|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4656134A
(en)
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US5149636A
(en)
|
1982-03-15 |
1992-09-22 |
Trustees Of Columbia University In The City Of New York |
Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US4956288A
(en)
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5057604A
(en)
|
1988-08-03 |
1991-10-15 |
Washington University |
Novel monoclonal antibodies
|
|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5266491A
(en)
|
1989-03-14 |
1993-11-30 |
Mochida Pharmaceutical Co., Ltd. |
DNA fragment and expression plasmid containing the DNA fragment
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5580734A
(en)
|
1990-07-13 |
1996-12-03 |
Transkaryotic Therapies, Inc. |
Method of producing a physical map contigous DNA sequences
|
|
US5278299A
(en)
|
1991-03-18 |
1994-01-11 |
Scripps Clinic And Research Foundation |
Method and composition for synthesizing sialylated glycosyl compounds
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5641670A
(en)
|
1991-11-05 |
1997-06-24 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US5733761A
(en)
|
1991-11-05 |
1998-03-31 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
WO1993010260A1
(en)
|
1991-11-21 |
1993-05-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
DK0871490T3
(da)
|
1995-12-22 |
2003-07-07 |
Bristol Myers Squibb Co |
Forgrenede hydrazonlinkere
|
|
HUP0003513A3
(en)
|
1997-09-11 |
2004-05-28 |
Chugai Pharmaceutical Co Ltd |
Monoclonal antibody inducing apoptosis
|
|
CA2226962A1
(en)
|
1998-02-16 |
1999-08-16 |
Marie Sarfati |
Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection
|
|
US7696325B2
(en)
|
1999-03-10 |
2010-04-13 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptide inducing apoptosis
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
US7393531B2
(en)
*
|
2003-01-21 |
2008-07-01 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of MCSP
|
|
US20040213792A1
(en)
|
2003-04-24 |
2004-10-28 |
Clemmons David R. |
Method for inhibiting cellular activation by insulin-like growth factor-1
|
|
US8613922B2
(en)
|
2003-04-24 |
2013-12-24 |
The University Of North Carolina At Chapel Hill |
Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
|
|
JP3936673B2
(ja)
|
2003-06-02 |
2007-06-27 |
国立大学法人群馬大学 |
Ｃｄ４７部分ペプチドと抗ｓｈｐｓ−１モノクロナール抗体
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
CA2545166A1
(en)
|
2003-11-11 |
2005-05-19 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized anti-cd47 antibody
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
ES2708763T3
(es)
|
2005-07-07 |
2019-04-11 |
Seattle Genetics Inc |
Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
|
|
US7514229B2
(en)
|
2005-09-29 |
2009-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for diagnosing and evaluating treatment of blood disorders
|
|
US20090304719A1
(en)
|
2007-08-22 |
2009-12-10 |
Patrick Daugherty |
Activatable binding polypeptides and methods of identification and use thereof
|
|
EP2573112A1
(en)
|
2007-10-11 |
2013-03-27 |
The Hospital For Sick Children |
Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
KR100936277B1
(ko)
|
2007-11-20 |
2010-01-13 |
한국과학기술연구원 |
스핑고모나스 속 박테리아 균주와 아스페질러스 속 곰팡이균주의 혼합배양방법, 이로부터 유래한 신규항암-항생물질인 글리오니트린, 및 상기 글리오니트린 또는이의 약학적으로 허용가능한 염을 유효성분으로 하는약학적 조성물
|
|
EP3043181B1
(en)
|
2008-01-15 |
2020-04-08 |
The Board of Trustees of the Leland Stanford Junior University |
Markers of acute myeloid leukemia stem cells
|
|
ES2582340T3
(es)
|
2008-01-15 |
2016-09-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Métodos para manipular fagocitosis mediada por CD47
|
|
EP2111869A1
(en)
|
2008-04-23 |
2009-10-28 |
Stichting Sanquin Bloedvoorziening |
Compositions and methods to enhance the immune system
|
|
WO2009135181A2
(en)
|
2008-05-02 |
2009-11-05 |
Seattle Genetics, Inc. |
Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
|
|
AU2009279676C1
(en)
|
2008-08-07 |
2015-08-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Radioprotectants targeting thrombospondin-1 and CD47
|
|
US8895702B2
(en)
*
|
2008-12-08 |
2014-11-25 |
City Of Hope |
Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies
|
|
RU2636046C2
(ru)
|
2009-01-12 |
2017-11-17 |
Сайтомкс Терапьютикс, Инк |
Композиции модифицированных антител, способы их получения и применения
|
|
EP2478013B1
(en)
|
2009-09-16 |
2018-10-24 |
F.Hoffmann-La Roche Ag |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
US20110206696A1
(en)
|
2010-01-25 |
2011-08-25 |
The Washington University |
Methods for inhibiting bone loss and bone metastasis
|
|
PT2569013T
(pt)
*
|
2010-05-14 |
2017-02-08 |
Univ Leland Stanford Junior |
Anticorpos monoclonais humanizados e quiméricos para cd47
|
|
US20140271683A1
(en)
|
2010-12-21 |
2014-09-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor
|
|
ES2816647T3
(es)
|
2012-01-17 |
2021-04-05 |
Univ Leland Stanford Junior |
Reactivos SIRP-alfa de alta afinidad
|
|
KR102100388B1
(ko)
|
2012-02-06 |
2020-04-13 |
인히브릭스, 인크. |
Cd47 항체 및 그 사용 방법
|
|
US9487590B2
(en)
*
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
DK3725807T3
(da)
|
2012-12-03 |
2026-01-12 |
Novimmune Sa |
Anti-cd47 antistoffer og fremgangsmåder til anvendelse deraf
|
|
BR112015013431A2
(pt)
|
2012-12-12 |
2017-11-14 |
Vasculox Inc |
anticorpos monoclonais ou respectivos fragmentos ligantes de antígenos, composição farmacêutica, e usos de anticorpo monoclonal ou respectivo fragmento ligante de antígenos
|
|
US9221908B2
(en)
|
2012-12-12 |
2015-12-29 |
Vasculox, Inc. |
Therapeutic CD47 antibodies
|
|
CN105008918A
(zh)
|
2013-01-04 |
2015-10-28 |
西托姆克斯治疗公司 |
用于检测生物系统中的蛋白酶活性的组合物和方法
|
|
EP2953633B1
(en)
|
2013-02-05 |
2017-10-04 |
The Board of Trustees of the Leland Stanford Junior University |
Cd47 targeted therapies for the treatment of infectious disease
|
|
AU2014244083B2
(en)
|
2013-03-13 |
2018-09-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods for modulating chemotherapeutic cytotoxicity
|
|
CN112245586A
(zh)
|
2013-03-15 |
2021-01-22 |
小利兰·斯坦福大学托管委员会 |
用于实现治疗有效剂量的抗cd47剂的方法
|
|
US9945870B2
(en)
|
2013-05-17 |
2018-04-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for determining responsiveness to an anti-CD47 agent
|
|
WO2014193973A2
(en)
|
2013-05-28 |
2014-12-04 |
Dcb-Usa Llc |
Antibody locker for the inactivation of protein drug
|
|
NZ718283A
(en)
|
2013-09-25 |
2022-05-27 |
Cytomx Therapeutics Inc |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
|
|
WO2015086727A2
(en)
|
2013-12-11 |
2015-06-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New prognostic method for patients suffering of a cancer
|
|
CN105611944A
(zh)
|
2013-12-20 |
2016-05-25 |
豪夫迈·罗氏有限公司 |
抗ang2抗体和cd40激动剂的组合疗法
|
|
CN106456748A
(zh)
|
2014-01-08 |
2017-02-22 |
小利兰·斯坦福大学托管委员会 |
小细胞肺癌的靶向疗法
|
|
US10385380B2
(en)
|
2014-10-02 |
2019-08-20 |
The Regents Of The University Of California |
Personalized protease assay to measure protease activity in neoplasms
|
|
EP3204420B1
(en)
|
2014-10-10 |
2020-09-02 |
The United States of America, as represented by The Secretary, Department of Health and Human Services |
Methods to eliminate cancer stem cells by targeting cd47
|
|
CA2959821C
(en)
|
2014-10-24 |
2024-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for inducing phagocytosis of MHC class I positive cells and for overcoming resistance to anti-CD47 agents/SIRPA
|
|
BR112017008959A2
(pt)
|
2014-10-29 |
2018-01-16 |
Seattle Genetics, Inc. |
método para tratamento de uma doença.
|
|
EP3221358B1
(en)
|
2014-11-18 |
2021-07-21 |
Janssen Pharmaceutica, N.V. |
Cd47 antibodies, methods, and uses
|
|
MX391051B
(es)
|
2014-12-30 |
2025-03-21 |
Celgene Corp |
Anticuerpos anti-cd47 y usos de los mismos.
|
|
KR102625835B1
(ko)
|
2015-03-04 |
2024-01-17 |
주식회사유한양행 |
Cd47에 결합하는 항체 치료제
|
|
CA2984892A1
(en)
*
|
2015-05-04 |
2016-11-10 |
Cytomx Therapeutics, Inc. |
Anti-itga3 antibodies, activatable anti-itga3 antibodies, and methods of use thereof
|
|
WO2017012771A1
(en)
|
2015-07-23 |
2017-01-26 |
Ratiopharm Gmbh |
Crystalline filgotinib sulfonic acid addition salts
|
|
TWI572317B
(zh)
|
2015-08-05 |
2017-03-01 |
梓源生技有限公司 |
體內固定裝置
|
|
US20170071918A1
(en)
|
2015-09-16 |
2017-03-16 |
The University Of Hong Kong |
Combination Use of CD47 Antibodies/Inhibitors with Sorafenib for Treatment of Liver Cancer
|
|
RU2748401C2
(ru)
|
2015-09-18 |
2021-05-25 |
Арч Онколоджи, Инк. |
Терапевтические антитела к CD47
|
|
WO2017053423A1
(en)
|
2015-09-21 |
2017-03-30 |
Erasmus University Medical Center |
Anti-cd47 antibodies and methods of use
|
|
CN108367073A
(zh)
|
2015-12-11 |
2018-08-03 |
小利兰·斯坦福大学托管委员会 |
以双重靶向cd47和egfr来治疗癌症
|
|
PT3402820T
(pt)
*
|
2016-01-11 |
2020-08-20 |
Forty Seven Inc |
Anticorpos monoclonais anti-cd47 quiméricos, de ratinho ou humanizados
|
|
US20170210803A1
(en)
|
2016-01-21 |
2017-07-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of cancer with combinations of immunoregulatory agents
|
|
EP3454900A4
(en)
|
2016-05-09 |
2020-01-29 |
Celgene Corporation |
CD47 ANTIBODIES AND METHODS OF USE
|
|
US20190135921A1
(en)
|
2016-05-19 |
2019-05-09 |
Adaerata, Limited Partnership |
Methods of preventing or treating slamf7 positive and slamf7 negative cancers
|
|
CN106084052B
(zh)
|
2016-06-17 |
2019-12-27 |
长春金赛药业股份有限公司 |
抗cd47单克隆抗体及其应用
|
|
CN117717604A
(zh)
|
2016-07-19 |
2024-03-19 |
梯瓦制药澳大利亚股份有限公司 |
抗cd47联合治疗
|
|
AU2017332960B2
(en)
|
2016-10-20 |
2019-09-12 |
I-Mab Biopharma Us Limited |
Novel CD47 monoclonal antibodies and uses thereof
|
|
US11352425B2
(en)
|
2016-11-08 |
2022-06-07 |
Absos, Llc |
Anti-CD47 antibodies
|
|
CN108779179B
(zh)
|
2016-11-28 |
2022-02-08 |
江苏恒瑞医药股份有限公司 |
Cd47抗体、其抗原结合片段及其医药用途
|
|
BR112019011564A2
(pt)
|
2016-12-09 |
2019-10-22 |
Seattle Genetics Inc |
anticorpos bivalentes mascarados por hélices superenroladas
|
|
EP3345924A1
(en)
|
2017-01-10 |
2018-07-11 |
Universität Duisburg-Essen |
Use of cd47 antibodies
|
|
WO2018137705A1
(en)
|
2017-01-26 |
2018-08-02 |
Zai Lab (Shanghai) Co., Ltd. |
Cd47 antigen binding unit and uses thereof
|
|
JP7262440B2
(ja)
|
2017-08-02 |
2023-04-21 |
フェインズ セラピューティクス，インコーポレーテッド |
抗ｃｄ４７抗体及びその使用
|
|
CN109422811A
(zh)
|
2017-08-29 |
2019-03-05 |
信达生物制药(苏州)有限公司 |
抗cd47抗体及其用途
|
|
CN108503708B
(zh)
|
2017-09-01 |
2021-07-30 |
北京智仁美博生物科技有限公司 |
抗人cd47抗体及其用途
|