MA50522A - Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a - Google Patents

Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a

Info

Publication number
MA50522A
MA50522A MA050522A MA50522A MA50522A MA 50522 A MA50522 A MA 50522A MA 050522 A MA050522 A MA 050522A MA 50522 A MA50522 A MA 50522A MA 50522 A MA50522 A MA 50522A
Authority
MA
Morocco
Prior art keywords
vegf
polypeptide
administration
lipid nanoparticles
modified rna
Prior art date
Application number
MA050522A
Other languages
English (en)
Other versions
MA50522B1 (fr
Inventor
Kerry Benenato
Regina Fritsche-Danielson
Kenny Mikael Hansson
Annika Pålsson
Maria Wågberg
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA50522A publication Critical patent/MA50522A/fr
Publication of MA50522B1 publication Critical patent/MA50522B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA50522A 2017-10-31 2018-10-31 Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a MA50522B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762579671P 2017-10-31 2017-10-31
PCT/US2018/058541 WO2019089818A1 (fr) 2017-10-31 2018-10-31 Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a

Publications (2)

Publication Number Publication Date
MA50522A true MA50522A (fr) 2021-05-26
MA50522B1 MA50522B1 (fr) 2022-09-30

Family

ID=64557129

Family Applications (1)

Application Number Title Priority Date Filing Date
MA50522A MA50522B1 (fr) 2017-10-31 2018-10-31 Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a

Country Status (22)

Country Link
US (1) US11696892B2 (fr)
EP (1) EP3703658B1 (fr)
JP (2) JP7308000B2 (fr)
KR (1) KR20200081420A (fr)
CN (1) CN111356444A (fr)
AU (1) AU2018358049A1 (fr)
BR (1) BR112020008404A2 (fr)
CA (1) CA3080592A1 (fr)
DK (1) DK3703658T3 (fr)
EA (1) EA202090919A1 (fr)
ES (1) ES2922462T3 (fr)
HR (1) HRP20220843T1 (fr)
HU (1) HUE059049T2 (fr)
IL (1) IL274230B2 (fr)
LT (1) LT3703658T (fr)
MA (1) MA50522B1 (fr)
PL (1) PL3703658T3 (fr)
PT (1) PT3703658T (fr)
RS (1) RS63389B1 (fr)
SG (1) SG11202003941XA (fr)
SI (1) SI3703658T1 (fr)
WO (1) WO2019089818A1 (fr)

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HRP20220872T1 (hr) 2015-10-22 2022-12-23 Modernatx, Inc. Cjepiva protiv respiratornih virusa
SI3464338T1 (sl) 2016-06-07 2022-02-28 Modernatx, Inc., Modificirana RNA, ki kodira polipeptide VEGF-A, formulacije in uporabe v zvezi s tem
WO2018126084A1 (fr) 2016-12-30 2018-07-05 Phaserx, Inc. Molécules de peg ramifié, compositions et procédés associés
WO2018187590A1 (fr) 2017-04-05 2018-10-11 Modernatx, Inc. Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée
WO2018232357A1 (fr) 2017-06-15 2018-12-20 Modernatx, Inc. Formulations d'arn
WO2019036685A1 (fr) 2017-08-18 2019-02-21 Modernatx, Inc. Procédés pour analyse par clhp
JP7408098B2 (ja) 2017-08-18 2024-01-05 モデルナティエックス インコーポレイテッド Ｒｎａポリメラーゼバリアント
EP3668977A4 (fr) 2017-08-18 2021-04-21 Modernatx, Inc. Procédés analytiques par hplc
EP3675817A1 (fr) 2017-08-31 2020-07-08 Modernatx, Inc. Procédés de fabrication de nanoparticules lipidiques
BR112020008404A2 (pt) 2017-10-31 2020-11-03 Modernatx, Inc. nanopartículas lipídicas para a entrega de rna modificado codificando um polipeptídeo vegf-a
JP2022532075A (ja) * 2019-05-08 2022-07-13 アストラゼネカ アクチボラグ Ｖｅｇｆ－ａポリペプチドをコードする改変ｒｎａを送達するために脂質ナノ粒子を使用する方法、及びこの脂質ナノ粒子を含む医薬組成物
CA3150061A1 (fr) * 2019-08-07 2021-02-11 Modernatx, Inc. Compositions et methodes pour une administration amelioree d'agents
MX2022009410A (es) * 2020-01-31 2022-10-18 Modernatx Inc Metodos de preparacion de nanoparticulas lipidicas.
CN113185421B (zh) * 2020-11-27 2022-01-25 广州市锐博生物科技有限公司 脂质化合物及其组合物
CN114149337B (zh) * 2021-07-07 2022-04-29 天津键凯科技有限公司 一种用于核酸递送的新型可电离脂质及其lnp组合物
WO2023031394A1 (fr) 2021-09-03 2023-03-09 CureVac SE Nouvelles nanoparticules lipidiques pour l'administration d'acides nucléiques
CN113941011A (zh) * 2021-10-15 2022-01-18 浙江汇科泽华生物技术有限公司 一种含可离子化阳离子脂质的纳米脂质体颗粒及制备方法
WO2023073228A1 (fr) 2021-10-29 2023-05-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
WO2023144330A1 (fr) 2022-01-28 2023-08-03 CureVac SE Inhibiteurs de facteurs de transcription codés par un acide nucleique
CN114456081A (zh) * 2022-02-15 2022-05-10 浙江汇科泽华生物技术有限公司 一种可离子化脂质及其制备方法和应用
WO2023227608A1 (fr) 2022-05-25 2023-11-30 Glaxosmithkline Biologicals Sa Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli
WO2024037578A1 (fr) * 2022-08-18 2024-02-22 Suzhou Abogen Biosciences Co., Ltd. Composition de nanoparticules lipidiques
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SI3464338T1 (sl) 2016-06-07 2022-02-28 Modernatx, Inc., Modificirana RNA, ki kodira polipeptide VEGF-A, formulacije in uporabe v zvezi s tem
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BR112020008404A2 (pt) 2017-10-31 2020-11-03 Modernatx, Inc. nanopartículas lipídicas para a entrega de rna modificado codificando um polipeptídeo vegf-a
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Also Published As

Publication number Publication date
KR20200081420A (ko) 2020-07-07
MA50522B1 (fr) 2022-09-30
AU2018358049A1 (en) 2020-05-21
CA3080592A1 (fr) 2019-05-09
PT3703658T (pt) 2022-07-18
IL274230B2 (en) 2023-12-01
IL274230A (en) 2020-06-30
US20200338004A1 (en) 2020-10-29
JP2021508434A (ja) 2021-03-11
PL3703658T3 (pl) 2022-08-22
HUE059049T2 (hu) 2022-10-28
RS63389B1 (sr) 2022-08-31
BR112020008404A2 (pt) 2020-11-03
DK3703658T3 (da) 2022-07-18
SI3703658T1 (sl) 2022-09-30
IL274230B1 (en) 2023-08-01
LT3703658T (lt) 2022-07-25
JP7308000B2 (ja) 2023-07-13
HRP20220843T1 (hr) 2022-10-14
ES2922462T3 (es) 2022-09-15
SG11202003941XA (en) 2020-05-28
US11696892B2 (en) 2023-07-11
EA202090919A1 (ru) 2020-09-09
CN111356444A (zh) 2020-06-30
EP3703658A1 (fr) 2020-09-09
WO2019089818A1 (fr) 2019-05-09
EP3703658B1 (fr) 2022-05-04
JP2023138984A (ja) 2023-10-03

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