JP2021508434A5 - - Google Patents
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- JP2021508434A5 JP2021508434A5 JP2020524225A JP2020524225A JP2021508434A5 JP 2021508434 A5 JP2021508434 A5 JP 2021508434A5 JP 2020524225 A JP2020524225 A JP 2020524225A JP 2020524225 A JP2020524225 A JP 2020524225A JP 2021508434 A5 JP2021508434 A5 JP 2021508434A5
- Authority
- JP
- Japan
- Prior art keywords
- glycero
- pharmaceutical composition
- phosphocholine
- composition according
- nanoparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023107089A JP2023138984A (ja) | 2017-10-31 | 2023-06-29 | Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するための脂質ナノ粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579671P | 2017-10-31 | 2017-10-31 | |
| US62/579,671 | 2017-10-31 | ||
| PCT/US2018/058541 WO2019089818A1 (en) | 2017-10-31 | 2018-10-31 | Lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107089A Division JP2023138984A (ja) | 2017-10-31 | 2023-06-29 | Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するための脂質ナノ粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021508434A JP2021508434A (ja) | 2021-03-11 |
| JP2021508434A5 true JP2021508434A5 (https=) | 2021-12-02 |
| JP7308000B2 JP7308000B2 (ja) | 2023-07-13 |
Family
ID=64557129
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524225A Active JP7308000B2 (ja) | 2017-10-31 | 2018-10-31 | Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するための脂質ナノ粒子 |
| JP2023107089A Pending JP2023138984A (ja) | 2017-10-31 | 2023-06-29 | Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するための脂質ナノ粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023107089A Pending JP2023138984A (ja) | 2017-10-31 | 2023-06-29 | Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するための脂質ナノ粒子 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11696892B2 (https=) |
| EP (1) | EP3703658B1 (https=) |
| JP (2) | JP7308000B2 (https=) |
| KR (1) | KR20200081420A (https=) |
| CN (1) | CN111356444A (https=) |
| AU (1) | AU2018358049A1 (https=) |
| BR (1) | BR112020008404A2 (https=) |
| CA (1) | CA3080592A1 (https=) |
| CY (1) | CY1125373T1 (https=) |
| DK (1) | DK3703658T3 (https=) |
| EA (1) | EA202090919A1 (https=) |
| ES (1) | ES2922462T3 (https=) |
| HR (1) | HRP20220843T1 (https=) |
| HU (1) | HUE059049T2 (https=) |
| IL (1) | IL274230B2 (https=) |
| LT (1) | LT3703658T (https=) |
| MA (1) | MA50522B1 (https=) |
| PL (1) | PL3703658T3 (https=) |
| PT (1) | PT3703658T (https=) |
| RS (1) | RS63389B1 (https=) |
| SG (1) | SG11202003941XA (https=) |
| SI (1) | SI3703658T1 (https=) |
| SM (1) | SMT202200296T1 (https=) |
| WO (1) | WO2019089818A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014296278C1 (en) | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| JP2018509387A (ja) | 2015-01-21 | 2018-04-05 | フェーズアールエックス インコーポレイテッド | 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム |
| MA42543A (fr) | 2015-07-30 | 2018-06-06 | Modernatx Inc | Arn épitope peptidiques concatémériques |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| WO2017201342A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| CN116606861A (zh) | 2016-06-07 | 2023-08-18 | 摩登纳特斯有限公司 | 编码vegf-a多肽的经修饰的rna、配制品和关于它们的用途 |
| CA3036831A1 (en) | 2016-09-14 | 2018-03-22 | Modernatx, Inc. | High purity rna compositions and methods for preparation thereof |
| MA46766A (fr) | 2016-11-11 | 2019-09-18 | Modernatx Inc | Vaccin antigrippal |
| EP3562510A4 (en) | 2016-12-30 | 2021-01-06 | Genevant Sciences GmbH | BRANCHED PEG MOLECULES AND ASSOCIATED COMPOSITIONS AND PROCEDURES |
| US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| EP3668979A4 (en) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | METHOD OF HPLC ANALYSIS |
| WO2019036682A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | RNA VARIANTS POLYMERASE |
| MA49914A (fr) | 2017-08-18 | 2021-04-21 | Modernatx Inc | Procédés analytiques par hplc |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| SI3703658T1 (sl) | 2017-10-31 | 2022-09-30 | Astrazeneca Ab | Lipidni nanodelci za dostavljanje spremenjene RNA, ki kodira polipeptid VEGF-A |
| EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA Vaccines |
| CN112399860B (zh) | 2018-06-06 | 2024-08-16 | 麻省理工学院 | 用于在真核细胞中翻译的环状rna |
| WO2020061295A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| CN113874502A (zh) | 2019-03-11 | 2021-12-31 | 摩登纳特斯有限公司 | 补料分批体外转录方法 |
| US12070495B2 (en) | 2019-03-15 | 2024-08-27 | Modernatx, Inc. | HIV RNA vaccines |
| WO2020227690A1 (en) * | 2019-05-08 | 2020-11-12 | Modernatx, Inc. | Methods of using lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide and pharmaceutical compositions comprising the same |
| BR112021023411A2 (pt) * | 2019-05-22 | 2022-02-01 | Massachusetts Inst Technology | Composições e métodos de rna circular |
| EP4009955A1 (en) * | 2019-08-07 | 2022-06-15 | ModernaTX, Inc. | Compositions and methods for enhanced delivery of agents |
| CN114901253A (zh) | 2019-08-14 | 2022-08-12 | 爱康泰生治疗公司 | 用于递送核酸的改进的脂质纳米颗粒 |
| CA3169669A1 (en) * | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| CN113185421B (zh) * | 2020-11-27 | 2022-01-25 | 广州市锐博生物科技有限公司 | 脂质化合物及其组合物 |
| EP4274607A1 (en) | 2021-01-11 | 2023-11-15 | ModernaTX, Inc. | Seasonal rna influenza virus vaccines |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| CN113941011A (zh) * | 2021-10-15 | 2022-01-18 | 浙江汇科泽华生物技术有限公司 | 一种含可离子化阳离子脂质的纳米脂质体颗粒及制备方法 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US12529047B1 (en) | 2021-12-21 | 2026-01-20 | Modernatx, Inc. | mRNA quantification methods |
| CN114044741B (zh) | 2022-01-13 | 2022-04-15 | 北京悦康科创医药科技股份有限公司 | 一种阳离子脂质化合物、包含其的组合物及用途 |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN114456081B (zh) * | 2022-02-15 | 2025-03-11 | 浙江汇科泽华生物技术有限公司 | 一种可离子化脂质及其制备方法和应用 |
| CN117137870A (zh) * | 2022-05-24 | 2023-12-01 | 北京华芢生物技术有限公司 | 含有聚乳酸-羟基乙酸共聚物的纳米脂质体颗粒递送载体 |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| WO2024037578A1 (en) * | 2022-08-18 | 2024-02-22 | Suzhou Abogen Biosciences Co., Ltd. | Composition of lipid nanoparticles |
| CN115197431B (zh) * | 2022-09-15 | 2022-11-29 | 清华大学 | 脂质偶联完全可降解水溶性聚合物的合成及应用 |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| CN116474120A (zh) * | 2023-04-03 | 2023-07-25 | 臻赫医药(杭州)有限公司 | 重编程因子抗衰老mRNA组合物、制备方法及应用 |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| IL326647A (en) | 2023-09-01 | 2026-04-01 | Novoarc Gmbh | Lipid nanoparticles with a nucleic acid charge and an ionizable lipid |
| WO2026039780A1 (en) * | 2024-08-16 | 2026-02-19 | Modernatx, Inc. | Stable lipid nanoparticle compositions prepared without polymeric lipids and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004035227A1 (de) | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
| RU2497532C2 (ru) | 2008-12-03 | 2013-11-10 | Эморсайт, Инк. | Композиции, улучшающие перфузию в области инфаркта и способы восстановления сосудистого повреждения |
| ES2600781T3 (es) | 2008-12-04 | 2017-02-10 | Curna, Inc. | Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf |
| WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| EP2651445A2 (en) | 2010-12-16 | 2013-10-23 | SPRNA GmbH | Pharmaceutical composition consisting of rna having alkali metal as counter ion and formulated with dications |
| EP3460064B8 (en) * | 2011-04-03 | 2024-03-20 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Efficient protein expression in vivo using modified rna (mod-rna) |
| CA3018046A1 (en) * | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US20140275229A1 (en) * | 2012-04-02 | 2014-09-18 | Moderna Therapeutics, Inc. | Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1 |
| WO2013151665A2 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) * | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501513B2 (en) * | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US9663564B2 (en) * | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| KR102354389B1 (ko) | 2013-08-21 | 2022-01-20 | 큐어백 아게 | Rna―암호화된 단백질의 발현을 증가시키는 방법 |
| RU2727639C2 (ru) | 2014-01-15 | 2020-07-22 | Ф.Хоффманн-Ля Рош Аг | Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а |
| EP3247398A4 (en) | 2015-01-23 | 2018-09-26 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| JP6948313B6 (ja) * | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| CN116606861A (zh) | 2016-06-07 | 2023-08-18 | 摩登纳特斯有限公司 | 编码vegf-a多肽的经修饰的rna、配制品和关于它们的用途 |
| WO2018104540A1 (en) | 2016-12-08 | 2018-06-14 | Curevac Ag | Rnas for wound healing |
| MX389934B (es) | 2016-12-09 | 2025-03-20 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A De C V | Composición coadyuvante de un factor de crecimiento y un neuropéptido para acelerar la cicatrización de heridas y la repitelización de órganos. |
| SI3703658T1 (sl) | 2017-10-31 | 2022-09-30 | Astrazeneca Ab | Lipidni nanodelci za dostavljanje spremenjene RNA, ki kodira polipeptid VEGF-A |
| JP2022532078A (ja) | 2019-05-08 | 2022-07-13 | アストラゼネカ アクチボラグ | 皮膚及び創傷のための組成物並びにその使用の方法 |
-
2018
- 2018-10-31 SI SI201830719T patent/SI3703658T1/sl unknown
- 2018-10-31 CA CA3080592A patent/CA3080592A1/en active Pending
- 2018-10-31 HU HUE18811407A patent/HUE059049T2/hu unknown
- 2018-10-31 WO PCT/US2018/058541 patent/WO2019089818A1/en not_active Ceased
- 2018-10-31 SG SG11202003941XA patent/SG11202003941XA/en unknown
- 2018-10-31 IL IL274230A patent/IL274230B2/en unknown
- 2018-10-31 EA EA202090919A patent/EA202090919A1/ru unknown
- 2018-10-31 PT PT188114078T patent/PT3703658T/pt unknown
- 2018-10-31 HR HRP20220843TT patent/HRP20220843T1/hr unknown
- 2018-10-31 SM SM20220296T patent/SMT202200296T1/it unknown
- 2018-10-31 CN CN201880070861.3A patent/CN111356444A/zh active Pending
- 2018-10-31 RS RS20220666A patent/RS63389B1/sr unknown
- 2018-10-31 MA MA50522A patent/MA50522B1/fr unknown
- 2018-10-31 US US16/760,406 patent/US11696892B2/en active Active
- 2018-10-31 PL PL18811407.8T patent/PL3703658T3/pl unknown
- 2018-10-31 DK DK18811407.8T patent/DK3703658T3/da active
- 2018-10-31 LT LTEPPCT/US2018/058541T patent/LT3703658T/lt unknown
- 2018-10-31 JP JP2020524225A patent/JP7308000B2/ja active Active
- 2018-10-31 BR BR112020008404-2A patent/BR112020008404A2/pt not_active IP Right Cessation
- 2018-10-31 EP EP18811407.8A patent/EP3703658B1/en active Active
- 2018-10-31 ES ES18811407T patent/ES2922462T3/es active Active
- 2018-10-31 AU AU2018358049A patent/AU2018358049A1/en not_active Abandoned
- 2018-10-31 KR KR1020207015020A patent/KR20200081420A/ko not_active Ceased
-
2022
- 2022-07-19 CY CY20221100489T patent/CY1125373T1/el unknown
-
2023
- 2023-06-29 JP JP2023107089A patent/JP2023138984A/ja active Pending
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