JP2021508236A5 - - Google Patents
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- JP2021508236A5 JP2021508236A5 JP2020527921A JP2020527921A JP2021508236A5 JP 2021508236 A5 JP2021508236 A5 JP 2021508236A5 JP 2020527921 A JP2020527921 A JP 2020527921A JP 2020527921 A JP2020527921 A JP 2020527921A JP 2021508236 A5 JP2021508236 A5 JP 2021508236A5
- Authority
- JP
- Japan
- Prior art keywords
- human animal
- trkb
- endogenous
- seq
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 claims description 54
- 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 claims description 54
- 101100517383 Homo sapiens NTRK2 gene Proteins 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 39
- 230000001086 cytosolic effect Effects 0.000 claims description 29
- 108091026890 Coding region Proteins 0.000 claims description 24
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 20
- 230000008685 targeting Effects 0.000 claims description 19
- 101150056950 Ntrk2 gene Proteins 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 210000001161 mammalian embryo Anatomy 0.000 claims description 9
- 210000004102 animal cell Anatomy 0.000 claims description 7
- 230000000324 neuroprotective effect Effects 0.000 claims description 7
- 102000005937 Tropomyosin Human genes 0.000 claims description 6
- 108010030743 Tropomyosin Proteins 0.000 claims description 6
- 239000000556 agonist Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 230000003833 cell viability Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 210000003994 retinal ganglion cell Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 102000025171 antigen binding proteins Human genes 0.000 claims description 4
- 108091000831 antigen binding proteins Proteins 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000004060 metabolic process Effects 0.000 claims description 4
- 210000001328 optic nerve Anatomy 0.000 claims description 4
- 150000003384 small molecules Chemical group 0.000 claims description 4
- 208000030768 Optic nerve injury Diseases 0.000 claims description 3
- 238000002266 amputation Methods 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102000043136 MAP kinase family Human genes 0.000 claims description 2
- 108091054455 MAP kinase family Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 108091007960 PI3Ks Proteins 0.000 claims description 2
- 241000283984 Rodentia Species 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 210000000577 adipose tissue Anatomy 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 claims description 2
- 102000006261 human tropomyosin-related kinase-B Human genes 0.000 claims description 2
- 108010058135 human tropomyosin-related kinase-B Proteins 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000033001 locomotion Effects 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 230000026731 phosphorylation Effects 0.000 claims description 2
- 238000006366 phosphorylation reaction Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 108091005682 Receptor kinases Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 102000038030 PI3Ks Human genes 0.000 claims 1
- 108020005004 Guide RNA Proteins 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 6
- 101710163270 Nuclease Proteins 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 108091033409 CRISPR Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 210000002257 embryonic structure Anatomy 0.000 description 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023171306A JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762592905P | 2017-11-30 | 2017-11-30 | |
| US62/592,905 | 2017-11-30 | ||
| US201862661373P | 2018-04-23 | 2018-04-23 | |
| US62/661,373 | 2018-04-23 | ||
| PCT/US2018/063390 WO2019108983A1 (en) | 2017-11-30 | 2018-11-30 | Non-human animals comprising a humanized trkb locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171306A Division JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021508236A JP2021508236A (ja) | 2021-03-04 |
| JP2021508236A5 true JP2021508236A5 (https=) | 2021-12-16 |
| JP7361031B2 JP7361031B2 (ja) | 2023-10-13 |
Family
ID=64734209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527921A Active JP7361031B2 (ja) | 2017-11-30 | 2018-11-30 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| JP2023171306A Active JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023171306A Active JP7610672B2 (ja) | 2017-11-30 | 2023-10-02 | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11419318B2 (https=) |
| EP (2) | EP4299732A3 (https=) |
| JP (2) | JP7361031B2 (https=) |
| KR (1) | KR102709884B1 (https=) |
| CN (2) | CN111655031B (https=) |
| AU (2) | AU2018375796B2 (https=) |
| CA (1) | CA3076377A1 (https=) |
| ES (1) | ES2973937T3 (https=) |
| IL (2) | IL310006A (https=) |
| SG (1) | SG11202002456WA (https=) |
| WO (1) | WO2019108983A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| JP7524158B2 (ja) * | 2019-03-04 | 2024-07-29 | 公益財団法人東京都医学総合研究所 | Ｔｒｋ断片をコードする核酸構築物、及びその利用 |
| EP4099821A1 (en) * | 2020-02-07 | 2022-12-14 | Regeneron Pharmaceuticals, Inc. | <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5877016A (en) * | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| AU8587598A (en) | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| WO2002003071A2 (en) | 2000-07-05 | 2002-01-10 | Pangene Corporation | Modulators of trk protein activity, compositions and uses |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US7060429B2 (en) * | 2001-02-22 | 2006-06-13 | University Of Maryland, Baltimore | Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms |
| AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| CN101117633B (zh) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | 一种细胞核移植方法 |
| CN101157730A (zh) | 2006-09-25 | 2008-04-09 | 南方医科大学珠江医院 | 一种携带神经营养因子穿过血脑屏障的融合蛋白及其编码基因与用途 |
| EP2214706A1 (en) * | 2007-10-23 | 2010-08-11 | Novartis AG | Use of trkb antibodies for the treatment of respiratory disorders |
| JP2011517838A (ja) | 2008-04-11 | 2011-06-16 | ユーティーシー パワー コーポレイション | マニホルド・サンプを備えたバイポーラプレートおよび燃料電池 |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8518392B2 (en) | 2009-08-14 | 2013-08-27 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| CA2779858C (en) | 2009-10-29 | 2019-10-29 | Regeneron Pharmaceuticals, Inc. | Multifunctional alleles |
| SMT202200205T1 (it) | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| SMT201900478T1 (it) | 2011-10-28 | 2019-09-09 | Regeneron Pharma | Topi con complesso maggiore di istocompatibilita' geneticamente modificati |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| SG11201406547YA (en) | 2012-04-25 | 2014-11-27 | Regeneron Pharma | Nuclease-mediated targeting with large targeting vectors |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| WO2014033644A2 (en) | 2012-08-28 | 2014-03-06 | Novartis Ag | Methods of nuclease-based genetic engineering |
| MX377561B (es) | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| PL3360964T3 (pl) | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| CN111484999B (zh) | 2013-02-20 | 2024-10-25 | 瑞泽恩制药公司 | 人源化的t细胞共受体的小鼠 |
| MX384291B (es) | 2013-02-20 | 2025-03-14 | Regeneron Pharma | Modificación genética de ratas. |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| RU2671101C1 (ru) | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| KR102170502B1 (ko) | 2013-12-11 | 2020-10-28 | 리제너론 파마슈티칼스 인코포레이티드 | 게놈의 표적화된 변형을 위한 방법 및 조성물 |
| RU2711322C1 (ru) | 2013-12-20 | 2020-01-16 | Ф. Хоффманн-Ля Рош Аг | Улучшенные способы получения рекомбинантного полипептида |
| EP3107565A4 (en) * | 2014-02-21 | 2017-08-23 | Regeneron Pharmaceuticals, Inc. | Methods, compositions and kits for cell specific modulation of target antigens |
| CN111690052B (zh) | 2014-04-08 | 2024-06-04 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| ES2936810T3 (es) * | 2014-05-16 | 2023-03-22 | Pfizer | Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería |
| MX2016014995A (es) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| IL287519B2 (en) | 2014-06-19 | 2024-01-01 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
| ES2781323T3 (es) | 2014-06-23 | 2020-09-01 | Regeneron Pharma | Montaje de ADN mediado por nucleasas |
| SI3161128T1 (sl) | 2014-06-26 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| KR102531016B1 (ko) | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| RU2726446C2 (ru) | 2014-11-24 | 2020-07-14 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| HUE064960T2 (hu) * | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN113412818B (zh) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| EP4248744A3 (en) | 2015-04-06 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| WO2017087780A1 (en) * | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| US11066474B2 (en) * | 2017-11-30 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Anti-TrkB monoclonal antibodies and methods of use |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
-
2018
- 2018-11-30 JP JP2020527921A patent/JP7361031B2/ja active Active
- 2018-11-30 AU AU2018375796A patent/AU2018375796B2/en active Active
- 2018-11-30 IL IL310006A patent/IL310006A/en unknown
- 2018-11-30 CN CN201880087972.5A patent/CN111655031B/zh active Active
- 2018-11-30 US US16/206,330 patent/US11419318B2/en active Active
- 2018-11-30 SG SG11202002456WA patent/SG11202002456WA/en unknown
- 2018-11-30 CN CN202211340155.0A patent/CN116064611A/zh active Pending
- 2018-11-30 CA CA3076377A patent/CA3076377A1/en active Pending
- 2018-11-30 IL IL274740A patent/IL274740B2/en unknown
- 2018-11-30 EP EP23207807.1A patent/EP4299732A3/en active Pending
- 2018-11-30 KR KR1020207013978A patent/KR102709884B1/ko active Active
- 2018-11-30 ES ES18821882T patent/ES2973937T3/es active Active
- 2018-11-30 EP EP18821882.0A patent/EP3585164B1/en active Active
- 2018-11-30 WO PCT/US2018/063390 patent/WO2019108983A1/en not_active Ceased
-
2022
- 2022-06-30 US US17/810,029 patent/US12396444B2/en active Active
-
2023
- 2023-10-02 JP JP2023171306A patent/JP7610672B2/ja active Active
-
2025
- 2025-02-07 AU AU2025200858A patent/AU2025200858A1/en active Pending
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