JP2021502333A5 - - Google Patents
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- Publication number
- JP2021502333A5 JP2021502333A5 JP2020523700A JP2020523700A JP2021502333A5 JP 2021502333 A5 JP2021502333 A5 JP 2021502333A5 JP 2020523700 A JP2020523700 A JP 2020523700A JP 2020523700 A JP2020523700 A JP 2020523700A JP 2021502333 A5 JP2021502333 A5 JP 2021502333A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- iii
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OMVZUSOTKKSRIM-CMDGGOBGSA-N CC(C)CC(CC(C(C(O)=O)C(O)=O)/C=C/c1ccccc1)=O Chemical compound CC(C)CC(CC(C(C(O)=O)C(O)=O)/C=C/c1ccccc1)=O OMVZUSOTKKSRIM-CMDGGOBGSA-N 0.000 description 1
- ZISJNXNHJRQYJO-CMDGGOBGSA-N CC(C)c(c(O)cc(/C=C/c1ccccc1)c1)c1O Chemical compound CC(C)c(c(O)cc(/C=C/c1ccccc1)c1)c1O ZISJNXNHJRQYJO-CMDGGOBGSA-N 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021113606A JP7166399B2 (ja) | 2017-11-10 | 2021-07-08 | タピナロフを調製するためのプロセス |
| JP2022148508A JP2023002516A (ja) | 2017-11-10 | 2022-09-16 | タピナロフを調製するためのプロセス |
| JP2024022828A JP2024069233A (ja) | 2017-11-10 | 2024-02-19 | タピナロフを調製するためのプロセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762584192P | 2017-11-10 | 2017-11-10 | |
| US62/584,192 | 2017-11-10 | ||
| PCT/US2018/060749 WO2019094934A1 (en) | 2017-11-10 | 2018-11-13 | Process for preparing tapinarof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020216295A Division JP2021063100A (ja) | 2017-11-10 | 2020-12-25 | タピナロフを調製するためのプロセス |
| JP2021113606A Division JP7166399B2 (ja) | 2017-11-10 | 2021-07-08 | タピナロフを調製するためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502333A JP2021502333A (ja) | 2021-01-28 |
| JP2021502333A5 true JP2021502333A5 (https=) | 2021-03-18 |
| JP6912664B2 JP6912664B2 (ja) | 2021-08-04 |
Family
ID=66431171
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523700A Active JP6912664B2 (ja) | 2017-11-10 | 2018-11-13 | タピナロフを調製するためのプロセス |
| JP2020216295A Pending JP2021063100A (ja) | 2017-11-10 | 2020-12-25 | タピナロフを調製するためのプロセス |
| JP2021113606A Active JP7166399B2 (ja) | 2017-11-10 | 2021-07-08 | タピナロフを調製するためのプロセス |
| JP2022148508A Pending JP2023002516A (ja) | 2017-11-10 | 2022-09-16 | タピナロフを調製するためのプロセス |
| JP2024022828A Pending JP2024069233A (ja) | 2017-11-10 | 2024-02-19 | タピナロフを調製するためのプロセス |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020216295A Pending JP2021063100A (ja) | 2017-11-10 | 2020-12-25 | タピナロフを調製するためのプロセス |
| JP2021113606A Active JP7166399B2 (ja) | 2017-11-10 | 2021-07-08 | タピナロフを調製するためのプロセス |
| JP2022148508A Pending JP2023002516A (ja) | 2017-11-10 | 2022-09-16 | タピナロフを調製するためのプロセス |
| JP2024022828A Pending JP2024069233A (ja) | 2017-11-10 | 2024-02-19 | タピナロフを調製するためのプロセス |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US10647649B2 (https=) |
| EP (1) | EP3706725A4 (https=) |
| JP (5) | JP6912664B2 (https=) |
| KR (1) | KR102773538B1 (https=) |
| CN (1) | CN111511357B (https=) |
| AU (2) | AU2018365241B2 (https=) |
| BR (1) | BR112020009158A2 (https=) |
| CA (2) | CA3253169A1 (https=) |
| CL (3) | CL2020001226A1 (https=) |
| CO (1) | CO2020007018A2 (https=) |
| IL (2) | IL274439B2 (https=) |
| MX (2) | MX2020004785A (https=) |
| SG (1) | SG11202002576TA (https=) |
| WO (1) | WO2019094934A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107666902B (zh) | 2015-05-21 | 2021-09-21 | 德玛万科学有限责任公司 | 局部药物组合物 |
| US11617724B2 (en) | 2015-05-21 | 2023-04-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
| BR112020009158A2 (pt) | 2017-11-10 | 2020-10-27 | Dermavant Sciences GmbH | processo para o preparo de um composto, composto e composição farmacêutica |
| US11497718B2 (en) | 2018-11-13 | 2022-11-15 | Dermavant Sciences GmbH | Use of tapinarof for the treatment of atopic dermatitis |
| CN115884959A (zh) * | 2020-04-22 | 2023-03-31 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 生物活性的苯酚盐离子络合物 |
| WO2021236709A1 (en) | 2020-05-19 | 2021-11-25 | Teva Pharmaceuticals International Gmbh | Solid state forms of tapinarof |
| JP2023550085A (ja) * | 2020-11-23 | 2023-11-30 | ダーマバント、サイエンシーズ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | タピナロフのゲル、軟膏、およびフォーム製剤ならびに使用方法 |
| CN115703700B (zh) * | 2021-08-03 | 2024-08-16 | 北京颖泰嘉和生物科技股份有限公司 | 1,3-环己二酮的制备方法 |
| WO2023067606A1 (en) * | 2021-10-21 | 2023-04-27 | Sol-Gel Technologies Ltd. | Crystalline polymorph of tapinarof |
| CN121487913A (zh) | 2023-07-21 | 2026-02-06 | 因特奎姆私人控股公司 | 制备本维莫德的方法 |
| WO2025031935A1 (en) | 2023-08-04 | 2025-02-13 | Sandoz Ag | Crystalline forms of tapinarof |
| WO2025043084A2 (en) * | 2023-08-24 | 2025-02-27 | Taro Pharmaceutical Industries Ltd. | Methods of preparing tapinarof and related compounds |
| IT202300023508A1 (it) | 2023-11-08 | 2025-05-08 | Procos Spa | Processo per la preparazione della forma polimorfa iii di tapinarof |
Family Cites Families (44)
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|---|---|---|---|---|
| FR1442295A (fr) | 1964-10-08 | 1966-06-17 | Smith Kline French Lab | Nouveaux dérivés de l'acide beta, beta-diphényl acrylique et leur procédé de préparation |
| JPS5111748A (en) | 1974-07-16 | 1976-01-30 | Taisho Pharmaceutical Co Ltd | Suchirubenjudotaino seizoho |
| JPS5721341A (en) * | 1980-07-15 | 1982-02-04 | Nippon Zeon Co Ltd | Preparation of substituted acetic ester |
| JPS58159410A (ja) | 1982-03-18 | 1983-09-21 | Mitsubishi Chem Ind Ltd | 抗炎症剤 |
| US4515883A (en) | 1983-04-14 | 1985-05-07 | Ricoh Company, Ltd. | Stilbene derivatives, distyryl derivatives and electrophotographic photoconductor comprising at least one of the derivatives |
| EP0170105B1 (en) | 1984-07-07 | 1990-10-17 | Koichi Prof. Dr. Shudo | Benzoic acid derivatives |
| ES2056983T3 (es) | 1988-03-21 | 1994-10-16 | Boehringer Ingelheim Pharma | Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa. |
| GB8915104D0 (en) * | 1989-06-30 | 1989-08-23 | Beecham Group Plc | Chemical process |
| US5268517A (en) | 1989-07-14 | 1993-12-07 | Basf Aktiengesellschaft | Stereoselective preparation of Z-1,2-diarylallyl chlorides and the conversion thereof into azolylmethyloxiranes, and novel intermediates |
| GB9106177D0 (en) | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| JPH06135948A (ja) | 1992-10-30 | 1994-05-17 | Taiho Yakuhin Kogyo Kk | スチレン誘導体又はその塩 |
| EP0640586B1 (en) | 1993-03-10 | 1999-06-09 | Morinaga Milk Industry Co., Ltd. | Stilbene derivative and stilbene analog derivative, and use thereof |
| JPH0753359A (ja) | 1993-06-11 | 1995-02-28 | Kao Corp | リポキシゲナーゼ阻害剤 |
| WO1996041789A1 (fr) * | 1995-06-08 | 1996-12-27 | Firmenich S.A. | Procede pour l'obtention de cetones cycloaliphatiques insaturees |
| JPH1072330A (ja) | 1996-09-03 | 1998-03-17 | Kansai Kouso Kk | チロシナーゼ活性阻害剤及び化粧料 |
| FR2777183B1 (fr) | 1998-04-10 | 2001-03-02 | Oreal | Utilisation d'au moins un hydroxystilbene dans une composition destinee a favoriser la desquamation de la peau et composition le comprenant |
| US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| AU4084599A (en) | 1998-05-18 | 1999-12-06 | Oklahoma Medical Research Foundation | Resveratrol inhibition of myeloperoxidase |
| FR2785284B1 (fr) | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| DE60043120D1 (de) | 1999-12-06 | 2009-11-19 | Welichem Biotech Inc | Polyhydroxystilbene und -stilbenoxide als antipsoriasismittel und proteinkinasehemmer |
| US20080255245A1 (en) * | 1999-12-06 | 2008-10-16 | Welichem Biotech Inc. | Anti-Inflammatory and Psoriasis Treatment and Protein Kinase Inhibition by Hydroxystilbenes and Novel Stilbene Derivatives and Analogues |
| US7321050B2 (en) | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
| JP2001261585A (ja) | 2000-03-15 | 2001-09-26 | Chemiprokasei Kaisha Ltd | ハロゲン化ビニル化合物の合成法 |
| US6410596B1 (en) | 2000-08-16 | 2002-06-25 | Insmed Incorporated | Compositions containing hypoglycemically active stillbenoids |
| US6552085B2 (en) | 2000-08-16 | 2003-04-22 | Insmed Incorporated | Compositions containing hypoglycemically active stilbenoids |
| EP1368306B1 (en) | 2001-01-18 | 2013-01-16 | Welichem Biotech Inc. | Novel 1,2-diphenylethene derivatives for treatment of immune diseases |
| US20030073712A1 (en) | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| AU2003271470B2 (en) | 2002-10-01 | 2010-03-18 | Welichem Biotech Inc. | Novel bioactive diphenyl ethene compounds and their therapeutic applications |
| US9308239B2 (en) | 2008-02-26 | 2016-04-12 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
| JP4426633B2 (ja) * | 2008-04-11 | 2010-03-03 | 花王株式会社 | ２−アルキル−２−シクロアルケン−１−オンの製造方法 |
| US8524782B2 (en) | 2008-07-23 | 2013-09-03 | Laurus Labs Private Limited | Key intermediate for the preparation of Stilbenes, solid forms of Pterostilbene, and methods for making the same |
| CN101531571B (zh) | 2009-04-17 | 2013-03-20 | 河北科技大学 | 六次甲基四胺氧化合成二苯乙烯类化合物的方法 |
| CN101564537B (zh) | 2009-06-08 | 2011-05-25 | 河北科技大学 | 3，5-二羟基-4-异丙基二苯乙烯-溴乙酸乙酯-聚乙二醇复合物及其合成方法 |
| CN101648851B (zh) * | 2009-09-03 | 2012-10-10 | 河北科技大学 | (e)-3,5-二羟基-4-异丙基二苯乙烯的清洁制备方法 |
| CN103172497A (zh) * | 2011-12-23 | 2013-06-26 | 重庆市科学技术研究院 | 治疗牛皮癣新药苯烯莫德的工业化生产工艺 |
| CN104003848B (zh) * | 2013-02-25 | 2016-02-10 | 武汉诺安药业有限公司 | （e）-3,5-二羟基-4-异丙基二苯乙烯制备方法 |
| CN103992212B (zh) * | 2014-05-29 | 2015-07-01 | 河北科技大学 | 顺式苯烯莫德的合成方法及顺式苯烯莫德的应用 |
| EP3229840B1 (en) | 2014-12-12 | 2020-09-09 | Dermavant Sciences GmbH | 3,5-dihydroxy-4-isopropyl-trans-stilbene for use in the topical treatment of acne |
| CN105884581A (zh) * | 2014-12-30 | 2016-08-24 | 上海复星医药产业发展有限公司 | 苯烯莫德的制备方法 |
| US11617724B2 (en) | 2015-05-21 | 2023-04-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
| CN107666902B (zh) | 2015-05-21 | 2021-09-21 | 德玛万科学有限责任公司 | 局部药物组合物 |
| WO2019063002A1 (zh) | 2017-09-30 | 2019-04-04 | 北京文丰天济医药科技有限公司 | 苯烯莫德的晶型及其用途与制备方法 |
| BR112020009158A2 (pt) | 2017-11-10 | 2020-10-27 | Dermavant Sciences GmbH | processo para o preparo de um composto, composto e composição farmacêutica |
| WO2021236709A1 (en) | 2020-05-19 | 2021-11-25 | Teva Pharmaceuticals International Gmbh | Solid state forms of tapinarof |
-
2018
- 2018-11-13 BR BR112020009158-8A patent/BR112020009158A2/pt unknown
- 2018-11-13 CA CA3253169A patent/CA3253169A1/en active Pending
- 2018-11-13 AU AU2018365241A patent/AU2018365241B2/en active Active
- 2018-11-13 IL IL274439A patent/IL274439B2/en unknown
- 2018-11-13 KR KR1020207016222A patent/KR102773538B1/ko active Active
- 2018-11-13 US US16/189,268 patent/US10647649B2/en active Active
- 2018-11-13 CA CA3082115A patent/CA3082115A1/en active Pending
- 2018-11-13 JP JP2020523700A patent/JP6912664B2/ja active Active
- 2018-11-13 MX MX2020004785A patent/MX2020004785A/es unknown
- 2018-11-13 SG SG11202002576TA patent/SG11202002576TA/en unknown
- 2018-11-13 CN CN201880071224.8A patent/CN111511357B/zh active Active
- 2018-11-13 EP EP18875722.3A patent/EP3706725A4/en active Pending
- 2018-11-13 WO PCT/US2018/060749 patent/WO2019094934A1/en not_active Ceased
- 2018-11-13 IL IL304090A patent/IL304090B2/en unknown
-
2020
- 2020-04-15 US US16/849,346 patent/US10961175B2/en active Active
- 2020-05-08 CL CL2020001226A patent/CL2020001226A1/es unknown
- 2020-06-09 CO CONC2020/0007018A patent/CO2020007018A2/es unknown
- 2020-07-13 MX MX2022015106A patent/MX2022015106A/es unknown
- 2020-12-25 JP JP2020216295A patent/JP2021063100A/ja active Pending
-
2021
- 2021-02-12 US US17/174,566 patent/US11597692B2/en active Active
- 2021-07-08 JP JP2021113606A patent/JP7166399B2/ja active Active
-
2022
- 2022-09-16 JP JP2022148508A patent/JP2023002516A/ja active Pending
-
2023
- 2023-01-16 CL CL2023000154A patent/CL2023000154A1/es unknown
- 2023-02-03 US US18/164,309 patent/US12275696B2/en active Active
- 2023-12-04 AU AU2023274224A patent/AU2023274224B2/en active Active
-
2024
- 2024-02-19 JP JP2024022828A patent/JP2024069233A/ja active Pending
- 2024-12-16 CL CL2024003879A patent/CL2024003879A1/es unknown
-
2025
- 2025-03-12 US US19/077,700 patent/US20250270158A1/en active Pending
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