JP2016166203A5 - - Google Patents
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- JP2016166203A5 JP2016166203A5 JP2016045111A JP2016045111A JP2016166203A5 JP 2016166203 A5 JP2016166203 A5 JP 2016166203A5 JP 2016045111 A JP2016045111 A JP 2016045111A JP 2016045111 A JP2016045111 A JP 2016045111A JP 2016166203 A5 JP2016166203 A5 JP 2016166203A5
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- Prior art keywords
- pharmaceutical composition
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- sequence
- antibody
- egfr
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 5
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229940123237 Taxane Drugs 0.000 claims 3
- 229940121647 egfr inhibitor Drugs 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 2
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 2
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 2
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 102000015694 estrogen receptors Human genes 0.000 claims 2
- 108010038795 estrogen receptors Proteins 0.000 claims 2
- 238000002509 fluorescent in situ hybridization Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 2
- 230000004544 DNA amplification Effects 0.000 claims 1
- 101150054472 HER2 gene Proteins 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 102100025803 Progesterone receptor Human genes 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108700020302 erbB-2 Genes Proteins 0.000 claims 1
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical compound [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229950008001 matuzumab Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 229950010203 nimotuzumab Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
- -1 taxanes Substances 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31289510P | 2010-03-11 | 2010-03-11 | |
| US61/312,895 | 2010-03-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Division JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016166203A JP2016166203A (ja) | 2016-09-15 |
| JP2016166203A5 true JP2016166203A5 (enExample) | 2016-10-27 |
| JP6185102B2 JP6185102B2 (ja) | 2017-08-23 |
Family
ID=44513103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Pending JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
| JP2016045111A Expired - Fee Related JP6185102B2 (ja) | 2010-03-11 | 2016-03-09 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Pending JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8895001B2 (enExample) |
| EP (2) | EP2544680B1 (enExample) |
| JP (2) | JP2013522237A (enExample) |
| KR (1) | KR101798679B1 (enExample) |
| CN (1) | CN102858335B (enExample) |
| AU (1) | AU2011224186C1 (enExample) |
| BR (1) | BR112012022802A2 (enExample) |
| CA (1) | CA2792327C (enExample) |
| DK (1) | DK2544680T3 (enExample) |
| EA (1) | EA201201186A1 (enExample) |
| ES (1) | ES2535503T3 (enExample) |
| IL (1) | IL221693A (enExample) |
| MX (1) | MX344355B (enExample) |
| NZ (1) | NZ602084A (enExample) |
| PL (1) | PL2544680T3 (enExample) |
| PT (1) | PT2544680E (enExample) |
| SG (1) | SG183532A1 (enExample) |
| UA (1) | UA111149C2 (enExample) |
| WO (1) | WO2011112953A2 (enExample) |
| ZA (1) | ZA201206425B (enExample) |
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| KR20110084280A (ko) | 2008-11-03 | 2011-07-21 | 알레시아 바이오쎄라퓨틱스 인코포레이티드 | 종양 항원의 생물 활성을 특이적으로 차단하는 항체 |
| DK2516469T3 (en) | 2009-12-22 | 2016-05-02 | Roche Glycart Ag | ANTI-HER3 antibodies and uses thereof |
| EA201201186A1 (ru) * | 2010-03-11 | 2013-11-29 | Мерримак Фармасьютикалс, Инк. | ИСПОЛЬЗОВАНИЕ ErbB3 ИНГИБИТОРОВ В ЛЕЧЕНИИ ТРИЖДЫ НЕГАТИВНОГО И БАЗАЛЬНО-ПОДОБНОГО ВИДОВ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ |
| PT2606070T (pt) | 2010-08-20 | 2017-03-31 | Novartis Ag | Anticorpos para o recetor 3 do fator de crescimento epidérmico (her3) |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
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- 2011-03-11 EA EA201201186A patent/EA201201186A1/ru unknown
- 2011-03-11 US US13/583,949 patent/US8895001B2/en not_active Expired - Fee Related
- 2011-03-11 ES ES11730112.7T patent/ES2535503T3/es active Active
- 2011-03-11 EP EP11730112.7A patent/EP2544680B1/en not_active Revoked
- 2011-03-11 DK DK11730112T patent/DK2544680T3/en active
- 2011-03-11 JP JP2012557285A patent/JP2013522237A/ja active Pending
- 2011-03-11 NZ NZ602084A patent/NZ602084A/en not_active IP Right Cessation
- 2011-03-11 KR KR1020127025753A patent/KR101798679B1/ko not_active Expired - Fee Related
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- 2011-03-11 EP EP20140196121 patent/EP2859893A1/en not_active Ceased
- 2011-03-11 PL PL11730112T patent/PL2544680T3/pl unknown
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- 2011-03-11 CN CN201180013330.9A patent/CN102858335B/zh not_active Expired - Fee Related
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