JP2022540668A5 - - Google Patents

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Publication number
JP2022540668A5
JP2022540668A5 JP2022502215A JP2022502215A JP2022540668A5 JP 2022540668 A5 JP2022540668 A5 JP 2022540668A5 JP 2022502215 A JP2022502215 A JP 2022502215A JP 2022502215 A JP2022502215 A JP 2022502215A JP 2022540668 A5 JP2022540668 A5 JP 2022540668A5
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JP
Japan
Prior art keywords
polymorph
degrees
mixture
xrpd patterns
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022502215A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022540668A (ja
JP7624431B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/042387 external-priority patent/WO2021011807A1/en
Publication of JP2022540668A publication Critical patent/JP2022540668A/ja
Publication of JP2022540668A5 publication Critical patent/JP2022540668A5/ja
Priority to JP2025007662A priority Critical patent/JP7755090B2/ja
Application granted granted Critical
Publication of JP7624431B2 publication Critical patent/JP7624431B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022502215A 2019-07-17 2020-07-16 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形 Active JP7624431B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025007662A JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875350P 2019-07-17 2019-07-17
US62/875,350 2019-07-17
PCT/US2020/042387 WO2021011807A1 (en) 2019-07-17 2020-07-16 Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025007662A Division JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

Publications (3)

Publication Number Publication Date
JP2022540668A JP2022540668A (ja) 2022-09-16
JP2022540668A5 true JP2022540668A5 (https=) 2023-07-25
JP7624431B2 JP7624431B2 (ja) 2025-01-30

Family

ID=71995103

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022502215A Active JP7624431B2 (ja) 2019-07-17 2020-07-16 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形
JP2025007662A Active JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025007662A Active JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

Country Status (25)

Country Link
US (1) US20220315571A1 (https=)
EP (2) EP3999180B1 (https=)
JP (2) JP7624431B2 (https=)
KR (1) KR20220084008A (https=)
CN (3) CN114555590B (https=)
AU (1) AU2020313965A1 (https=)
BR (1) BR112022000494A2 (https=)
CA (1) CA3144975A1 (https=)
CL (1) CL2022000054A1 (https=)
DK (1) DK3999180T3 (https=)
ES (1) ES2980885T3 (https=)
FI (1) FI3999180T3 (https=)
HR (1) HRP20240713T1 (https=)
HU (1) HUE066891T2 (https=)
IL (1) IL289875A (https=)
LT (1) LT3999180T (https=)
MX (1) MX2022000504A (https=)
PH (1) PH12022550123A1 (https=)
PL (1) PL3999180T3 (https=)
PT (1) PT3999180T (https=)
RS (1) RS65611B1 (https=)
SI (1) SI3999180T1 (https=)
SM (1) SMT202400224T1 (https=)
TW (1) TWI865562B (https=)
WO (1) WO2021011807A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
PT4370116T (pt) 2021-07-16 2025-03-14 Cytokinetics Inc Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva
MX2024001294A (es) 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.
WO2024020468A1 (en) 2022-07-20 2024-01-25 Cytokinetics, Incorporated Methods for treating non-obstructive hypertrophic cardiomyopathy
EP4565230A1 (en) 2022-08-04 2025-06-11 Cytokinetics, Inc. Methods for treating obstructive hypertrophic cardiomyopathy
WO2024134498A1 (en) 2022-12-22 2024-06-27 Assia Chemical Industries Ltd. Solid state forms of aficamten and process for preparation thereof
WO2024179422A1 (zh) * 2023-03-02 2024-09-06 苏州科睿思制药有限公司 Aficamten的共晶及其制备方法和用途
US20250295639A1 (en) 2024-03-20 2025-09-25 Cytokinetics, Incorporated Methods for treating heart diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
MX2024001294A (es) * 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.

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