JP2021512087A5 - - Google Patents

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Publication number
JP2021512087A5
JP2021512087A5 JP2020541535A JP2020541535A JP2021512087A5 JP 2021512087 A5 JP2021512087 A5 JP 2021512087A5 JP 2020541535 A JP2020541535 A JP 2020541535A JP 2020541535 A JP2020541535 A JP 2020541535A JP 2021512087 A5 JP2021512087 A5 JP 2021512087A5
Authority
JP
Japan
Prior art keywords
egfr
alkyl
independently
halogen
monosubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020541535A
Other languages
English (en)
Japanese (ja)
Other versions
JP7427597B2 (ja
JP2021512087A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2019/073355 external-priority patent/WO2019149164A1/en
Publication of JP2021512087A publication Critical patent/JP2021512087A/ja
Publication of JP2021512087A5 publication Critical patent/JP2021512087A5/ja
Priority to JP2023180451A priority Critical patent/JP7738619B2/ja
Application granted granted Critical
Publication of JP7427597B2 publication Critical patent/JP7427597B2/ja
Priority to JP2025145276A priority patent/JP2025179139A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020541535A 2018-01-31 2019-01-28 Ｅｒｂｂ／ｂｔｋ阻害剤 Active JP7427597B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023180451A JP7738619B2 (ja) 2018-01-31 2023-10-19 Ｅｒｂｂ／ｂｔｋ阻害剤
JP2025145276A JP2025179139A (ja) 2018-01-31 2025-09-02 Ｅｒｂｂ／ｂｔｋ阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018074791 2018-01-31
CNPCT/CN2018/074791 2018-01-31
CNPCT/CN2018/118569 2018-11-30
CN2018118569 2018-11-30
PCT/CN2019/073355 WO2019149164A1 (en) 2018-01-31 2019-01-28 Erbb/btk inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023180451A Division JP7738619B2 (ja) 2018-01-31 2023-10-19 Ｅｒｂｂ／ｂｔｋ阻害剤

Publications (3)

Publication Number Publication Date
JP2021512087A JP2021512087A (ja) 2021-05-13
JP2021512087A5 true JP2021512087A5 (enExample) 2022-02-02
JP7427597B2 JP7427597B2 (ja) 2024-02-05

Family

ID=67478612

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020541535A Active JP7427597B2 (ja) 2018-01-31 2019-01-28 Ｅｒｂｂ／ｂｔｋ阻害剤
JP2023180451A Active JP7738619B2 (ja) 2018-01-31 2023-10-19 Ｅｒｂｂ／ｂｔｋ阻害剤
JP2025145276A Pending JP2025179139A (ja) 2018-01-31 2025-09-02 Ｅｒｂｂ／ｂｔｋ阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023180451A Active JP7738619B2 (ja) 2018-01-31 2023-10-19 Ｅｒｂｂ／ｂｔｋ阻害剤
JP2025145276A Pending JP2025179139A (ja) 2018-01-31 2025-09-02 Ｅｒｂｂ／ｂｔｋ阻害剤

Country Status (14)

Country Link
US (2) US11007198B2 (enExample)
EP (2) EP4356975A3 (enExample)
JP (3) JP7427597B2 (enExample)
KR (2) KR20250046340A (enExample)
CN (3) CN111909131B (enExample)
AU (2) AU2019215538B2 (enExample)
CA (1) CA3086616A1 (enExample)
DK (1) DK3746424T3 (enExample)
ES (1) ES2977484T3 (enExample)
MX (2) MX2020007947A (enExample)
PT (1) PT3746424T (enExample)
RU (2) RU2021139070A (enExample)
TW (1) TWI798334B (enExample)
WO (1) WO2019149164A1 (enExample)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
TWI798334B (zh) * 2018-01-31 2023-04-11 大陸商迪哲（江蘇）醫藥股份有限公司 Ｅｒｂｂ／ｂｔｋ抑制劑
US11896597B2 (en) * 2018-01-31 2024-02-13 Dizal (Jiangsu) Pharmaceutical Co., Ltd. ErbB/BTK inhibitors
US12157730B2 (en) 2019-03-19 2024-12-03 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
PT3943491T (pt) 2019-03-19 2025-07-28 Voronoi Inc Derivado de heteroarilo, método para a produção do mesmo e composição farmacêutica que compreende o mesmo como componente eficaz
TW202128670A (zh) * 2019-11-26 2021-08-01 大陸商上海翰森生物醫藥科技有限公司 含氮多環類衍生物抑制劑、其製備方法和應用
CN111057021B (zh) * 2019-12-11 2023-05-23 中国药科大学 均三嗪类化合物及其制备方法和用途
EP4087571A4 (en) * 2020-01-07 2024-03-27 Dana-Farber Cancer Institute, Inc. Cyano-pyrimidine inhibitors of egfr/her2
CN111875517B (zh) * 2020-06-28 2022-10-28 上海皓元生物医药科技有限公司 用于合成喜树碱衍生物的中间体及其制备方法和用途
CN112409281B (zh) * 2020-08-20 2022-11-18 上海大学 (e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法
CN112679446A (zh) * 2020-10-26 2021-04-20 都创(上海)医药科技有限公司 一种合成反式-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的方法
CN116670127A (zh) * 2021-03-30 2023-08-29 贝达药业股份有限公司 Egfr抑制剂及其组合物和用途
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
AU2022303386A1 (en) * 2021-07-02 2023-12-14 Aldeyra Therapeutics, Inc. Heterocyclic aldehyde trapping compounds and uses thereof
CA3224748A1 (en) * 2021-08-02 2023-02-09 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Novel pharmaceutical salts and polymorphic forms of an erbb and btk inhibitor
CN115181093B (zh) * 2022-08-01 2023-04-25 重庆医科大学 Sunvozertinib中间体的制备方法
EP4731307A1 (en) 2023-06-23 2026-04-29 Assia Chemical Industries Ltd. Solid state forms of sunvozertinib
WO2025247783A1 (en) 2024-05-29 2025-12-04 Syngenta Crop Protection Ag Pesticidally active dihydro-benzoxazinone compounds

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US7531532B2 (en) * 2004-02-27 2009-05-12 Eisai R&D Management Co., Ltd. Pyridine derivative and pyrimidine derivative
NZ603525A (en) * 2008-06-27 2015-02-27 Celgene Avilomics Res Inc Pyrimidine based compound and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
EA026353B1 (ru) * 2012-01-17 2017-03-31 Астеллас Фарма Инк. Соединение пиразинкарбоксамида
BR112014022790B1 (pt) * 2012-03-15 2022-04-19 Celgene Car Llc Sais de um inibidor de quinase de receptor de fator do crescimento epidermal, composição farmacêutica e usos do mesmo
WO2013169401A1 (en) * 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
CN104854101B (zh) 2012-11-06 2018-05-01 上海复尚慧创医药研究有限公司 Alk激酶抑制剂
EP3019489A4 (en) * 2013-07-11 2016-12-28 Betta Pharmaceuticals Co Ltd MODULATORS OF TYROSINE KINASE PROTEIN AND METHODS OF USE
CN105377835B (zh) * 2013-07-11 2018-08-17 贝达药业股份有限公司 酪氨酸蛋白激酶调节剂及其应用方法
US9415050B2 (en) 2013-08-12 2016-08-16 Pharmacyclics Llc Methods for the treatment of HER2 amplified cancer
CN105384694B (zh) * 2014-08-22 2020-09-04 四川海思科制药有限公司 一种取代的氨基嘧啶衍生物及其制备方法和药物用途
CN106883213B (zh) * 2015-12-15 2021-04-20 合肥中科普瑞昇生物医药科技有限公司 一种egfr和alk激酶的双重抑制剂
CN106905245B (zh) * 2015-12-23 2021-06-25 正大天晴药业集团股份有限公司 2,4-二取代的嘧啶类化合物
CN106928150B (zh) * 2015-12-31 2020-07-31 恩瑞生物医药科技（上海）有限公司 丙烯酰胺苯胺衍生物及其药学上的应用
CN106083736A (zh) * 2016-06-21 2016-11-09 郑州泰基鸿诺医药股份有限公司 一种嘧啶类化合物、egfr抑制剂及其应用
TWI798334B (zh) * 2018-01-31 2023-04-11 大陸商迪哲（江蘇）醫藥股份有限公司 Ｅｒｂｂ／ｂｔｋ抑制劑
WO2019177375A1 (ko) * 2018-03-13 2019-09-19 포로노이바이오 주식회사 2, 4, 5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물

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