JP7624431B2 - （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形 - Google Patents

（ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形 Download PDF

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JP7624431B2
JP7624431B2 JP2022502215A JP2022502215A JP7624431B2 JP 7624431 B2 JP7624431 B2 JP 7624431B2 JP 2022502215 A JP2022502215 A JP 2022502215A JP 2022502215 A JP2022502215 A JP 2022502215A JP 7624431 B2 JP7624431 B2 JP 7624431B2
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polymorph
dihydro
inden
ethyl
pyrazole
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JP2022540668A (ja
JP2022540668A5 (https=
Inventor
ノーマ トム，
マシュー ファイファー，
デニス アンデルセン，
チー ガオ，
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サイトキネティックス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022502215A 2019-07-17 2020-07-16 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形 Active JP7624431B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025007662A JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875350P 2019-07-17 2019-07-17
US62/875,350 2019-07-17
PCT/US2020/042387 WO2021011807A1 (en) 2019-07-17 2020-07-16 Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide

Related Child Applications (1)

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JP2025007662A Division JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

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JP2022540668A JP2022540668A (ja) 2022-09-16
JP2022540668A5 JP2022540668A5 (https=) 2023-07-25
JP7624431B2 true JP7624431B2 (ja) 2025-01-30

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JP2022502215A Active JP7624431B2 (ja) 2019-07-17 2020-07-16 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形
JP2025007662A Active JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

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JP2025007662A Active JP7755090B2 (ja) 2019-07-17 2025-01-20 （ｒ）－ｎ－（５－（５－エチル－１，２，４－オキサジアゾール－３－イル）－２，３－ジヒドロ－１ｈ－インデン－１－イル）－１－メチル－１ｈ－ピラゾール－４－カルボキサミドの多形

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Country Link
US (1) US20220315571A1 (https=)
EP (2) EP3999180B1 (https=)
JP (2) JP7624431B2 (https=)
KR (1) KR20220084008A (https=)
CN (3) CN114555590B (https=)
AU (1) AU2020313965A1 (https=)
BR (1) BR112022000494A2 (https=)
CA (1) CA3144975A1 (https=)
CL (1) CL2022000054A1 (https=)
DK (1) DK3999180T3 (https=)
ES (1) ES2980885T3 (https=)
FI (1) FI3999180T3 (https=)
HR (1) HRP20240713T1 (https=)
HU (1) HUE066891T2 (https=)
IL (1) IL289875A (https=)
LT (1) LT3999180T (https=)
MX (1) MX2022000504A (https=)
PH (1) PH12022550123A1 (https=)
PL (1) PL3999180T3 (https=)
PT (1) PT3999180T (https=)
RS (1) RS65611B1 (https=)
SI (1) SI3999180T1 (https=)
SM (1) SMT202400224T1 (https=)
TW (1) TWI865562B (https=)
WO (1) WO2021011807A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
PT4370116T (pt) 2021-07-16 2025-03-14 Cytokinetics Inc Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva
MX2024001294A (es) 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.
WO2024020468A1 (en) 2022-07-20 2024-01-25 Cytokinetics, Incorporated Methods for treating non-obstructive hypertrophic cardiomyopathy
EP4565230A1 (en) 2022-08-04 2025-06-11 Cytokinetics, Inc. Methods for treating obstructive hypertrophic cardiomyopathy
WO2024134498A1 (en) 2022-12-22 2024-06-27 Assia Chemical Industries Ltd. Solid state forms of aficamten and process for preparation thereof
WO2024179422A1 (zh) * 2023-03-02 2024-09-06 苏州科睿思制药有限公司 Aficamten的共晶及其制备方法和用途
US20250295639A1 (en) 2024-03-20 2025-09-25 Cytokinetics, Incorporated Methods for treating heart diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2024001294A (es) * 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
有機化合物結晶作製ハンドブック－原理とノウハウ－，2008年07月25日，pp. 57-79

Also Published As

Publication number Publication date
CA3144975A1 (en) 2021-01-21
IL289875A (en) 2022-03-01
CN118908951A (zh) 2024-11-08
EP3999180B1 (en) 2024-05-08
PL3999180T3 (pl) 2024-09-23
NZ784930A (en) 2025-03-28
SMT202400224T1 (it) 2024-07-09
JP2022540668A (ja) 2022-09-16
DK3999180T3 (da) 2024-05-21
HRP20240713T1 (hr) 2024-09-13
JP2025061484A (ja) 2025-04-10
EP4487911A1 (en) 2025-01-08
ES2980885T3 (es) 2024-10-03
AU2020313965A1 (en) 2022-03-03
LT3999180T (lt) 2024-08-26
US20220315571A1 (en) 2022-10-06
WO2021011807A1 (en) 2021-01-21
SI3999180T1 (sl) 2024-07-31
RS65611B1 (sr) 2024-07-31
HUE066891T2 (hu) 2024-09-28
KR20220084008A (ko) 2022-06-21
FI3999180T3 (fi) 2024-06-18
TWI865562B (zh) 2024-12-11
CN114555590B (zh) 2024-09-10
CN114555590A (zh) 2022-05-27
CL2022000054A1 (es) 2022-10-07
TW202116763A (zh) 2021-05-01
PH12022550123A1 (en) 2022-12-19
EP3999180A1 (en) 2022-05-25
JP7755090B2 (ja) 2025-10-15
BR112022000494A2 (pt) 2022-03-03
PT3999180T (pt) 2024-06-25
MX2022000504A (es) 2022-02-10
CN119119018A (zh) 2024-12-13

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