RU2018103093A - Гуманизированная скелетная мышца - Google Patents
Гуманизированная скелетная мышца Download PDFInfo
- Publication number
- RU2018103093A RU2018103093A RU2018103093A RU2018103093A RU2018103093A RU 2018103093 A RU2018103093 A RU 2018103093A RU 2018103093 A RU2018103093 A RU 2018103093A RU 2018103093 A RU2018103093 A RU 2018103093A RU 2018103093 A RU2018103093 A RU 2018103093A
- Authority
- RU
- Russia
- Prior art keywords
- gene
- mrf4
- myod
- myf5
- human animal
- Prior art date
Links
- 210000002027 skeletal muscle Anatomy 0.000 title claims 10
- 102100038379 Myogenic factor 6 Human genes 0.000 claims 26
- 101000958865 Homo sapiens Myogenic factor 5 Proteins 0.000 claims 25
- 210000002459 blastocyst Anatomy 0.000 claims 25
- 108010084677 myogenic factor 6 Proteins 0.000 claims 24
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims 22
- 210000004027 cell Anatomy 0.000 claims 21
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims 20
- 102100038380 Myogenic factor 5 Human genes 0.000 claims 19
- 241000282898 Sus scrofa Species 0.000 claims 18
- 101150097771 MYF5 gene Proteins 0.000 claims 15
- 101150042523 myod gene Proteins 0.000 claims 15
- 101150047028 MRF4 gene Proteins 0.000 claims 14
- 210000000472 morula Anatomy 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 210000004940 nucleus Anatomy 0.000 claims 8
- 210000000287 oocyte Anatomy 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000283073 Equus caballus Species 0.000 claims 3
- 101100025378 Homo sapiens MYF6 gene Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 108010054849 MyoD1 myogenic differentiation protein Proteins 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 102000049132 human MYF5 Human genes 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000004504 adult stem cell Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 210000004287 null lymphocyte Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 235000015277 pork Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187027P | 2015-06-30 | 2015-06-30 | |
| US62/187,027 | 2015-06-30 | ||
| PCT/US2016/040378 WO2017004367A1 (en) | 2015-06-30 | 2016-06-30 | Humanized skeletal muscle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018103093A true RU2018103093A (ru) | 2019-07-31 |
Family
ID=57609173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018103093A RU2018103093A (ru) | 2015-06-30 | 2016-06-30 | Гуманизированная скелетная мышца |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10874092B2 (https=) |
| EP (1) | EP3316898A4 (https=) |
| JP (1) | JP2018522553A (https=) |
| CN (1) | CN108135943A (https=) |
| AU (1) | AU2016288196A1 (https=) |
| BR (1) | BR112017028619A2 (https=) |
| CA (1) | CA2991053A1 (https=) |
| MX (1) | MX2018000273A (https=) |
| RU (1) | RU2018103093A (https=) |
| WO (1) | WO2017004367A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2978457A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| CN111808820A (zh) * | 2020-06-01 | 2020-10-23 | 贵州省种畜禽种质测定中心 | 基于CRISPRCAS9技术构建MyoD1基因敲除的MDBK细胞系的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2242666A1 (en) | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| EP1449431A4 (en) | 2001-10-24 | 2007-11-28 | Chugai Pharmaceutical Co Ltd | SGRF-TRANSGENIC NON-MENTAL ANIMAL |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| AU2003213813A1 (en) | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| JP2006506968A (ja) * | 2002-07-03 | 2006-03-02 | メルク エンド カムパニー インコーポレーテッド | アグーチ関連蛋白質欠損細胞、非ヒトトランスジェニック動物及びエネルギー代謝を調節する化合物の選択方法 |
| GB2398784B (en) * | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| DK2118271T3 (en) * | 2007-01-11 | 2018-07-23 | Univ Pittsburgh Commonwealth Sys Higher Education | MUSCLE DERIVATIVE CELLS FOR THE TREATMENT OF URINARY DISEASES AND PROCEDURES FOR THEIR PREPARATION AND USE |
| US20100107263A1 (en) | 2007-01-20 | 2010-04-29 | Boehringer Ingelheim International Gmbh & Co., Kg | C-reactive protein (crp) knockout mouse |
| JPWO2008102602A1 (ja) | 2007-02-22 | 2010-05-27 | 国立大学法人 東京大学 | Ｂｌａｓｔｏｃｙｓｔｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法 |
| WO2009104794A1 (ja) | 2008-02-22 | 2009-08-27 | 国立大学法人 東京大学 | 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法 |
| GB2475656B (en) | 2008-08-22 | 2013-04-24 | Univ Tokyo | Organ regeneration method utilizing ips cell and blastocyst complementation |
| US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| AU2010251151B2 (en) | 2009-05-20 | 2015-08-20 | Cardio3 Biosciences S.A. | Pharmaceutical Composition for the Treatment of Heart Diseases |
| BR112013021785A8 (pt) * | 2011-02-25 | 2018-07-03 | Recombinetics Inc | animais geneticamente modificados e métodos para fazer os mesmos |
| KR102068107B1 (ko) | 2011-04-27 | 2020-01-20 | 아미리스 인코퍼레이티드 | 게놈 변형 방법 |
| KR101970634B1 (ko) | 2011-06-02 | 2019-04-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 생체외 조직 배양 시스템을 위한 방법 및 용도 |
| WO2013073246A1 (en) * | 2011-11-18 | 2013-05-23 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| WO2015168125A1 (en) | 2014-04-28 | 2015-11-05 | Recombinetics, Inc. | Multiplex gene editing in swine |
| CA2978457A1 (en) | 2015-03-03 | 2016-09-09 | Regents Of The University Of Minnesota | Etv2 and uses thereof |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
| CN108697067A (zh) | 2015-10-27 | 2018-10-23 | 明尼苏达大学评议会 | 嵌合胚胎-辅助的器官制备的组合物和方法 |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 RU RU2018103093A patent/RU2018103093A/ru not_active Application Discontinuation
- 2016-06-30 CA CA2991053A patent/CA2991053A1/en not_active Abandoned
- 2016-06-30 AU AU2016288196A patent/AU2016288196A1/en not_active Abandoned
- 2016-06-30 JP JP2017568279A patent/JP2018522553A/ja active Pending
- 2016-06-30 CN CN201680049673.3A patent/CN108135943A/zh active Pending
- 2016-06-30 BR BR112017028619A patent/BR112017028619A2/pt not_active Application Discontinuation
- 2016-06-30 US US15/739,042 patent/US10874092B2/en active Active
- 2016-06-30 EP EP16818785.4A patent/EP3316898A4/en active Pending
- 2016-06-30 MX MX2018000273A patent/MX2018000273A/es unknown
- 2016-06-30 WO PCT/US2016/040378 patent/WO2017004367A1/en not_active Ceased
-
2020
- 2020-11-19 US US16/952,807 patent/US12089574B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016288196A1 (en) | 2018-02-01 |
| CN108135943A (zh) | 2018-06-08 |
| US10874092B2 (en) | 2020-12-29 |
| WO2017004367A1 (en) | 2017-01-05 |
| EP3316898A4 (en) | 2019-02-27 |
| BR112017028619A2 (pt) | 2018-09-04 |
| EP3316898A1 (en) | 2018-05-09 |
| US20180177166A1 (en) | 2018-06-28 |
| CA2991053A1 (en) | 2017-01-05 |
| US12089574B2 (en) | 2024-09-17 |
| JP2018522553A (ja) | 2018-08-16 |
| US20210161110A1 (en) | 2021-06-03 |
| MX2018000273A (es) | 2018-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hall et al. | Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals | |
| BR112016029650A2 (pt) | roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor? | |
| JP2015533284A5 (https=) | ||
| RU2018103093A (ru) | Гуманизированная скелетная мышца | |
| JP2016519955A5 (https=) | ||
| BR112016002385A2 (pt) | animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotente | |
| IL274740B2 (en) | Non-human animals comprising a humanized trkb locus | |
| Hong et al. | Dogs cloned from fetal fibroblasts by nuclear transfer | |
| RU2017132331A (ru) | Etv2 и его применения | |
| Singh et al. | The domesticated buffalo-an emerging model for experimental and therapeutic use of extraembryonic tissues | |
| RU2015122802A (ru) | Клонированное животное, отличное от человека, которое не содержит селективный маркер | |
| RU2018103234A (ru) | Гуманизированная мышца сердца | |
| JP2016502407A5 (https=) | ||
| JP2018522553A5 (https=) | ||
| JP2018506984A5 (https=) | ||
| JP2018523999A5 (https=) | ||
| Secher et al. | Initial embryology and pluripotent stem cells in the pig—The quest for establishing the pig as a model for cell therapy | |
| Ibtisham et al. | Animal cloning applications and issues | |
| Reardon | Hybrid zoo: introducing pig–human embryos and a rat–mouse | |
| JP2018520682A5 (https=) | ||
| Hussain et al. | CRISPR/Cas System and Stem Cell Editing: Prospects and Possibilities in Veterinary Sciences | |
| Singh et al. | Animal Stem Cells—A Perspective on Their Use in Human Health | |
| Song et al. | Developmental analysis of reconstructed embryos of second‐generation cloned transgenic goats | |
| JP6366944B2 (ja) | プライム型多能性幹細胞からキメラ形成能を向上させた多能性幹細胞を製造する方法並びにそのための組成物および組合せ | |
| Eghbalsaied et al. | In vivo evaluation of ovine sperm/embryo ability in mediating transgenic lamb |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20190701 |