JP2021512046A5 - - Google Patents

Download PDF

Info

Publication number
JP2021512046A5
JP2021512046A5 JP2020527111A JP2020527111A JP2021512046A5 JP 2021512046 A5 JP2021512046 A5 JP 2021512046A5 JP 2020527111 A JP2020527111 A JP 2020527111A JP 2020527111 A JP2020527111 A JP 2020527111A JP 2021512046 A5 JP2021512046 A5 JP 2021512046A5
Authority
JP
Japan
Prior art keywords
cancer
optionally
optionally substituted
pharmaceutically acceptable
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020527111A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021512046A (ja
JP7353281B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/061250 external-priority patent/WO2019099646A1/en
Publication of JP2021512046A publication Critical patent/JP2021512046A/ja
Publication of JP2021512046A5 publication Critical patent/JP2021512046A5/ja
Priority to JP2023122183A priority Critical patent/JP2023156359A/ja
Application granted granted Critical
Publication of JP7353281B2 publication Critical patent/JP7353281B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020527111A 2017-11-15 2018-11-15 大環状化合物およびそれらの使用 Active JP7353281B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023122183A JP2023156359A (ja) 2017-11-15 2023-07-27 大環状化合物およびそれらの使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762586416P 2017-11-15 2017-11-15
US62/586,416 2017-11-15
US201862765310P 2018-08-20 2018-08-20
US62/765,310 2018-08-20
PCT/US2018/061250 WO2019099646A1 (en) 2017-11-15 2018-11-15 Macrocyclic compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023122183A Division JP2023156359A (ja) 2017-11-15 2023-07-27 大環状化合物およびそれらの使用

Publications (3)

Publication Number Publication Date
JP2021512046A JP2021512046A (ja) 2021-05-13
JP2021512046A5 true JP2021512046A5 (enExample) 2021-12-23
JP7353281B2 JP7353281B2 (ja) 2023-09-29

Family

ID=64664436

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020527111A Active JP7353281B2 (ja) 2017-11-15 2018-11-15 大環状化合物およびそれらの使用
JP2023122183A Pending JP2023156359A (ja) 2017-11-15 2023-07-27 大環状化合物およびそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023122183A Pending JP2023156359A (ja) 2017-11-15 2023-07-27 大環状化合物およびそれらの使用

Country Status (6)

Country Link
US (3) US11407762B2 (enExample)
EP (2) EP4403560A3 (enExample)
JP (2) JP7353281B2 (enExample)
CN (2) CN111566113B (enExample)
ES (1) ES2974243T3 (enExample)
WO (1) WO2019099646A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017520586A (ja) 2014-06-30 2017-07-27 プレジデント アンド フェローズ オブ ハーバード カレッジ ハリコンドリン類似体の合成およびその使用
HUE060466T2 (hu) 2017-04-05 2023-03-28 Harvard College Makrociklusos vegyület és alkalmazása
BR112020000141A2 (pt) 2017-07-06 2020-07-14 President And Fellows Of Harvard College síntese de halicondrinas
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
ES2974243T3 (es) * 2017-11-15 2024-06-26 Harvard College Compuestos macrocíclicos y usos de los mismos

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
JPS61191687A (ja) 1985-02-20 1986-08-26 Fujisawa Pharmaceut Co Ltd ハリコンドリンb
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
GB9206244D0 (en) 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge
DE4229425A1 (de) 1992-09-03 1994-03-10 Kodak Ag Vorrichtung zum stapelweisen Ablegen und Ausrichten von einzeln zugeführten Blättern
US5426194A (en) 1993-01-19 1995-06-20 Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 1
US5352804A (en) 1993-01-19 1994-10-04 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Isolation and structure of Halistatin 2
JP2818381B2 (ja) 1994-01-18 1998-10-30 帝人株式会社 7−チアプロスタグランジン類およびその製造法
US5519050A (en) * 1995-04-07 1996-05-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structural elucidation of halistatin 3
CN1216051C (zh) 1998-06-17 2005-08-24 卫材株式会社 大环类似物及其使用和制备的方法
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
US8097648B2 (en) * 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
JP2001305734A (ja) 2000-04-20 2001-11-02 Fuji Photo Film Co Ltd 光重合性組成物
JP2003261447A (ja) 2002-03-07 2003-09-16 Kyosei Seiyaku Kk 抗腫瘍剤
EP2522663B1 (en) 2004-06-03 2015-04-01 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
EP1831697A4 (en) 2004-12-09 2011-01-26 Eisai R&D Man Co Ltd SCREENING OF TUBULIN ISOTYPE IN CANCER THERAPY USING ANALOGUES OF HALICHONDRIN B
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
CN103856986A (zh) 2007-03-07 2014-06-11 交互数字技术公司 在无线通信单元中使用的方法和装置
JP2010530437A (ja) 2007-06-18 2010-09-09 メディミューン,エルエルシー EphA2およびErbB2を発現する細胞の相乗的治療
RU2489437C2 (ru) 2007-10-03 2013-08-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Промежуточные соединения и способы синтеза аналогов галихондрина в
CA2705383A1 (en) 2007-11-16 2009-05-22 Eisai R&D Management Co., Ltd. Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate
US8598373B2 (en) 2008-04-04 2013-12-03 Eisai R&D Management Co., Ltd. Halichondrin B analogs
JP5800834B2 (ja) 2010-01-26 2015-10-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンb類似体の合成において有用なフロ[3,2−b]ピラン誘導体
EP2663337A4 (en) 2011-01-10 2014-06-11 Harvard College METHOD OF DELIVERING AGENTS IN CELLS BY BACTERIAL TOXINE
WO2012147900A1 (en) 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
US9062020B2 (en) 2011-12-29 2015-06-23 Alphora Research Inc. 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
EP2831082B1 (en) 2012-03-30 2019-02-20 Sandoz AG Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
US9650397B2 (en) 2013-05-15 2017-05-16 Alphora Research Inc. 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
CA2916537C (en) 2013-07-03 2021-07-27 Alphora Research Inc. Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups
CN114716453A (zh) 2013-11-04 2022-07-08 卫材R&D管理有限公司 软海绵素b的类似物合成中有用的大环化反应和中间体
JP6443812B2 (ja) 2013-12-06 2018-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンb類縁体の合成に有用な方法
JP2017520586A (ja) 2014-06-30 2017-07-27 プレジデント アンド フェローズ オブ ハーバード カレッジ ハリコンドリン類似体の合成およびその使用
US10208058B2 (en) 2014-09-09 2019-02-19 Cipla Limited Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
WO2016179607A1 (en) 2015-05-07 2016-11-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
US10947472B2 (en) 2016-07-07 2021-03-16 New Japan Chemical Co., Ltd. Lubricant base oil for power transmission
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
US20210187059A1 (en) 2017-02-20 2021-06-24 Polyphor Ag Pharmaceutical combinations for treating cancer
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
HUE060466T2 (hu) * 2017-04-05 2023-03-28 Harvard College Makrociklusos vegyület és alkalmazása
JP2019013861A (ja) 2017-07-03 2019-01-31 住友化学株式会社 ガス分離膜エレメント、ガス分離膜モジュール、及びガス分離装置
US20230135188A1 (en) 2017-07-06 2023-05-04 President And Fellows Of Harvard College Fe/cu-mediated ketone synthesis
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
WO2019009956A1 (en) 2017-07-06 2019-01-10 President And Fellows Of Harvard College SUMMARY OF MEDIUM MEDIATED KETONE
BR112020000141A2 (pt) * 2017-07-06 2020-07-14 President And Fellows Of Harvard College síntese de halicondrinas
ES2974243T3 (es) 2017-11-15 2024-06-26 Harvard College Compuestos macrocíclicos y usos de los mismos

Similar Documents

Publication Publication Date Title
JP2021512046A5 (enExample)
JP2018504418A5 (enExample)
TWI789700B (zh) 抗體-藥物結合物
JP2019501204A5 (enExample)
CA2715166C (en) Monoclonal antibodies for tumor treatment
JP2011519941A5 (enExample)
JP2016166203A5 (enExample)
JP6425653B2 (ja) 抗腫瘍剤及び抗腫瘍効果増強剤
JP2024178243A (ja) 抗体-薬物コンジュゲートとチューブリン阻害剤の組み合わせ
JP2013540694A (ja) Her3結合剤の前立腺治療における使用
JP2014509593A5 (enExample)
IL276514B2 (en) Glypican 3 antibodies and conjugates thereof
JP2006519862A5 (enExample)
JP2018537975A5 (enExample)
JP2020509027A5 (enExample)
RU2013155455A (ru) Антитела для лечения раковых заболеваний, при которых эскспрессируется клаудин 6
JP2010535713A5 (enExample)
JPWO2019214634A5 (enExample)
JP2016540826A5 (enExample)
JPWO2021260579A5 (enExample)
JPWO2021263026A5 (enExample)
JPWO2020204033A5 (enExample)
RU2019135531A (ru) Макроциклическое соединение и его применения
CN120957726A (zh) 抗体-药物偶联物与癌症疗法的组合及其用途
JPWO2022019259A5 (enExample)