TW200529829A - Antineoplastic combinations - Google Patents
Antineoplastic combinations Download PDFInfo
- Publication number
- TW200529829A TW200529829A TW093105371A TW93105371A TW200529829A TW 200529829 A TW200529829 A TW 200529829A TW 093105371 A TW093105371 A TW 093105371A TW 93105371 A TW93105371 A TW 93105371A TW 200529829 A TW200529829 A TW 200529829A
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- Prior art keywords
- cancer
- aromatic ring
- tumor
- inhibitor
- patent application
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- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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- A—HUMAN NECESSITIES
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Landscapes
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- Veterinary Medicine (AREA)
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- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
| ZA200603888B (en) * | 2001-06-01 | 2007-05-30 | Wyeth Corp | Antineoplastic combinations |
| KR20060052880A (ko) * | 2003-07-25 | 2006-05-19 | 와이어쓰 | 동결건조된 ｃｃｉ- 779 제형 |
| RU2006122517A (ru) * | 2004-01-08 | 2008-02-20 | Вайет (Us) | Фармацевтический состав для прямого прессования, предназначенный для перорального введения cci-779 |
| AR047988A1 (es) * | 2004-03-11 | 2006-03-15 | Wyeth Corp | Combinaciones antineoplásicas de cci-779 y rituximab |
| AU2005302004A1 (en) * | 2004-10-28 | 2006-05-11 | Wyeth | Use of an mTOR inhibitor in treatment of uterine leiomyoma |
| RU2405566C9 (ru) * | 2005-02-03 | 2012-04-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ лечения рака, устойчивого к гефитинибу |
| PE20070763A1 (es) * | 2005-11-04 | 2007-08-08 | Wyeth Corp | COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272 |
| AU2006314444C1 (en) * | 2005-11-21 | 2018-01-04 | Novartis Ag | Neuroendocrine tumor treatment using mTOR inhibitors |
| DE102006008074B4 (de) * | 2006-02-22 | 2013-08-14 | RUHR-UNIVERSITäT BOCHUM | Behandlung von Krebs mit Geruchsrezeptor-Liganden |
| DE102006011507A1 (de) * | 2006-03-14 | 2007-09-20 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffbeladene Nanopartikel auf Basis hydrophiler Proteine |
| RU2010104916A (ru) * | 2006-08-16 | 2011-08-20 | Михаил В. Благосклонный (US) | Способ профилактики и лечения возрастных заболеваний |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
| TW200901989A (en) * | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| DK2310011T3 (da) | 2008-06-17 | 2013-10-14 | Wyeth Llc | Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin |
| SG10202102855RA (en) | 2008-08-04 | 2021-05-28 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
| CN102209539B (zh) * | 2008-11-11 | 2013-06-12 | 伊莱利利公司 | P70 s6激酶抑制剂和mtor抑制剂的组合治疗剂 |
| JP5992325B2 (ja) | 2009-04-06 | 2016-09-14 | ワイス・エルエルシー | 乳癌のための、ネラチニブを活用する治療計画 |
| EP2416792A4 (en) * | 2009-04-10 | 2012-10-24 | Haiyan Qi | NOVEL ANTI-AGING AGENTS AND METHODS OF IDENTIFICATION |
| EP2648721B1 (de) * | 2011-01-31 | 2018-09-19 | LUCOLAS-M.D. Ltd. | Kombinationen von aromatase inhibitoren und antioxidanzien |
| US9682066B2 (en) * | 2012-12-04 | 2017-06-20 | University Of Cincinnati | Methods of treating primary brain tumors by administering letrozole |
| WO2015014284A1 (zh) * | 2013-07-31 | 2015-02-05 | 北京盛诺基医药科技有限公司 | 一种乳腺癌的治疗方法 |
| CN113768881A (zh) | 2013-10-08 | 2021-12-10 | 人工智能治疗公司 | 用于治疗淋巴管平滑肌瘤病的雷帕霉素 |
| CA2944075C (en) | 2014-04-04 | 2022-06-28 | Lam Therapeutics, Inc. | An inhalable rapamycin formulation for treating age-related conditions |
| WO2016057712A1 (en) | 2014-10-07 | 2016-04-14 | Lam Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
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| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US6A (en) * | 1836-08-10 | Thomas Blanchard | Machine for forming end pieces of plank blocks for ships | |
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
| US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
| US5080899A (en) * | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
| US5321009A (en) * | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
| ZA924953B (en) * | 1991-07-25 | 1993-04-28 | Univ Louisville Res Found | Method of treating ocular inflammation |
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| US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| US5288711A (en) * | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
| US5496832A (en) * | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| CN100448487C (zh) * | 2000-08-11 | 2009-01-07 | 惠氏公司 | 治疗雌激素受体阳性癌的方法 |
| TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| PT2269603E (pt) * | 2001-02-19 | 2015-09-09 | Novartis Ag | Tratamento de tumores da mama com um derivado de rapamicina em combinação com exemestano |
| TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
| TWI296196B (en) * | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
| PL363991A1 (en) * | 2001-04-06 | 2004-11-29 | Wyeth | Antineoplastic combinations such as rapamycin together with gemcitabine or fluorouracil |
| UA78706C2 (en) * | 2001-06-01 | 2007-04-25 | Wyeth Corp | Combination of rapamycin derivative and antitumor alkylating agent and method for treating soft tissue sarcoma and colonic cancer |
| BR0210101A (pt) * | 2001-06-01 | 2004-06-08 | Wyeth Corp | Combinações antineoplásticas |
| UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
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- 2004-03-01 NZ NZ542738A patent/NZ542738A/xx unknown
- 2004-03-01 AU AU2004218439A patent/AU2004218439A1/en not_active Withdrawn
- 2004-03-01 WO PCT/US2004/006354 patent/WO2004078133A2/en not_active Ceased
- 2004-03-01 CA CA002516353A patent/CA2516353A1/en not_active Abandoned
- 2004-03-01 CN CNA200480005869XA patent/CN1756549A/zh active Pending
- 2004-03-01 JP JP2006509002A patent/JP2006519862A/ja active Pending
- 2004-03-01 BR BRPI0408024-6A patent/BRPI0408024A/pt not_active IP Right Cessation
- 2004-03-01 KR KR1020057016528A patent/KR20050109965A/ko not_active Ceased
- 2004-03-01 RU RU2005130767/14A patent/RU2355399C2/ru not_active IP Right Cessation
- 2004-03-02 TW TW093105371A patent/TW200529829A/zh unknown
-
2005
- 2005-08-12 CR CR7942A patent/CR7942A/es not_active Application Discontinuation
- 2005-09-01 NI NI200500148A patent/NI200500148A/es unknown
- 2005-09-05 EC EC2005006001A patent/ECSP056001A/es unknown
- 2005-09-06 NO NO20054133A patent/NO20054133L/no not_active Application Discontinuation
- 2005-10-04 ZA ZA200508029A patent/ZA200508029B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR7942A (es) | 2006-02-07 |
| AU2004218439A1 (en) | 2004-09-16 |
| AR043403A1 (es) | 2005-07-27 |
| NI200500148A (es) | 2006-03-30 |
| NZ542738A (en) | 2009-02-28 |
| UA83484C2 (uk) | 2008-07-25 |
| EP1603561A2 (en) | 2005-12-14 |
| ZA200508029B (en) | 2007-04-25 |
| RU2355399C2 (ru) | 2009-05-20 |
| NO20054133D0 (no) | 2005-09-06 |
| CN1756549A (zh) | 2006-04-05 |
| BRPI0408024A (pt) | 2006-02-14 |
| JP2006519862A (ja) | 2006-08-31 |
| NO20054133L (no) | 2005-10-03 |
| RU2005130767A (ru) | 2006-02-10 |
| US20040176339A1 (en) | 2004-09-09 |
| WO2004078133A3 (en) | 2004-11-11 |
| MXPA05009246A (es) | 2005-10-19 |
| ECSP056001A (es) | 2006-01-27 |
| WO2004078133A2 (en) | 2004-09-16 |
| CA2516353A1 (en) | 2004-09-16 |
| WO2004078133A8 (en) | 2005-09-01 |
| KR20050109965A (ko) | 2005-11-22 |
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