SI3999180T1 - Polimorfi(r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1 -il)-1-metil-1h-pirazol-4-karboksamida - Google Patents

Polimorfi(r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1 -il)-1-metil-1h-pirazol-4-karboksamida

Info

Publication number
SI3999180T1
SI3999180T1 SI202030443T SI202030443T SI3999180T1 SI 3999180 T1 SI3999180 T1 SI 3999180T1 SI 202030443 T SI202030443 T SI 202030443T SI 202030443 T SI202030443 T SI 202030443T SI 3999180 T1 SI3999180 T1 SI 3999180T1
Authority
SI
Slovenia
Prior art keywords
polymorphi
inden
oxadiazole
carboxamide
pyrazole
Prior art date
Application number
SI202030443T
Other languages
English (en)
Slovenian (sl)
Inventor
Norma TOM
Matthew Pfeiffer
Denise Andersen
Qi Gao
Original Assignee
Cytokinetics, Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=71995103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3999180(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cytokinetics, Inc., filed Critical Cytokinetics, Inc.,
Publication of SI3999180T1 publication Critical patent/SI3999180T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
SI202030443T 2019-07-17 2020-07-16 Polimorfi(r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1 -il)-1-metil-1h-pirazol-4-karboksamida SI3999180T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875350P 2019-07-17 2019-07-17
EP20753562.6A EP3999180B1 (en) 2019-07-17 2020-07-16 Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide
PCT/US2020/042387 WO2021011807A1 (en) 2019-07-17 2020-07-16 Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide

Publications (1)

Publication Number Publication Date
SI3999180T1 true SI3999180T1 (sl) 2024-07-31

Family

ID=71995103

Family Applications (1)

Application Number Title Priority Date Filing Date
SI202030443T SI3999180T1 (sl) 2019-07-17 2020-07-16 Polimorfi(r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1 -il)-1-metil-1h-pirazol-4-karboksamida

Country Status (25)

Country Link
US (1) US20220315571A1 (https=)
EP (2) EP3999180B1 (https=)
JP (2) JP7624431B2 (https=)
KR (1) KR20220084008A (https=)
CN (3) CN114555590B (https=)
AU (1) AU2020313965A1 (https=)
BR (1) BR112022000494A2 (https=)
CA (1) CA3144975A1 (https=)
CL (1) CL2022000054A1 (https=)
DK (1) DK3999180T3 (https=)
ES (1) ES2980885T3 (https=)
FI (1) FI3999180T3 (https=)
HR (1) HRP20240713T1 (https=)
HU (1) HUE066891T2 (https=)
IL (1) IL289875A (https=)
LT (1) LT3999180T (https=)
MX (1) MX2022000504A (https=)
PH (1) PH12022550123A1 (https=)
PL (1) PL3999180T3 (https=)
PT (1) PT3999180T (https=)
RS (1) RS65611B1 (https=)
SI (1) SI3999180T1 (https=)
SM (1) SMT202400224T1 (https=)
TW (1) TWI865562B (https=)
WO (1) WO2021011807A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
PT4370116T (pt) 2021-07-16 2025-03-14 Cytokinetics Inc Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva
MX2024001294A (es) 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.
WO2024020468A1 (en) 2022-07-20 2024-01-25 Cytokinetics, Incorporated Methods for treating non-obstructive hypertrophic cardiomyopathy
EP4565230A1 (en) 2022-08-04 2025-06-11 Cytokinetics, Inc. Methods for treating obstructive hypertrophic cardiomyopathy
WO2024134498A1 (en) 2022-12-22 2024-06-27 Assia Chemical Industries Ltd. Solid state forms of aficamten and process for preparation thereof
WO2024179422A1 (zh) * 2023-03-02 2024-09-06 苏州科睿思制药有限公司 Aficamten的共晶及其制备方法和用途
US20250295639A1 (en) 2024-03-20 2025-09-25 Cytokinetics, Incorporated Methods for treating heart diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
MX2024001294A (es) * 2021-08-03 2024-02-13 Cytokinetics Inc Proceso para la preparacion de aficamten.

Also Published As

Publication number Publication date
CA3144975A1 (en) 2021-01-21
IL289875A (en) 2022-03-01
CN118908951A (zh) 2024-11-08
EP3999180B1 (en) 2024-05-08
PL3999180T3 (pl) 2024-09-23
NZ784930A (en) 2025-03-28
SMT202400224T1 (it) 2024-07-09
JP2022540668A (ja) 2022-09-16
DK3999180T3 (da) 2024-05-21
HRP20240713T1 (hr) 2024-09-13
JP2025061484A (ja) 2025-04-10
JP7624431B2 (ja) 2025-01-30
EP4487911A1 (en) 2025-01-08
ES2980885T3 (es) 2024-10-03
AU2020313965A1 (en) 2022-03-03
LT3999180T (lt) 2024-08-26
US20220315571A1 (en) 2022-10-06
WO2021011807A1 (en) 2021-01-21
RS65611B1 (sr) 2024-07-31
HUE066891T2 (hu) 2024-09-28
KR20220084008A (ko) 2022-06-21
FI3999180T3 (fi) 2024-06-18
TWI865562B (zh) 2024-12-11
CN114555590B (zh) 2024-09-10
CN114555590A (zh) 2022-05-27
CL2022000054A1 (es) 2022-10-07
TW202116763A (zh) 2021-05-01
PH12022550123A1 (en) 2022-12-19
EP3999180A1 (en) 2022-05-25
JP7755090B2 (ja) 2025-10-15
BR112022000494A2 (pt) 2022-03-03
PT3999180T (pt) 2024-06-25
MX2022000504A (es) 2022-02-10
CN119119018A (zh) 2024-12-13

Similar Documents

Publication Publication Date Title
SI3999180T1 (sl) Polimorfi(r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1 -il)-1-metil-1h-pirazol-4-karboksamida
PT3433232T (pt) Novo sal de adição de ácido de 1-(5-(2,4-difluorofenil)-1-((3-fluorofenil)sulfonil)-4-metoxi-1h-pirrol-3-il)-n-metilmetanamina
CL2020002056A1 (es) Formas cristalinas novedosas.
EP3860987C0 (en) PESTICIDE-ACTIVE AZOLE-AMIDE COMPOUNDS
DK3573983T3 (da) N-[4-fluor-5-[[(2s,4s)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-1-piperidyl]methyl]thiazol-2-yl]acetamid som oga-inhibitor
MX2022004992A (es) Uso de compuestos de 3-isoxazolidinonas como herbicidas selectivos.
UY37517A (es) Métodos de síntesis de compuestos tiazoles sustituidos
IL289881A (en) Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h- tetrazole-5-carboxamide
HRP20230770T8 (hr) Kristalni oblici 1-(1,2-dimetilpropil)-n-etil-5-metil-n-piridazin-4-il-pirazol-4-karboksamida
DK3752490T3 (da) Herbicide 3-azaspiro[5.5]undecan-8,10-dionforbindelser
IL260403B (en) Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
MX2023001805A (es) Formas solidas de 2-(5-(4-(2-morfolinoetoxi)fenil)piridin-2-il)-n- bencilacetamida.
IL254943A0 (en) -(4-(4-(((3r,5r)-5-((1h-4,2,1-triazol-1-yl)methyl)-5-(4,2-difluorophenyl)tetrahydrofuran-3-yl (Methoxy)-3-methylphenyl)piperazin-1-yl)-n-(2-hydroxycyclohexyl)benzamide antifungal or a pharmaceutically acceptable salt thereof
DK3853219T3 (da) Herbicidt virksomme substituerede phenylpyrimidinhydrazider
NZ716494A (en) Processes and intermediates for the preparation of a pde10 inhibitor
HK40075684B (en) Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide
MX2022006133A (es) Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
HK40074727A (en) Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide
UA97377U (en) 3 - ((2-chloroethyl) thio) -5- (3,4,5-trimethoxyphenyl) -1h-1,2,4-triazole which exhibits hypoglycemic activity
UA97633U (xx) 3-((2-хлоретил)тіо)-5-(4-метоксифеніл)-1н-1,2,4-триазол, що проявляє гіпоглікемічну активність
RU2015153084A (ru) Замещенные 3-(3-пиридил)изоксазолидины, обладающие фунгицидной активностью
RU2016149494A (ru) 2-(4-Метоксифениламино)-4-(2,4-диметилфенил)-1-(пиперазин-1-ил)бут-2-ен-1,4-диона гидрохлорид, обладающий гемостатической активностью
RU2015149448A (ru) 2-(4-Бромфениламино)-1-(пиперазин-1-ил)-4-фенилбут-2-ен-1,4-диона гидрохлорид, обладающий инсектицидным действием
RU2024122437A (ru) Замещенное производное тетрагидроизохинолина, как позитивный аллостерический модулятор d1
UA94549U (xx) 3-(гексилтіо)-5-(3,4,5-триметоксифеніл)-1н-1,2,4-триазол, що проявляє жарознижуючу активність