JP2006519862A5 - - Google Patents

Info

Publication number

JP2006519862A5

JP2006519862A5 JP2006509002A JP2006509002A JP2006519862A5 JP 2006519862 A5 JP2006519862 A5 JP 2006519862A5 JP 2006509002 A JP2006509002 A JP 2006509002A JP 2006509002 A JP2006509002 A JP 2006509002A JP 2006519862 A5 JP2006519862 A5 JP 2006519862A5

Authority

JP

Japan

Prior art keywords

aromatase inhibitor

cancer

letrozole

tumor

cci

Prior art date

2004-03-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000003886 aromatase inhibitor Substances 0.000 claims 26
• 229940122815 Aromatase inhibitor Drugs 0.000 claims 25
• 206010028980 Neoplasm Diseases 0.000 claims 17
• 229960003881 letrozole Drugs 0.000 claims 13
• HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 13
• -1 atamestan Chemical compound 0.000 claims 11
• CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 10
• 229960000235 temsirolimus Drugs 0.000 claims 10
• 241000124008 Mammalia Species 0.000 claims 9
• HKVAMNSJSFKALM-CPXURSODSA-N everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)\C(C)=C\C=C\C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-CPXURSODSA-N 0.000 claims 8
• CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 claims 6
• BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 6
• 229960002932 anastrozole Drugs 0.000 claims 6
• YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 229960000255 exemestane Drugs 0.000 claims 6
• 229950011548 fadrozole Drugs 0.000 claims 6
• 229960004421 formestane Drugs 0.000 claims 6
• OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 5
• 102000015694 estrogen receptors Human genes 0.000 claims 5
• 108010038795 estrogen receptors Proteins 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 230000000259 anti-tumor effect Effects 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 206010073059 Malignant neoplasm of unknown primary site Diseases 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
• 229940046844 aromatase inhibitors Drugs 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000028830 lung neuroendocrine neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
• 206010046766 uterine cancer Diseases 0.000 claims 1