CN111356444A - 用于递送编码vegf-a多肽的经修饰的rna的脂质纳米颗粒 - Google Patents

用于递送编码vegf-a多肽的经修饰的rna的脂质纳米颗粒 Download PDF

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CN111356444A
CN111356444A CN201880070861.3A CN201880070861A CN111356444A CN 111356444 A CN111356444 A CN 111356444A CN 201880070861 A CN201880070861 A CN 201880070861A CN 111356444 A CN111356444 A CN 111356444A
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glycero
phosphocholine
peg
modified
lipid
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Chinese (zh)
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K.M.汉松
K.贝内纳托
M.瓦格贝里
A.帕尔松
R.弗里特谢-丹尼尔松
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ModernaTx Inc
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ModernaTx Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K38/1858—Platelet-derived growth factor [PDGF]
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201880070861.3A 2017-10-31 2018-10-31 用于递送编码vegf-a多肽的经修饰的rna的脂质纳米颗粒 Pending CN111356444A (zh)

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US201762579671P 2017-10-31 2017-10-31
US62/579671 2017-10-31
PCT/US2018/058541 WO2019089818A1 (en) 2017-10-31 2018-10-31 Lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide

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US (1) US11696892B2 (https=)
EP (1) EP3703658B1 (https=)
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KR (1) KR20200081420A (https=)
CN (1) CN111356444A (https=)
AU (1) AU2018358049A1 (https=)
BR (1) BR112020008404A2 (https=)
CA (1) CA3080592A1 (https=)
CY (1) CY1125373T1 (https=)
DK (1) DK3703658T3 (https=)
EA (1) EA202090919A1 (https=)
ES (1) ES2922462T3 (https=)
HR (1) HRP20220843T1 (https=)
HU (1) HUE059049T2 (https=)
IL (1) IL274230B2 (https=)
LT (1) LT3703658T (https=)
MA (1) MA50522B1 (https=)
PL (1) PL3703658T3 (https=)
PT (1) PT3703658T (https=)
RS (1) RS63389B1 (https=)
SG (1) SG11202003941XA (https=)
SI (1) SI3703658T1 (https=)
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CN113185421A (zh) * 2020-11-27 2021-07-30 广州市锐博生物科技有限公司 脂质化合物及其组合物
CN113941011A (zh) * 2021-10-15 2022-01-18 浙江汇科泽华生物技术有限公司 一种含可离子化阳离子脂质的纳米脂质体颗粒及制备方法
CN114173826A (zh) * 2019-05-08 2022-03-11 阿斯利康(瑞典)有限公司 使用脂质纳米颗粒用于递送编码vegf-a多肽的经修饰的rna的方法和包含其的药物组合物
CN114456081A (zh) * 2022-02-15 2022-05-10 浙江汇科泽华生物技术有限公司 一种可离子化脂质及其制备方法和应用
CN115197431A (zh) * 2022-09-15 2022-10-18 清华大学 脂质偶联完全可降解水溶性聚合物的合成及应用
WO2023279836A1 (zh) * 2021-07-07 2023-01-12 天津键凯科技有限公司 一种用于核酸递送的可电离脂质化合物及其lnp组合物
CN116474120A (zh) * 2023-04-03 2023-07-25 臻赫医药(杭州)有限公司 重编程因子抗衰老mRNA组合物、制备方法及应用
CN117137870A (zh) * 2022-05-24 2023-12-01 北京华芢生物技术有限公司 含有聚乳酸-羟基乙酸共聚物的纳米脂质体颗粒递送载体

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