KR20200140805A - Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 - Google Patents
Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 Download PDFInfo
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- KR20200140805A KR20200140805A KR1020207026765A KR20207026765A KR20200140805A KR 20200140805 A KR20200140805 A KR 20200140805A KR 1020207026765 A KR1020207026765 A KR 1020207026765A KR 20207026765 A KR20207026765 A KR 20207026765A KR 20200140805 A KR20200140805 A KR 20200140805A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862633502P | 2018-02-21 | 2018-02-21 | |
| US62/633,502 | 2018-02-21 | ||
| US201862635954P | 2018-02-27 | 2018-02-27 | |
| US62/635,954 | 2018-02-27 | ||
| US201862665998P | 2018-05-02 | 2018-05-02 | |
| US62/665,998 | 2018-05-02 | ||
| US201862778679P | 2018-12-12 | 2018-12-12 | |
| US62/778,679 | 2018-12-12 | ||
| PCT/US2019/018947 WO2019165067A1 (en) | 2018-02-21 | 2019-02-21 | Camk2d antisense oligonucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200140805A true KR20200140805A (ko) | 2020-12-16 |
Family
ID=65729436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207026765A Pending KR20200140805A (ko) | 2018-02-21 | 2019-02-21 | Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11083444B2 (https=) |
| EP (1) | EP3755800A1 (https=) |
| JP (1) | JP7500426B2 (https=) |
| KR (1) | KR20200140805A (https=) |
| CN (1) | CN112020559A (https=) |
| AU (1) | AU2019226001B2 (https=) |
| BR (1) | BR112020016347A2 (https=) |
| CA (1) | CA3091789A1 (https=) |
| IL (2) | IL320427A (https=) |
| MX (1) | MX2020008581A (https=) |
| SG (1) | SG11202007652UA (https=) |
| WO (1) | WO2019165067A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE524121T1 (de) | 2004-11-24 | 2011-09-15 | Abdou Samy | Vorrichtungen zur platzierung eines orthopädischen intervertebralen implantats |
| US8764806B2 (en) | 2009-12-07 | 2014-07-01 | Samy Abdou | Devices and methods for minimally invasive spinal stabilization and instrumentation |
| US11998184B2 (en) * | 2010-03-11 | 2024-06-04 | Globus Medical, Inc | Tissue retractor and methods of use |
| US8845728B1 (en) | 2011-09-23 | 2014-09-30 | Samy Abdou | Spinal fixation devices and methods of use |
| US20130226240A1 (en) | 2012-02-22 | 2013-08-29 | Samy Abdou | Spinous process fixation devices and methods of use |
| US9198767B2 (en) | 2012-08-28 | 2015-12-01 | Samy Abdou | Devices and methods for spinal stabilization and instrumentation |
| US9320617B2 (en) | 2012-10-22 | 2016-04-26 | Cogent Spine, LLC | Devices and methods for spinal stabilization and instrumentation |
| US10857003B1 (en) | 2015-10-14 | 2020-12-08 | Samy Abdou | Devices and methods for vertebral stabilization |
| US10898175B2 (en) | 2016-10-04 | 2021-01-26 | Jgmg Bengochea, Llc | Retractor extension clip systems |
| US10744000B1 (en) | 2016-10-25 | 2020-08-18 | Samy Abdou | Devices and methods for vertebral bone realignment |
| US10973648B1 (en) | 2016-10-25 | 2021-04-13 | Samy Abdou | Devices and methods for vertebral bone realignment |
| KR20200140805A (ko) | 2018-02-21 | 2020-12-16 | 브리스톨-마이어스 스큅 컴퍼니 | Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 |
| US11806250B2 (en) | 2018-02-22 | 2023-11-07 | Warsaw Orthopedic, Inc. | Expandable spinal implant system and method of using same |
| US11179248B2 (en) | 2018-10-02 | 2021-11-23 | Samy Abdou | Devices and methods for spinal implantation |
| KR20200071198A (ko) | 2018-12-10 | 2020-06-19 | 네오이뮨텍, 인코퍼레이티드 | Nrf2 발현 조절 기반 T 세포 항암면역치료법 |
| US11602337B2 (en) | 2019-04-24 | 2023-03-14 | Nuvasive, Inc. | Transmission assembly |
| US11547395B2 (en) | 2019-06-18 | 2023-01-10 | Nuvasive, Inc. | Tissue retraction system |
| US11253243B2 (en) | 2019-06-18 | 2022-02-22 | Nuvasive, Inc. | Tissue retraction system |
| CN110731803B (zh) * | 2019-11-20 | 2021-05-25 | 吕振乾 | 一种心外科手术辅助器 |
| US11944286B2 (en) * | 2020-01-24 | 2024-04-02 | Lsi Solutions, Inc. | Surgical rib retractor |
| WO2021158810A1 (en) | 2020-02-05 | 2021-08-12 | Bristol-Myers Squibb Company | Oligonucleotides for splice modulation of camk2d |
| US11224415B1 (en) * | 2020-07-10 | 2022-01-18 | Warsaw Orthopedic, Inc. | Tissue retractor |
| US12349889B2 (en) * | 2020-07-10 | 2025-07-08 | Warsaw Orthopedic, Inc. | Tissue retractor, retraction modules, and associated methods |
| US12096923B2 (en) * | 2020-07-10 | 2024-09-24 | Warsaw Orthopedic, Inc. | Tissue retractor, retraction modules, and associated methods |
| US12383249B2 (en) * | 2020-07-10 | 2025-08-12 | Warsaw Orthopedic, Inc. | Tissue retractor, retraction modules, and associated methods |
| US11833059B2 (en) | 2020-11-05 | 2023-12-05 | Warsaw Orthopedic, Inc. | Expandable inter-body device, expandable plate system, and associated methods |
| US11285014B1 (en) | 2020-11-05 | 2022-03-29 | Warsaw Orthopedic, Inc. | Expandable inter-body device, system, and method |
| US11638653B2 (en) | 2020-11-05 | 2023-05-02 | Warsaw Orthopedic, Inc. | Surgery instruments with a movable handle |
| US12171439B2 (en) | 2020-11-05 | 2024-12-24 | Warsaw Orthopedic, Inc. | Protected drill |
| US12121453B2 (en) | 2020-11-05 | 2024-10-22 | Warsaw Orthopedic, Inc. | Dual wedge expandable implant with eyelets, system, and method of use |
| US11517443B2 (en) | 2020-11-05 | 2022-12-06 | Warsaw Orthopedic, Inc. | Dual wedge expandable implant, system and method of use |
| US11376134B1 (en) | 2020-11-05 | 2022-07-05 | Warsaw Orthopedic, Inc. | Dual expanding spinal implant, system, and method of use |
| US11963881B2 (en) | 2020-11-05 | 2024-04-23 | Warsaw Orthopedic, Inc. | Expandable inter-body device, system, and method |
| US12318308B2 (en) | 2020-11-05 | 2025-06-03 | Warsaw Orthopedic, Inc. | Dual expandable inter-body device |
| US12239544B2 (en) | 2020-11-05 | 2025-03-04 | Warsaw Orthopedic, Inc. | Rhomboid shaped implants |
| US11291554B1 (en) | 2021-05-03 | 2022-04-05 | Medtronic, Inc. | Unibody dual expanding interbody implant |
| US11564724B2 (en) | 2020-11-05 | 2023-01-31 | Warsaw Orthopedic, Inc. | Expandable inter-body device, system and method |
| US11395743B1 (en) | 2021-05-04 | 2022-07-26 | Warsaw Orthopedic, Inc. | Externally driven expandable interbody and related methods |
| WO2022251644A1 (en) | 2021-05-28 | 2022-12-01 | Lyell Immunopharma, Inc. | Nr4a3-deficient immune cells and uses thereof |
| US12268614B2 (en) | 2021-06-24 | 2025-04-08 | Warsaw Orthopedic, Inc. | Interbody implant with adjusting shims |
| WO2022271280A1 (en) | 2021-06-24 | 2022-12-29 | Warsaw Orthopedic, Inc. | Expandable interbody implant and corresponding surgical tool |
| US12440349B2 (en) | 2021-11-01 | 2025-10-14 | Warsaw Orthopedic, Inc. | Expandable interbody implant and breakoff screw |
| US12485019B2 (en) | 2021-06-24 | 2025-12-02 | Warsaw Orthopedic, Inc. | Parallel jaw inserter |
| US12295865B2 (en) | 2021-06-24 | 2025-05-13 | Warsaw Orthopedic, Inc. | Expandable interbody implant and corresponding inserter |
| US11612499B2 (en) | 2021-06-24 | 2023-03-28 | Warsaw Orthopedic, Inc. | Expandable interbody implant |
| US11730608B2 (en) | 2021-07-13 | 2023-08-22 | Warsaw Orthopedic, Inc. | Monoblock expandable interbody implant |
| US20240336896A1 (en) | 2021-10-14 | 2024-10-10 | Lonza Sales Ag | Modified producer cells for extracellular vesicle production |
| US11850163B2 (en) | 2022-02-01 | 2023-12-26 | Warsaw Orthopedic, Inc. | Interbody implant with adjusting shims |
| KR20250027283A (ko) | 2022-05-19 | 2025-02-25 | 라이엘 이뮤노파마, 인크. | nr4a3을 표적하는 폴리뉴클레오타이드 및 이의 용도 |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| CN118853661A (zh) * | 2023-04-28 | 2024-10-29 | 时夕(广州)生物科技有限公司 | 编辑rna的方法、组合物及其应用 |
| US12533241B2 (en) | 2023-05-16 | 2026-01-27 | Warsaw Orthopedic, Inc. | Distracting and angling expandable interbody device |
| WO2025217398A1 (en) | 2024-04-10 | 2025-10-16 | Lyell Immunopharma, Inc. | Methods for culturing cells with improved culture medium |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3749088A (en) | 1971-06-23 | 1973-07-31 | W Kohlmann | Surgical retractor device |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1993007883A1 (en) | 1991-10-24 | 1993-04-29 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| WO1998021366A1 (en) | 1996-11-13 | 1998-05-22 | Qbi Enterprises, Ltd. | Gene identification method |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
| US6139493A (en) * | 1998-07-08 | 2000-10-31 | Koros; Tibor B. | Retractor with adjustable length blades and light pipe guides |
| CZ296576B6 (cs) | 1999-02-12 | 2006-04-12 | Sankyo Company Limited | Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem |
| EP1178999B1 (en) | 1999-05-04 | 2007-03-14 | Santaris Pharma A/S | L-ribo-lna analogues |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| GB2375172A (en) | 2000-02-07 | 2002-11-06 | Quark Biotech Inc | Fas pathway genes |
| WO2002060330A1 (en) * | 2001-01-29 | 2002-08-08 | Stephen Ritland | Retractor and method for spinal pedicle screw placement |
| WO2005060667A2 (en) | 2003-12-19 | 2005-07-07 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| WO2003016475A2 (en) | 2001-08-14 | 2003-02-27 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| AU2002351828A1 (en) | 2001-11-05 | 2003-05-19 | Deutsches Krebsforschungszentrum | Novel genetic markers for leukemias |
| US20030157082A1 (en) | 2002-01-31 | 2003-08-21 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480,20893, 33230,1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules |
| US20040101855A1 (en) * | 2002-11-22 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of PPAR binding protein expression |
| US9259144B2 (en) | 2002-07-11 | 2016-02-16 | Nuvasive, Inc. | Surgical access system and related methods |
| WO2004012817A2 (en) | 2002-07-31 | 2004-02-12 | Kylix B.V. | Use of genes identified to be involved in tumor development for the development of anti-cancer drugs |
| JP2006513701A (ja) | 2002-10-11 | 2006-04-27 | アーラム バイオシステムズ インコーポレイテッド | 核酸ベースのシグナルトランスデューサーを含む立体構造的に敏感なプローブを有する標的検出システム |
| US7850608B2 (en) | 2002-10-25 | 2010-12-14 | K2M, Inc. | Minimal incision maximal access MIS spine instrumentation and method |
| US9045518B2 (en) * | 2002-11-18 | 2015-06-02 | Santaris Pharma A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
| US7691057B2 (en) | 2003-01-16 | 2010-04-06 | Nuvasive, Inc. | Surgical access system and related methods |
| US7256200B2 (en) | 2003-02-10 | 2007-08-14 | The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois | Method and composition for potentiating an oplate analgesic |
| US7819801B2 (en) | 2003-02-27 | 2010-10-26 | Nuvasive, Inc. | Surgical access system and related methods |
| US20050085436A1 (en) | 2003-07-08 | 2005-04-21 | Hao Li | Method to treat conditions associated with insulin signalling dysregulation |
| US7481766B2 (en) | 2003-08-14 | 2009-01-27 | Synthes (U.S.A.) | Multiple-blade retractor |
| US20050137461A1 (en) * | 2003-12-18 | 2005-06-23 | Depuy Spine, Inc. | Telescoping blade assembly and instruments for adjusting an adjustable blade |
| US7374927B2 (en) * | 2004-05-03 | 2008-05-20 | Affymetrix, Inc. | Methods of analysis of degraded nucleic acid samples |
| US9622732B2 (en) * | 2004-10-08 | 2017-04-18 | Nuvasive, Inc. | Surgical access system and related methods |
| JP2006223228A (ja) | 2005-02-18 | 2006-08-31 | Dainippon Sumitomo Pharma Co Ltd | 自己免疫疾患治療剤のスクリーニング方法 |
| US20060287584A1 (en) * | 2005-06-16 | 2006-12-21 | Javier Garcia-Bengochia | Surgical retractor extensions |
| CN1904900A (zh) * | 2005-07-28 | 2007-01-31 | 中国科学院生物物理研究所 | 人类的内源性siRNA序列及其应用和筛选方法 |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| WO2007059533A2 (en) * | 2005-11-18 | 2007-05-24 | Myogen, Inc. | Uses for camki i and hdacs in the treatment of heart conditions |
| JP5342881B2 (ja) | 2006-01-27 | 2013-11-13 | アイシス ファーマシューティカルズ, インコーポレーテッド | 6−修飾された二環式核酸類似体 |
| US20090156540A1 (en) * | 2006-03-07 | 2009-06-18 | Mckenna Katherine | Method for diagnosing and/or predicting the development of an allergic disorder and agents for treating and/or preventing same |
| EP2023940B1 (en) | 2006-05-05 | 2011-06-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of sglt2 |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| AU2007249349B2 (en) | 2006-05-11 | 2012-03-08 | Isis Pharmaceuticals, Inc. | 5'-Modified bicyclic nucleic acid analogs |
| WO2008020435A2 (en) | 2006-08-15 | 2008-02-21 | Quark Pharmaceuticals, Inc | Compositions and methods for treatment of mood disorders |
| ES2534430T3 (es) | 2006-08-28 | 2015-04-22 | The University Of Western Australia | Método de modulación de la expresión del receptor del factor de crecimiento epidérmico (EGFR) que implica miARN |
| GB0617222D0 (en) | 2006-08-31 | 2006-10-11 | Vereniging Het Nl Kanker I | Antibiotics |
| US8062217B2 (en) * | 2007-01-26 | 2011-11-22 | Theken Spine, Llc | Surgical retractor with removable blades and method of use |
| WO2008113832A2 (en) | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| WO2008152636A2 (en) * | 2007-06-15 | 2008-12-18 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting nadph oxidase expression |
| CA2692579C (en) | 2007-07-05 | 2016-05-03 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| DE202007012284U1 (de) | 2007-09-01 | 2007-10-25 | Aesculap Ag & Co. Kg | Chirurgischer Retraktor |
| US8546556B2 (en) | 2007-11-21 | 2013-10-01 | Isis Pharmaceuticals, Inc | Carbocyclic alpha-L-bicyclic nucleic acid analogs |
| US8841423B2 (en) | 2008-04-28 | 2014-09-23 | University Of Iowa Research Foundation | Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II |
| WO2010036698A1 (en) | 2008-09-24 | 2010-04-01 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
| EP2177615A1 (en) | 2008-10-10 | 2010-04-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases |
| US8226554B2 (en) | 2008-10-30 | 2012-07-24 | Warsaw Orthopedic, Inc. | Retractor assemblies for surgery in a patient |
| WO2010120969A1 (en) | 2009-04-15 | 2010-10-21 | Board Of Regents, The University Of Texas System | Targeting of the mir-30 family and let-7 family as a treatment for heart disease |
| ES2555057T3 (es) * | 2009-06-12 | 2015-12-28 | Roche Innovation Center Copenhagen A/S | Nuevos potentes compuestos antisentido anti-ApoB |
| US8563528B2 (en) * | 2009-07-21 | 2013-10-22 | Santaris Pharma A/S | Antisense oligomers targeting PCSK9 |
| EP2462153B1 (en) | 2009-08-06 | 2015-07-29 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| EP2490699A1 (en) | 2009-10-20 | 2012-08-29 | Santaris Pharma A/S | Oral delivery of therapeutically effective lna oligonucleotides |
| US9737288B2 (en) * | 2010-03-11 | 2017-08-22 | Globus Medical, Inc | Tissue retractor and methods of use |
| EP2580228B1 (en) | 2010-06-08 | 2016-03-23 | Ionis Pharmaceuticals, Inc. | Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
| WO2012024255A2 (en) | 2010-08-16 | 2012-02-23 | Duke University | Camkk-beta as a target for treating cancer |
| EP3778896A1 (en) | 2011-08-09 | 2021-02-17 | Fred Hutchinson Cancer Research Center | Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells |
| EP3453761A1 (en) | 2011-08-29 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| WO2013033436A1 (en) * | 2011-09-01 | 2013-03-07 | University Of Iowa Research Foundation | Oligonucleotide-based probes for detection of bacterial nucleases |
| CA2857374A1 (en) | 2011-09-02 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Camkii, ip3r, calcineurin, p38 and mk2/3 inhibitors to treat metabolic disturbances of obesity |
| CN104136451A (zh) | 2011-09-07 | 2014-11-05 | 玛瑞纳生物技术有限公司 | 具有构象限制的单体的核酸化合物的合成和用途 |
| WO2013151999A1 (en) | 2012-04-02 | 2013-10-10 | President And Fellows Of Harvard College | Cancer treatment and immune system regulation through fat10 pathway inhibition |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| US20150141320A1 (en) * | 2012-05-16 | 2015-05-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| US10077443B2 (en) | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| WO2014077693A1 (en) | 2012-11-16 | 2014-05-22 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Means and methods for reducing an effect of aging in a mammalian cell |
| AU2014225889B2 (en) | 2013-03-06 | 2018-12-06 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| US20140329755A1 (en) | 2013-05-01 | 2014-11-06 | Gilead Sciences, Inc. | Combination therapy for the treatment of arrhythmias or heart failure |
| ES2770667T3 (es) | 2013-06-27 | 2020-07-02 | Roche Innovation Ct Copenhagen As | Oligómeros antisentido y conjugados que se dirigen a PCSK9 |
| WO2016037106A1 (en) | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
| PL3265563T3 (pl) | 2015-02-02 | 2021-09-13 | Meiragtx Uk Ii Limited | Regulacja ekspresji genów poprzez modulację alternatywnego splicingu za pośrednictwem aptamerów |
| EP3286318A2 (en) | 2015-04-22 | 2018-02-28 | Mina Therapeutics Limited | Sarna compositions and methods of use |
| US10494632B2 (en) * | 2015-07-10 | 2019-12-03 | Alnylam Pharmaceuticals, Inc. | Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof |
| US20210052631A1 (en) | 2015-09-25 | 2021-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP3353306A4 (en) | 2015-09-25 | 2019-06-05 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| CA3005090A1 (en) * | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Compositions and methods for treatment of liver diseases |
| AU2017292173B2 (en) * | 2016-07-06 | 2022-01-13 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| SMT202400091T1 (it) | 2016-08-03 | 2024-05-14 | Meiragtx Uk Ii Ltd | Screening ad alta produzione basato su cellule per 5 aptameri |
| WO2019049148A1 (en) | 2017-09-10 | 2019-03-14 | Carmel Haifa University Economic Corporation Ltd. | METHOD OF TREATING DEPRESSION AND MAJOR DEPRESSIVE DISORDER |
| US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
| KR20200140805A (ko) | 2018-02-21 | 2020-12-16 | 브리스톨-마이어스 스큅 컴퍼니 | Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 |
| WO2019217459A1 (en) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
-
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| US11083444B2 (en) | 2021-08-10 |
| AU2019226001B2 (en) | 2025-07-10 |
| CA3091789A1 (en) | 2019-08-29 |
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