JP2018522553A5 - - Google Patents
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- JP2018522553A5 JP2018522553A5 JP2017568279A JP2017568279A JP2018522553A5 JP 2018522553 A5 JP2018522553 A5 JP 2018522553A5 JP 2017568279 A JP2017568279 A JP 2017568279A JP 2017568279 A JP2017568279 A JP 2017568279A JP 2018522553 A5 JP2018522553 A5 JP 2018522553A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- mrf4
- myod
- myf5
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100038379 Myogenic factor 6 Human genes 0.000 claims description 53
- 210000002459 blastocyst Anatomy 0.000 claims description 50
- 108010084677 myogenic factor 6 Proteins 0.000 claims description 50
- 101000958865 Homo sapiens Myogenic factor 5 Proteins 0.000 claims description 48
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims description 45
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims description 41
- 102100038380 Myogenic factor 5 Human genes 0.000 claims description 35
- 210000000472 morula Anatomy 0.000 claims description 28
- 210000004102 animal cell Anatomy 0.000 claims description 26
- 101150047028 MRF4 gene Proteins 0.000 claims description 24
- 101150042523 myod gene Proteins 0.000 claims description 24
- 101150097771 MYF5 gene Proteins 0.000 claims description 22
- 241000282898 Sus scrofa Species 0.000 claims description 17
- 230000035772 mutation Effects 0.000 claims description 17
- 210000000130 stem cell Anatomy 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 14
- 210000000287 oocyte Anatomy 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 108700028369 Alleles Proteins 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 210000001519 tissue Anatomy 0.000 claims description 9
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 6
- 241000283073 Equus caballus Species 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 210000002363 skeletal muscle cell Anatomy 0.000 claims description 6
- 101100025378 Homo sapiens MYF6 gene Proteins 0.000 claims description 4
- 108010054849 MyoD1 myogenic differentiation protein Proteins 0.000 claims description 4
- 102000049132 human MYF5 Human genes 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 101100025371 Homo sapiens MYF5 gene Proteins 0.000 claims description 2
- 235000008708 Morus alba Nutrition 0.000 claims description 2
- 240000000249 Morus alba Species 0.000 claims description 2
- 210000004504 adult stem cell Anatomy 0.000 claims description 2
- 210000004700 fetal blood Anatomy 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 210000002027 skeletal muscle Anatomy 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 3
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187027P | 2015-06-30 | 2015-06-30 | |
| US62/187,027 | 2015-06-30 | ||
| PCT/US2016/040378 WO2017004367A1 (en) | 2015-06-30 | 2016-06-30 | Humanized skeletal muscle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522553A JP2018522553A (ja) | 2018-08-16 |
| JP2018522553A5 true JP2018522553A5 (https=) | 2019-08-08 |
Family
ID=57609173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568279A Pending JP2018522553A (ja) | 2015-06-30 | 2016-06-30 | ヒト化骨格筋 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10874092B2 (https=) |
| EP (1) | EP3316898A4 (https=) |
| JP (1) | JP2018522553A (https=) |
| CN (1) | CN108135943A (https=) |
| AU (1) | AU2016288196A1 (https=) |
| BR (1) | BR112017028619A2 (https=) |
| CA (1) | CA2991053A1 (https=) |
| MX (1) | MX2018000273A (https=) |
| RU (1) | RU2018103093A (https=) |
| WO (1) | WO2017004367A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2978457A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| CN111808820A (zh) * | 2020-06-01 | 2020-10-23 | 贵州省种畜禽种质测定中心 | 基于CRISPRCAS9技术构建MyoD1基因敲除的MDBK细胞系的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2242666A1 (en) | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| EP1449431A4 (en) | 2001-10-24 | 2007-11-28 | Chugai Pharmaceutical Co Ltd | SGRF-TRANSGENIC NON-MENTAL ANIMAL |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| AU2003213813A1 (en) | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| JP2006506968A (ja) * | 2002-07-03 | 2006-03-02 | メルク エンド カムパニー インコーポレーテッド | アグーチ関連蛋白質欠損細胞、非ヒトトランスジェニック動物及びエネルギー代謝を調節する化合物の選択方法 |
| GB2398784B (en) * | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| DK2118271T3 (en) * | 2007-01-11 | 2018-07-23 | Univ Pittsburgh Commonwealth Sys Higher Education | MUSCLE DERIVATIVE CELLS FOR THE TREATMENT OF URINARY DISEASES AND PROCEDURES FOR THEIR PREPARATION AND USE |
| US20100107263A1 (en) | 2007-01-20 | 2010-04-29 | Boehringer Ingelheim International Gmbh & Co., Kg | C-reactive protein (crp) knockout mouse |
| JPWO2008102602A1 (ja) | 2007-02-22 | 2010-05-27 | 国立大学法人 東京大学 | Ｂｌａｓｔｏｃｙｓｔｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法 |
| WO2009104794A1 (ja) | 2008-02-22 | 2009-08-27 | 国立大学法人 東京大学 | 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法 |
| GB2475656B (en) | 2008-08-22 | 2013-04-24 | Univ Tokyo | Organ regeneration method utilizing ips cell and blastocyst complementation |
| US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| AU2010251151B2 (en) | 2009-05-20 | 2015-08-20 | Cardio3 Biosciences S.A. | Pharmaceutical Composition for the Treatment of Heart Diseases |
| BR112013021785A8 (pt) * | 2011-02-25 | 2018-07-03 | Recombinetics Inc | animais geneticamente modificados e métodos para fazer os mesmos |
| KR102068107B1 (ko) | 2011-04-27 | 2020-01-20 | 아미리스 인코퍼레이티드 | 게놈 변형 방법 |
| KR101970634B1 (ko) | 2011-06-02 | 2019-04-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 생체외 조직 배양 시스템을 위한 방법 및 용도 |
| WO2013073246A1 (en) * | 2011-11-18 | 2013-05-23 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| WO2015168125A1 (en) | 2014-04-28 | 2015-11-05 | Recombinetics, Inc. | Multiplex gene editing in swine |
| CA2978457A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
| CN108697067A (zh) | 2015-10-27 | 2018-10-23 | 明尼苏达大学评议会 | 嵌合胚胎-辅助的器官制备的组合物和方法 |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 RU RU2018103093A patent/RU2018103093A/ru not_active Application Discontinuation
- 2016-06-30 CA CA2991053A patent/CA2991053A1/en not_active Abandoned
- 2016-06-30 AU AU2016288196A patent/AU2016288196A1/en not_active Abandoned
- 2016-06-30 JP JP2017568279A patent/JP2018522553A/ja active Pending
- 2016-06-30 CN CN201680049673.3A patent/CN108135943A/zh active Pending
- 2016-06-30 BR BR112017028619A patent/BR112017028619A2/pt not_active Application Discontinuation
- 2016-06-30 US US15/739,042 patent/US10874092B2/en active Active
- 2016-06-30 EP EP16818785.4A patent/EP3316898A4/en active Pending
- 2016-06-30 MX MX2018000273A patent/MX2018000273A/es unknown
- 2016-06-30 WO PCT/US2016/040378 patent/WO2017004367A1/en not_active Ceased
-
2020
- 2020-11-19 US US16/952,807 patent/US12089574B2/en active Active
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