CN111566113B - 大环化合物及其用途 - Google Patents

大环化合物及其用途 Download PDF

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Publication number
CN111566113B
CN111566113B CN201880085912.XA CN201880085912A CN111566113B CN 111566113 B CN111566113 B CN 111566113B CN 201880085912 A CN201880085912 A CN 201880085912A CN 111566113 B CN111566113 B CN 111566113B
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cancer
compound
tumor
pharmaceutically acceptable
alkyl
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CN111566113A (zh
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Y.岸
吉良和信
伊藤宪
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Eisai R&D Management Co Ltd
Harvard University
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Eisai R&D Management Co Ltd
Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201880085912.XA 2017-11-15 2018-11-15 大环化合物及其用途 Active CN111566113B (zh)

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Applications Claiming Priority (5)

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US201762586416P 2017-11-15 2017-11-15
US62/586,416 2017-11-15
US201862765310P 2018-08-20 2018-08-20
US62/765,310 2018-08-20
PCT/US2018/061250 WO2019099646A1 (en) 2017-11-15 2018-11-15 Macrocyclic compounds and uses thereof

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CN111566113A CN111566113A (zh) 2020-08-21
CN111566113B true CN111566113B (zh) 2024-01-09

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US (3) US11407762B2 (enExample)
EP (2) EP3710454B1 (enExample)
JP (2) JP7353281B2 (enExample)
CN (2) CN117924310A (enExample)
ES (1) ES2974243T3 (enExample)
WO (1) WO2019099646A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
EP3160970A4 (en) 2014-06-30 2017-12-27 President and Fellows of Harvard College Synthesis of halichondrin analogs and uses thereof
KR102634732B1 (ko) 2017-04-05 2024-02-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 마크로시클릭 화합물 및 그의 용도
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
EP4169924A3 (en) 2017-07-06 2023-07-05 President And Fellows Of Harvard College Synthesis of halichondrins
CN117924310A (zh) * 2017-11-15 2024-04-26 哈佛大学的校长及成员们 大环化合物及其用途

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WO2018187331A1 (en) * 2017-04-05 2018-10-11 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
CN111433211A (zh) * 2017-07-06 2020-07-17 哈佛大学的校长及成员们 软海绵素的合成

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US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
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WO2018187331A1 (en) * 2017-04-05 2018-10-11 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
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EP3710454A1 (en) 2020-09-23
US20200325152A1 (en) 2020-10-15
JP2023156359A (ja) 2023-10-24
JP7353281B2 (ja) 2023-09-29
ES2974243T3 (es) 2024-06-26
US20240309014A1 (en) 2024-09-19
US11407762B2 (en) 2022-08-09
EP4403560A3 (en) 2024-10-23
US11814398B2 (en) 2023-11-14
CN111566113A (zh) 2020-08-21
WO2019099646A8 (en) 2020-01-23
EP4403560A2 (en) 2024-07-24
EP3710454B1 (en) 2024-01-03
WO2019099646A1 (en) 2019-05-23
US20230016686A1 (en) 2023-01-19
JP2021512046A (ja) 2021-05-13
CN117924310A (zh) 2024-04-26

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