MA50522B1 - Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a - Google Patents
Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-aInfo
- Publication number
- MA50522B1 MA50522B1 MA50522A MA50522A MA50522B1 MA 50522 B1 MA50522 B1 MA 50522B1 MA 50522 A MA50522 A MA 50522A MA 50522 A MA50522 A MA 50522A MA 50522 B1 MA50522 B1 MA 50522B1
- Authority
- MA
- Morocco
- Prior art keywords
- vegf
- polypeptide
- modified rna
- rna encoding
- delivery
- Prior art date
Links
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 title abstract 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title abstract 3
- 239000002105 nanoparticle Substances 0.000 title abstract 3
- 239000000470 constituent Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
L'invention concerne des nanoparticules comprenant un constituant lipidique et un arn modifié codant pour un polypeptide vegf-a. Des aspects de l'invention concernent en outre des utilisations de nanoparticules comprenant un constituant lipidique et un arn modifié codant pour un polypeptide vegf-a, pour améliorer la cicatrisation des plaies chez un sujet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762579671P | 2017-10-31 | 2017-10-31 | |
PCT/US2018/058541 WO2019089818A1 (fr) | 2017-10-31 | 2018-10-31 | Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a |
Publications (2)
Publication Number | Publication Date |
---|---|
MA50522A MA50522A (fr) | 2021-05-26 |
MA50522B1 true MA50522B1 (fr) | 2022-09-30 |
Family
ID=64557129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA50522A MA50522B1 (fr) | 2017-10-31 | 2018-10-31 | Nanoparticules lipidiques pour l'administration d'un arn modifié codant pour un polypeptide vegf-a |
Country Status (22)
Country | Link |
---|---|
US (1) | US11696892B2 (fr) |
EP (1) | EP3703658B1 (fr) |
JP (2) | JP7308000B2 (fr) |
KR (1) | KR20200081420A (fr) |
CN (1) | CN111356444A (fr) |
AU (1) | AU2018358049A1 (fr) |
BR (1) | BR112020008404A2 (fr) |
CA (1) | CA3080592A1 (fr) |
DK (1) | DK3703658T3 (fr) |
EA (1) | EA202090919A1 (fr) |
ES (1) | ES2922462T3 (fr) |
HR (1) | HRP20220843T1 (fr) |
HU (1) | HUE059049T2 (fr) |
IL (1) | IL274230B2 (fr) |
LT (1) | LT3703658T (fr) |
MA (1) | MA50522B1 (fr) |
PL (1) | PL3703658T3 (fr) |
PT (1) | PT3703658T (fr) |
RS (1) | RS63389B1 (fr) |
SG (1) | SG11202003941XA (fr) |
SI (1) | SI3703658T1 (fr) |
WO (1) | WO2019089818A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3027221A1 (fr) | 2013-07-30 | 2016-06-08 | PhaseRx, Inc. | Copolymères séquencés et leur conjugués ou complexes avec des oligonucléotides |
WO2016118697A1 (fr) | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Procédés, compositions et systèmes permettant l'administration d'agents thérapeutiques et diagnostiques dans des cellules |
HUE059127T2 (hu) | 2015-10-22 | 2022-10-28 | Modernatx Inc | Légúti vírusok elleni vakcinák |
PL3464338T3 (pl) | 2016-06-07 | 2021-12-27 | Modernatx, Inc. | Zmodyfikowany RNA kodujący polipeptydy VEGF, formulacje i zastosowania z nimi związane |
EP3562510A4 (fr) | 2016-12-30 | 2021-01-06 | Genevant Sciences GmbH | Molécules de peg ramifié, compositions et procédés associés |
MA48047A (fr) | 2017-04-05 | 2020-02-12 | Modernatx Inc | Réduction ou élimination de réponses immunitaires à des protéines thérapeutiques administrées par voie non intraveineuse, par exemple par voie sous-cutanée |
MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
EP3668977A4 (fr) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | Procédés analytiques par hplc |
CN111212905A (zh) | 2017-08-18 | 2020-05-29 | 摩登纳特斯有限公司 | Rna聚合酶变体 |
MA49922A (fr) | 2017-08-18 | 2021-06-02 | Modernatx Inc | Procédés pour analyse par clhp |
WO2019046809A1 (fr) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
PL3703658T3 (pl) | 2017-10-31 | 2022-08-22 | Astrazeneca Ab | Nanocząstki lipidowe do dostarczania zmodyfikowanego rna kodującego polipeptyd vegf-a |
CN114173826A (zh) * | 2019-05-08 | 2022-03-11 | 阿斯利康(瑞典)有限公司 | 使用脂质纳米颗粒用于递送编码vegf-a多肽的经修饰的rna的方法和包含其的药物组合物 |
AU2020325221A1 (en) * | 2019-08-07 | 2022-03-03 | Modernatx, Inc. | Compositions and methods for enhanced delivery of agents |
WO2021155274A1 (fr) * | 2020-01-31 | 2021-08-05 | Modernatx, Inc. | Procédés de préparation de nanoparticules lipidiques |
CN113185421B (zh) * | 2020-11-27 | 2022-01-25 | 广州市锐博生物科技有限公司 | 脂质化合物及其组合物 |
CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
AU2022336209A1 (en) | 2021-09-03 | 2024-01-18 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
CN113941011A (zh) * | 2021-10-15 | 2022-01-18 | 浙江汇科泽华生物技术有限公司 | 一种含可离子化阳离子脂质的纳米脂质体颗粒及制备方法 |
WO2023073228A1 (fr) | 2021-10-29 | 2023-05-04 | CureVac SE | Arn circulaire amélioré pour exprimer des protéines thérapeutiques |
WO2023144330A1 (fr) | 2022-01-28 | 2023-08-03 | CureVac SE | Inhibiteurs de facteurs de transcription codés par un acide nucleique |
CN114456081A (zh) * | 2022-02-15 | 2022-05-10 | 浙江汇科泽华生物技术有限公司 | 一种可离子化脂质及其制备方法和应用 |
WO2023227608A1 (fr) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique codant pour un polypeptide antigénique fimh d'escherichia coli |
WO2024037578A1 (fr) * | 2022-08-18 | 2024-02-22 | Suzhou Abogen Biosciences Co., Ltd. | Composition de nanoparticules lipidiques |
CN115197431B (zh) * | 2022-09-15 | 2022-11-29 | 清华大学 | 脂质偶联完全可降解水溶性聚合物的合成及应用 |
WO2024089638A1 (fr) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Vaccin à base d'acide nucléique |
CN116474120A (zh) * | 2023-04-03 | 2023-07-25 | 臻赫医药(杭州)有限公司 | 重编程因子抗衰老mRNA组合物、制备方法及应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004035227A1 (de) | 2004-07-21 | 2006-02-16 | Curevac Gmbh | mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen |
JP5705127B2 (ja) | 2008-12-03 | 2015-04-22 | アモーサイト インコーポレイテッド | 梗塞領域灌流改善組成物および血管損傷修復の方法 |
JP5971948B2 (ja) | 2008-12-04 | 2016-08-17 | クルナ・インコーポレーテッド | Vegfに対する天然アンチセンス転写物の抑制による血管内皮増殖因子(vegf)関連疾患の治療 |
WO2011069529A1 (fr) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Solution contenant du mannose pour la lyophilisation, la transfection et/ou l'injection d'acides nucléiques |
WO2012103985A2 (fr) | 2010-12-16 | 2012-08-09 | Steve Pascolo | Composition pharmaceutique à base d'arn qui comprend un métal alcalin en tant que contre-ion et formulé avec des dications |
WO2012138453A1 (fr) | 2011-04-03 | 2012-10-11 | The General Hospital Corporation | Expression protéique efficace in vivo à l'aide d'arn modifié (mod-arn) |
LT2791160T (lt) * | 2011-12-16 | 2022-06-10 | Modernatx, Inc. | Modifikuotos mrnr sudėtys |
US9283287B2 (en) * | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US10501513B2 (en) * | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
US20140275229A1 (en) * | 2012-04-02 | 2014-09-18 | Moderna Therapeutics, Inc. | Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1 |
US9192651B2 (en) | 2012-04-02 | 2015-11-24 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of secreted proteins |
US9663564B2 (en) * | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
EP2971010B1 (fr) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation et administration de compositions de nucléosides, de nucléotides, et d'acides nucléiques modifiés |
KR102354389B1 (ko) | 2013-08-21 | 2022-01-20 | 큐어백 아게 | Rna―암호화된 단백질의 발현을 증가시키는 방법 |
JP6786392B2 (ja) | 2014-01-15 | 2020-11-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | FcRn結合特性が改変され、プロテインA結合特性が保持されているFc領域変異体 |
EP3247398A4 (fr) | 2015-01-23 | 2018-09-26 | Moderna Therapeutics, Inc. | Compositions de nanoparticules lipidiques |
ES2910425T3 (es) * | 2015-09-17 | 2022-05-12 | Modernatx Inc | Compuestos y composiciones para la administración intracelular de agentes terapéuticos |
PL3464338T3 (pl) | 2016-06-07 | 2021-12-27 | Modernatx, Inc. | Zmodyfikowany RNA kodujący polipeptydy VEGF, formulacje i zastosowania z nimi związane |
WO2018104540A1 (fr) | 2016-12-08 | 2018-06-14 | Curevac Ag | Arn pour la cicatrisation des plaies |
MX2016016339A (es) | 2016-12-09 | 2018-06-08 | Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A S De C V | Composicion coadyuvante de un factor de crecimiento y un neuropeptido para acelerar la cicatrizacion de heridas y la repitelizacion de organos. |
PL3703658T3 (pl) | 2017-10-31 | 2022-08-22 | Astrazeneca Ab | Nanocząstki lipidowe do dostarczania zmodyfikowanego rna kodującego polipeptyd vegf-a |
US20220226438A1 (en) | 2019-05-08 | 2022-07-21 | Astrazeneca Ab | Compositions for skin and wounds and methods of use thereof |
-
2018
- 2018-10-31 PL PL18811407.8T patent/PL3703658T3/pl unknown
- 2018-10-31 SG SG11202003941XA patent/SG11202003941XA/en unknown
- 2018-10-31 SI SI201830719T patent/SI3703658T1/sl unknown
- 2018-10-31 WO PCT/US2018/058541 patent/WO2019089818A1/fr unknown
- 2018-10-31 ES ES18811407T patent/ES2922462T3/es active Active
- 2018-10-31 MA MA50522A patent/MA50522B1/fr unknown
- 2018-10-31 HU HUE18811407A patent/HUE059049T2/hu unknown
- 2018-10-31 US US16/760,406 patent/US11696892B2/en active Active
- 2018-10-31 CA CA3080592A patent/CA3080592A1/fr active Pending
- 2018-10-31 HR HRP20220843TT patent/HRP20220843T1/hr unknown
- 2018-10-31 LT LTEPPCT/US2018/058541T patent/LT3703658T/lt unknown
- 2018-10-31 JP JP2020524225A patent/JP7308000B2/ja active Active
- 2018-10-31 KR KR1020207015020A patent/KR20200081420A/ko not_active Application Discontinuation
- 2018-10-31 DK DK18811407.8T patent/DK3703658T3/da active
- 2018-10-31 EP EP18811407.8A patent/EP3703658B1/fr active Active
- 2018-10-31 BR BR112020008404-2A patent/BR112020008404A2/pt unknown
- 2018-10-31 CN CN201880070861.3A patent/CN111356444A/zh active Pending
- 2018-10-31 RS RS20220666A patent/RS63389B1/sr unknown
- 2018-10-31 EA EA202090919A patent/EA202090919A1/ru unknown
- 2018-10-31 PT PT188114078T patent/PT3703658T/pt unknown
- 2018-10-31 IL IL274230A patent/IL274230B2/en unknown
- 2018-10-31 AU AU2018358049A patent/AU2018358049A1/en active Pending
-
2023
- 2023-06-29 JP JP2023107089A patent/JP2023138984A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RS63389B1 (sr) | 2022-08-31 |
US20200338004A1 (en) | 2020-10-29 |
LT3703658T (lt) | 2022-07-25 |
EP3703658A1 (fr) | 2020-09-09 |
MA50522A (fr) | 2021-05-26 |
PT3703658T (pt) | 2022-07-18 |
US11696892B2 (en) | 2023-07-11 |
IL274230B2 (en) | 2023-12-01 |
IL274230B1 (en) | 2023-08-01 |
DK3703658T3 (da) | 2022-07-18 |
JP2023138984A (ja) | 2023-10-03 |
JP2021508434A (ja) | 2021-03-11 |
SG11202003941XA (en) | 2020-05-28 |
BR112020008404A2 (pt) | 2020-11-03 |
WO2019089818A1 (fr) | 2019-05-09 |
AU2018358049A1 (en) | 2020-05-21 |
ES2922462T3 (es) | 2022-09-15 |
CA3080592A1 (fr) | 2019-05-09 |
EA202090919A1 (ru) | 2020-09-09 |
IL274230A (en) | 2020-06-30 |
HRP20220843T1 (hr) | 2022-10-14 |
EP3703658B1 (fr) | 2022-05-04 |
PL3703658T3 (pl) | 2022-08-22 |
SI3703658T1 (sl) | 2022-09-30 |
KR20200081420A (ko) | 2020-07-07 |
HUE059049T2 (hu) | 2022-10-28 |
JP7308000B2 (ja) | 2023-07-13 |
CN111356444A (zh) | 2020-06-30 |
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