JP2021193148A5 - - Google Patents
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- Publication number
- JP2021193148A5 JP2021193148A5 JP2021160423A JP2021160423A JP2021193148A5 JP 2021193148 A5 JP2021193148 A5 JP 2021193148A5 JP 2021160423 A JP2021160423 A JP 2021160423A JP 2021160423 A JP2021160423 A JP 2021160423A JP 2021193148 A5 JP2021193148 A5 JP 2021193148A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- pharmaceutical preparation
- pharmaceutical
- diazoxide
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims 45
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 13
- 229960004042 diazoxide Drugs 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 229940127557 pharmaceutical product Drugs 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 102000002265 Human Growth Hormone Human genes 0.000 claims 4
- 108010000521 Human Growth Hormone Proteins 0.000 claims 4
- 239000000854 Human Growth Hormone Substances 0.000 claims 4
- 201000001388 Smith-Magenis syndrome Diseases 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 206010020710 Hyperphagia Diseases 0.000 claims 3
- 235000020830 overeating Nutrition 0.000 claims 3
- YLLWQNAEYILHLV-UHFFFAOYSA-N 7-chloro-3-methyl-1$l^{6},2,4-benzothiadiazin-2-ide 1,1-dioxide;2-hydroxyethyl(trimethyl)azanium Chemical group C[N+](C)(C)CCO.C1=C(Cl)C=C2S(=O)(=O)[N-]C(C)=NC2=C1 YLLWQNAEYILHLV-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 210000003141 lower extremity Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 206010004716 Binge eating Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 208000014679 binge eating disease Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023023047A JP7645913B2 (ja) | 2014-11-14 | 2023-02-17 | プラダー－ウィリ症候群またはスミス－マゲニス症候群を有する対象を処置するための方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080150P | 2014-11-14 | 2014-11-14 | |
| US62/080,150 | 2014-11-14 | ||
| US201562138245P | 2015-03-25 | 2015-03-25 | |
| US62/138,245 | 2015-03-25 | ||
| US201562170035P | 2015-06-02 | 2015-06-02 | |
| US62/170,035 | 2015-06-02 | ||
| US201562221359P | 2015-09-21 | 2015-09-21 | |
| US62/221,359 | 2015-09-21 | ||
| JP2020002555A JP6955039B2 (ja) | 2014-11-14 | 2020-01-10 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020002555A Division JP6955039B2 (ja) | 2014-11-14 | 2020-01-10 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023047A Division JP7645913B2 (ja) | 2014-11-14 | 2023-02-17 | プラダー－ウィリ症候群またはスミス－マゲニス症候群を有する対象を処置するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021193148A JP2021193148A (ja) | 2021-12-23 |
| JP2021193148A5 true JP2021193148A5 (https=) | 2022-03-15 |
| JP7232300B2 JP7232300B2 (ja) | 2023-03-02 |
Family
ID=55955075
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544842A Active JP6709226B2 (ja) | 2014-11-14 | 2015-11-12 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
| JP2020002555A Active JP6955039B2 (ja) | 2014-11-14 | 2020-01-10 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
| JP2021160423A Active JP7232300B2 (ja) | 2014-11-14 | 2021-09-30 | プラダー－ウィリ症候群またはスミス－マゲニス症候群を有する対象を処置するための方法 |
| JP2023023047A Active JP7645913B2 (ja) | 2014-11-14 | 2023-02-17 | プラダー－ウィリ症候群またはスミス－マゲニス症候群を有する対象を処置するための方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544842A Active JP6709226B2 (ja) | 2014-11-14 | 2015-11-12 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
| JP2020002555A Active JP6955039B2 (ja) | 2014-11-14 | 2020-01-10 | プラダー−ウィリ症候群またはスミス−マゲニス症候群を有する対象を処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023047A Active JP7645913B2 (ja) | 2014-11-14 | 2023-02-17 | プラダー－ウィリ症候群またはスミス－マゲニス症候群を有する対象を処置するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US10058557B2 (https=) |
| EP (1) | EP3217963B1 (https=) |
| JP (4) | JP6709226B2 (https=) |
| KR (4) | KR102323613B1 (https=) |
| CN (3) | CN121910740A (https=) |
| AU (2) | AU2015346196B2 (https=) |
| BR (1) | BR112017009986A2 (https=) |
| CA (4) | CA3125839C (https=) |
| DK (1) | DK3217963T3 (https=) |
| EA (1) | EA036103B1 (https=) |
| ES (1) | ES2806977T3 (https=) |
| HU (1) | HUE050895T2 (https=) |
| IL (1) | IL252111B (https=) |
| MX (2) | MX381305B (https=) |
| MY (1) | MY187610A (https=) |
| NZ (1) | NZ768958A (https=) |
| PL (1) | PL3217963T3 (https=) |
| SG (1) | SG11201703721SA (https=) |
| WO (1) | WO2016077629A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1781265B1 (en) | 2004-08-25 | 2010-04-07 | Essentialis, Inc. | Pharmaceutical formulations of potassium atp channel openers and uses thereof |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| EP2404604B1 (en) | 2006-01-05 | 2019-02-06 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
| KR102323613B1 (ko) | 2014-11-14 | 2021-11-09 | 에센셜리스 인코포레이티드 | 프라더-윌리 증후군 또는 스미스-마제니스 증후군을 가지는 대상체를 치료하는 방법 |
| AU2017275652B2 (en) * | 2016-06-03 | 2023-02-16 | Levo Therapeutics, Inc. | Methods of treating Prader-Willi syndrome |
| WO2018204721A1 (en) | 2017-05-05 | 2018-11-08 | Nino Sorgente | Methods and compositions for improving eye health |
| US11382881B2 (en) | 2017-05-05 | 2022-07-12 | Nino Sorgente | Methods and compositions for diagnosing and treating glaucoma |
| TW202031283A (zh) * | 2018-09-20 | 2020-09-01 | 馬克 Ｃ 曼寧 | 穩定卡貝縮宮素鼻內製劑 |
| CN111888330B (zh) * | 2020-09-18 | 2022-08-16 | 常州市第四制药厂有限公司 | 一种二氮嗪口服混悬溶液及制备方法 |
| CN120530097A (zh) * | 2022-10-18 | 2025-08-22 | 节奏制药公司 | 新颖的atp敏感性钾通道增效剂、其制备和用途 |
| WO2025057119A1 (en) * | 2023-09-15 | 2025-03-20 | Soleno Therapeutics, Inc. | Methods of managing glycemic control in prader-willi syndrome patients |
| WO2025222188A1 (en) * | 2024-04-18 | 2025-10-23 | Rhythm Pharmaceuticals, Inc. | Novel potassium channel opener compounds and related uses |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2986573A (en) | 1961-01-18 | 1961-05-30 | Schering Corp | Method for the treatment of hypertension |
| GB8601204D0 (en) | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| GB2186485B (en) | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
| US5284845A (en) | 1991-03-14 | 1994-02-08 | Paulsen Elsa P | Use of oral diazoxide for the treatment of disorders in glucose metabolism |
| US5629045A (en) | 1992-09-17 | 1997-05-13 | Richard L. Veech | Biodegradable nosiogenic agents for control of non-vertebrate pests |
| US5399359A (en) | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
| FR2725623A1 (fr) | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| US6225310B1 (en) * | 1996-01-17 | 2001-05-01 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
| AU4133997A (en) | 1996-09-12 | 1998-04-02 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
| US6197765B1 (en) | 1999-06-08 | 2001-03-06 | Pnina Vardi | Use of diazoxide for the treatment of metabolic syndrome and diabetes complications |
| WO2002000223A1 (en) | 2000-06-26 | 2002-01-03 | Novo Nordisk A/S | Use of potassium channel agonists for reducing fat food comsumption |
| TW478039B (en) | 2001-04-09 | 2002-03-01 | Promos Technologies Inc | Phase shift alignment system |
| US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| US6960346B2 (en) | 2002-05-09 | 2005-11-01 | University Of Tennessee Research Foundation | Vehicles for delivery of biologically active substances |
| US20040143213A1 (en) | 2002-11-12 | 2004-07-22 | Collegium Pharmaceutical, Inc. | Inertial drug delivery system |
| US20040204472A1 (en) | 2003-03-04 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents |
| CA2571717A1 (en) * | 2004-06-23 | 2006-01-05 | Josette-Nicole Mahy Gehenne | Compounds for the treatment of inflammation of the central nervous system |
| CN101043879A (zh) * | 2004-08-25 | 2007-09-26 | 伊森舍丽斯有限公司 | 钾atp通道开放剂的药物制剂及其应用 |
| EP1781265B1 (en) | 2004-08-25 | 2010-04-07 | Essentialis, Inc. | Pharmaceutical formulations of potassium atp channel openers and uses thereof |
| AU2005298692A1 (en) * | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CB1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type I, obesity and related conditions |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| CN101257897A (zh) * | 2005-07-07 | 2008-09-03 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| EP2404604B1 (en) | 2006-01-05 | 2019-02-06 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
| US20070293552A1 (en) * | 2006-06-15 | 2007-12-20 | Gorczynski Richard J | Antihypertensive therapy method |
| EP2170341A4 (en) | 2007-07-02 | 2010-12-01 | Essentialis Inc | SALTS OF KALIUM ATP CHANNEL OPENERS AND ITS USES |
| US20120238554A1 (en) | 2007-07-02 | 2012-09-20 | Cowen Neil M | Salts of potassium atp channel openers and uses thereof |
| EP2395987A1 (en) * | 2009-02-12 | 2011-12-21 | Coöperatieve Mirzorg U.A., Arnhem | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| HRP20190062T1 (hr) * | 2011-12-15 | 2019-03-08 | Millendo Therapeutics Sas | Fragmenti neaciliranog grelina za uporabu u liječenju prader-willi sindroma |
| EP2819675A4 (en) | 2012-02-27 | 2015-07-22 | Essentialis Inc | SALTS OF KALIUM ATP CHANNEL OPENERS AND USES THEREOF |
| JP2014074004A (ja) * | 2012-10-05 | 2014-04-24 | Shinichi Niijima | 精神症状の改善剤 |
| WO2014197753A1 (en) | 2013-06-08 | 2014-12-11 | Sedogen, Llc | Method of treating prader willi syndrome and conditions associated with low basal metabolic rate or hyperphagia |
| KR102323613B1 (ko) | 2014-11-14 | 2021-11-09 | 에센셜리스 인코포레이티드 | 프라더-윌리 증후군 또는 스미스-마제니스 증후군을 가지는 대상체를 치료하는 방법 |
-
2015
- 2015-11-12 KR KR1020177016089A patent/KR102323613B1/ko active Active
- 2015-11-12 ES ES15859169T patent/ES2806977T3/es active Active
- 2015-11-12 BR BR112017009986-1A patent/BR112017009986A2/pt not_active Application Discontinuation
- 2015-11-12 CA CA3125839A patent/CA3125839C/en active Active
- 2015-11-12 EP EP15859169.3A patent/EP3217963B1/en active Active
- 2015-11-12 HU HUE15859169A patent/HUE050895T2/hu unknown
- 2015-11-12 MY MYPI2017701659A patent/MY187610A/en unknown
- 2015-11-12 MX MX2017006244A patent/MX381305B/es unknown
- 2015-11-12 CA CA2966907A patent/CA2966907C/en active Active
- 2015-11-12 AU AU2015346196A patent/AU2015346196B2/en active Active
- 2015-11-12 EA EA201791067A patent/EA036103B1/ru unknown
- 2015-11-12 CA CA3125835A patent/CA3125835C/en active Active
- 2015-11-12 WO PCT/US2015/060455 patent/WO2016077629A1/en not_active Ceased
- 2015-11-12 MX MX2021003982A patent/MX393030B/es unknown
- 2015-11-12 DK DK15859169.3T patent/DK3217963T3/da active
- 2015-11-12 NZ NZ768958A patent/NZ768958A/en unknown
- 2015-11-12 SG SG11201703721SA patent/SG11201703721SA/en unknown
- 2015-11-12 CN CN202511504739.0A patent/CN121910740A/zh active Pending
- 2015-11-12 CN CN201580072525.9A patent/CN107106500B/zh active Active
- 2015-11-12 KR KR1020217035884A patent/KR102452254B1/ko active Active
- 2015-11-12 KR KR1020237010935A patent/KR102598666B1/ko active Active
- 2015-11-12 PL PL15859169T patent/PL3217963T3/pl unknown
- 2015-11-12 JP JP2017544842A patent/JP6709226B2/ja active Active
- 2015-11-12 CA CA3210794A patent/CA3210794A1/en active Pending
- 2015-11-12 CN CN202110786768.6A patent/CN113599386B/zh active Active
- 2015-11-12 KR KR1020227029800A patent/KR102517840B1/ko active Active
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2017
- 2017-05-04 IL IL252111A patent/IL252111B/en unknown
- 2017-08-08 US US15/671,792 patent/US10058557B2/en active Active
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2018
- 2018-07-20 US US16/041,237 patent/US10456408B2/en active Active
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2019
- 2019-04-25 AU AU2019202906A patent/AU2019202906B2/en active Active
- 2019-09-17 US US16/573,965 patent/US10874676B2/en active Active
-
2020
- 2020-01-10 JP JP2020002555A patent/JP6955039B2/ja active Active
- 2020-11-25 US US17/104,433 patent/US20210322434A1/en not_active Abandoned
-
2021
- 2021-09-30 JP JP2021160423A patent/JP7232300B2/ja active Active
-
2023
- 2023-02-17 JP JP2023023047A patent/JP7645913B2/ja active Active
-
2024
- 2024-01-24 US US18/421,914 patent/US12109216B2/en active Active
- 2024-09-04 US US18/824,811 patent/US12178823B1/en active Active
- 2024-12-19 US US18/988,636 patent/US12343348B2/en active Active
-
2025
- 2025-05-30 US US19/224,580 patent/US12419895B1/en active Active
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