JP2021502113A5 - - Google Patents

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JP2021502113A5
JP2021502113A5 JP2020543733A JP2020543733A JP2021502113A5 JP 2021502113 A5 JP2021502113 A5 JP 2021502113A5 JP 2020543733 A JP2020543733 A JP 2020543733A JP 2020543733 A JP2020543733 A JP 2020543733A JP 2021502113 A5 JP2021502113 A5 JP 2021502113A5
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cells
seq
tgfbr2
nuclease
cancer
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JP2020543733A
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JP7785452B2 (ja
JP2021502113A (ja
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Priority claimed from PCT/US2018/058635 external-priority patent/WO2019089884A2/en
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Priority to JP2023146660A priority Critical patent/JP2023179469A/ja
Priority to JP2025129240A priority patent/JP2025156493A/ja
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JP2020543733A 2017-11-01 2018-11-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素 Active JP7785452B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023146660A JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Applications Claiming Priority (3)

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US201762580320P 2017-11-01 2017-11-01
US62/580,320 2017-11-01
PCT/US2018/058635 WO2019089884A2 (en) 2017-11-01 2018-11-01 Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy

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JP2023146660A Division JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

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JP2021502113A JP2021502113A (ja) 2021-01-28
JP2021502113A5 true JP2021502113A5 (https=) 2021-12-09
JP7785452B2 JP7785452B2 (ja) 2025-12-15

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JP2020543733A Active JP7785452B2 (ja) 2017-11-01 2018-11-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2023146660A Pending JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A Pending JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

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JP2023146660A Pending JP2023179469A (ja) 2017-11-01 2023-09-11 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素
JP2025129240A Pending JP2025156493A (ja) 2017-11-01 2025-08-01 免疫療法のためのｔ細胞におけるｔｇｆｂｒ２のｃｒｉｓｐｒ－ｃａｓ９編集のための方法、組成物、および構成要素

Country Status (12)

Country Link
US (1) US20230061455A1 (https=)
EP (1) EP3704251A2 (https=)
JP (3) JP7785452B2 (https=)
CN (1) CN111527209B (https=)
AU (2) AU2018358250B2 (https=)
BR (1) BR112020008478A2 (https=)
CA (1) CA3081456A1 (https=)
IL (1) IL274299B1 (https=)
MA (1) MA50858A (https=)
MX (2) MX2020004608A (https=)
SG (1) SG11202003862PA (https=)
WO (1) WO2019089884A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
CN110904045A (zh) * 2018-09-17 2020-03-24 中国科学院动物研究所 经修饰的t细胞、其制备方法及用途
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
WO2020223535A1 (en) * 2019-05-01 2020-11-05 Juno Therapeutics, Inc. Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
BR112021021149A2 (pt) 2019-05-29 2021-12-14 Monsanto Technology Llc Métodos e composições para a geração de alelos dominantes utilizando a edição de genomas
MX2021014229A (es) 2019-05-29 2022-01-06 Monsanto Technology Llc Metodos y composiciones para generar alelos dominantes de baja estatura utilizando edicion genomica.
AU2020288829A1 (en) * 2019-06-04 2021-12-02 Nkarta, Inc. Combinations of engineered natural killer cells and engineered T cells for immunotherapy
WO2021011864A1 (en) * 2019-07-18 2021-01-21 Memorial Sloan Kettering Cancer Center METHODS AND COMPOSITIONS FOR TARGETING TGF-β SIGNALING IN CD4+ HELPER T CELLS FOR CANCER IMMUNOTHERAPY
AU2020388690A1 (en) * 2019-11-20 2022-06-09 Cartherics Pty. Ltd. Method for providing immune cells with enhanced function
EP4076476A4 (en) * 2019-12-17 2023-11-22 The General Hospital Corporation MODIFIED IMMUNE CELLS WITH REDUCED TOXICITY AND THEIR USES
IL293946A (en) * 2019-12-18 2022-08-01 Editas Medicine Inc Engineered cells for therapy
KR20210116324A (ko) 2020-03-12 2021-09-27 기초과학연구원 게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법
CN114164231B (zh) * 2020-09-10 2024-05-17 上海邦耀生物科技有限公司 对细胞中的靶位点进行基因编辑的方法
CN116322716A (zh) * 2020-09-23 2023-06-23 克里斯珀医疗股份公司 Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性
US12171813B2 (en) 2021-02-05 2024-12-24 Christiana Care Gene Editing Institute, Inc. Methods of and compositions for reducing gene expression and/or activity
EP4326291A4 (en) * 2021-04-20 2025-03-12 Board of Regents, The University of Texas System Methods and compositions for genetic modification and therapeutic use of immune cells
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
JP2025504931A (ja) * 2022-01-26 2025-02-19 オーソバイオ・セラピューティクス，インコーポレイテッド 関節機能を改善する遺伝子編集
US20230331841A1 (en) * 2022-03-23 2023-10-19 Crispr Therapeutics Ag Anti-cd83 car-t cells with regnase-1 and/or tgfbrii disruption
WO2024058589A1 (ko) * 2022-09-16 2024-03-21 한국과학기술연구원 유전자 가위 넉-인을 이용하여 제조한 키메릭 항원 수용체 세포 및 이의 용도
IL322949A (en) 2023-03-03 2025-10-01 Arsenal Biosciences Inc Systems targeting PSMA and CA9
CN116515766A (zh) * 2023-06-30 2023-08-01 上海贝斯昂科生物科技有限公司 一种自然杀伤细胞、其制备方法及用途
WO2025038637A1 (en) * 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
IL326191A (en) * 2023-08-14 2026-03-01 Intellia Therapeutics Inc Compositions and methods for genetic modification of transforming growth factor beta receptor type 2 (tgfβr2)
WO2025137646A1 (en) 2023-12-22 2025-06-26 Recode Therapeutics, Inc. Gene editing methods and compositions for treating cystic fibrosis
WO2025165915A1 (en) * 2024-01-31 2025-08-07 Adicet Therapeutics, Inc. Compositions and methods for enhancing engineered t cell therapies
US20250345431A1 (en) 2024-05-10 2025-11-13 Juno Therapeutics, Inc. Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
IN165717B (https=) 1986-08-07 1989-12-23 Battelle Memorial Institute
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
ATE533784T1 (de) 1997-10-02 2011-12-15 Altor Bioscience Corp Lösliche, einzelkettige proteine des t- zellrezeptors
WO1999060120A2 (en) 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
EP1109921A4 (en) 1998-09-04 2002-08-28 Sloan Kettering Inst Cancer FUSION RECEPTORS SPECIFIC TO MEMBRANE SPECIFIC PROSTATIC ANTIGEN AND USES THEREOF
US6410319B1 (en) 1998-10-20 2002-06-25 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US20020131960A1 (en) 2000-06-02 2002-09-19 Michel Sadelain Artificial antigen presenting cells and methods of use thereof
ATE338124T1 (de) 2000-11-07 2006-09-15 Hope City Cd19-spezifische umgezielte immunzellen
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
CA2501870C (en) 2002-10-09 2013-07-02 Avidex Limited Single chain recombinant t cell receptors
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
ATE475669T1 (de) 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
JP2008514685A (ja) 2004-10-01 2008-05-08 メディジーン リミテッド 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター
WO2008109546A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof
SI2856876T1 (en) 2007-03-30 2018-04-30 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
EP2486049A1 (en) 2009-10-06 2012-08-15 The Board Of Trustees Of The UniversityOf Illinois Human single-chain t cell receptors
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9987308B2 (en) 2011-03-23 2018-06-05 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
CN104080797A (zh) 2011-11-11 2014-10-01 弗雷德哈钦森癌症研究中心 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法
CA2861491C (en) 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
EP2844743B1 (en) 2012-05-03 2021-01-13 Fred Hutchinson Cancer Research Center Enhanced affinity t cell receptors and methods for making the same
BR122020002986A8 (pt) 2012-08-20 2023-04-18 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Método e composições para imunoterapia celular
MX370148B (es) 2012-10-02 2019-12-03 Memorial Sloan Kettering Cancer Center Composiciones y su uso para inmunoterapia.
CN105247040A (zh) * 2012-10-05 2016-01-13 儿童医院医疗中心 皮脂细胞培养和使用方法
CN104781789B (zh) 2012-12-20 2018-06-05 三菱电机株式会社 车载装置
CN112301024A (zh) * 2013-03-15 2021-02-02 通用医疗公司 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
WO2014204723A1 (en) * 2013-06-17 2014-12-24 The Broad Institute Inc. Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
WO2015048577A2 (en) * 2013-09-27 2015-04-02 Editas Medicine, Inc. Crispr-related methods and compositions
CN106459995B (zh) * 2013-11-07 2020-02-21 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
ES2745769T3 (es) 2014-03-10 2020-03-03 Editas Medicine Inc Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
EP4464338A3 (en) 2014-11-07 2025-02-12 Editas Medicine, Inc. Systems for improving crispr/cas-mediated genome-editing
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
GB2592821B (en) 2015-07-31 2022-01-12 Univ Minnesota Modified cells and methods of therapy
EP3347026A4 (en) * 2015-09-09 2019-05-08 Seattle Children's Hospital (DBA Seattle Children's Research Institute) GENEMANIPULATION OF MACROPHAGES FOR IMMUNOTHERAPY

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