2 (en) 2006-08-15 2008-02-21 Quark Pharmaceuticals, Inc Compositions and methods for treatment of mood disorders
US8673872B2 (en) 2006-08-28 2014-03-18 The University Of Western Australia Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA
GB0617222D0 (en) 2006-08-31 2006-10-11 Vereniging Het Nl Kanker I Antibiotics
US8062217B2 (en) * 2007-01-26 2011-11-22 Theken Spine, Llc Surgical retractor with removable blades and method of use
DK2149605T3 (da) 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
CA2688321A1 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
DK2173760T4 (en) 2007-06-08 2016-02-08 Isis Pharmaceuticals Inc Carbocyclic bicyclic nukleinsyreanaloge
WO2008152636A2 (en) * 2007-06-15 2008-12-18 Quark Pharmaceuticals, Inc. Compositions and methods for inhibiting nadph oxidase expression
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
DE202007012284U1 (de) 2007-09-01 2007-10-25 Aesculap Ag & Co. Kg Chirurgischer Retraktor
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
US8841423B2 (en) 2008-04-28 2014-09-23 University Of Iowa Research Foundation Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II
DK2356129T3 (da) 2008-09-24 2013-05-13 Isis Pharmaceuticals Inc Substituerede alpha-L-bicykliske nukleosider
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
US8226554B2 (en) 2008-10-30 2012-07-24 Warsaw Orthopedic, Inc. Retractor assemblies for surgery in a patient
WO2010120969A1 (en) 2009-04-15 2010-10-21 Board Of Regents, The University Of Texas System Targeting of the mir-30 family and let-7 family as a treatment for heart disease
CA2764822A1 (en) * 2009-06-12 2010-12-16 Santaris Pharma A/S New potent anti apob antisense compounds
EP2456870A1 (en) * 2009-07-21 2012-05-30 Santaris Pharma A/S Antisense oligomers targeting pcsk9
US9012421B2 (en) 2009-08-06 2015-04-21 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
EP2490699A1 (en) 2009-10-20 2012-08-29 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
US9737288B2 (en) * 2010-03-11 2017-08-22 Globus Medical, Inc Tissue retractor and methods of use
EP2580228B1 (en) 2010-06-08 2016-03-23 Ionis Pharmaceuticals, Inc. Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
US20130253035A1 (en) 2010-08-16 2013-09-26 Duke University Camkk-beta as a target for treating cancer
US9273317B2 (en) 2011-08-09 2016-03-01 Fred Hutchinson Cancer Research Center Methods and compositions for inhibiting the growth and/or proliferation of MYC-driven tumor cells
WO2013033230A1 (en) 2011-08-29 2013-03-07 Isis Pharmaceuticals, Inc. Oligomer-conjugate complexes and their use
US9603949B2 (en) * 2011-09-01 2017-03-28 University Of Iowa Research Foundation Oligonucleotide-based probes for detection of bacterial nucleases
CN103930165B (zh) * 2011-09-02 2018-05-25 纽约市哥伦比亚大学理事会 用以治疗肥胖症的代谢紊乱的CaMKII、IP3R、钙调神经磷酸酶、P38和MK2/3抑制剂
EP2753631A1 (en) 2011-09-07 2014-07-16 Marina Biotech, Inc. Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
WO2013151999A1 (en) 2012-04-02 2013-10-10 President And Fellows Of Harvard College Cancer treatment and immune system regulation through fat10 pathway inhibition
EP2850092B1 (en) 2012-04-09 2017-03-01 Ionis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
US20150141320A1 (en) * 2012-05-16 2015-05-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression
CN104837996A (zh) 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 抗apob反义缀合物化合物
WO2014077693A1 (en) 2012-11-16 2014-05-22 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Means and methods for reducing an effect of aging in a mammalian cell
US9951061B2 (en) 2013-03-06 2018-04-24 Allosteros Therapeutics, Inc. CaMKII inhibitors and uses thereof
DK2992098T3 (da) 2013-05-01 2019-06-17 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
WO2014179492A1 (en) 2013-05-01 2014-11-06 Gilead Sciences, Inc. Combination therapy for the treatment of arrhythmias or heart failure
HUE048738T2 (hu) * 2013-06-27 2020-08-28 Roche Innovation Ct Copenhagen As Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg
CN107074856A (zh) 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途
KR102699584B1 (ko) 2015-02-02 2024-08-28 메이라지티엑스 유케이 Ii 리미티드 대안적 스플라이싱의 압타머 매개 조절에 의한 유전자 발현 제어
US20180305689A1 (en) 2015-04-22 2018-10-25 Mina Therapeutics Limited Sarna compositions and methods of use
WO2017011286A1 (en) * 2015-07-10 2017-01-19 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
US20210052631A1 (en) 2015-09-25 2021-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
JP2018528783A (ja) 2015-09-25 2018-10-04 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． コンジュゲートアンチセンス化合物及びその使用
JP2019500345A (ja) * 2015-12-14 2019-01-10 コールド スプリング ハーバー ラボラトリー 肝臓病の処置のための組成物および方法
CN109843914B (zh) * 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
EP3494229B1 (en) 2016-08-03 2023-10-25 Meiragtx UK II Limited High throughput cell-based screening for aptamers
US11376302B2 (en) 2017-09-10 2022-07-05 Carmel Haifa University Economic Corporation Ltd. Methods for treating depression and major depressive disorder
EP3740576A4 (en) 2018-01-18 2021-10-20 Advanced Regen Medical Technologies, LLC THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS
MX2020008581A (es) 2018-02-21 2020-09-21 Bristol Myers Squibb Co Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos.
MX2020011570A (es) 2018-05-07 2020-11-24 Alnylam Pharmaceuticals Inc Administracion extrahepatica.

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