BR112017009986A2 - métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenis - Google Patents
métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenisInfo
- Publication number
- BR112017009986A2 BR112017009986A2 BR112017009986-1A BR112017009986A BR112017009986A2 BR 112017009986 A2 BR112017009986 A2 BR 112017009986A2 BR 112017009986 A BR112017009986 A BR 112017009986A BR 112017009986 A2 BR112017009986 A2 BR 112017009986A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- syndrome
- katp
- prader
- smith
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 201000010769 Prader-Willi syndrome Diseases 0.000 title abstract 2
- 201000001388 Smith-Magenis syndrome Diseases 0.000 title 1
- 102000016924 KATP Channels Human genes 0.000 abstract 3
- 108010053914 KATP Channels Proteins 0.000 abstract 3
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- 208000031295 Animal disease Diseases 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
trata-se de administração imediata ou prolongada de certos abridores de canal de potássio-atp (katp), opcionalmente em combinação com hormônio de crescimento, a um indivíduo para alcançar resultados farmacodinâmicos, farmacocinéticos, terapêuticos, fisiológicos, metabólicos e composicionais inovadores no tratamento de doenças ou afecções que envolvem canais katp. também são fornecidas formulações farmacêuticas, métodos de administração e dosagem de abridores de canal katp que alcançam esses resultados e reduzem a incidência de efeitos adversos em indivíduos tratados. são fornecidos adicionalmente os métodos de coadministração de abridores de canal katp com outros fármacos (por exemplo, em combinação com hormônio de crescimento) para tratar doenças de humanos e animais (por exemplo, síndrome de prader-willi (pws), síndrome de smith?magenis (sms) e semelhantes.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462080150P | 2014-11-14 | 2014-11-14 | |
US62/080,150 | 2014-11-14 | ||
US201562138245P | 2015-03-25 | 2015-03-25 | |
US62/138,245 | 2015-03-25 | ||
US201562170035P | 2015-06-02 | 2015-06-02 | |
US62/170,035 | 2015-06-02 | ||
US201562221359P | 2015-09-21 | 2015-09-21 | |
US62/221,359 | 2015-09-21 | ||
PCT/US2015/060455 WO2016077629A1 (en) | 2014-11-14 | 2015-11-12 | Methods for treating subjects with prader-willi syndrome or smith-magenis syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017009986A2 true BR112017009986A2 (pt) | 2018-02-14 |
Family
ID=55955075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017009986-1A BR112017009986A2 (pt) | 2014-11-14 | 2015-11-12 | métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenis |
Country Status (20)
Country | Link |
---|---|
US (5) | US10058557B2 (pt) |
EP (1) | EP3217963B1 (pt) |
JP (4) | JP6709226B2 (pt) |
KR (4) | KR102598666B1 (pt) |
CN (2) | CN113599386A (pt) |
AU (2) | AU2015346196B2 (pt) |
BR (1) | BR112017009986A2 (pt) |
CA (4) | CA3125839C (pt) |
DK (1) | DK3217963T3 (pt) |
EA (1) | EA036103B1 (pt) |
ES (1) | ES2806977T3 (pt) |
HK (1) | HK1243954A1 (pt) |
HU (1) | HUE050895T2 (pt) |
IL (1) | IL252111B (pt) |
MX (2) | MX2017006244A (pt) |
MY (1) | MY187610A (pt) |
NZ (1) | NZ768958A (pt) |
PL (1) | PL3217963T3 (pt) |
SG (1) | SG11201703721SA (pt) |
WO (1) | WO2016077629A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008510835A (ja) | 2004-08-25 | 2008-04-10 | エッセンシャリス,インク. | カリウムatpチャンネル開放因子の製剤処方、及びその使用 |
US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
PL1968601T3 (pl) | 2006-01-05 | 2012-03-30 | Essentialis Inc | Sole związków otwierających kanały potasowe ATP i ich zastosowanie |
PL3217963T3 (pl) | 2014-11-14 | 2020-10-19 | Essentialis, Inc. | Sposoby leczenia osobników z zespołem pradera-williego lub smith-magenis |
JP7044768B2 (ja) | 2016-06-03 | 2022-03-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | プラダー・ウィリー症候群を治療する方法 |
US11382881B2 (en) | 2017-05-05 | 2022-07-12 | Nino Sorgente | Methods and compositions for diagnosing and treating glaucoma |
AU2018261756B2 (en) | 2017-05-05 | 2022-01-20 | Nino Sorgente | Methods and compositions for improving eye health |
CA3112185A1 (en) * | 2018-09-20 | 2020-03-26 | Levo Therapeutics, Inc. | Stable intranasal formulations of carbetocin |
CN111888330B (zh) * | 2020-09-18 | 2022-08-16 | 常州市第四制药厂有限公司 | 一种二氮嗪口服混悬溶液及制备方法 |
WO2024086252A1 (en) * | 2022-10-18 | 2024-04-25 | Rhythm Pharmaceuticals, Inc. | Novel atp-sensitive potassium channel potentiators, their preparation and use |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2986573A (en) | 1961-01-18 | 1961-05-30 | Schering Corp | Method for the treatment of hypertension |
GB8601204D0 (en) | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
GB2186485B (en) | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
US5284845A (en) | 1991-03-14 | 1994-02-08 | Paulsen Elsa P | Use of oral diazoxide for the treatment of disorders in glucose metabolism |
US5629045A (en) | 1992-09-17 | 1997-05-13 | Richard L. Veech | Biodegradable nosiogenic agents for control of non-vertebrate pests |
US5399359A (en) | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
FR2725623A1 (fr) | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
US6225310B1 (en) * | 1996-01-17 | 2001-05-01 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
AU4133997A (en) | 1996-09-12 | 1998-04-02 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
US6197765B1 (en) | 1999-06-08 | 2001-03-06 | Pnina Vardi | Use of diazoxide for the treatment of metabolic syndrome and diabetes complications |
AU2001265840A1 (en) | 2000-06-26 | 2002-01-08 | Novo-Nordisk A/S | Use of potassium channel agonists for reducing fat food comsumption |
TW478039B (en) | 2001-04-09 | 2002-03-01 | Promos Technologies Inc | Phase shift alignment system |
US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
US6960346B2 (en) | 2002-05-09 | 2005-11-01 | University Of Tennessee Research Foundation | Vehicles for delivery of biologically active substances |
AU2003287640A1 (en) | 2002-11-12 | 2004-06-03 | Collegium Pharmaceutical, Inc. | Inertial drug delivery system |
US20040204472A1 (en) | 2003-03-04 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents |
AU2005256675A1 (en) | 2004-06-23 | 2006-01-05 | Neurotec Pharma, S.L. | Compounds for the treatment of inflammation of the central nervous system |
JP2008510835A (ja) * | 2004-08-25 | 2008-04-10 | エッセンシャリス,インク. | カリウムatpチャンネル開放因子の製剤処方、及びその使用 |
CN101043879A (zh) * | 2004-08-25 | 2007-09-26 | 伊森舍丽斯有限公司 | 钾atp通道开放剂的药物制剂及其应用 |
MX2007004889A (es) | 2004-10-25 | 2007-09-11 | Solvay Pharm Gmbh | Composiciones farmaceuticas que comprenden antagonistas del receptor cannabinoide cb1 y activadores de canales de potasio para el tratamiento de la diabetes mellitus tipo i, la obesidad y trastornos relacionados. |
US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
PL1968601T3 (pl) | 2006-01-05 | 2012-03-30 | Essentialis Inc | Sole związków otwierających kanały potasowe ATP i ich zastosowanie |
AU2008272923A1 (en) | 2007-07-02 | 2009-01-08 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
US20120238554A1 (en) | 2007-07-02 | 2012-09-20 | Cowen Neil M | Salts of potassium atp channel openers and uses thereof |
EP2395987A1 (en) * | 2009-02-12 | 2011-12-21 | Coöperatieve Mirzorg U.A., Arnhem | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
LT2790721T (lt) * | 2011-12-15 | 2019-02-11 | Millendo Therapeutics Sas | Neacilinto grelino fragmentai, skirti naudoti preiderio-vilio sindromo gydymui |
EP2819675A4 (en) | 2012-02-27 | 2015-07-22 | Essentialis Inc | SALTS OF KALIUM ATP CHANNEL OPENERS AND USES THEREOF |
JP2014074004A (ja) * | 2012-10-05 | 2014-04-24 | Shinichi Niijima | 精神症状の改善剤 |
WO2014197753A1 (en) | 2013-06-08 | 2014-12-11 | Sedogen, Llc | Method of treating prader willi syndrome and conditions associated with low basal metabolic rate or hyperphagia |
PL3217963T3 (pl) | 2014-11-14 | 2020-10-19 | Essentialis, Inc. | Sposoby leczenia osobników z zespołem pradera-williego lub smith-magenis |
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2015
- 2015-11-12 PL PL15859169T patent/PL3217963T3/pl unknown
- 2015-11-12 MX MX2017006244A patent/MX2017006244A/es unknown
- 2015-11-12 SG SG11201703721SA patent/SG11201703721SA/en unknown
- 2015-11-12 EA EA201791067A patent/EA036103B1/ru unknown
- 2015-11-12 EP EP15859169.3A patent/EP3217963B1/en active Active
- 2015-11-12 KR KR1020237010935A patent/KR102598666B1/ko active IP Right Grant
- 2015-11-12 AU AU2015346196A patent/AU2015346196B2/en active Active
- 2015-11-12 KR KR1020177016089A patent/KR102323613B1/ko active IP Right Grant
- 2015-11-12 HU HUE15859169A patent/HUE050895T2/hu unknown
- 2015-11-12 CN CN202110786768.6A patent/CN113599386A/zh active Pending
- 2015-11-12 BR BR112017009986-1A patent/BR112017009986A2/pt not_active Application Discontinuation
- 2015-11-12 MX MX2021003982A patent/MX2021003982A/es unknown
- 2015-11-12 CA CA3125839A patent/CA3125839C/en active Active
- 2015-11-12 CA CA3210794A patent/CA3210794A1/en active Pending
- 2015-11-12 NZ NZ768958A patent/NZ768958A/en unknown
- 2015-11-12 KR KR1020227029800A patent/KR102517840B1/ko active IP Right Grant
- 2015-11-12 DK DK15859169.3T patent/DK3217963T3/da active
- 2015-11-12 CN CN201580072525.9A patent/CN107106500B/zh active Active
- 2015-11-12 KR KR1020217035884A patent/KR102452254B1/ko active IP Right Grant
- 2015-11-12 CA CA3125835A patent/CA3125835C/en active Active
- 2015-11-12 ES ES15859169T patent/ES2806977T3/es active Active
- 2015-11-12 MY MYPI2017701659A patent/MY187610A/en unknown
- 2015-11-12 CA CA2966907A patent/CA2966907C/en active Active
- 2015-11-12 JP JP2017544842A patent/JP6709226B2/ja active Active
- 2015-11-12 WO PCT/US2015/060455 patent/WO2016077629A1/en active Application Filing
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2017
- 2017-05-04 IL IL252111A patent/IL252111B/en unknown
- 2017-08-08 US US15/671,792 patent/US10058557B2/en active Active
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2018
- 2018-03-14 HK HK18103580.0A patent/HK1243954A1/zh unknown
- 2018-07-20 US US16/041,237 patent/US10456408B2/en active Active
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2019
- 2019-04-25 AU AU2019202906A patent/AU2019202906B2/en active Active
- 2019-09-17 US US16/573,965 patent/US10874676B2/en active Active
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2020
- 2020-01-10 JP JP2020002555A patent/JP6955039B2/ja active Active
- 2020-11-25 US US17/104,433 patent/US20210322434A1/en not_active Abandoned
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2021
- 2021-09-30 JP JP2021160423A patent/JP7232300B2/ja active Active
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2023
- 2023-02-17 JP JP2023023047A patent/JP2023056025A/ja active Pending
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2024
- 2024-01-24 US US18/421,914 patent/US20240207284A1/en active Pending
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