CA3083946A1 - Cd47 antibodies and uses thereof for treating cancer - Google Patents
Cd47 antibodies and uses thereof for treating cancer Download PDFInfo
- Publication number
- CA3083946A1 CA3083946A1 CA3083946A CA3083946A CA3083946A1 CA 3083946 A1 CA3083946 A1 CA 3083946A1 CA 3083946 A CA3083946 A CA 3083946A CA 3083946 A CA3083946 A CA 3083946A CA 3083946 A1 CA3083946 A1 CA 3083946A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- antibody
- nos
- cancer
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762593712P | 2017-12-01 | 2017-12-01 | |
| US62/593,712 | 2017-12-01 | ||
| PCT/US2018/062961 WO2019108733A2 (en) | 2017-12-01 | 2018-11-29 | Cd47 antibodies and uses thereof for treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3083946A1 true CA3083946A1 (en) | 2019-06-06 |
Family
ID=64665131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3083946A Pending CA3083946A1 (en) | 2017-12-01 | 2018-11-29 | Cd47 antibodies and uses thereof for treating cancer |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11180552B2 (https=) |
| EP (1) | EP3717515A2 (https=) |
| JP (2) | JP7391845B2 (https=) |
| KR (1) | KR20200091901A (https=) |
| CN (1) | CN111448213A (https=) |
| AR (1) | AR113862A1 (https=) |
| AU (1) | AU2018375375A1 (https=) |
| BR (1) | BR112020009805A2 (https=) |
| CA (1) | CA3083946A1 (https=) |
| EA (1) | EA202091339A1 (https=) |
| IL (1) | IL274519A (https=) |
| MA (1) | MA51208A (https=) |
| MX (1) | MX2020005463A (https=) |
| SG (1) | SG11202004864TA (https=) |
| TW (1) | TWI831759B (https=) |
| WO (1) | WO2019108733A2 (https=) |
| ZA (1) | ZA202002923B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210163562A1 (en) * | 2018-07-25 | 2021-06-03 | AskGene Pharma, Inc. | Novel IL-21 Prodrugs and Methods of Use Thereof |
| US12600762B2 (en) | 2020-01-11 | 2026-04-14 | AskGene Pharma, Inc. | Masked cytokines and methods of use thereof |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201991353A1 (ru) * | 2016-12-09 | 2019-11-29 | Двухвалентные антитела, маскированные спирализованными спиралями | |
| US20220233709A1 (en) * | 2019-06-05 | 2022-07-28 | Seagen Inc. | Masked Antibody Formulations |
| US20220306727A1 (en) * | 2019-06-05 | 2022-09-29 | Seagen Inc. | Methods of Purifying Masked Antibodies |
| EP3986935A4 (en) * | 2019-06-19 | 2023-08-30 | Lepu Biopharma Co., Ltd. | Anti-cd47 antibodies and uses thereof |
| CN114761041A (zh) | 2019-07-16 | 2022-07-15 | 吉利德科学公司 | Hiv疫苗及其制备和使用方法 |
| CN114555123B (zh) | 2019-10-18 | 2024-04-02 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
| KR20220091576A (ko) | 2019-10-31 | 2022-06-30 | 포티 세븐, 인코포레이티드 | 혈액암의 항-cd47 및 항-cd20 기반 치료 |
| LT4081305T (lt) | 2019-12-24 | 2024-11-25 | Carna Biosciences, Inc. | Diacilglicerolio kinazę moduliuojantys junginiai |
| KR20260017503A (ko) | 2020-02-14 | 2026-02-05 | 길리애드 사이언시즈, 인코포레이티드 | Ccr8에 결합하는 항체 및 융합 단백질, 및 이의 용도 |
| CN115485300A (zh) * | 2020-02-26 | 2022-12-16 | 索伦托药业有限公司 | 具有通用掩蔽部分的可活化的抗原结合蛋白 |
| US12091681B2 (en) | 2020-03-27 | 2024-09-17 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| BR112022019841A2 (pt) | 2020-04-09 | 2022-12-06 | Cytomx Therapeutics Inc | Composições contendo anticorpos ativáveis |
| EP4168451A2 (en) | 2020-06-22 | 2023-04-26 | NGM Biopharmaceuticals, Inc. | Lair-1-binding agents and methods of use thereof |
| CN116133679A (zh) | 2020-06-30 | 2023-05-16 | 门德斯有限公司 | 白血病衍生细胞在卵巢癌疫苗中的用途 |
| WO2022007947A1 (zh) * | 2020-07-10 | 2022-01-13 | 信达生物制药(苏州)有限公司 | 抗cd47抗体或其抗原结合片段和dna甲基化转移酶抑制剂的组合及其用途 |
| JP7789304B2 (ja) * | 2020-07-31 | 2025-12-22 | バイオ－テラ ソリュ－ションズ，エルティーディー． | Ｃｄ４７抗体及びその応用 |
| WO2022057939A1 (en) * | 2020-09-21 | 2022-03-24 | I-Mab Biopharma Co., Ltd. | Pharmaceutical composition comprising cd47 antibody and pd-1/pd-l1 inhibitor |
| US20220119549A1 (en) * | 2020-10-15 | 2022-04-21 | Tavotek Biotherapeutics (Hong Kong) Limited | Shielded biologics with masking domains to shield antigen binding capability of biologics and uses thereof |
| MX2023009717A (es) * | 2021-02-19 | 2024-01-08 | Shaperon Inc | Anticuerpo de dominio individual contra cúmulo de diferenciación 47 (cd47) y uso del mismo. |
| KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP2024527551A (ja) | 2021-06-29 | 2024-07-25 | シージェン インコーポレイテッド | 非フコシル化抗ｃｄ７０抗体及びｃｄ４７アンタゴニストの組み合わせを用いるがんを処置する方法 |
| EP4370211A1 (en) * | 2021-07-14 | 2024-05-22 | Seagen Inc. | Antibody masking domains |
| CN115925940B (zh) * | 2021-08-24 | 2026-02-27 | 上海鑫湾生物科技有限公司 | 特异性结合cd47的抗体、其重组溶瘤病毒及其用途 |
| AR127270A1 (es) * | 2021-10-09 | 2024-01-03 | Hutchmed Ltd | Formulación de anticuerpos anti-cd47 |
| WO2023070353A1 (en) * | 2021-10-27 | 2023-05-04 | Adagene Pte. Ltd. | Anti-cd47 antibodies and methods of use thereof |
| US20230183216A1 (en) | 2021-10-28 | 2023-06-15 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| EP4422756A1 (en) | 2021-10-29 | 2024-09-04 | Gilead Sciences, Inc. | Cd73 compounds |
| CN118488946A (zh) | 2021-12-22 | 2024-08-13 | 吉利德科学公司 | Ikaros锌指家族降解剂及其用途 |
| EP4452415B1 (en) | 2021-12-22 | 2026-02-25 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023122882A1 (zh) * | 2021-12-27 | 2023-07-06 | 上海鑫湾生物科技有限公司 | 双特异性t细胞衔接器、其重组溶瘤病毒及其用途 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| CA3253296A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Zinc Finger Degradation Agents of the Ikaros Family and Their Uses |
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-
2018
- 2018-11-29 KR KR1020207018697A patent/KR20200091901A/ko not_active Withdrawn
- 2018-11-29 AU AU2018375375A patent/AU2018375375A1/en not_active Abandoned
- 2018-11-29 CN CN201880077186.7A patent/CN111448213A/zh active Pending
- 2018-11-29 MA MA051208A patent/MA51208A/fr unknown
- 2018-11-29 CA CA3083946A patent/CA3083946A1/en active Pending
- 2018-11-29 JP JP2020529364A patent/JP7391845B2/ja active Active
- 2018-11-29 MX MX2020005463A patent/MX2020005463A/es unknown
- 2018-11-29 TW TW107142777A patent/TWI831759B/zh not_active IP Right Cessation
- 2018-11-29 US US16/203,809 patent/US11180552B2/en active Active
- 2018-11-29 SG SG11202004864TA patent/SG11202004864TA/en unknown
- 2018-11-29 AR ARP180103511A patent/AR113862A1/es not_active Application Discontinuation
- 2018-11-29 WO PCT/US2018/062961 patent/WO2019108733A2/en not_active Ceased
- 2018-11-29 BR BR112020009805-1A patent/BR112020009805A2/pt not_active IP Right Cessation
- 2018-11-29 EP EP18819299.1A patent/EP3717515A2/en not_active Withdrawn
- 2018-11-29 EA EA202091339A patent/EA202091339A1/ru unknown
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2020
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- 2020-05-19 ZA ZA2020/02923A patent/ZA202002923B/en unknown
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2021
- 2021-10-20 US US17/505,911 patent/US12071480B2/en active Active
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210163562A1 (en) * | 2018-07-25 | 2021-06-03 | AskGene Pharma, Inc. | Novel IL-21 Prodrugs and Methods of Use Thereof |
| US12459980B2 (en) * | 2018-07-25 | 2025-11-04 | AskGene Pharma, Inc. | IL-21 prodrugs and methods of use thereof |
| US12600762B2 (en) | 2020-01-11 | 2026-04-14 | AskGene Pharma, Inc. | Masked cytokines and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202002923B (en) | 2022-12-21 |
| JP2021503927A (ja) | 2021-02-15 |
| MX2020005463A (es) | 2020-09-07 |
| US11180552B2 (en) | 2021-11-23 |
| AR113862A1 (es) | 2020-06-17 |
| US20190185561A1 (en) | 2019-06-20 |
| WO2019108733A3 (en) | 2019-08-15 |
| TW201925227A (zh) | 2019-07-01 |
| KR20200091901A (ko) | 2020-07-31 |
| MA51208A (fr) | 2020-10-07 |
| US20220135674A1 (en) | 2022-05-05 |
| BR112020009805A2 (pt) | 2020-10-13 |
| JP7391845B2 (ja) | 2023-12-05 |
| SG11202004864TA (en) | 2020-06-29 |
| TWI831759B (zh) | 2024-02-11 |
| JP2024026144A (ja) | 2024-02-28 |
| AU2018375375A1 (en) | 2020-05-28 |
| EA202091339A1 (ru) | 2020-10-21 |
| WO2019108733A2 (en) | 2019-06-06 |
| CN111448213A (zh) | 2020-07-24 |
| IL274519A (en) | 2020-06-30 |
| US12071480B2 (en) | 2024-08-27 |
| EP3717515A2 (en) | 2020-10-07 |
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