JP2021511331A5 - - Google Patents
Info
- Publication number
- JP2021511331A5 JP2021511331A5 JP2020539814A JP2020539814A JP2021511331A5 JP 2021511331 A5 JP2021511331 A5 JP 2021511331A5 JP 2020539814 A JP2020539814 A JP 2020539814A JP 2020539814 A JP2020539814 A JP 2020539814A JP 2021511331 A5 JP2021511331 A5 JP 2021511331A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- substituted
- acceptable salt
- unsubstituted
- Prior art date
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023163639A JP2023169374A (ja) | 2018-01-19 | 2023-09-26 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
| JP2025065043A JP2025106500A (ja) | 2018-01-19 | 2025-04-10 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862619643P | 2018-01-19 | 2018-01-19 | |
| US62/619,643 | 2018-01-19 | ||
| US201862745724P | 2018-10-15 | 2018-10-15 | |
| US62/745,724 | 2018-10-15 | ||
| PCT/US2019/014344 WO2019144041A1 (en) | 2018-01-19 | 2019-01-18 | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023163639A Division JP2023169374A (ja) | 2018-01-19 | 2023-09-26 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021511331A JP2021511331A (ja) | 2021-05-06 |
| JPWO2019144041A5 JPWO2019144041A5 (https=) | 2022-01-25 |
| JP2021511331A5 true JP2021511331A5 (https=) | 2022-01-25 |
| JP7401439B2 JP7401439B2 (ja) | 2023-12-19 |
Family
ID=65324663
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539814A Active JP7401439B2 (ja) | 2018-01-19 | 2019-01-18 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
| JP2023163639A Withdrawn JP2023169374A (ja) | 2018-01-19 | 2023-09-26 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
| JP2025065043A Pending JP2025106500A (ja) | 2018-01-19 | 2025-04-10 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023163639A Withdrawn JP2023169374A (ja) | 2018-01-19 | 2023-09-26 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
| JP2025065043A Pending JP2025106500A (ja) | 2018-01-19 | 2025-04-10 | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US10836755B2 (https=) |
| EP (2) | EP3740481B9 (https=) |
| JP (3) | JP7401439B2 (https=) |
| KR (1) | KR102797441B1 (https=) |
| CN (3) | CN117964573B (https=) |
| AU (2) | AU2019208331C1 (https=) |
| BR (1) | BR112020014428A2 (https=) |
| CA (2) | CA3252332A1 (https=) |
| CL (2) | CL2020001871A1 (https=) |
| CO (1) | CO2020009225A2 (https=) |
| DK (1) | DK3740481T5 (https=) |
| EC (1) | ECSP20044709A (https=) |
| ES (1) | ES2986630T3 (https=) |
| FI (1) | FI3740481T3 (https=) |
| HR (1) | HRP20241014T2 (https=) |
| HU (1) | HUE067913T2 (https=) |
| IL (1) | IL276094B2 (https=) |
| LT (1) | LT3740481T (https=) |
| MA (1) | MA51620B1 (https=) |
| MD (1) | MD3740481T3 (https=) |
| MX (2) | MX2020007532A (https=) |
| MY (1) | MY203855A (https=) |
| NZ (1) | NZ765795A (https=) |
| PH (1) | PH12020551090A1 (https=) |
| PL (1) | PL3740481T3 (https=) |
| PT (1) | PT3740481T (https=) |
| RS (1) | RS66042B9 (https=) |
| SG (1) | SG11202006296YA (https=) |
| SI (1) | SI3740481T1 (https=) |
| SM (1) | SMT202400329T1 (https=) |
| TW (2) | TWI898447B (https=) |
| UY (1) | UY38057A (https=) |
| WO (1) | WO2019144041A1 (https=) |
Families Citing this family (23)
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| BR112020014428A2 (pt) | 2018-01-19 | 2020-12-01 | Cytokinetics, Inc. | composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco |
| EP3814342B1 (en) * | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7610985B2 (ja) * | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| JP7447089B2 (ja) | 2018-08-31 | 2024-03-11 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
| KR20250172745A (ko) * | 2019-05-03 | 2025-12-09 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| CA3144974A1 (en) * | 2019-07-17 | 2021-01-21 | Norma TOM | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide |
| EP3999180B1 (en) * | 2019-07-17 | 2024-05-08 | Cytokinetics, Inc. | Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide |
| HRP20240200T1 (hr) * | 2019-07-17 | 2024-04-26 | Cytokinetics, Inc. | Oralne formulacije inhibitora kardijskih sarkomera |
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| EP4370116B1 (en) * | 2021-07-16 | 2025-01-15 | Cytokinetics, Inc. | Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy |
| SMT202600028T1 (it) | 2021-08-03 | 2026-03-09 | Cytokinetics Inc | Processo per preparare aficamten |
| US20230338378A1 (en) | 2022-04-26 | 2023-10-26 | MyoKardia, Inc. | Methods of Administering Myosin Inhibitors |
| US20240091203A1 (en) | 2022-07-20 | 2024-03-21 | Cytokinetics, Incorporated | Methods for treating non-obstructive hypertrophic cardiomyopathy |
| CN119907668A (zh) | 2022-08-04 | 2025-04-29 | 赛特凯恩蒂克公司 | 用于治疗阻塞性肥厚性心肌病的方法 |
| WO2024040190A1 (en) | 2022-08-18 | 2024-02-22 | Cytokinetics, Incorporated | Indane and coumaran derivatives as fast skeletal muscle myosin inhibitors |
| WO2024134498A1 (en) | 2022-12-22 | 2024-06-27 | Assia Chemical Industries Ltd. | Solid state forms of aficamten and process for preparation thereof |
| CN115894361A (zh) * | 2022-12-28 | 2023-04-04 | 上海合全药业股份有限公司 | 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法 |
| WO2024179422A1 (zh) * | 2023-03-02 | 2024-09-06 | 苏州科睿思制药有限公司 | Aficamten的共晶及其制备方法和用途 |
| WO2025096779A2 (en) | 2023-11-01 | 2025-05-08 | Bristol Myers Squibb Company | Methods of treatment with a myosin inhibitor using protein levels |
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| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7447089B2 (ja) | 2018-08-31 | 2024-03-11 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
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| EP3999180B1 (en) | 2019-07-17 | 2024-05-08 | Cytokinetics, Inc. | Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide |
| CA3144974A1 (en) | 2019-07-17 | 2021-01-21 | Norma TOM | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide |
| HRP20240200T1 (hr) | 2019-07-17 | 2024-04-26 | Cytokinetics, Inc. | Oralne formulacije inhibitora kardijskih sarkomera |
| CA3190060A1 (en) | 2020-08-28 | 2022-03-03 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| MX2023010125A (es) | 2021-03-04 | 2023-09-11 | Cytokinetics Inc | Inhibidores del sarcomero cardiaco. |
| EP4370116B1 (en) | 2021-07-16 | 2025-01-15 | Cytokinetics, Inc. | Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy |
| SMT202600028T1 (it) | 2021-08-03 | 2026-03-09 | Cytokinetics Inc | Processo per preparare aficamten |
| US20230338378A1 (en) | 2022-04-26 | 2023-10-26 | MyoKardia, Inc. | Methods of Administering Myosin Inhibitors |
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2019
- 2019-01-18 BR BR112020014428-2A patent/BR112020014428A2/pt active Search and Examination
- 2019-01-18 AU AU2019208331A patent/AU2019208331C1/en active Active
- 2019-01-18 CA CA3252332A patent/CA3252332A1/en active Pending
- 2019-01-18 CN CN202311746655.9A patent/CN117964573B/zh active Active
- 2019-01-18 MA MA51620A patent/MA51620B1/fr unknown
- 2019-01-18 JP JP2020539814A patent/JP7401439B2/ja active Active
- 2019-01-18 EP EP19703917.5A patent/EP3740481B9/en active Active
- 2019-01-18 HR HRP20241014TT patent/HRP20241014T2/hr unknown
- 2019-01-18 WO PCT/US2019/014344 patent/WO2019144041A1/en not_active Ceased
- 2019-01-18 UY UY38057A patent/UY38057A/es active IP Right Grant
- 2019-01-18 LT LTEPPCT/US2019/014344T patent/LT3740481T/lt unknown
- 2019-01-18 US US16/252,483 patent/US10836755B2/en active Active
- 2019-01-18 SI SI201930788T patent/SI3740481T1/sl unknown
- 2019-01-18 MY MYPI2020003691A patent/MY203855A/en unknown
- 2019-01-18 CA CA3087283A patent/CA3087283C/en active Active
- 2019-01-18 EP EP24179234.0A patent/EP4491622A3/en active Pending
- 2019-01-18 PT PT197039175T patent/PT3740481T/pt unknown
- 2019-01-18 PL PL19703917.5T patent/PL3740481T3/pl unknown
- 2019-01-18 TW TW113106914A patent/TWI898447B/zh active
- 2019-01-18 RS RS20241047A patent/RS66042B9/sr unknown
- 2019-01-18 CN CN201980009128.5A patent/CN111757875B/zh active Active
- 2019-01-18 CN CN202311746636.6A patent/CN117924208A/zh active Pending
- 2019-01-18 DK DK19703917.5T patent/DK3740481T5/da active
- 2019-01-18 FI FIEP19703917.5T patent/FI3740481T3/fi active
- 2019-01-18 KR KR1020207023807A patent/KR102797441B1/ko active Active
- 2019-01-18 SM SM20240329T patent/SMT202400329T1/it unknown
- 2019-01-18 ES ES19703917T patent/ES2986630T3/es active Active
- 2019-01-18 MD MDE20201196T patent/MD3740481T3/ro unknown
- 2019-01-18 NZ NZ765795A patent/NZ765795A/en unknown
- 2019-01-18 MX MX2020007532A patent/MX2020007532A/es unknown
- 2019-01-18 TW TW108101933A patent/TWI835770B/zh active
- 2019-01-18 HU HUE19703917A patent/HUE067913T2/hu unknown
- 2019-01-18 SG SG11202006296YA patent/SG11202006296YA/en unknown
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2020
- 2020-07-14 CL CL2020001871A patent/CL2020001871A1/es unknown
- 2020-07-14 MX MX2022014312A patent/MX2022014312A/es unknown
- 2020-07-16 IL IL276094A patent/IL276094B2/en unknown
- 2020-07-16 PH PH12020551090A patent/PH12020551090A1/en unknown
- 2020-07-27 CO CONC2020/0009225A patent/CO2020009225A2/es unknown
- 2020-07-31 EC ECSENADI202044709A patent/ECSP20044709A/es unknown
- 2020-09-04 US US17/013,472 patent/US11472796B2/en active Active
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2022
- 2022-04-28 CL CL2022001091A patent/CL2022001091A1/es unknown
- 2022-08-31 US US17/823,910 patent/US12065436B2/en active Active
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2023
- 2023-09-26 JP JP2023163639A patent/JP2023169374A/ja not_active Withdrawn
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2024
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2025
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